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High levels of serum platelet-derived growth factor-AA and human epidermal growth factor receptor-2 are predictors of colorectal cancer liver metastasis

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World Journal of Gastroenterology 2017年第7期23卷 1233-1240页

作者： Hong-Da Pan Yi-fan peng Gang Xiao Jin Gu Department of Gastrointestinal Surgery Beijing Hospital National Center of Gerontology Department of Colorectal Surgery Peking University Cancer Hospital and Institute Beijing Cancer Hospital

AIM To develop predictive markers in blood for colorectal cancer liver *** Twenty colorectal cancer patients were selected and divided into two groups. Group A consisted of 10 patients whose pathological TNM stage was ⅢC(T3-4N2M0), while another 10 patients with synchronous liver metastasis(TNM stage Ⅳ) were recruited for group B. During the surgical procedure, a 10-ml drainage vein(DV) blood sample was obtained from the DV of the tumor-bearing segment prior to the ligation of the DV. At the same time, a 10-ml peripheral vein(PV) blood sample was collected via peripheral venipuncture. The serum levels of 24 molecules that are potentially involved in the mechanism of liver metastasis in both DV blood and PV blood were analyzed by using high-throughput enzyme-linked immunosorbent assay *** Univariate analysis revealed that platelet-derivedgrowth factor AA(PDGFAA) in DV blood(d PDGFAA)(P = 0.001), PDGFAA in PV blood(p PDGFAA)(P = 0.007), and human epidermal growth factor receptor-2 in PV blood(p HER2)(P = 0.001), p MMP7(P = 0.028), pR ANTES(P = 0.013), and pE GF(P = 0.007) were significantly correlated with synchronous liver metastasis. Multivariate analysis identified d PDGFAA(HR = 1.001, P = 0.033) and p HER2(HR = 1.003, P = 0.019) as independent predictive factors for synchronous liver metastasis. Besides, high peripheral HER2 level may also be a risk factor for metachronous liver metastasis, although the difference did not reach statistical significance(P = 0.06). Significant correlations were found between paired DV and PV blood levels for PDGFAA(r = 0.794, P < 0.001), but not for HER2(r = 0.189, P = 0.424).CONCLUSION PDGFAA in tumor drainage and HER2 in PV blood may be useful predictive factors for synchronous liver metastasis of colorectal cancer.

关键词： Platelet-derived growth factor AA Human epidermal growth factor receptor-2 Colorectal cancer Liver metastasis

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Trans-anal minimally invasive surgery for rectal neoplasia:Experience from single tertiary institution in China

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World Journal of Gastrointestinal Oncology 2018年第6期10卷 137-144页

作者： Nan Chen Yi-fan peng Yun-Feng Yao Jin Gu Department of Gastrointestinal Center Unit Ⅲ Peking University Hospital and InstituteBeijing 100142China

AIM To evaluate the feasibility and safety of trans-anal minimally invasive surgery(TAMIS) from single institute in China. METHODS A retrospective review was conducted for patients with rectal neoplasia, who underwent TAMIS using single incision laparoscopic surgery-Port from January 2013 till January 2016 by a group of colorectal surgeons from Gastrointestinal Center Unit Ⅲ, Peking University Cancer Hospital. Patients' demographic data, surgical related information, post-operational pathology, as well as perioperative follow-up were all collected. RESULTS Twenty-five patients with rectal neoplasia were identified consequently. Complete full-thickness excision was achieved in all cases without conversion. 22(88%) cases had rectal malignancies [6 were adenocarcinomas and 16 were neuroendocrine tumors(NET)], while 3 patients had adenomas. Mean surgical duration was 61.3 min, and mean post-operative stay were 2.7 d. Post-operational examination demonstrated 5 cases had positive resection margin: 2 adenocarcinoma cases and 1 NET case with positive lateral margin, and the other 2 NET cases with positive basal margin. The curve of operation time for TAMIS cases suggested a minimum of 10 cases for a laparoscopic surgeon proficient withthis technique. CONCLUSION TAMIS was demonstrated to be reproducible and safe,with a relatively short learning process for laparoscopic surgeons in selected cases for rectal neoplasia. Longterm oncological outcome needs to be determined by further investigation.

关键词： Rectal neoplasia Resection margin Transanal minimally invasive surgery

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Multilocus phylogeny suggests a distinct species status for the Nepal population of Assam macaques(Macaca assamensis):implications for evolution and conservation

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Zoological Research 2021年第1期42卷 3-13页

作者： Laxman Khanal Mukesh Kumar Chalise peng-Fei fan Randall CKyes Xue-Long Jiang Central Department of Zoology Institute of Science and TechnologyTribhuvan UniversityKathmandu 44613Nepal State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650203China Nepal Biodiversity Research Society(NEBORS) Lalitpur 23513Nepal School of Life Sciences Sun Yat-sen UniversityGuangzhouGuangdong 510275China Department of Psychology Global Healthand AnthropologyCenter for Global Field Studyand Washington National Primate Research CenterUniversity of WashingtonSeattle 98195USA

Phylogenetic relationships within the sinica-group of macaques based on morphological,behavioral,and molecular characteristics have remained *** Nepal population of Assam macaques(Macaca assamensis)(NPAM),the westernmost population of the species,is morphologically distinct but has never been used in phylogenetic ***,the phylogenetic relationship of NPAM with other congeners was tested using multiple mitochondrial and Ychromosomal *** divergence times and evolutionary genetic distances among macaques were also *** revealed two major mitochondrial DNA clades of macaques under the sinica-group:the first clade included ***,***,and eastern subspecies of Assam macaque(*** assamensis);the second clade included *** together with species from the eastern and central Himalaya,namely,***,***,and *** the second-clade species,NPAM was the first to diverge from the other members of the clade around 1.9 million years *** results revealed that NPAM is phylogenetically distinct from the eastern Assam macaques and closer to other species and hence may represent a separate *** of its phylogenetic distinctiveness,isolated distribution,and small population size,the Nepal population of sinica-group macaques warrants detailed taxonomic revision and high conservation priority.

关键词： Himalaya Macaques Paraphyletic sinica-group Taxonomy

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CPL-active hybrid copper(Ⅰ)halides enabled by cation inclusion with chiral crown-ether

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Science China Chemistry 2024年第10期67卷 3283-3290页

作者： peng fan Li-Xuan Cai Xiao-fang Duan fan Yin Chen-Chen Li Zhong-Hua Deng Xiao-Zhen Li Qing-Fu Sun College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350117China Strait Institute of Flexible Electronics(Future Technologies) Fujian Key Laboratory of Flexible ElectronicsFujian Normal University and Strait Laboratory of Flexible ElectronicsFuzhou 350117China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Fujian College University of Chinese Academy of SciencesFuzhou 350002China

Chiral hybrid metal halides with high photoluminescence quantum yield(PLQY)and superior dissymmetry factor(g_(lum))are promising candidates for circularly polarized luminescence(CPL)emitting ***,it is a great challenge to achieve both high g_(lum)and large ***,we report a new supramolecular strategy to fabricate chiral hybrid Cu(Ⅰ)-halides with nearunity quantum yields and intense CPL *** dissymmetry factor can be dramatically modulated by tuning the hostguest *** to the chirality and variable conformations of the host-guest complexes,a series of chiral[G@L^(R/S)]_(2)Cu_(4)I_(6)have been *** incorporation of different cations within the chiral L^(R/S)hosts leads to variations of packing modes along the c-axis and different extent of distortions in the[Cu_(4)I_(6)]_(2)-*** them,[H_(3)O@L^(R/S)]+cations are stacked based on Van der Waals interactions and hierarchically self-assemble into a right/left-handed helix in[H_(3)O@L^(R/S)]_(2)Cu_(4)I_(6),which results in a high g_(lum)of-7×10^(-3)and a large PLQY of 96.92%.Notably,[G@L^(R/S)]_(2)Cu_(4)I_(6)shows promising applications in single-component white light emitting diodes(WLEDs),exhibiting a maximum dissymmetry factor of-1.2×10^(-3).The effective host-guest complexation and oriented hierarchical self-assembly provide an effective strategy for the development of high-performance CPL materials.

关键词： host-guest interaction circularly polarized luminescence copper iodide cluster hierarchical self-assembly chirality

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Comprehensive two-dimensional river ice model based on boundary-fitted coordinate transformation method

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Water Science and Engineering 2014年第1期7卷 90-105页

作者： Ze-yu MAO Jing YUAN Jun BAO Xiao-fan peng Guo-qiang TANG Department of Hydraulic Engineering Tsinghua University

River ice is a natural phenomenon in cold regions, influenced by meteorology, geomorphology, and hydraulic conditions. River ice processes involve complex interactions between hydrodynamic, mechanical, and thermal processes, and they are also influenced by weather and hydrologic conditions. Because natural rivers are serpentine, with bends, narrows, and straight reaches, the commonly-used one-dimensional river ice models and two-dimensional models based on the rectangular Cartesian coordinates are incapable of simulating the physical phenomena accurately. In order to accurately simulate the complicated river geometry and overcome the difficulties of numerical simulation resulting from both complex boundaries and differences between length and width scales, a two-dimensional river ice numerical model based on a boundary-fitted coordinate transformation method was developed. The presented model considers the influence of the frazil ice accumulation under ice cover and the shape of the leading edge of ice cover during the freezing process. The model is capable of determining the velocity field, the distribution of water temperature, the concentration distribution of frazil ice, the transport of floating ice, the progression, stability, and thawing of ice cover, and the transport, accumulation, and erosion of ice under ice cover. A MacCormack scheme was used to solve the equations numerically. The model was validated with field observations from the Hequ Reach of the Yellow River. Comparison of simulation results with field data indicates that the model is capable of simulating the river ice process with high accuracy.

关键词： two-dimensional river ice numerical model boundary-fitted coordinate technology river ice process freeze-up MacCormack scheme natural river

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Long-term follow-up of HER2 overexpression in patients with rectal cancer after preoperative radiotherapy:A prospective cohort study

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2048-2060页

作者： Nan Chen Chang-Long Li Yi-fan peng Yun-Feng Yao Department of Gastrointestinal Surgery WardⅢKey laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND The role of HER2 overexpression in rectal cancer is *** To assess the role of HER2 overexpression in the long-term prognosis of rectal *** Data from patients with locally advanced rectal cancer who underwent total mesorectal excision after short-course radiotherapy at Beijing Cancer Hospital between May 2002 and October 2005 were collected.A total of 151 tissue samples of rectal cancer were obtained using rigid proctoscopy before neoadjuvant radiotherapy,followed by immunohistochemistry and fluorescence in situ hybridisation to determine the patients’HER2 expression *** and multivariate analyses of the associations between the clinicopathological factors and HER2 status were *** was estimated and compared using the Kaplan-Meier method based on HER2 expression status,and the differences between groups were verified using the log-rank *** A total of 151 patients were enrolled in this study.A total of 27(17.9%)patients were ultimately confirmed to be *** follow-up duration ranged from 9 mo to 210 mo,with a median of 134 *** metastasis and local recurrence occurred in 60(39.7%)and 24(15.9%)patients,***2 positivity was significantly associated with the pre-treatment lymph node stage(pre-N)(P=0.040),while there were no differences between HER2 status and age,sex,preoperative CEA levels(pre-CEA),T stage,and lympho-vascular *** terms of prognosis,HER2 overexpression was correlated with distant meta stasis(P=0.002)rather than local recurrence(P>0.05).The multivariate analysis demonstrated that elevated pre-CEA[P=0.002,odds ratio(OR)=3.277,97.5%confidence interval(CI):1.543-7.163],post N(+)(P=0.022,OR=2.437,97.5%CI:1.143-5.308)and HER2(+)(P=0.003,OR=4.222,97.5%CI:1.667-11.409)were risk factors for distant *** survival analysis showed that there were significant differences between rectal cancer patients in terms of disease-free survival(DFS)[hazard ra

关键词： HER2 Rectal cancer Distant metastasis Local recurrence Survival

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Coupling mechanism of roof and supporting wall in gob-side entry retaining in fully-mechanized mining with gangue backfilling

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Mining Science and Technology 2011年第6期21卷 829-833页

作者： Ma Zhanguo Gong peng fan Jinquan Geng Minmin Zhang Guowei State Key Laboratory of Geomechanics ＆ Deep Underground Engineering School of Mechanics ＆ Civil Engineering China University of Mining ＆ Technology Xuzhou 221008 China

We analyzed the deformation characteristics of overlying stratum in backfilling with fully-mechanized and retaining roadways along the gob area coal mining technology, and established a mechanical model for the roof key stratum of retaining roadways along gob under the conditions of backfilling and fully- mechanized coal mining technology. Using Winkler elastic foundation theory, we analyzed a part of the key stratum under the action of elastic foundation coupling problem, and derived deflection analyt- ical expressions. Combined with specific conditions, we obtained the deflection curves for the roof key stratum of retaining roadways along gob under the conditions of backfilling and fully-mechanized coal mining technology. On this basis, we adopted the Coulomb's earth pressure theory to solve the problem of lateral pressure of the gangue filling area on the supporting wall beside the roadway and to provide the theoretical basis for reasonable selection of the distance between gangue concrete wall and roof and fur- ther discussion on the supporting stability of roadway.

关键词： Elastic foundation Coal mining with gangue backfilling Gob-side entry retaining Key stratum

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Exploring Majorana zero modes in iron-based superconductors

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Chinese Physics B 2022年第8期31卷 1-13页

作者： Geng Li Shiyu Zhu peng fan Lu Cao Hong-Jun Gao Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

Majorana zero modes(MZMs) are Majorana-fermion-like quasiparticles existing in crystals or hybrid platforms with topologically non-trivial electronic structures. They obey non-Abelian braiding statistics and are considered promising to realize topological quantum computing. Discovery of MZM in the vortices of the iron-based superconductors(IBSs)has recently fueled the Majorana research in a way which not only removes the material barrier requiring construction of complicated hybrid artificial structures, but also enables observation of pure MZMs under higher temperatures. So far,MZMs have been observed in iron-based superconductors including FeTe_(0.55)Se_(0.45),(Li_(0.84)Fe_(0.16))OHFe Se, Ca KFe_(4)As_(4),and Li Fe As. In this topical review, we present an overview of the recent STM studies on the MZMs in IBSs. We start with the observation of MZMs in the vortices in FeTe_(0.55)Se_(0.45)and discuss the pros and cons of FeTe_(0.55)Se_(0.45) compared with other platforms. We then review the following up discovery of MZMs in vortices of Ca KFe_(4)As_(4), impurity-assisted vortices of Li Fe As, and quantum anomalous vortices in FeTe_(0.55)Se_(0.45), illustrating the pathway of the developments of MZM research in IBSs. Finally, we give perspective on future experimental works in this field.

关键词： Majorana zero mode iron-based superconductors topological surface states scanning tunneling microscopy

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Effect of matrix cracking on the time delayed buckling of viscoelastic laminated circular cylindrical shells

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Science China(Technological Sciences) 2008年第12期51卷 2142-2154页

作者： peng fan,FU YiMing & CHEN YaoJun College of Mechanics and Aerospace,Hunan University,Changsha 410082,China College of Mechanics and Aerospace Hunan University Changsha 410082 China

The effect of matrix cracking on the bifurcation creep buckling of viscoelastic laminated circular cylindrical shells is *** viscoelastic behavior of laminas is modeled by Schapery's integral constitutive equation with growing matrix *** values of damage variables are correlated to non-dimensional density of matrix cracks relying on the formulas from mesomechanics approach,and the evolution equation predicting the growth rate of density of matrix cracks is assumed to follow a power type relation with transverse tensile *** governing equations for prebuckling creep deformation and bifurcation buckling of laminated circular cylindrical shells under axial compression are obtained on the basis of the Donnell type shallow shell theory and Kármán-Donnell geometrically nonlinear *** solution strategy is constructed by integrating finite-difference technique,trigonometric series expansion method and Taylor's numerical recursive scheme for convolution *** bifurcation creep buckling of symmetrically laminated glass-epoxy circular cylindrical shells with matrix creep cracking coupled are examined for various geometrical parameters and parameters of damage evolution as well as boundary *** numerical results show that matrix creep cracking remarkably shortens the critic time of bifurcation buckling and reduces the durable critic loads,and its effects become weak and finally vanish with the increase of the ratio of radius to thickness in the case of short laminated circular cylindrical shells,also the influence of the matrix creep cracking is mainly dependent on the boundary conditions at two ends for moderately long circular cylindrical shells.

关键词： viscoelasticity matrix cracking laminated circular cylindrical shell pre-buckling bifurcation creep

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Elevating the comprehensive thermal properties of rare-earth cerates through high-entropy design

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Journal of Materiomics 2024年第5期10卷 1126-1136页

作者： Zhaoxuan Zhang Yiling Huang fan peng Wei Zheng Caifen Jiang Xuemei Song Yi Zeng School of Microelectronics Shanghai UniversityShanghai201800China The State Key Lab of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of ScienceShanghai200050China

In the rapidly evolving aerospace sector,the quest for sophisticated thermal barrier coating(TBC)materials has *** materials are primarily sought for their superior comprehensive thermal characteristics,which include a low thermal conductivity coupled with a high coefficient of thermal expansion(CTE)that synergizes with the *** our study,we adopt a solid-state method to synthesize a series of high-entropy rare-earth cerates:La_(2)Ce_(2)O_(7)(1RC),(La_(1/2)Nd_(1/2))2Ce_(2)O_(7)(2RC),(La_(1/3)Nd_(1/3)Sm_(1/3))_(2)Ce_(2)O_(7)(3RC),(La_(1/4)Nd_(1/4)Sm_(1/4)Eu_(1/4))_(2)Ce_(2)O_(7)(4RC),and(La_(1/5)Nd_(1/5)Sm_(1/5)Eu_(1/5)Gd_(1/5))_(2)Ce_(2)O_(7)(5RC),all sintered at 1,600℃ for 10 *** thoroughly examine their phase structure,morphology,elemental distribution,and thermal *** in-depth analysis of the phonon scattering mechanisms reveals that 4RC and 5RC exhibit exceptional thermal properties:high CTEs of 13.00×10^(−6) K^(−1) and 12.77×10^(−6) K^(−1) at 1,400℃,and low thermal conductivities of 1.55 W/(m·K)and 1.68 W/(m·K)at 1,000℃,*** to other TBC systems,4RC and 5RC stand out for their excellent thermal *** study significantly contributes to the development of high-entropy oxides for TBC applications.

关键词： Thermal barrier coatings(TBCs) Comprehensive thermal properties Coefficient of thermal expansion Thermal conductivity Phonon scattering mechanisms

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