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Chinese Journal of Natural Medicines 2016年第10期14卷 776-782页

作者： pan rong-hua HE Hong-Mei DAI Yue XIA Yu-Feng The Chinese Traditional Medical Hospital of Liyang City Liyang 213300China Department of Chinese Materia Medica Analysis China Pharmaceutical UniversityNanjing 210009China Department of Pharmacology of Chinese Materia Medica China Pharmaceutical UniversityNanjing 210009China

Bergenin, isolated from the herb of Saxifrage stolonifera Curt.(Hu-Er-Cao) has hepatoprotective, anti-inflammatory, antitussive, and neuroprotective activities. The aim of the present study was to establish a simple, rapid, and sensitive RP-HPLC method for determination of bergenin in rat plasma and compare its oral pharmacokinetic behaviors in normal and CCl_4-induced hepatic injury rats. With norisoboldine as an internal standard, chromatographic separation was performed on a C_(18) analytical column with acetonitrile and water(11 : 89, V/V) containing 0.1% formic acid as the mobile phase. A good linearity was obtained over the range of 100^(–1)0 000 ng·m L^(–1). The lower limit of quantification was 50 ng·m L~(^(–1)). The developed method was successfully applied to a study of the pharmacokinetic difference of bergenin(100 mg·kg^(–1)) between normal and hepatic injury rats after oral administration. Marked alterations of pharmacokinetic parameters in hepatic injury rats were observed. Compared to normal rats, the AUC_((0–∞)) of bergenin in hepatic injury rats was elevated to 2.11-fold and C_(max) was increased by 130%, whereas CL value was only 55% of the normal rats, suggesting that the systemic exposure of bergenin was significantly increased under hepatic injury status.

关键词： Bergenin Saxifrage stolonifera Curt HPLC Pharmacokinetic Hepatic injury

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Protective Effects of traditional chinese medicine Pai-Du-Yang-Shen Formula against 5/6 Nepluectomy Induced chronic Renal Failure in Rats

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Protective Effects of traditional chinese medicine Pai-Du-Ya...

Deciphering the role of mtH2O2 in hepatic ischemia-reperfusion injury mechanisms with low-background super-resolution fluorogenic probe

中国中西医结合学会肾脏疾病专业委员会2015年学术年会

作者： pan rong hua 江苏省溧阳市中医院

Objective:To investigate the mechanism of Yang Shen Pai Du Fang(YSPDF)delaying evolve of chronic renal failure and interstitial renal fibrosis by observing the renal function,routine examination of blood,extracelluar ...

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Science China Chemistry 2025年第1期68卷 297-307页

作者： Bin Fang Limin Wang Haoqin Li Jiaxin Zhang Yang Ding pan pan Li Bo Peng hua Bai Lin Li Frontiers Science Center for Flexible Electronics Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials &Engineering Northwestern Polytechnical University Institute of Flexible Electronics (IFE Future Technologies) Xiamen University

Hepatic ischemia-reperfusion injury（HIRI） is characterized by mitochondrial dysfunction and oxidative stress. Monitoring mitochondrial hydrogen peroxide（mtH2O2） levels in real-time through super-resolution imaging is crucial for elucidating its distribution in live cells and its mechanism of action during HIRI. However, low-background fluorogenic probes have been overlooked in the context of super-resolution imaging. In this study, we developed a low-background fluorogenic probe（MitoWG） with the potential for super-resolution morphology-correlated mitochondrial identification to track the fluctuates of mtH2O2in HIRI. Activation of the desirable fluorescence properties of the probe by mtH2O2was confirmed using structural illumination microscopy（SIM）, enabling high-quality mitochondrial imaging with exceptional specificity and *** in mtH2O2levels were successfully observed in both cellular and rat models of HIRI. Furthermore, we associated the decline in mitochondrial redox homeostasis with accelerated mtH2O2production during HIRI, which triggered mitophagy deficiency and led to cell death. In conclusion, Mito-WG possesses excellent photophysical and low-background properties for SIM imaging, making it a promising tool for mtH2O2tracking in HIRI research and clinical diagnosis.

关键词： hepatic ischemia-reperfusion injury low-background mtH2O2-activatable super-resolution imaging fluorogenic probe

Enantioselective reductive conjugate alkenylation of α,β-enones with keto alkenyl acetates by nickel catalysis

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Science China Chemistry 2025年第1期68卷 157-162页

作者： rong-De He Yun-Lei Luo Qiu-Quan pan Qi-Wei Yao Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University

Reactions involving alkenyl acetates offer cost-effective and environmentally friendly routes for alkene synthesis, yet their asymmetric variant remains elusive. Concurrently, asymmetric conjugate alkenylation predominantly centered on nucleophilic addition using alkenyl–M. This manuscript presents an asymmetric reductive conjugate alkenylation reaction involving alkenyl acetates. The method facilitates the enantioselective addition of keto alkenyl groups to α,β-enones, resulting in the formation of unsaturated diketones—a class of useful structural motifs that are challenging to access otherwise. The use of electron-rich Pyroxy ligand is essential for achieving both high reaction efficiency and enantioselectivity.

关键词： nickel alkenylation asymmetric cross-coupling alkenes

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和谐社会的精神健康及其政策选择

中华医院管理杂志 2006年第7期22卷 433-437页

作者：潘荣华安徽医科大学人文学院合肥230032

人的身心健康和全面发展是和谐社会的基本特征,只有科学防治精神疾病,有效促进全民精神健康,依法保障病患群体的基本人权,切实维护家庭和谐、社区和谐,才能构建安定有序的和谐社会。作者简述了和谐社会精神健康的内涵,指出精神健康问题... 详细信息

人的身心健康和全面发展是和谐社会的基本特征,只有科学防治精神疾病,有效促进全民精神健康,依法保障病患群体的基本人权,切实维护家庭和谐、社区和谐,才能构建安定有序的和谐社会。作者简述了和谐社会精神健康的内涵,指出精神健康问题首先是一个公共卫生问题,国家和政府应当高度重视精神健康工作,积极创新精神健康政策,努力营造良好的政策环境,科学防治精神疾病,有效促进全民精神健康和共享和谐社会。

关键词：精神健康政府公共政策和谐社会

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清末民初留日医学生报刊传播西医活动述论

华侨华人历史研究 2011年第3期 58-66页

作者：潘荣华杨芳安徽医科大学人文学院安徽合肥230032

文章以留日医学生报刊为中心,对清末民初留日医学生传播西医活动进行梳理,在此基础上努力复原留日医学生"学医"和"传医"活动的真实面貌,进而管窥留日医学生及其创办的报刊在中国近代西医传播史上的重要地位。清末民初,大批爱国志士心怀... 详细信息

文章以留日医学生报刊为中心,对清末民初留日医学生传播西医活动进行梳理,在此基础上努力复原留日医学生"学医"和"传医"活动的真实面貌,进而管窥留日医学生及其创办的报刊在中国近代西医传播史上的重要地位。清末民初,大批爱国志士心怀医学救国之梦,东渡日本学习现代医学,标志着国人被动接受西医的终结。赴日医学生组织学会,创办报刊,致力于德日派西医体系的传播。德日派西医在中国现代医学史上虽然没有英美派西医的影响力大,但是也为中国医学的近现代转型做出重大贡献。赴日留学生报刊对开启民智,振奋民族精神发挥了不可低估的作用。

关键词：日本留学生西医东渐医学救国华文报刊汪惕予丁福保

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精神障碍患者治疗康复中的伦理和法律问题