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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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Low-protein diets supplemented with glutamic acid or aspartic acid ameliorate intestinal damage in weaned piglets challenged with hydrogen peroxide

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Animal Nutrition 2021年第2期7卷 356-364页

作者： Shuai Chen Xin Wu jielin Duan pan Huang Tiejun Li Yulong Yin Jie Yin College of Animal Science and Technology Hunan Agriculture UniversityHunan Co-Innovation Center of Animal Production SafetyChangsha410128China Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central Ministry of AgricultureHunan Provincial Engineering Research Center of Healthy LivestockKey Laboratory of Agro-ecological Processes in Subtropical RegionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha410125China University of Chinese Academy of Sciences Beijing 100049China

Glutamic acid(Glu)and aspartic acid(Asp)are acidic amino acids with regulatory roles in nutrition,energy metabolism,and oxidative *** study aimed to evaluate the effects of low-protein diets supplemented with Glu and Asp on the intestinal barrier function and energy metabolism in weaned piglets challenged with hydrogen peroxide(H2O2).Forty piglets were randomly divided into 5 groups:NC,PC,PGA,PG,and PA(n=8 for each group).Pigs in the NC and PC groups were fed a low-protein diet,while pigs in the PGA,PG,or PA groups were fed the low-protein diet supplemented with 2.0%Glu+1.0%Asp,2.0%Glu,or 1.0%Asp,*** day 8 and 11,pigs in the NC group were intraperitoneally injected with saline(1 mL/kg BW),while pigs in the other groups were intraperitoneally administered 10%H2O2(1 mL/kg BW).On day 14,all pigs were sacrificed to collect jejunum and ileum following the blood sample collection in the ***,low-protein diets supplemented with Glu or Asp ameliorated the intestinal oxidative stress response in H2O2-challenged piglets by decreasing intestinal expression of genes(P<0.05)(e.g.,manganese superoxide dismutase[MnSOD],glutathione peroxidase[Gpx]-1,and Gpx-4)encoding oxidative stress-associated proteins,reducing the serum concentration of diamine oxidase(P<0.05),and inhibiting apoptosis of the intestinal *** and Asp supple-mentation attenuated the upregulated expression of energy metabolism-associated genes(such as hexokinase and carnitine palmitoyltransferase-1)and the H2O2-induced activation of acetyl-coenzyme A carboxylase(ACC)in the jejunum and adenosine monophosphate-activated protein kinase-acetyl-ACC signaling in the *** Glu and Asp also ameliorated intestinal barrier damage as indicated by restored intestinal histology and *** conclusion,low-protein diets supplemented with Glu and Asp protected against oxidative stress-induced intestinal dysfunction in piglets,suggesting that this approach could be used as a nut

关键词： Glutamate Aspartate Oxidative stress Hydrogen peroxide Apoptosis AMPK

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金代经学与诗学关系研究

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河南社会科学 2025年第1期33卷 111-117页

作者：潘链钰中南财经政法大学新闻与文化传播学院湖北武汉430073

金代经学与诗学发展紧密相关,具体表现在三个方面:一是在经学以儒为本的大纛下,诗学始终保持对风雅精神的传继。二是金源学者变汉宋经学本体之“道”为金源经学之“意”,发为“诚意”“己意”“中意”三端,促进了以意为主的诗学观之建... 详细信息

金代经学与诗学发展紧密相关,具体表现在三个方面:一是在经学以儒为本的大纛下,诗学始终保持对风雅精神的传继。二是金源学者变汉宋经学本体之“道”为金源经学之“意”,发为“诚意”“己意”“中意”三端,促进了以意为主的诗学观之建构。三是金源经学呈现出博采多元的格局,影响了诗学复古与创变两条路径的共同演进。

关键词：金代经学诗学

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Broadband and perfect terahertz absorber based on multilayer metamaterial with cross-ring patterned structures

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Optoelectronics Letters 2025年第1期21卷 1-6页

作者： WEN Jin LIU Zhanzhi WU Zhengwei pan Yu ZHANG Ying School of Science Xi'an Shiyou University Shaanxi Key Laboratory of Measurement and Control Technology for Oil and Gas Wells

Broadband and perfect terahertz absorber based on multilayer metamaterial using cross-ring patterned structures is proposed and investigated. The structure of the absorber is double absorption layers consisting of a chromium cross ring and eight isosceles right triangles. The unique structure of the double absorbing layers excites the electric dipole multimode resonance, giving rise to high absorption performance. Meanwhile, the influence of construal parameters on absorber behavior is also discussed. The numerical results show that the absorption achieves over 90% ranging from 2.45 THz to 6.25 THz and 99% absorption in the range of 3.7—5.3 THz. The realization of broadband and perfect absorber is described using the impedance matching principle. It is obviously found that the absorber is insensitive to the high angle of incidence for both transverse electric(TE) and transverse magnetic(TM) polarizations. Compared with the former reports, this absorber has remarkable improved absorption efficiency and smaller period. The terahertz absorber may be found applications in the fields of energy capture and thermal detection.

关键词： Metamaterials

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Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： Chen Chen Hongyu Xue Qilin Hu Mengfan Wang pan Shang Ziyan Liu Tao Peng Deyang Zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

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MAGiC序列应用于青年志愿者骶髂关节扫描的可行性研究

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磁共振成像 2020年第7期11卷 568-572页

作者：占颖莺姜云萍张珂李文娟潘洁琳方义杰李绍林洪国斌中山大学附属第五医院放射科珠海519000

目的探讨MR集合序列(magnetic resonance image compilation,MAGiC)用于青年志愿者骶髂关节扫描的可行性。材料与方法30名青年志愿者分别行骶髂关节MRI常规序列和MAGiC序列扫描。首先由2名研究者分别对常规序列(T1WI-FSE、T2WIFSE、STIR... 详细信息

目的探讨MR集合序列(magnetic resonance image compilation,MAGiC)用于青年志愿者骶髂关节扫描的可行性。材料与方法30名青年志愿者分别行骶髂关节MRI常规序列和MAGiC序列扫描。首先由2名研究者分别对常规序列(T1WI-FSE、T2WIFSE、STIR)和MAGiC序列(T1WI、T2WI、STIR)图像质量进行评分,采用Kappa检验评价一致性。然后测量信号噪声比(signal noise ratio,SNR)和对比噪声比(carrier to noise ratio,CNR);最后利用MAGiC T2-mapping序列测量骶髂关节面下骨髓T2值。结果60侧骶髂关节纳入本研究。常规序列和MAGiC序列图像质量评分有显著差异(P0.60。MAGiC序列图像的SNR和CNR均优于常规序列(P<0.05)。MAGiC T2-mapping测得骶髂关节面下骨质的T2值(83±8)ms,且髂侧稍高于骶侧(P<0.05)。结论青年志愿者骶髂关节MAGiC序列的图像质量评分较常规序列稍低,但SNR和CNR较优且能获得多组定量参数,可用于骶髂关节MR扫描。

关键词：磁共振成像骶髂关节诊断技术和方法

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

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Characterization of ultraviolet communication in a mixed aerosol environment

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Optoelectronics Letters 2025年第2期 77-84页

作者： ZHAO Taifei SUN Yuxin WANG Wuxin ZHANG Haijun pan Feixiang WU Hao Artificial Intelligence Key Laboratory of Sichuan Province Sichuan University of Science & Engineering Faculty of Automation and Information Engineering Xi'an University of Technology

Wireless ultraviolet (UV) has strong scattering characteristics and can communicate through non-direct *** UV signals are transmitted in the atmosphere,they are affected by the absorption and scattering effects of atmospheric particles and atmospheric turbulence,resulting in attenuation of UV signal energy and reduced reliability of the communication *** paper focuses on the channel model of UV non-direct-view single scattering communication,and simulates and analyzes the communication characteristics of UV light in atmospheric turbulence and mixed aerosol environment under horizontal,vertical and oblique range communication *** results show that at equal relative humidity,the wireless UV non-directive scattering communication performance for vertical communication scenarios is more affected by the mixed aerosol environment and the communication performance is worse.

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动态序列情境对面部表情知觉的影响和作用机制

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心理科学进展 2025年第1期33卷 1-10页

作者：方霞潘之禾浙江大学心理与行为科学系杭州310058

现实生活中,面部表情通常随时间推移呈动态变化,个体对任一表情的解读都可能受其所处的动态序列情境的影响。尽管近年来有研究表明同时呈现的情境信息会对目标表情的知觉产生影响,但对于序列变化的表情信息如何影响目标表情知觉却知之... 详细信息

现实生活中,面部表情通常随时间推移呈动态变化,个体对任一表情的解读都可能受其所处的动态序列情境的影响。尽管近年来有研究表明同时呈现的情境信息会对目标表情的知觉产生影响,但对于序列变化的表情信息如何影响目标表情知觉却知之甚少。本研究拟通过行为实验和眼动技术,借助人工合成和真人表演的动态表情,考察序列变化的表情信息(即动态序列情境)对初始表情和最终表情的知觉的影响及其作用机制。研究成果有助于揭示生态化情境下的面部表情加工机制,为基于人工智能的动态表情识别提供参考。

关键词：面部表情情绪知觉动态序列情境

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A Decoupling-Type Strategy for the Allen-Cahn Equation on Curved Surfaces

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Journal of Mathematical Research with Applications 2025年第1期 73-83页

作者： Xiaoman XIE Qing pan School of Computer and Communication Engineering Changsha University of Science & Technology

In this paper, we construct an efficient decoupling-type strategy for solving the Allen-Cahn equation on curved surfaces. It is based on an FEM-EIEQ(Finite Element Method and explicit-Invariant Energy Quadratization) fully discrete scheme with unconditional energy stability. Spatially the FEM is adopted, using a triangular mesh discretization strategy that can be adapted to complex regions. Temporally, the EIEQ approach is considered, which not only linearizes the nonlinear potential but also gives a new variable that we combine with the nonlocal splitting method to achieve the fully decoupled computation. The strategy can successfully transform the Allen-Cahn system into some completely independent algebraic equations and linear elliptic equations with constant coefficients, we only need to solve these simple equations at each time step. Moreover, we conducted some numerical experiments to demonstrate the effectiveness of the strategy.

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