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Science China(Life Sciences) 2011年第9期54卷 828-834页

作者： FENG ShangYuan pan jianji WU YanAn LIN Duo CHEN YanPing XI GangQin LIN JuQiang CHEN Rong Key Laboratory of OptoElectronic Science and Technology j~Jr Medicine Ministry of Education of China Fujian Normal University Fuzhou 350007 China Fujian Provincial Tumor Hospital Fuzhou 350001 China Fujian Provincial Hospital Fuzhou 350001 China

A surface-enhanced Raman spectroscopy (SERS) method combined with multivariate analysis was developed for non-invasive gastric cancer detection. SERS measurements were performed on two groups of blood plasma samples: one group from 32 gastric patients and the other group from 33 healthy volunteers. Tentative assignments of the Raman bands in the measured SERS spectra suggest interesting cancer-specific biomolecular changes, including an increase in the relative amounts of nucleic acid, collagen, phospholipids and phenylalanine and a decrease in the percentage of amino acids and saccharide in the blood plasma of gastric cancer patients as compared with those of healthy subjects. Principal components analysis (PCA) and linear discriminant analysis (LDA) were employed to develop effective diagnostic algorithms for classification of SERS spectra between normal and cancer plasma with high sensitivity (79.5%) and specificity (91%). A receiver operating characteristic (ROC) curve was employed to assess the accuracy of diagnostic algorithms based on PCA-LDA. The results from this exploratory study demonstrate that SERS plasma analysis combined with PCA-LDA has tremendous potential for the non-invasive detection of gastric cancers.

关键词： surface-enhanced Raman spectroscopy (SERS) blood plasma gastric cancer detection

Prognostic Values of Soluble PD-L1 in Nasopharyngeal Carcinoma

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The initial results of Epstein-Barr virus (EBV)-encoded latent membrane protein-1 (LMP-1) for screening nasopharyngeal carcinoma (NPC)

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： Chen,Yiping Lu,Tianzhu Guo,Qiaojuan Ye,Yunbin pan,jianji Fujian Medical University Cancer Hospital

Background/Objectives:The blockades of the immune checkpoint proteins play significant roles in tumor immunotherapies,particularly the inhibitors of the PD-1/*** aim of this study is to explore the expression difference of immune checkpoint proteins between NPC patients and healthy donors,and investigate the prognostic values of soluble form of programmed death-ligand1 (sPD-L1) in NPC.

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The Chinese-German Journal of Clinical Oncology 2011年第1期10卷 51-55页

作者： Shaojun Lin Qiaojuan Guo Jin Lin Jingfeng Zong Lu Han jianji pan Department of Radiation Oncology Fujian Provincial Cancer Hospital Fujian Medical University Fuzhou 350014China

Objective: Early diagnosis of nasopharyngeal carcinoma (NPC) is an important method to improve the survival ***,the sensitivity and specificity of the screening protocols which was widely used in clinic now are considered to be ***-Barr virus (EBV)-encoded latent membrane protein-1 (LMP-1) is one of the proteins that have been suggested to be a classic oncogene with transformation *** current study set out to discuss the clinical significance of LMP-1 on the screening of ***: Three hundred patients who visited our institution (Department of Radiation Oncology,Fujian Provincial Cancer Hospital,Fuzhou,China) with ENT symptoms between 2007 and 2008 were involved in this study,and all of them were agreed to be involved in this *** only did they undergo nasopharyngeal swab to obtain cells for the LMP-1 polymerase chain reaction (PCR) analysis,but also nasopharyngeal biopsy were taken to identify the ***: An amount of DNA that was sufficient for PCR was extracted from 243 (81%) swab samples,the positive rate of LMP-1 of those with non-nasopharyngeal carcinoma was 3.85% (4/108),which was much lower than those with nasopharyngeal carcinoma (P < 0.05).By detecting LMP-1 in nasopharyngeal swabs,NPC was diagnosed with a sensitivity of 88.15% (119 of 135 patients),specificity of 96.30% (104 of 108 patients),a positive predictive value of 95.2% (119 of 123 patients),a negative predictive value of 86.67% (104 of 120 patients),accuracy of 91.77%,and Youden index of 84.45%.Conclusion: The nasopharyngeal swab coupled with PCR-based EBV LMP-1 detection have high sensitivity and specificity,and also good repeatability,it could serve as part of the screening program for high-risk populations.

关键词： nasopharyngeal carcinoma (NPC) Epstein-Barr virus (EBV) latent membrane protein-1 (LMP-1) early diagnosis

Recombinant adenovirus-p53(Gendicine) sensitizes a pancreatic carcinoma cell line to radiation

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Chinese Journal of Cancer Research 2013年第6期25卷 715-721页

作者： Jinluan Li jianji pan Xianggao Zhu Ying Su Lingling Bao Sufang Qiu Changyan Zou Yong Cai Junxin Wu Ivan W.K.Tham Department of Radiation Oncology Teaching Hospital of Fujian Medical UniversityFujian Provincial Cancer Hospital Department of Radiation Oncology Peking University People's Hospital Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Radiation OncologyPeking University Cancer Hospital & Institute Department of Radiation Oncology National University Cancer Institute

Objective： In this study, we examine the effects of recombinant adenovirus-p53 （rAd-p53） on the pancreatic carcinoma cell line SW1990. Specifically, we determine if expression of rAd-p53 sensitizes these cells to radiation. Methods： Following transfection of SW1990 cells with rAd-p53, we measured expression of P53, P21 and Bax by immunocytochemistry. Both transfected and control cell lines were irradiated with a range of doses, and the survival fractions （SF） were calculated. Dose survival cttrves were constructed and modeled for comparison. Results： Transfection of SW1990 cells with rAd-p53 resulted in increased expression of P53, P21 and Bax in a time-dependent manner. At 96 h after transfection, 89.92% of cells expressed P53, 56.8% expressed P21, and 76.50% expressed Bax. The SF following radiation was lower in the rAd-p53 transfected cells compared to the control cells, suggesting that rAd-p53 sensitizes SW1990 cells to radiation （Do for the experimental and control groups was 2.199 and 2.462, respectively）. Conclusions： Use of the adenoviral vector is an effective means of transfecting SW1990 cells with wild-type P53, and this sensitizes the cell line to irradiation. This work suggests that combining rAd-p53 with radiation therapy in pancreatic cancer may be therapeutically beneficial.

关键词： pancreatic carcinoma recombinant adenovirus-p5 3 (rAd-p 5 3 ) transfection radiosensitization

磁共振全身成像在初诊鼻咽癌远处转移中的应用价值

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中国肿瘤临床 2012年第12期29卷 849-852,860页

作者：肖友平陈韵彬潘建基福建省肿瘤医院放射诊断科福州市350014 福建省肿瘤医院放射治疗科

目的:探讨磁共振全身成像对鼻咽癌初诊患者远处转移的诊断价值。方法:2008年11月至2009年8月对福建省肿瘤医院经病理证实的291例鼻咽癌初诊患者在治疗前一周内行全身磁共振成像(Whole Body Magnetic Resonance Imaging,WB-MRI)、X线胸... 详细信息

目的:探讨磁共振全身成像对鼻咽癌初诊患者远处转移的诊断价值。方法:2008年11月至2009年8月对福建省肿瘤医院经病理证实的291例鼻咽癌初诊患者在治疗前一周内行全身磁共振成像(Whole Body Magnetic Resonance Imaging,WB-MRI)、X线胸片、肝脏超声和^(99m)Tc-MDP核素骨扫描,记录每例患者检出的骨、肺、肝转移灶数目,采用SPSS15.0统计软件,对几种影像方法各自检出的骨、肺、肝转移灶数目行McNemar's检验,比较检出率的差异。结果:本组研究共检出骨转移者24例,共发现骨转移灶95个,其中WB-MRI和骨扫描分别检出71个和36个,两者之间差异有统计学意义(P=0.004)。WB-MRI诊断出肺转移6例,而X线胸片诊断出3例,两者间差异无统计学意义(P>0.25);WB-MRI诊断出肝转移6例,而肝脏超声诊断处4例,两者间差异亦无统计学意义(P>0.05)。此外,WB-MRI和超声分别检出肝血管瘤12例和24例(P<0.01),以及肝囊肿34例和16例(P<0.005)。结论:WB-MRI在检测鼻咽癌全身远处转移有较高的应用价值,可作为其M分期的首选影像学检查。

关键词：全身磁共振弥散加权成像鼻咽癌远处转移

Diagnostic and prognostic Value of Circulating EBV-miR BART 7-3p and miR BART13-3p in Naspharyngeal Carcinoma

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Diagnostic and prognostic Value of Circulating EBV-miR BART ...

外放疗联合仑伐替尼和卡瑞利珠单抗治疗不可切除肝癌的疗效与安全性评价

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： Lu,Tianzhu Guo,Qiaojuan Lin,Keyu Su,Ying Chen,Yan Lin,Shaojun Zong,Jingfeng pan,jianji Fujian University Cancer Hospital Fujian Cancer Hospital

Background Nasopharyngeal carcinoma is an Epstein-Barr virus (EBV) associated *** BamHI A rightward transcripts (BART) encode miRNAs,especially miR BARTs,abnormally highly expressed,and play an essential role in the d...

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中国肿瘤 2024年第5期33卷 420-427页

作者：季洪兵潘建基刘文晖福建医科大学孟超肝胆医院福建福州350028 福建省肿瘤医院福建福州350014

[目的]评价外放疗联合仑伐替尼和卡瑞利珠单抗治疗不可切除肝细胞癌(HCC)的疗效和安全性。[方法]回顾性分析福建医科大学孟超肝胆医院2018年5月1日至2021年3月1日收治85例不可切除的HCC病例,30例不可切除的HCC患者纳入外放疗联合仑伐替... 详细信息

[目的]评价外放疗联合仑伐替尼和卡瑞利珠单抗治疗不可切除肝细胞癌(HCC)的疗效和安全性。[方法]回顾性分析福建医科大学孟超肝胆医院2018年5月1日至2021年3月1日收治85例不可切除的HCC病例,30例不可切除的HCC患者纳入外放疗联合仑伐替尼和卡瑞利珠单抗组(RT+LC),55例纳入仑伐替尼和卡瑞利珠单抗组(LC)。主要研究终点为无进展生存期(PFS)和总生存期(OS)。次要研究终点包括根据改良的实体肿瘤反应评估标准评估肿瘤治疗反应,以及采用不良事件通用术语标准5.0评估的治疗相关不良事件(TRAEs)。采用单因素和多因素Cox回归分析来确定独立的预后因素。[结果]RT+LC组和LC组的中位PFS分别为11.61个月和7.25个月(P=0.036)。RT+LC组和LC组的中位OS分别为20.07个月和12.03个月(P=0.019)。Cox回归分析显示,联合RT是PFS和OS的独立因素(P均0.05),安全性相当。[结论]外放疗联合仑伐替尼和卡瑞利珠单抗治疗不可切除HCC临床效果显著,不良反应可控,是一种安全、有效的治疗方法。

关键词：肝细胞癌放射治疗仑伐替尼卡瑞利珠单抗

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根治性放疗后远处转移鼻咽癌患者的预后分析

中华肿瘤杂志 2015年第3期37卷 216-221页

作者：陈炬辉宗井凤吴君心潘建基福建医科大学省立临床医学院福建省肿瘤医院放疗科福州350014

目的：分析鼻咽癌根治性放疗后发生远处转移患者的预后及其影响因素。方法回顾性分析根治性放疗后发生远处转移的184例鼻咽癌患者的临床资料，分析其预后及其影响因素。结果全组患者的中位生存时间为12个月，1、2、3年生存率分别为50．... 详细信息

目的：分析鼻咽癌根治性放疗后发生远处转移患者的预后及其影响因素。方法回顾性分析根治性放疗后发生远处转移的184例鼻咽癌患者的临床资料，分析其预后及其影响因素。结果全组患者的中位生存时间为12个月，1、2、3年生存率分别为50．6％、30．7％和20．9％。 Cox单因素分析结果显示，放疗后发生转移患者的预后与患者性别、年龄、初诊时T分期、临床分期、初诊治疗时化疗的周期数、初诊放疗技术和剂量无关（均P＞0．05），而与初诊时N分期、初诊时是否化疗、放疗结束至发生远处转移的时间间隔、转移部位、转移后是否化疗及化疗的周期数、转移后是否行姑息放疗有关（均P＜0．05）。初诊时的N分期越晚、初诊时有化疗者、治疗后发生转移的间隔时间短者、多脏器转移以及转移后无放疗或化疗者预后较差（均P＜0．05）。多因素分析结果显示，初诊时N分期、转移部位、转移后是否化疗、转移后是否姑息放疗、初治放疗结束至远处转移的时间间隔是影响远处转移鼻咽癌患者预后的独立因素（均P＜0．05）。结论初诊时N分期、转移部位、转移后是否化疗、转移后是否姑息放疗、初治放疗结束至远处转移的时间间隔是影响远处转移鼻咽癌患者预后的独立因素。全身化疗和局部姑息放疗是转移性鼻咽癌患者的主要治疗方式。

关键词：鼻咽肿瘤肿瘤转移预后治疗

Effects of oral maintenance chemotherapy and predictive value of circulating EBV DNA in metastatic nasopharyngeal carcinoma

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Effects of oral maintenance chemotherapy and predictive valu...

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： Zhou,Han Lu,Tianzhu Guo,Qiaojuan Chen,Yan Chen,Mengwei Chen,Yansong Lin,Yingying Chen,Chuanben Ma,Liqin Xu,Yun Lin,Shaojun pan,jianji Department of Radiation Oncology Fujian Cancer Hospital & Fujian Medical University Cancer Hospital Department of Clinical Laboratory Fujian Cancer Hospital and Fujian Medical University Cancer Hospital

Oral maintenance chemotherapy can effectively prolong overall survival(OS) in many types of metastatic cancer,but its role in metastatic nasopharyngeal carcinoma(mNPC) is *** this study,the efficacy of oral maintenance chemotherapy in mNPC and the effectiveness of circulating tumor EBV-DNA for screening patients were *** June 2016 and December 2017,141 patients with mNPC who received platinum-based systemic chemotherapy were included(median follow-up time,21 months).Patients were classified into two groups according to the administration of oral maintenance *** samples were collected before,during,and after treatment for the measurement of circulating EBV *** 2-year OS was higher for patients who received maintenance chemotherapy than for patients without maintenance chemotherapy(78.9% vs.62.7%,p = 0.016).Patients with undetectable post-treatment EBV-DNA after 4–6 cycles of systemic chemotherapy(n = 73) had a higher 2-year OS than that of patients with detectable EBV-DNA(n = 68)(82.16% vs.51.45%,p = 0.001).For patients with undetectable post-treatment EBV-DNA,OS was better for those with maintenance chemotherapy than for those without(86.7% vs.73%,p = 0.027).For patients with detectable post-treatment EBV-DNA,maintenance chemotherapy did not improve outcomes(49.5% vs.55.4%,p = 0.824).The most common acute events were hematological toxicity,and all were tolerable and *** maintenance chemotherapy with S1 or capecitabine can improve OS in ***-treatment EBV-DNA was an independent prognostic factor for m *** patients with detectable EBV-DNA after systematic chemotherapy,maintenance chemotherapy was not sufficient.

关键词： metastatic nasopharyngeal carcinoma oral maintenance chemotherapy EBV-DNA prognosis

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原发性肝癌术前放疗及免疫治疗的研究进展

中华放射医学与防护杂志 2022年第3期42卷 235-240页

作者：刘文晖郑晓莲胡彩容季洪兵潘建基陈炬辉福建医科大学孟超肝胆医院放疗科福州350025 福建医科大学附属肿瘤医院福建省肿瘤医院放疗科福州350014

我国是肝癌大国,近年来肝癌治疗方式越来越趋于综合性的治疗,主要包括手术、消融、介入栓塞、放疗、化疗、靶向、免疫、肝移植等治疗。目前,肝癌手术切除率低是影响预后主要因素之一,肝癌术前新辅助治疗或转化治疗可以最大程度的提高手... 详细信息

我国是肝癌大国,近年来肝癌治疗方式越来越趋于综合性的治疗,主要包括手术、消融、介入栓塞、放疗、化疗、靶向、免疫、肝移植等治疗。目前,肝癌手术切除率低是影响预后主要因素之一,肝癌术前新辅助治疗或转化治疗可以最大程度的提高手术切除率,改善预后。随着放疗和免疫治疗在肝癌综合治疗中的快速发展,肝癌术前放疗及免疫独特的治疗效果逐渐被证实改善患者预后。故本文通过搜索国内外相关文献报道,综述了肝癌术前放疗及免疫治疗的研究进展。

关键词：原发性肝癌术前放疗免疫治疗新辅助治疗