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Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science China Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan Liu Guanghui Jin Ze Li Shujie Chen Xiaoshuang Dai Liujing Huang Zijing Fan Guihua pan Xiaohan pan Xiangmin Li Michael C Yu Jia Sun Jingxing Ou Hong Chen Liwei Xie College of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the Chromatin immunoprecipitation(ChIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by ChIP-qPCR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang pan Xiong Xin Wang Junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao pan Chenzhe Ma Bin Qi Qingqiang Min Ming Li Huabing Chen Hengte Ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan pan Hao-Lin Zhang Kun-Huan Zhang Jia-Qian Ju Jing-Cai Liu Shao-Chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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Design high-performance narrowband emitters for blue light-emitting diodes through manipulating resonance structure of aromatic heterocycles

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Science China Chemistry 2025年

作者： Yue Yu Lei Xu Wenle Tan Yuyu pan Jiyin Xiao Bohan Wang Guangjun Tian Yuguang Ma Lei Ying Institute of Polymer Optoelectronic Materials and Devices Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials State Key Laboratory of Luminescent Materials and Devices South China University of Technology School of Petrochemical Engineering Shenyang University of Technology Key Laboratory for Microstructural Material Physics of Hebei Province School of Science Yanshan University

Narrowband light-emitting materials play critical roles in improving the color gamut and energy consumption of electroluminescence. Herein we demonstrated that by regulating the ground state resonance structure form of emitters with polycyclic aromatic heterocycles, the high-energy vibration of the C–C bond can be effectively suppressed, resulting in narrow emission like classical cyanine dyes. The designed compounds consist of twist and planar conformation, while having differences in the orientation of the positioning electron-donating(nitrogen) and electron-accepting(carbonyl) groups in the polycyclic aromatic hydrocarbon skeleton. The resulting compound Ac-Ph-Ac with a dominated zwitterionic resonance structure exhibits a relatively wide electroluminescent profile with the full width at half maximum(FWHM) of 42 nm and moderate device performance. In contrast, the “soliton transition” of 2AcPh based on the cyanine limit character effectively suppresses C–C stretching vibration in the polycyclic aromatic heterocycle skeleton, leading to a narrow electroluminescent profile with FWHM of 30 nm(0.16 eV)associated with an impressively high external quantum efficiency of 28.52%, which is among the highest efficiencies of so far reported non-sensitized organic light-emitting diodes.

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High sensitivity dual polarization four channels surface plasmon resonance refractive index sensor with wide detection range and high linearity based on photonic crystal fiber

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Optoelectronics Letters 2025年

作者： CUI Nan pan Honggang ZHANG Ailing ZHAO Zihong CHEN Zhipan ZHANG Bo Tianjin Key Laboratory of Film Electronic and Communication Devices， Engineering Research Center of Optoelectronic Devices and Communication Technology， Ministry of Education， School of Integrated Circuit Science and Engineering， Tianjin University of Technology

In this paper， we propose and numerically characterize the optical characteristics of a high sensitivity dual polarization four channels surface plasmon resonance refractive index sensor with wide detection range and high linearity based on photonic crystal fiber （PCF）. Four light transmission channels are constructed by using big air holes. The small rectangular air hole in the center of the fiber core is used to add asymmetry. We use gold plasma material to achieve better sensing performance. A thin film of TiO2is placed on the PCF surface， which assists gold in the adhesion on PCF. The maximum wavelength sensitivity of the sensor can reach 20000 nm/RIU in both x and y polarization modes. While the maximum wavelength resolution of the sensor is 5×10-6RIU. The average wavelength sensitivity reached 15900nm/RIU and 15800nm/RIU in x and y polarization mode. The sensor features R2=0.9969 / R2=0.9966 high linear performance in x and y polarization mode and the maximum FOM values 509.13 RIU-1/ 489.63 RIU-1in x and y polarization mode. Besides the sensor’s detection range is 1.26-1.36， which is a wide refractive index detection range. The sensor has a wide range of applications in biomedical and other fields.

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Design of a terahertz slotted waveguide array antenna based on photonic crystal

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Optoelectronics Letters 2025年

作者： pan Wu YE Kuan ZHANG Zhen LI Renpu QIU Sen HUANG Lei College of Photoelectronic Engineering， Chongqing University of Posts and Telecommunications Chongqing Municipal Key Laboratory of Photoelectric Information Sensing and Transmission Technology， Chongqing University of Posts and Telecommunications Laboratory of Quantum Information Technology， Chongqing University of Posts and Telecommunications

In this paper， a terahertz slotted waveguide array antenna is designed based on photonic crystal， which can realize efficient radiation of terahertz waves. The electromagnetic wave is fed from the rectangular waveguide at the bottom of the antenna， coupled to photonic crystal waveguide through photonic crystal cavity， and radiated outward through slots at the top layer of antenna. The simulation results show that the antenna achieves a peak gain of 13.45dBi at 360 GHz， a half-power beamwidth of 10.9o， and a side lobe level of -13.9dB. The antenna based on photonic crystal has the advantages of low profile， low loss， and high radiation efficiency， which can be applied to terahertz wireless communication systems.

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Sensitivity improvement by Vernier effect in microwave photonic filter based on F-P fiber ring

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Optoelectronics Letters 2025年

作者： LIN Rui ZHANG Ailing CHANG Pengxiang pan Honggang WANG Minghe WANG Bo Engineering Research Center of Optoelectronic Devices & Communication Technology， Ministry of Education， Tianjin Key Laboratory of Film Electronic and Communication Devices， School of Electrical and Electronic Engineering， Tianjin University of Technology

A high sensitivity fiber optic temperature sensor based on Vernier effect in microwave photonic filter based on two paralleled F-P (Fabry-Perot) fiber ring is proposed and experimentally verified. Sensitivity is improved through the Vernier effect， which is caused by two parallel F-P fiber rings with approximate lengths. Temperature interrogation is achieved by monitoring the notch frequency of the superimposed frequency response curve. The temperature sensitivity of -484.514kHz/℃ is achieved in experiment， which is 57 times of the sensor without Vernier effect. The improved sensitivity and simple structure make it have wide potential applications in temperature monitoring of power systems.

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Characterization of ultraviolet communication in a mixed aerosol environment

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Optoelectronics Letters 2025年第2期 77-84页

作者： ZHAO Taifei SUN Yuxin WANG Wuxin ZHANG Haijun pan Feixiang WU Hao Artificial Intelligence Key Laboratory of Sichuan Province Sichuan University of Science & Engineering Faculty of Automation and Information Engineering Xi'an University of Technology

Wireless ultraviolet (UV) has strong scattering characteristics and can communicate through non-direct *** UV signals are transmitted in the atmosphere,they are affected by the absorption and scattering effects of atmospheric particles and atmospheric turbulence,resulting in attenuation of UV signal energy and reduced reliability of the communication *** paper focuses on the channel model of UV non-direct-view single scattering communication,and simulates and analyzes the communication characteristics of UV light in atmospheric turbulence and mixed aerosol environment under horizontal,vertical and oblique range communication *** results show that at equal relative humidity,the wireless UV non-directive scattering communication performance for vertical communication scenarios is more affected by the mixed aerosol environment and the communication performance is worse.

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