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World Journal of Pediatrics 2016年第3期12卷 347-352页

作者： Yong-Hong Sun Xiao-Yan Lei Yi-pa Sai Jun-Hui Chen Yuan-Chun Sun Xia Gao Department of Pediatrics People's Hospital of Gansu ProvinceLanzhouGansuChina

Background:Hepatitis B virus-associated glomerulonephritis(HBV-GN)is one of the extrahepatic manifestations after HBV infection,which would cause great clinical harm to *** present study was undertaken to investigate the HBV-GN genotypes and its clinical relevance in Chinese ***:A total of 41 HBV-infected children diagnosed with HBV-GN were enrolled in the *** patients underwent liver and kidney *** genotypes and cccDNA were detected in their serum samples to analyze the relationship between HBV genotypes and clinical characteristics,cccDNA,and ***:Among the 41 children with HBV-GN,29(70.7%)had genotype C,10(24.4%)had genotype B,2(4.9%)had genotype B/C,and none of them had genotype non-B/*** children had genotypes B or C;moreover,the genotype C was the most frequent *** incidence of hematuria and albuminuria,reduction in complement C3,increase in serum alanine aminotransferase levels and renal insufficiency in the children with genotype C were signifi cantly higher than those in the children with genotype B(Ppatomegaly(P>0.05).The frequency of HBV cccDNA positive in the genotype C group was significantly higher than that in the genotype B group(72.4%vs.30.0%,Ppatic inflammation grades and stages of fibrosis between the two groups(P>0.05).Conclusion:Genotype C was the most frequent genotype in the described group of patients with HBV-GN,and the liver and kidney damage indicators were more likely to occur in patients with genotype C.

关键词： cccDNA genotypes glomerulonephritis hepatitis B virus pathology

The significance of cherts as markers of Ocean Plate Stratigraphy and paleoenvironmental conditions:New insights from the Neoproterozoic-Cambrian Blovice accretionary wedge,Bohemian Massif

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Geoscience Frontiers 2023年第1期14卷 162-180页

作者： LukášAckerman Jirízák Václav Kachlík Jan pašava KarelZák Andreas pack František Veselovsky Ladislav Strnad Institute of Geology of the Czech Academy of Sciences Rozvojová269CZ-16500 Prague 6Czech Republic Czech Geological Survey Klárov3CZ-11821 Prague 1Czech Republic Institute of Geology and paleontology Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic Geowissenschaftliches Zentrum Universität GöttingenGoldschmidtstraβe 1D-37077 GöttingenGermany Laboratories of the Geological Institutes Faculty of ScienceCharles UniversityAlbertov 6Prague 12843Czech Republic

The Ediacaran to early Cambrian Blovice accretionary complex,Bohemian Massif,hosts abundant chert bodies that formed on an oceanic plate and were involved in subduction beneath the northern margin of *** relationships of cherts to their host,their microstructure and elemental as well as isotopic compositions revealed diverse processes of chert petrogenesis reflecting depositional environment and position on the oceanic *** deep-water cherts formed through a hydrothermal precipitation of silica-rich gels on outer trench swell of the subducted slab with none or only minor addition of terrigenous *** the contrary,the shallow-water cherts formed in lagoons on seamount slopes,and at least some of them represent a product of hydrothermal replacement of former carbonate and/or evaporite *** both chert types,the hydrothermal fluids were of low temperature and continuous pervasive hydrothermal alteration of oceanic crust,together with an elevated Si content in Neoproterozoic seawater,served as the major source of *** the other hand,minor carbon enrichment in chert is mostly linked to variable incorporation of organic matter that was deposited on the *** earth element(REE)systematics of the cherts indicate predominantly oxygenated environment for the shallow-water cherts whereas the deep-water cherts were deposited in diverse redox conditions,depending on their distance from hydrothermal *** these data,we demonstrate that the cherts once formed a part of Ocean Plate Stratigraphy(OPS)now dismembered and mixed with terrigenous siliciclastic material to form OPS mé*** our data with those from the existing literature,we show that cherts can serve as significant markers of OPS since the Archean,recording a complex interplay between seafloor-related volcanic(production of MORB-and OIB-like magmas)and sedimentary processes,hydrothermal activity at mid-ocean ridges and seamount chains as well as at outer slopes o

关键词： Chert Accretionary wedge Ediacaran Triple oxygen isotopes Strontium isotopes Ocean Plate Stratigraphy

Evaluation of Activity patterns in Quinpirole-Treated Rats

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Journal of Behavioral and Brain Science 2014年第7期4卷 291-296页

作者： Carlos L. paíno Servicio de Neurobiología-Investigación Hospital Ramón y Cajal Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS) Madrid Spain

The present study aims to evaluate in rats the activity changes associated to treatments with D2-like receptor agonists using a simple behavioral procedure. Rats receiving a single dose of 1 mg/kg quinpirole or vehicle were scored for 6 spontaneous behaviors at different post-injection times. In each time point, the animals were placed in testing cages for 12 min and video-recorded during the last 2 min. The number of forelimb steps and the time spent sniffing were significantly increased by 15 min post-injection in the quinpirole group. Forelimb steps remained increased for at least 24 h. Scores of time spent sniffing, as well as time inactive and number of hindlimb steps appeared greatly altered at 90 and 180 min, but not at later time points. By 48 h, no differences between control and quinpirole-treated rats were observed. In conclusion, the simple behavioral procedure here proposed—or adaptations of it—provides a sensitive test to evaluate the time course of the effects of D2-like receptor agonists on rat spontaneous activity. Additionally, this test takes into account context-dependent sensitization. It can be adapted to different treatment conditions. This methodology would be useful for the preclinical screening of D2-like receptor drugs, using reduced numbers of animals to test those doses and treatment schedules producing less side-effects.

关键词： Behavioral Activity D2-Like Receptor Agonist Spontaneous Behavior Stepping Sniffing

A new endophytic insect-associated Daldinia species, recognised from a comparison of secondary metabolite profiles and molecular phylogeny

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Fungal Diversity 2013年第3期60卷 107-123页

作者： Sylvie pažoutová Stefanie Follert Jens Bitzer Matthias Keck Frank Surup PetrŠrůtka Jaroslav Holuša Marc Stadler Institute of Microbiology of the ASCR v.v.i.Vídeňská108314220 Prague 4Czech Republic Department Microbial Drugs Helmholtz-Zentrum für Infektionsforschung GmbHInhoffenstrasse 738124 BraunschweigGermany IMD Natural Solutions GmbH Otto-Hahn-Strasse 1544227 DortmundGermany Faculty of Forestry and Wood Sciences Czech University of Life SciencesKamýcká12916521 Prague 6Czech Republic

Xylariaceous endophytes are commonly encountered in plants,and it has recently been found out that insect vectors play a major role in their life cycle,as well as in the apparent host-specificity of the fungal *** this study,a new insect-associated,endophytic anamorph species of Daldinia is recognised from a comparison of (a)morphological and ecological data;(b)molecular phylogenetic data based on rDNA,alpha-actin and beta-tubulin genes;and (c)secondary metabolite profiles based on high performance liquid chromatography/diode array/mass spectrometry(HPLC-DAD/MS)and gas chromatography/mass spectrometry(GC-MS)in comparison with authentic strains of Daldinia and other *** new species,Daldinia hawksworthii,is a symbiont of the willow woodwasp,Xiphydria prolongata,which is in turn preferentially associated with Salix.A comparison of HPLCDAD/MS profiles from standardised cultures revealed the presence of a specific compound,which was not encountered in any of the ca.250 Daldinia strains studied for *** compound was isolated after fermentation of the fungus in 10 l scale by preparative *** elucidation by NMR spectroscopy revealed a novel pyrone,for which the name dalsymbiopyrone is *** compound showed weak antimicrobial and cytotoxic effects and might be a signal molecule involved in the trilateral ecological interaction between the host plant,the insect,and its fungal symbiont.

关键词： Fungi Endophytes Evolution Xylariales Bioactive metabolites Natural products Alpha-pyrones

Transcriptomic signatures decode Th17 cell pathogenicity

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Cellular & Molecular Immunology 2016年第5期13卷 557-559页

作者： pa Reyfman ET Bartom BD Singer Northwestern University Feinberg School of Medicine Department of Medicine Division of Pulmonary and Critical Care Medicine Chicago IL 60611 USA Northwestern University Feinberg School of Medicine Department of Biochemistry and Molecular Genetics Chicago IL 60611 USA

Systems immunology is a growing field that attempts to integrate high-throughput experiments with sophisticated computational analysis and modeling approaches. In the field of systems immunology, single-cell transcrip- tomic profiling （RNA-seq） is an experimental technique that has proven effective for delineating molecular heterogeneity within immune cell subtypes.

关键词： Transcriptomic signatures decode

Adaptive phase field modelling of crack propagation in orthotropic functionally graded materials

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Defence Technology（防务技术） 2021年第1期17卷 185-195页

作者： Hirshikesh Emilio Martínez-paneda Sundararajan Natarajan Department of Mechanical Engineering Indian Institute of Technology MadrasChennai600036India Department of Civil and Environmental Engineering Imperial College LondonLondonSW72AZUK

In this work,we extend the recently proposed adaptive phase field method to model fracture in orthotropic functionally graded materials(FGMs).A recovery type error indicator combined with quadtree decomposition is employed for adaptive mesh *** proposed approach is capable of capturing the fracture process with a localized mesh refinement that provides notable gains in computational *** implementation is validated against experimental data and other numerical experiments on orthotropic materials with different material *** results reveal an increase in the stiffness and the maximum force with increasing material orientation *** study is then extended to the analysis of orthotropic *** is observed that,if the gradation in fracture properties is neglected,the material gradient plays a secondary role,with the fracture behaviour being dominated by the orthotropy of the ***,when the toughness increases along the crack propagation path,a substantial gain in fracture resistance is observed.

关键词： Functionally graded materials Phase field fracture Polygonal finite element method Orthotropic materials Recovery based error indicator

Selective removal technology using chemical etching and excimer assistance in precision recycle of color filter

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 210-214页

作者： pai-shan pa Digital Content Design Graduate School of Toy and Game Design National Taipei University of Education Taipei City 10671 China

Color filters are produced using semiconductor production techniques although problems with low yield remain to be addressed. This study presents a new means of selective removal using excimer irradiation, chemical etching, or electrochemical machining on the fifth generation TFT LCDs. The selective removal of microstructure layers from the color filter surface of an optoelectronic flat panel display, as well as complete removal of the ITO thin-films, RGB layer, or resin black matrix (BM) layer from the substrate is possible. Individual defective film layers can be removed, or all films down to the Cr layer or bare glass can be completely eliminated. Experimental results demonstrate that defective ITO thin-films, RGB layers, or the resin BM layer can now be recycled with a great precision. When the ITO or RGB layer proves difficult to remove, excimer light can be used to help with removal. During this recycling process, the use of 225 nm excimer irradiation before chemical etching, or electrochemical machining, makes removal of stubborn film residues easy, effectively improving the quality of recycled color filters and reducing fabrication cost.

关键词： chemical etching excimer light selective removal technology display color filter

An effective round ball tool in electrochemistry process as novel reuse fabrication technology

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中国有色金属学会会刊：英文版 2012年第S3期22卷 825-830页

作者： P.S.pa Department of Digital Content Design Graduate School of Toy and Game DesignNational Taipei University of Education

A reuse fabrication module using micro electrochemistry (MECM) with a round-ball tool to remove the defective In2O3 SnO2 thin film from the surfaces of digital paper display was *** etching effect improves that the number of the round-balls decreases for promoting the concentration of electric power and increasing discharge *** a small size of the round-ball tool takes less time for the same amount of In2O3 SnO 2 layer removal since the effect of MECM is easily developed for supplying of sufficient electrochemical power.A higher feed rate of the poly ethylene terephthalate (PET) diaphragm combines with enough electric power to drive fast etching rate.A pulsed direct current can improve the effect of dreg discharge and is advantageous to couple this current with the fast feed rate of the *** the ultra-precise etching of In2O 3 SnO2,the optoelectronic semiconductor industry can effectively reuse the defective products,reducing production *** precision etching process is of high efficiency and requires only a short period of time to remove the In2O3 SnO2 nanostructures.

关键词： thin film round-ball tool In2O3SnO2 micro electrochemistry digital paper display

Laryngopharyngeal reflux in patients with reflux esophagitis

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World Journal of Gastroenterology 2008年第28期14卷 4523-4528页

作者： Yung-Chih Lai pa-Chun Wang Jun-Chen Lin Division of Gastroenterology Department of Internal Medicine Cathay General Hospital School of Medicine National Taiwan University School of Medicine Taipei Medical University Taipei 10630 Taiwan China Department of Otolaryngology Cathay General Hospital School of Medicine Fu Jen Catholic University Taipei 10630 School of Public Health China Medical University Taichung 40402 Taiwan China Department of Otolaryngology Cathay General Hospital Taipei 10630 Taiwan China

AIM: To assess the prevalence of laryngopharyngeal reflux (LPR) in patients with reflux esophagitis and dis-close factors contributing to the development of LPR. METHODS: A total of 167 patients who proved to have reflux esophagitis by endoscopy were enrolled. They received laryngoscopy to grade the reflux find-ings for the diagnosis of LPR. We used validated ques-tionnaires to identify the presence of laryngopharyn-geal symptoms, and stringent criteria of inclusion to increase the specificity of laryngoscopic findings. The data of patients were analyzed statistically to find out factors related to LPR. RESULTS: The prevalence rate of LPR in studied sub-jects with reflux esophagitis was 23.9%. Age, hoarse- ness and hiatus hernia were factors significantly as-sociated with LPR. In 23 patients with a hiatus hernia, the group with LPR was found to have a lower trend of esophagitis grading. CONCLUSION: Laryngopharyngeal reflux is present in patients with reflux esophagitis, and three predicting factors were identified. However, the development of LPR might be different from that of reflux esophagi-tis. The importance of hiatus hernia deserves further study.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux disease Reflux esophagitis

pain management in mice using methanol extracts of three plants belongs to family Amaranthaceae

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Asian pacific Journal of Tropical Medicine 2010年第7期3卷 527-530页

作者： Ashok Kumar BS Lakshman K Jayaveera KN Vel Murgan C Arun Kumar pa Vinod Kumar R Meghda Hegade Sridhar SM Department of Pharmacognosy.Sri K.V.College of Pharmacy ChickballapurKarnataka-562101India Department of Pharmacognosy PES College of PharmacyBangaloreKarnatakaIndia Department of Chemistry Jawaharlal Nehru Technological University of College of EngineeringAnantapurAndhra Pradesh.India Department of Pharmacology Sri K.V.College of PharmacyChickbaltapurKarnataka-562101.India Department of Pharmacology Sri K.V.College of PharmacyChickballapurKarnataka-562101India

Objective:To investigate the analgesic activity of methanolic extract of Amaranthus viridis(A. viridis),Amaranthus caudatus(***) and Amaranthus spinosus(***).Methods:In this study,the analgesic activity of methanol extracts of all three plants at doses of 200 and 400 mg/kg were investigated by acetic acid-induced writhings test,hot plate test and tail immersion test for ***:It was found that all the three plants showed significant pain management effect(P<0.01) at a dose of 400 mg/kg,but showed a less significant effect at a dose of 20 mg/kg in the entire tests used for evaluation of analgesic activities(P<0.05).Conclusions:Methanol extracts of ***,*** and *** show potent analgesic activities,and this study provides the scientific proof for their traditional claims.

关键词： Amaranthus viridis Linn Amaranthus caudatus Linn Amaranthus spinosus Linn Analgesic Acetic acid induced writhings