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色谱 2012年第11期30卷 1194-1202页

作者： André Moreni LOpES Jorge Sánchez ROMEU Rolando páez MEIRELES Gabriel Marquez pERERA Rolando perdomo MORALES Adalberto pESSOA Lourdes Zumalacárregui CáRDENAS Department of Biochemical and pharmaceutical Technology School of Pharmaceutical SciencesUniversity of So Paulo(FCF/USP) purification Development Department Center for Genetic Engineering and Biotechnology(CIGB) Center for pharmaceuticals Research and Development(CIDEM) Higher polytechnic Institute José Antonio Echeverría(CUJAE)

Endotoxins(also known as lipopolysaccharides(LpS)) are undesirable by-products of recombinant proteins,purified from Escherichia *** can be considered stable under a wide range of temperature and pH,making their removal one of the most difficult tasks in downstream processes during protein *** inherent toxicity of LpS makes their removal an important step for the application of these proteins in several biological assays and for a safe parenteral *** metal affinity chromatography(IMAC) enables the affinity interactions between the metal ions(immobilized on the support through the chelating compound) and the target molecules,thus enabling high-efficiency separation of the target molecules from other components present in a *** chromatography is applied with ca2+-iminodiacetic acid(IDA) to remove most of the LpS contaminants from the end product(more than90%).In this study,the adsorption of LpS on an IDA-ca2+ was *** adsorption Freundlich isotherm of LpS-IDA-ca2+ provides a theoretical basis for LpS *** was found that LpS is bound mainly by interactions between the phosphate group in LpS and ca2+ ligands on the *** factors such as pH(4.0 or 5.5) and ionic strength(1.0 mol/L) are essential to obtain effective removal of LpS for contaminant levels between endotoxin' concentration values less than100 EU/mL and 100 000 EU/*** new protocol represents a substantial advantage in time,effort,and production costs.

关键词： immobilized metal affinity chromatography(IMAC) lipopolysaccharides(LpS) endotoxin removal recombinant proteins isotherms protein purification

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电渣重熔过程的建模及智能控制方法

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控制与决策 2010年第3期25卷 425-429页

作者：曹方王伟大连理工大学电子与信息工程学院辽宁大连116023

针对电渣炉系统是一个多变量耦合、时滞、参数时变的复杂被控对象,系统难以控制的缺陷,通过大量实验和分析,确立了熔速、磁性调压与二次电压、熔炼电流的相互关系,建立起工程化的控制模型,并提出一种智能控制方法,包括多变量解耦控制策... 详细信息

针对电渣炉系统是一个多变量耦合、时滞、参数时变的复杂被控对象,系统难以控制的缺陷,通过大量实验和分析,确立了熔速、磁性调压与二次电压、熔炼电流的相互关系,建立起工程化的控制模型,并提出一种智能控制方法,包括多变量解耦控制策略、滞后时间模糊自整定和粒子群优化算法整定pID控制器参数.工业应用表明,该方法克服了电渣炉的非线性和强耦合,控制精度高,具有较强的鲁棒性和适应性.

关键词：电渣重熔解耦 pID控制器粒子群优化算法

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Adaptive Agent-Based Modeling Framework for Collective Decision-Making in Crowd Building Evacuation

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Journal of Shanghai Jiaotong university(Science) 2021年第4期26卷 522-533页

作者： CHEN Feier ZHA0 Qiyuan ca0 Mingming CHEN Jiagi FU Guiguan State Key Laboratory of Ocean Engineering Key Laboratory of Marine Intelligent Equipment and System of Ministry of EducationShanghai Jiao Tong UniversityShanghai200240China Marautec Co. Ltd.Shanghai201206China Zhiyuan College Shanghai Jiao Tong UniversityShanghai200240China School of Mathematical Sciences Shanghai Jiao Tong UniversityShanghai200240China Institute of Fintech Shanghai University of Finance and EconomicsShanghai200433China

Crowd evacuation in different situations is an important topic in the research field of safety. This paper presents a hybrid model for heterogeneous pedestrian evacuation simulation. Our adaptive agent-based model (ABM) combines the strength of human crowd behavior description from classical social force models with discrete dynamics expression from cellular automaton models by extending the conception of floor field. Several important factors which may influence the results of decision-making of pedestrians are taken into consideration, such as the location of sign, the attraction of exit, and the interaction among pedestrians. To compare the effect of information on the pedestrians, we construct three decision-making mechanisms with different assumptions. To validate these three simulation models, we compare the numerical results from different perspectives with rational range in the case study where the Tampere Theater evacuation was carried out. The ABM framework is open for rules modification and could be applied to different building plans and has implication for architectural design of gates and signs in order to increase the evacuation efficiency.

关键词： adaptive agent-based model evacuation simulation emergency interaction heterogeneity

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Upscaling conductivity and porosity in three-dimensional heterogeneous porous media

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Chinese Science Bulletin 2004年第22期49卷 2415-2423页

作者： ZHANG Yong Hydrologic Science,University of california,Davis,ca 95616,USA Desert Research Institute,2215 Raggio parkway,Reno,NV 89512,USA Hydrologic Science University of California Davis CA 95616 USA Desert Research Institute 2215 Raggio Parkway Reno NV 89512 USA

An empirical formula is presented to upscale the conductivity of 3-dimensional heterogeneous porous me- dia, in which the distribution of local-scale conductivity is non-Gaussian with a high variance. The upscaled conductiv- ity is determined as a function of the volumetric proportion, the spatial connectivity and the statistical geometric length of high-permeable inclusions, and the arithmetic mean of con- ductivities of all hydrofacies. A systematic comparison to other traditional upscaling methods indicates that this em- pirical formula provides a better estimation of the equivalent conductivity. In the second part of this study, numerical ex- periments of solute migration reveal that porosity also needs to be upscaled to capture the transport of contaminants in a heterogeneous medium using an effective or upscaled homo- geneous medium. This is due to the tendency of contaminants to be preferrentially transported by 3-dimensional pathways composed of high-permeable materials in heterogeneous aquifer systems. The apparent difference between the actual transport velocity of contaminants and the upscaled velocity, based on the equivalent conductivity, forces upscaling of po- rosity. Further systematic analyses demonstrate that the up- scaled porosity follows a non-linear trend as the content of high-permeable sediments decreases. Resultant upscaled porosity, with values varying between 0.004 and 1.5, is be- yond the definition of the traditional porosity on the representative elementary volume (REV) scale. When the content of high-permeable materials is less than 30%, the upscaling of porosity is critical in the simulation of the contaminant transport in a heterogeneous medium using an upscaled, homogeneous counterpart.

关键词：标度方法传导率多孔性三维空间异类多孔介质多孔材料

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polar Duals of Rotors

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Acta Mathematica Sinica,English Series 1996年第1期12卷 40-42页

作者： Ghandehari M. Department of Mathematics Noval postgraduate School Monterey, ca 93943 U. S. A. Department of Mathematics Noval Postgraduate School Monterey USA

Assume K is a rotor in a regular simplex of heihgt 1 in an n-dimensional Euclidean space. Let K~* denote the polar dual of K. Then the volume V(K~*) satisfies the inequality V(K~*)≥(n+1)~nω_n, where ω_n denotes the volume of an n-dimensional unit ball. Equality holds if and only if K is a ball centered at the centroid of the simplex.

关键词： Rotor polar dual Regulor Simplex

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perspectives on atmospheric mercury and its fate in aquatic ecosystems

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Journal of Environmental Sciences 2000年第S1期12卷 85-91页

作者： D.B. porcella (1034 Lindsey Court, Lafayette ca 94549 USA E mail: dporcell@***)

Mercury (Hg) is a neurotoxin to humans and wildlife that has a quantitatively important gas phase that makes its atmospheric cycle an important part of exposure pathways to these organisms. The important atmospheric forms are elemental Hg (Hg(0)), inorganic gas phase Hg (HgH gs ), and inorganic particulate Hg(HgIIp). Each form has different behavior depending on its chemical and physical properties. Generally, scientists have found with trace metal clean sampling and analytical techniques, that background Hg levels are 1—2 ng/m\+3 in air, 0.1—2 ng/L in surface waters, 5—25 ng/L in rainwater, and less than 0.1 μg/g in sediments remote from natural Hg minerals and wastewater sources. values in excess of these concentrations generally indicate local anthropogenic influences or contaminated samples. Broad scale estimates of Hg inputs to the atmosphere suggest that annual anthropogenic fluxes to the atmosphere as Hg(0) are about 40 percent of the total global cycle, oceanic evasion is about 40 percent, and (by difference) the remaining input to the global cycle (20 percent) is evasion from terrestrial sources, largely via soils and vegetation. This paper summarizes recent data that will constrain estimates from these sources. For example, terrestrial sources could approach 40 percent and annual anthropogenic inputs be correspondingly less. Furthermore, a historic perspective is needed because Hg has cycled atmospherically over geologic time. In addition to the uncertainty in source quantification, methylation must be a focus of risk analysis, because this process is responsible for risks to human and ecosystem health for almost all modern day Hg exposures.

关键词： perspectives on atmospheric mercury and its fate in aquatic ecosystems

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小波包频带检索改进算法及其在电机故障诊断中的应用

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太原理工大学学报 2012年第3期43卷 391-395页

作者：吝伶艳宋建成谢特列太原理工大学电气与动力工程学院太原030024

针对目前在利用小波包处理非平稳信号的过程中,存在认为小波包分解频段是按频率连续递增排列的误区,在分析小波包原理和小波包分解重构过程中频段排列特点的基础上,提出一种将小波包分解的频段按照频段由小到大顺序排列的方法,以方便所... 详细信息

针对目前在利用小波包处理非平稳信号的过程中,存在认为小波包分解频段是按频率连续递增排列的误区,在分析小波包原理和小波包分解重构过程中频段排列特点的基础上,提出一种将小波包分解的频段按照频段由小到大顺序排列的方法,以方便所需频段的检索。在Lab-VIEW平台下进行了仿真验证,证明该方法的正确性,并利用改进频段顺序的小波包分解和重构程序对电机转子断条故障进行诊断,取得了很好的效果。

关键词：小波包 LabVIEW 频段排序故障诊断

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分子技术在白血病临床治疗中的应用

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国外医学（肿瘤学分册） 1993年第3期23卷 172-173页

作者： Westbrook ca 杨太成

费城染色体(ph')是最早发现与肿瘤特异性相关的细胞遗传学异常,大部分肿瘤学家对其分子基础都很熟悉.它是9号染色体上的ABL原癌基因和22号染色体上的BCR基因融合而成.BCR-ABL融合基因产生相应的mRNA及嵌合蛋白p210,这种嵌合蛋白质在多... 详细信息

费城染色体(ph')是最早发现与肿瘤特异性相关的细胞遗传学异常,大部分肿瘤学家对其分子基础都很熟悉.它是9号染色体上的ABL原癌基因和22号染色体上的BCR基因融合而成.BCR-ABL融合基因产生相应的mRNA及嵌合蛋白p210,这种嵌合蛋白质在多能造血干细胞中的出现被认为是引起慢粒(CML)的原因.ph'还出现于急性白血病,包括急性髓性的和急淋(ALL),特别是在成人ALL中出现率高达30%.

关键词：分子技术白血病

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白介素1在疾病中的作用

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国外医学（创伤与外科基本问题分册） 1993年第3期14卷 141-144页

作者： Dinarello ca 王群

白介素1(IL-1)族由两种促效剂(IL-1α和IL-1β)和一种拮抗剂(IL-1受体拮抗剂)组成。IL-1在多种疾病中具有致病作用,故减少其生成或阻断其作用适于治疗急、慢性疾病。

关键词：白细胞介素1 病理

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Highly compliant planar Hall effect sensor with sub 200 nT sensitivity

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npj Flexible Electronics 2019年第1期3卷 25-30页

作者： pablo Nicolás Granell Guoliang Wang Gilbert Santiago cañon Bermudez Tobias Kosub Federico Golmar Laura Steren Jürgen Fassbender Denys Makarov Helmholtz-Zentrum Dresden-Rossendorf e.V. Institute of Ion Beam Physics and Materials ResearchBautzner Landstrasse 40001328 DresdenGermany Instituto Nacional de Tecnología Industrial(INTI) Centro de Micro-y Nanoelectrónica del Bicentenario(CMNB)Av.Gral Paz 5445B1650KNA San MartínBuenos AiresArgentina Escuela de Ciencia y Tecnología UNSAMCampus MigueleteB1650KNA San MartínBuenos AiresArgentina Consejo Nacional de Investigaciones Científicas y Técnicas C1425FQB Ciudad Autónoma de Buenos AiresArgentina Instituto de Nanociencia y Nanotecnología B1650KNA San MartínBuenos AiresArgentina Dpto.Materia Condensada Centro Atómico ConstituyentesB1650 San MartínBuenos AiresArgentina

Being a facet of flexible electronics,mechanically reshapeable magnetic field sensorics enable novel device ideas for soft robotics,interactive devices for virtual-and augmented reality and point of care *** applications demand mechanically compliant yet robust sensor devices revealing high sensitivity to small magnetic *** push the detection limit of highly compliant and linear magnetic field sensors to be in the sub-µT range,we explore a new fundamental concept for magnetic field sensing,namely the planar Hall effect in magnetic thin *** their remarkable bendability down to 1 mm,these compliant planar Hall effect sensors allow for an efficient detection of magnetic fields as small as 200 nT with a limit of detection of 20 *** demonstrate the application potential of these devices as a direction(angle)as well as proximity(distance)sensors of tiny magnetic fields emanating from magnetically functionalized *** their intrinsic linearity and simplicity of fabrication,these compliant planar Hall effect sensors have the potential to become a standard solution for low field applications of shapeable magnetoelectronics in point of care applications and on-skin interactive electronics.

关键词： interactive planar limit

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