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Determination of 4-nonylphenol and 4-tert-octylphenol compounds in various types of wastewater and their removal rates in different treatment processes in nine wastewater treatment plants of Iran

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Chinese Journal of Chemical Engineering 2018年第1期26卷 183-190页

作者： Bijan Bina Farzaneh Mohammadi Mohammad Mehdi Amin Hamid Reza pourzamani Zeynab yavari Environment Research Center School of HealthIsfahan University of Medical Sciences Student Research Center School of HealthIsfahan University of Medical Sciences

Alkylphenols(Aps), considered as xenoestrogenic compounds, mainly exist as 4-nonylphenol(4-Np) and 4-tertoctylphenol(4-t-Op) in environments. The high stability and accumulation of Aps in aquatic systems have caused endocrine disruption. In this study we measured Aps in the wastewater influent and effluent samples, from the urban, rural, livestock, commercial and hospital wastewater treatment plants(WWTps) in Iran. Dispersive liquid–liquid microextraction(DLLME) combined with gas chromatography–mass spectrometry(GC–MS) was used for the extraction and determination of 4-Np and 4-t-Op. In these treatment plants, various processes such as activated sludge, aerated lagoon, moving bed biofilm reactor and activated sludge along with wetland were applied. The highest concentration of 4-Np and 4-t-Op was observed in commercial and livestock sewages. The activated sludge along with wetland and then the MBBR process showed the highest removal rates of pollutants. The rates of biodegradability and accumulation in sludge were determined and also the specific adsorption coefficient Kdand the organic carbon–water partition coefficient kOCof the sludge for Aps were calculated.

关键词： Alkylphenols DLLME Full scale WWTp Biodegradation Adsorption

A Review of Machine Learning and Algorithmic Methods for protein phosphorylation Site prediction

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Genomics, proteomics & Bioinformatics 2023年第6期21卷 1266-1285页

作者： Farzaneh Esmaili Mahdi pourmirzaei Shahin Ramazi Seyedehsamaneh Shojaeilangari Elham yavari Department of Information Technology Tarbiat Modares UniversityTehran 14115-111Iran Department of Biophysics Faculty of Biological SciencesTarbiat Modares UniversityTehran 14115-111Iran Biomedical Engineering Group Department of Electrical Engineering and Information TechnologyIranian Research Organization for Science and Technology(IROST)Tehran 33535-111Iran

post-translational modifications(pTMs)have key roles in extending the functional diversity of proteins and,as a result,regulating diverse cellular processes in prokaryotic and eukaryotic *** modification is a vital pTM that occurs in most proteins and plays a significant role in many biological *** in the phosphorylation process lead to multiple diseases,including neurological disorders and *** purpose of this review is to organize this body of knowledge associated with phosphorylation site(p-site)prediction to facilitate future research in this *** first,we comprehensively review all related databases and introduce all steps regarding dataset creation,data preprocessing,and method evaluation in p-site ***,we investigate p-site prediction methods,which are divided into two computational groups:algorithmic and machine learning(ML).Additionally,it is shown that there are basically two main approaches for p-site prediction by ML:conventional and end-to-end deep learning methods,both of which are given an ***,this review introduces the most important feature extraction techniques,which have mostly been used in p-site ***,we create three test sets from new proteins related to the released version of the database of protein post-translational modifications(dbpTM)in 2022 based on general and human *** online p-site prediction tools on newly added proteins introduced in the dbpTM 2022 release,distinct from those in the dbpTM 2019 release,reveals their *** other words,the actual performance of these online p-site prediction tools on unseen proteins is notably lower than the results reported in their respective research pape.

关键词： phosphorylation Machinelearning Deep learning post-translational modification Database

Serrated Flow Model for Metallic Glasses under Compressive Loading

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Acta Metallurgica Sinica(English Letters) 2013年第5期26卷 503-508页

作者： M.A.Yousfi K.Hajlaoui Z.Tourki A.R.yavari Laboratoire de Mcanique de Sousse LMS ENISo Universit de Sousse SIMap-LTpCM Institut National Polytechnique de Grenoble

A rheological model is proposed that incorporates the serrated flow nature of metallic glasses. It involves the process of the nucleation, propagation and the arrest of a shear bands in the samples subjected to compressive deformation at room temperature. Numerical resolution of the constitutive equations resulting from the model is compared with the stress-strain curve obtained from in-situ nano-compression test in SEM of Zrbased metallic glass. parametric identification method was applied and enabled us to release the physical parameters of the model. The obtained results showed that the model is adequately valid to describe the experimental data and the almost adjustable model parameters are physically meaningful and comparable to literature.

关键词： Metallic glasses Shear bands Serrated flow Rheological modelling Nanocrystallization

The occurrence,fate,and distribution of natural and synthetic hormones in different types of wastewater treatment plants in Iran

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Chinese Journal of Chemical Engineering 2018年第5期26卷 1132-1139页

作者： Mohammad Mehdi Amin Bijan Bina Afshin Ebrahimi Zeynab yavari Farzaneh Mohammadi Somayeh Rahimi Environment Research Center Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences Department of Environmental Health Engineering School of Health Isfahan University of Medical Sciences Student Research Committee Isfahan University of Medical Sciences

Over the past few years, the presence of steroid estrogens in the environment has become a major concern. In this study, the concentrations of estrone （El）, 17β-estradinl （E2）, and 17α-ethinyl estradiol （EE2） were measured in some wastewater treatment plants （WWTps） in lran. These samples were collected from the municipal, rural, livestock, commercial, and hospital WWTps, extracted by dispersive liquid-liquid micro extraction （DLLME） technique, derivatized, and detected by GC/MS. In these treatment plants, various processes including conven- tional activated sludge （CAS）, aerated lagoon （AL）, moving bed biofilm reactor （MBBR）, and activated sludge with wetland （AS ＋ WL） are used. The highest concentration of hormones was observed in the influents and effluents of livestock, municipal, commercial, and hospital WWTps, respectively. The maximum elimination rate was obtained in MBBR followed by AS ＋ WL CAS and AL The biodegradation and adsorption rates along with adsorption coefficients of 1g kd and 1g koc were measured for all target compounds.

关键词： Influent Effluent Estrogen Wastewater Biodegradation

Evaluation of the effects of Alkyl phenolic compounds on kinetic coefficients and biomass activity in MBBR by means of respirometric techniques

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Chinese Journal of Chemical Engineering 2018年第4期26卷 822-829页

作者： Bijan Bina Farzaneh Mohammadi Mohammad Mehdi Amin Hamid Reza pourzamani Zeynab yavari Environment Research Center Research Institute for Primordial Prevention of Non-communicable Disease Isfahan University of Medical Sciences Department of Environmental Health Engineering School of Health Isfahan University of Medical Sciences Student Research Committee Isfahan University of Medical Sciences

The presence of Alkyl phenols(Aps) in aquatic systems is considered as one of the environmental concerns in recent decades which are generally used as surfactants. Aps are endocrine disruptors and estrogen-mimicking,causing harmful effects such as feminization and carcinogenesis on aquatic environment and human *** most commercially important Aps are 4-Nonyl phenol(4-Np) and 4-tert-Octylp henol(4-t-Op). Moving bed biofilm reactor(MBBR), which combined attached and suspended growth advantages, is an advanced biological treatment process for municipal and industrial wastewaters that has drawn considerable attention from many researchers to remove toxic pollutants from wastewater. The aim of this research was to evaluate Bacterial activities and kinetic coefficients in the presence of Aps. This study was carried out using laboratory-scale MBBR fed with synthetic wastewater containing 4-Np and 4-t-Op. The reactor was operated at different loads of chemical oxygen demand(COD) and Aps and different hydraulic retention time(HRT). The respirometric technique was applied to investigate the effect of Aps on heterotrophic and autotrophic activity and kinetic coefficients in biomass obtained from MBBR. Respirometric technique demonstrates a reliable tool in order to assess the biofilm kinetic coefficients and biomass viability to insert in the mathematical models. The calculated kinetic parameters were in the range of conventional and extended aeration activated sludge processes. The results demonstrate that Aps have significant inhibitory effects on activity and growth rate of heterotrophic and autotrophic bacteria, heterotrophs have been less affected by the presence of 4-Np and 4-t-Op, and these compounds had greater inhibitory effects on autotrophic bacteria.

关键词： Alkyl phenols Autotrophs Heterotrophs Kinetic coefficients MBBR Respirometric techniques

Formation of thiazol-2(3H)-imines by reaction of α-amino acids, aroylisothiocyanates, and α-bromoketones in an ionic liquid

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Chinese Chemical Letters 2014年第1期25卷 119-122页

作者： Ashraf S.Shahvelayati Issa yavari Akram S.Delbari Department of Chemistry Shahr-e Ray BranchIslamic Azad UniversityTehran 18155-144Iran Department of Chemistry Tarbiat Modares UniversityTehran 14115-175Iran Department of Chemistry Islamshahr BranchIslamshahr 33135-369Iran

An efficient one-pot synthesis of functionalized thiazol-2（3H）-imines by a three-component reaction between aroylisothiocyanates, α-amino acids, and α-bromoketones in an ionic liquid is described.

关键词： Aroylisothiocyanate α-Amino acidsS-Nucleophile α-BromoketonesIonic liquid

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.V.p.Sakamuri Anil Sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Aero-thermal redesign of a high pressure turbine nozzle guide vane

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propulsion and power Research 2019年第4期8卷 310-319页

作者： Hadi yavari Ali Khavari Mohammad Alizadeh Behrad Kashfi Hiwa Khaledi School of Mechanical Engineering Sharif University of TechnologyTehranIran Islamic Azad University Science and Research BranchTehranIran College of Engineering University of TehranTehranIran K.N.Toosi University of Technology TehranIran

The current article presents conceptual,preliminary and detailed aero-thermal redesign of a typical high pressure turbine nozzle guide *** targets are lower coolant consumption,reduced manufacturing costs and improved *** goals are sought by 25%reduction in vane count number and lower number of airfoils per *** challenges such as higher airfoil loading,associate aerodynamic losses and higher thermal loads are *** order to maximize coolant flow reduction and avoid higher aerodynamic losses,airfoil Mach distribution is carefully *** has been an effort to limit design changes so that the proven design features of the original vane are used as much as ***,the same cooling concept is used with minor modifications of the internal structures in order to achieve desired coolant flow and internal heat transfer *** of the new design are quite similar to the original one except for cooling holes and application of thermal barrier coating(TBC).Detailed aerodynamics/heat transfer simulations reveals that the reduced trailing edge(T.E.)blockage and skin friction dominated the negative effect of increased secondary *** a result the reduced design performs acceptable in terms of total pressure loss and improving stage efficiency for a wide range of varying pressure ***,more than 20%cooling mass flow can be saved;while maximum and average metal temperatures as well as cross sectional temperature gradients have not been changed much.

关键词： Vane count number Aero-thermal redesign Cooling mass flow consumption High pressure nozzle guide vane Turbine aerodynamics

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika Orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional Sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of Speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule