检索结果-南通市图书馆

protein & Cell 2013年第9期4卷 664-676页

作者： Chi-Chun Ho Susanna K.p.lau patrick C.y.Woo Department of Microbiology The University of Hong KongHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Research Centre of Infection and Immunology The University of Hong KongHong KongChina Carol yu Centre of Infection The University of Hong KongHong KongChina

Cladistics is a biological philosophy that uses genealogi-cal relationship among species and an inferred sequence of divergence as the basis of classifi *** review critically surveys the chronological development of bio-logical classification from Aristotle through our post-genomic era with a central focus on *** 1957,Julian Huxley coined cladogenesis to denote splitting from *** 1960,the English translation of Willi Hennig’s 1950 work,Systematic phylogenetics,was published,which received strong opposition from phenet-icists,such as numerical taxonomists peter Sneath and Robert Sokal,and evolutionary taxonomist,Ernst Mayr,and sparked acrimonious debates in *** 1977-1990,Carl Woese pioneered in using small subunit rRNA gene sequences to delimitate the three domains of cellu-lar life and established major prokaryotic *** has since dominated *** being compatible with modern microbiological observations,*** with unusual phenotypes,restricted expression of charac-teristics and occasionally being uncultivable,increasing recognition of pervasiveness and abundance of horizon-tal gene transfer has challenged relevance and validity of *** mosaic nature of eukaryotic and prokary-otic genomes was also gradually *** the mid-2000s,high-throughput and whole-genome sequencing became routine and complex geneologies of organisms have led to the proposal of a reticulated web of *** genomics only indirectly leads to understanding of func-tional adaptations to ecological niches,computational modeling of entire organisms is underway and the gap between genomics and phenetics may soon be *** are not expected to settle as taxonomic classifi cations shall remain subjective to serve the human scientist,not the classifi ed.

关键词： cladistics phenetics phylogeny classifi ca-tion evolution

Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

在线全文

学校读者我要写书评

暂无评论

World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek Eyüp Can Savrunlu Umut Karaaslan Özlem yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Evolving treatment landscape for early and advanced pancreatic cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2017年第7期9卷 281-292页

作者： Sally C lau Winson y Cheung Division of Medical Oncology University of British Columbia British Columbia Cancer Agency Department of Oncology University of Calgary Tom Baker Cancer Center

pancreatic ductal adenocarcinoma is an infrequent cancer with a high disease related mortality rate, even in the context of early stage disease. Until recently, the rate of death from pancreatic cancer has remained largely similar whereby gemcitabine monotherapy was the mainstay of systemic treatment for most stages of disease. With the discovery of active multiagent chemotherapy regimens, namely FOLFIRINOX and gemcitabine plus nab-paclitaxel, the treatment landscape of pancreatic cancer is slowly evolving. FOLFIRINOX and gemcitabine plus nab-paclitaxel are now considered standard first line treatment options in metastatic pancreatic cancer. Studies are ongoing to investigate the utility of these same regimens in the adjuvant setting. The potential of these treatments to downstage disease is also being actively examined in the locally advanced context since neoadjuvant approaches may improve resection rates and surgical outcomes. As more emerging data become available, the management of pancreatic cancer is anticipated to change significantly in the coming years.

关键词： Cancer Neoplasm pancreas Adjuvant treatment Systemic treatment Gemcitabine FOLFIRINOX Nab-paclitaxel

A review of modified and hybrid anaerobic baffled reactors for industrial wastewater treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Water Science and Engineering 2022年第3期15卷 247-256页

作者： poh Lin lau Antoine p.Trzcinski Department of Civil Engineering School of Engineering and TechnologyUniversity of Technology SarawakSibuSarawak 96000Malaysia School of Agriculture and Environmental Science University of Southern QueenslandWest StreetQueensland 4350Australia

This review discusses high-strength wastewater treatment using anaerobic baffled reactors(ABRs)and modified *** research findings and applications of ABRs in treating various types of high strength wastewater generated from food companies,livestock,and industries were summarized and *** parameters affecting the performance of ABRs are briefly *** state-of-the-art laboratory studies are compiled and critically *** challenges and suggestions for future investigation are also addressed.

关键词： Anaerobic baffled reactor Industrial food wastewater Livestock wastewater High-strength wastewater Anaerobic digestion

Methods of vascular control technique during liver resection:a comprehensive review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & pancreatic Diseases International 2010年第5期9卷 473-481页

作者： Wan-yee lau Eric C.H.Lai Stephanie H.y.lau Faculty of Medicine the Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

BACKGROUND: Significant hemorrhage together with blood transfusion increases postoperative morbidity and mortality of hepatic resection. Hepatic vascular occlusion is effective in minimizing bleeding during hepatic parenchymal transection. This article aimed to review the current role and status of various techniques of hepatic vascular occlusion during hepatic resection. DATA SOURCES: The relevant manuscripts were identified by searching MEDLINE, and pubMed for articles published between January 1980 and April 2010 using the keywords 'vascular control', 'vascular clamping', 'vascular exclusion' and 'hepatectomy'. Additional papers were identified by a manual search of the references from the key articles. RESULTS: One randomized controlled trial (RCT) and 5 RCTs showed intermittent pringle maneuver and ischemic preconditioning followed by continuous pringle maneuver were superior to continuous pringle maneuver alone, respectively. Two RCTs compared the outcomes of hepatectomy with and without intermittent pringle maneuver. One showed pringle maneuver to be beneficial, while the other failed to show any benefit. One RCT showed that ischemic preconditioning had significantly less blood loss than using intermittent pringle maneuver. Four RCTs evaluated the use of hemihepatic vascular occlusion. One RCT showed it had significantly less blood loss than pringle maneuver, while the other 3 showed no significant difference. Only 1 RCT showed it had significantly less liver ischemic injury. No RCT had been carried out to assess segmental vascular occlusion. Two RCTs compared the outcomes of total hepatic vascular exclusion (THVE) and pringle maneuver. One RCT showed THVE resulted in similar blood loss, but a higher postoperative complication. The other RCT showed less blood loss using THVE but the postoperative complication rate was similar. Both studies showed similar degree of liver ischemic injury. Only one RCT showed that selective hepatic vascular exclusion (SHVE) had

关键词： vascular control vascular exclusion hepatectomy liver neoplasm pringle maneuver

The current role of neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for hepatocellular carcinoma:a systematic review

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & pancreatic Diseases International 2009年第2期8卷 124-133页

作者： Wan-yee lau Eric C.H.Lai Stephanie H.y.lau State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated HospitalZhejiang University School of Medicine

BACKGROUND: Following curative treatment for hepatocellular carcinoma (HCC), 50%-90% of postoperative death is due to recurrent disease. Intra-hepatic recurrence is frequently the only site of recurrence. Thus, any neoadjuvant or adjuvant therapy, which can decrease or delay the incidence of intra-hepatic recurrence, or any cancer chemoprevention which can prevent a new HCC from developing in the liver remnant, will improve the results of liver resection. This article systematically reviewed the current evidence of neoadjuvant, adjuvant, and chemoprevention in partial hepatectomy of HCC. DATA SOURCES: Studies were identified by searching MEDLINE and pubMed databases for articles from January 1990 to November 2008 using the keywords 'hepatocellular carcinoma', 'hepatectomy', 'adjuvant therapy', 'neoadjuvant therapy', and 'regional therapy'. Additional papers and book chapters were identified by a manual search of the references from the key articles. RESULTS: Neoadjuvant transarterial chemoembolization or adjuvant regional transarterial chemotherapy embolization+systemic chemotherapy did not add benefit. Both adjuvant transarterial radioembolization with (131)I-lipiodol and adjuvant systemic interferon showed promising results. However, there were only a limited number of such studies. CONCLUSIONS: Further randomized controlled studies need to be carried out. Currently, there is no consensus on a standard neoadjuvant/adjuvant/chemoprevention therapy in partial hepatectomy for HCC.

关键词： hepatocellular carcinoma hepatectomy adjuvant therapy neoadjuvant therapy therapeutic embolization

pheromone Static Routing Strategy for Complex Networks

在线全文

学校读者我要写书评

暂无评论

Chinese physics Letters 2012年第12期29卷 254-257页

作者： HU Mao-Bin Henry y.K.lau LING Xiang JIANG Rui Department of Industrial and Manufacturing Systems Engineering The University of Hong KongPokfulam RoadHong Kong School of Engineering Science University of Science and Technology of ChinaHefei 230026 School of Transportation Engineering Hefei University of TechnologyHefei 230009

We adopt the concept of using pheromones to generate a set of static paths that can reach the performance of global dynamic routing strategy[***.E 81(2010)016113].The path generation method consists of two *** the first stage,a pheromone is dropped to the nodes by packets forwarded according to the global dynamic routing *** the second stage,pheromone static paths are generated according to the pheromone *** output paths can greatly improve traffic systems'overall capacity on different network structures,including scale-free networks,small-world networks and random *** the paths are static,the system needs much less computational resources than the global dynamic routing strategy.

关键词： network networks Complex

Chromatic Uniqueness of Certain Complete Tripartite Graphs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2011年第5期27卷 919-926页

作者： G. C. lau y. H. pENG Faculty of Computer & Mathematical Sciences Universiti Teknologi MARA (Segamat Campus) 85100 Segamat Johor Malaysia Department of Mathematics and Institute for Mathematical Research Universiti Putra Malaysia 43400 UPM Serdang Malaysia

Let p（G,A） be the chromatic polynomial of a graph G. A graph G is chromatically unique if for any graph H, p（H, λ） = p（G, λ） implies H is isomorphic to G. Liu et al. [Liu, R. y., Zhao, H. X., ye, C. F.： A complete solution to a conjecture on chromatic uniqueness of complete tripartite graphs. Discrete Math., 289, 175 179 （2004）], and lau and peng [lau, G. C., peng, y. H.： Chromatic uniqueness of certain complete t-partite graphs. Ars Comb., 92, 353-376 （2009）] show that K（p - k,p - i,p） for i = 0, 1 are chromatically unique if p ≥ k ＋ 2 ≥ 4. In this paper, we show that if 2 〈 i 〈 4, the complete tripartite graph K（p - k,p - i,p） is chromatically unique for integers k ≥ i and p 〉 k2/4 ＋ i ＋ 1.

关键词： Complete tripartit graphs chromatic polynomial chromatic uniqueness