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Spastin and alsin protein interactome analyses begin to reveal key canonical p.thways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： Benjamin R.Helmold Angela Ahrens Zachary Fitzgerald p.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. this hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. this line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical p.thways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular p.thways. this line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SpAST spastin

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NORMALLY DISTRIBUTED pROBABILITY MEASURE ON thE METRIC SpACE OF NORMS

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Acta Mathematica Scientia 2013年第5期33卷 1231-1242页

作者： Á.G.HORVÁth Department of Geometry Mathematical Institute Budapest University of Technology and Economics

In this paper we propose a method to construct probability measures on the space of convex bodies. For this purpose, first, we introduce the notion of thinness of a body. then we show the existence of a measure with the property that its pushforward by the thinness function is a probability measure of truncated normal distribution. Finally, we improve this method to find a measure satisfying some important properties in geometric measure theory.

关键词： Hausdorff metric Borel Dirac Haar and Lebesgue-measure space of convex bodies metric space of norms

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Studies on Different Hydrolysis procedures for Drugs of Abuse in Hair

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Chinese Chemical Letters 1999年第3期10卷 239-242页

作者： Ma, C Zhou, th Chinese Acad Med Sci Inst Mat Med Beijing 100050 Peoples R China peking Union Med Coll Beijing 100050 Peoples R China

Different hydrolysis and extraction procedures have been studied for the determination of drugs of abuse in hair samples. the results showed that acid and enzymatic hydrolysis gave high extraction recoveries for 6-monoacetylmorphine, morphine, codeine and heroin. Enzymatic hydrolysis was more expensive. After alkaline hydrolysis, 6-monoacetylmorphine, a unique proof of heroin abuse, could not be detected and after methanolic extraction, the extract was dirty and the obtained chromatogram showed an interfering background. It is concluded that acid hydrolysis is the extraction method of choice.

关键词： drugs of abuse hydrolysis hair

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Monitoring spatiotemporal soil moisture changes in the subsurface of forest sites using electrical resistivity tomography (ERT)

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Journal of Forestry Research 2022年第5期33卷 1649-1662页

作者： Julian Fäth Julius Kunz Christof Kneisel Institute of Geography and Geology University of WürzburgAm Hubland97074 WürzburgGermany

the effects of drought on tree mortality at forest stands are not completely understood. For assessing their water supply, knowledge of the small-scale distribution of soil moisture as well as its temporal changes is a key issue in an era of climate change. However, traditional methods like taking soil samples or installing data loggers solely collect parameters of a single point or of a small soil volume. Electrical resistivity tomography (ERT) is a suitable method for monitoring soil moisture changes and has rarely been used in forests. this method was applied at two forest sites in Bavaria, Germany to obtain high-resolution data of temporal soil moisture variations. Geoelectrical measurements (2D and 3D) were conducted at both sites over several years (2015-2018/2020) and compared with soil moisture data (matric potential or volumetric water content) for the monitoring plots. the greatest variations in resistivity values that highly correlate with soil moisture data were found in the main rooting zone. Using the ERT data, temporal trends could be tracked in several dimensions, such as the interannual increase in the depth of influence from drought events and their duration, as well as rising resistivity values going along with decreasing soil moisture. the results reveal that resistivity changes are a good proxy for seasonal and interannual soil moisture variations. therefore, 2D- and 3D-ERT are recommended as comparatively non-laborious methods for small-spatial scale monitoring of soil moisture changes in the main rooting zone and the underlying subsurface of forested sites. Higher spatial and temporal resolution allows a better understanding of the water supply for trees, especially in times of drought.

关键词： Geoelectrical monitoring Forest ecology Hydrology Soil water content

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High Quality Fixture Quenching Fixture Types, Levels of Automation and Machine Types

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材料热处理学报 2004年第5期25卷 601-606页

作者： STRENG th HEESS K MUELLER-LAESSIG G HEESS GmbH & Co KG Lampertheim GermanyHEESS GmbH & Co KG Lampertheim GermanyHEESS GmbH & Co KG Lampertheim Germany

the paper shows, how the quality of workpieces to be heat treated can be improved by using the technology of fixture-quenching. Different fixture systems, like fixed mandrel, expanding mandrel and lamellar mandrel are described. In the next section there is a comparison between manual operation of hardening machines vs. automated lines. Since there are applications for each, manual and fully automated hardening systems, HEESS has not only focused to develop automated lines, but also refined manual operated hardening machines (Sp-Series). these take advantage of the latest technology, like for example quick tool change and pLC-control with workpiece parameter database. An overview over different machine types is given.

关键词：淬火机模压淬火自动控制人工操作

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Machine learning applications in healthcare clinical practice and research

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World Journal of Clinical Cases 2025年第1期13卷 16-21页

作者： Nikolaos-Achilleas Arkoudis Stavros p papadakos Research Unit of Radiology and Medical Imaging School of MedicineNational and Kapodistrian University of AthensAthens 11528Greece 2^(nd)Department of Radiology “Attikon”General University HospitalMedical SchoolNational and Kapodistrian University of AthensChaidari 12462Greece Department of Gastroenterology Laiko General HospitalNational and Kapodistrian University of AthensAthens 11527Greece

Machine learning(ML)is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis,thus creating machines that can complete tasks otherwise requiring human *** its various applications,it has proven groundbreaking in healthcare as well,both in clinical practice and *** this editorial,we succinctly introduce ML applications and present a study,featured in the latest issue of the World Journal of Clinical *** authors of this study conducted an analysis using both multiple linear regression(MLR)and ML methods to investigate the significant factors that may impact the estimated glomerular filtration rate in healthy women with and without non-alcoholic fatty liver disease(NAFLD).their results implicated age as the most important determining factor in both groups,followed by lactic dehydrogenase,uric acid,forced expiratory volume in one second,and *** addition,for the NAFLD-group.the 5th and 6th most important impact factors were thyroid-stimulating hormone and systolic blood pressure,as compared to plasma calcium and body fat for the NAFLD+***,the study's distinctive contribution lies in its adoption of ML methodologies,showcasing their superiority over traditional statistical approaches(herein MLR),thereby highlighting the potential of ML to represent an invaluable advanced adjunct tool in clinical practice and research.

关键词： Machine Learning Artificial Intelligence Clinical practice Research Glomerular filtration rate Non-alcoholic fatty liver disease Medicine

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primitive to conventional geometry projection for efficient phonon transport calculations

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npj Computational Materials 2023年第1期9卷 365-371页

作者： Xun Li Simon thébaud Lucas Lindsay Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTNUSA Univ Rennes INSA RennesCNRSInstitut FOTON-UMR 6082RennesFrance

the primitive Wigner-Seitz cell and corresponding first Brillouin zone(FBZ)are typically used in calculations of lattice vibrational and transport properties as they contain the smallest number of degrees of freedom and thus have the cheapest computational ***,in complex materials,the FBZ can take on irregular shapes where lattice symmetries are not ***,conventional cells(with more atoms and regular shapes)are often used to describe materials,though dynamical and transport calculations are more *** we discuss an efficient anharmonic lattice dynamic method that maps conventional cell dynamics to primitive cell dynamics based on translational *** symmetries have not been utilized in typical lattice dynamical *** leads to phase interference conditions that act like conserved quantum numbers and a conservation rule for phonon scattering that is hidden in conventional dynamics which significantly reduces the computational *** demonstrate this method for phonon transport in a variety of materials with inputs from first-principles calculations and attribute its efficiency to reduced scattering phase space and fewer summations in scattering matrix element calculations.

关键词： phonon conventional primitive

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Using mixed integer programming and airborne laser scanning to generate forest management units

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Journal of Forestry Research 2022年第1期33卷 217-226页

作者： Adrián pascual Sándor FTóth Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisboaPortugal School of Forest Sciences University of Eastern FinlandP.O.Box 11180101 JoensuuFinland School of Environmental and Forest Sciences University of WashingtonSeattleWAUSA

Airborne laser scanning(ALS)has been widely applied to estimate tree and forest attributes,but it can also drive the segmentation of forest *** algorithms are the dominant technique in segmentation but spatial optimization using exact methods remains *** study presents a novel approach to segmentation based on mixed integer programming to create forest management units(FMUs).this investigation focuses on using raster information derived from ALS *** mainstream clustering algorithms were compared to the new MIp formula that simultaneously accounts for area and adjacency restrictions,FMUs size and homogeneity in terms of vegetation *** optimal problem solution was found when using less than 150 cells,showing the problem formulation is *** results for MIp were better than for the clustering algorithms;FMUs were more compact based on the intravariation of canopy height and the variability in size was *** MIp model allows the user to strictly control the size of FMUs,which is not possible in heuristic optimization and in the clustering algorithms *** definition of forest management units based on remote sensing data is an important operation and our study pioneers the use of MIp ALS-based optimal segmentation.

关键词： Segmentation precision forestry Optimization Mathematical programming Airborne laser scanning

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流化床转鼓造粒工艺(FDG)及其各种用途

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中氮肥 1987年第6期 79-82页

作者： p.thüring E.Vogel 郑友竹化肥司

一、前言 Kaltenbach-thüring公司(以下简称KT)的流化床转鼓造粒器由转鼓造粒器和装在造粒器里面的流化床组成。根据各种用途,提供流化床以冷空气或热空气。本工艺适用于许多类型肥料和各种产品的造粒。

关键词：成球造粒塔流化床沸腾床化工机械料浆转鼓 FDG 中试装置中间试验装置压紧颗粒尺寸

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Effect of polymer and fiber additives on pressure drop in a rectangular channel

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Journal of Hydrodynamics 2017年第5期29卷 871-878页

作者： Amir Eshghinejadfard Kashyapa Sharma Dominique thévenin Laboratory of Fluid Dynamics and Technical Flows University of Magdeburg"Otto von Guericke"Universitatsplatz 239106 MagdeburgGermany

the influence of minute amounts of additives on pressure drop is an interesting fundamental phenomenon, potentially with important practical applications. Change of the pressure drop in a quasi-two-dimensional channel flow using various additives is experimentally investigated. Tests were conducted for a wide range of concentrations（100 ppm-500 ppm） and Reynolds numbers（16 000-36 000） with two polymers and four rigid fibers used as additive. Maximum drag reduction of 22% was observed for xanthan gum. However, xanthan gum loses its drag-reducing property rapidly. It was also seen that drag reduction percentage of xanthan gum remains almost constant for different Reynolds numbers. Guar flour demonstrated good drag reduction property at high Reynolds numbers. Drag reduction of 17.5% at Re= 33 200 using 300 ppm solution was observed. However, at low Reynolds numbers guar flour will cause an increase in pressure drop. Fiber fillers（aspect ratio=21） have been tested as well. In contrast to polymers, they increased the drag for the range of examined concentrations and Reynolds numbers. polyacrylonitrile fiber with three different aspect ratios（106, 200, 400） was also used, which showed an increase in pressure drop at low aspect ratios. polyacrylonitrile fibers of larger lengths（6 mm） demonstrated minor drag-reducing effects（up to 3%）.

关键词： pressure drop polymer fiber channel flow

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