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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 27-27页

作者： Kuokkanen M. Myllyniemi M. Vauhkonen M. p.sipponen 宋平 Dept.of pathology Helsinki University Central Hospital02740 EspooFrance Dr.

Background and study aims:The usefulness of a new quick test for endoscopic diagnosis of adult-type hypolactasia was tested in duodenal *** this test,an endoscopic biopsy from the postbulbar duodenum is incubated with lactose on a test plate,and a color reaction develops within 20 min as a result of hydrolyzed lactose(a positive result) in patients with normolactasia,whereas no reaction(a negative result) develops in patients with severe *** and methods:Two postbulbar duodenal biopsies were taken from 80 prospectively enrolled adult outpatients with *** biopsies were used for the Quick Lactase Test(Biohit pLC,Helsinki,Finland) and in biochemical disaccharidase(lactase,sucrase,and maltase) *** addition,the C/T-13910 genotype was determined from DNA extracted from gastric antral biopsies using polymerase chain reaction sequencing in genomic analysis of adult-type ***:Twenty-one of 22 patients(95% ;95% CI,87-100%) with biochemical lactase activity protein,but none of the 58 patients with lactase activity of 10 U/g protein or more had a negative result in the Quick Lactase *** of the 80 patients(9% ;95% CI,3-15%) had a Quick Lactase Test result that indicated mild hypolactasia(a mild color reaction) .All patients with celiac disease(n = 6) had a negative Quick Lactase Test *** of 74 patients(six patients with celiac disease were excluded) had a CC-13910 genotype in genomic testing,indicating adult-type *** of them had negative test results with the Quick Lactase ***-six patients had a TT genotype,indicating normolactasia,and none of these patients had a negative test result in the Quick Lactase *** of 39 patients(15% ;95% CI,4-27%) with a CT genotype had a negative result in the Quick Lactase ***:The Quick Lactase Test effectively identifies patients with severe duodenal *** comparison with CC(adult-type hypolactasia) and TT individuals(n

关键词：乳糖酶缺乏上消化道快速检测法内镜活检乳糜泻成人型阴性结果试验结果双糖酶显色反应

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Association of autoimmune type atrophic corpus gastritis with Helicobacter pylori infection

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World Journal of Gastroenterology 2010年第1期16卷 83-88页

作者： Lea Irene Veijola Aino Mirjam Oksanen pentti Ilmari sipponen Hilpi Iris Kaarina Rautelin Herttoniemi Hospital City of Helsinki Department of Bacteriology and Immunology Haartman InstituteUniversity of Helsinki Repolar Oy Box 2602101 EspooFinland HUSLAB Helsinki University Central Hospital Laboratory Department of Medical Sciences University of Uppsala

AIM:To study the association between Helicobacter pylori(***)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present *** *** addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(pCA), and intrinsic factor(IF),antibodies]were determined. RESULTS:Of the 14 patients with severe gastricatrophy,as demonstrated by histology and serum markers,and no evidence for an ongoing *** infection,eight showed *** antibodies by *** eight had elevated pCA and 4/8 also had IF *** the six immunoblot-negative patients with severe corpus atrophy,pCA and IF antibodies were detected in *** the patients with low to moderate grade atrophic gastritis(all except one with an ongoing *** infection),serum markers for gastric atrophy and autoimmunity were seldom ***,one *** negative patient with mild atrophic gastritis had pCA and IF antibodies suggestive of a pre-atrophic autoimmune gastritis. CONCLUSION:Signs of *** infection in autoimmune gastritis,and positive autoimmune serum markers in *** gastritis suggest an etiological role for *** in autoimmune gastritis.

关键词： Helicobacter pylori Autoimmune gastritis Gastric atrophy Vitamin B12 deficiency

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Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal,healthy stomach

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World Journal of Gastroenterology 2009年第7期15卷 853-859页

作者： Katsunori Iijima Yasuhiko Abe Ryosuke Kikuchi Tomoyuki Koike Shuichi Ohara pentti sipponen Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Department of pathology Helsinki University Central HospitalJorvi Hospital

AIM:To study the value of serum biomarker tests to differentiate between patients with healthy or diseased stomach mucosa:*** with Helicobacter pylori(H pylori)gastritis or atrophic gastritis,who have a high risk of gastric cancer or peptic ulcer ***:Among 162 Japanese outpatients,pepsinogen-(pg-)and(pg)were measured using a conventional Japanese technique,and the European Gastropanel examination(pg and pg,gastrin-17 and H pylori antibodies).Gastroscopy with gastric biopsies was performed to classify the patients into those with healthy stomach mucosa,H pylori non-atrophic gastritis or atrophic ***:pg-and pg assays with the Gastropanel and the Japanese method showed a highly significant *** methodological reasons,however,serum pg-,but not pg,was twice as high with the Gastropanel test as with the Japanese *** biomarker assays revealed that 5%of subjects had advanced atrophic corpus gastritis which was also verified by endoscopic *** examination revealed an additional seven patients who had either advanced atrophic gastritis limited to the antrum or antrum-predominant H pylori *** compared to the endoscopic biopsy findings,the Gastropanel examination classified the patients into groups with "healthy" or "diseased" stomach mucosa with 94% accuracy,95% sensitivity and 93% specifi ***:Serum biomarker tests can be used to differentiate between subjects with healthy and diseased gastric mucosa with high accuracy.

关键词： Gastric atrophy He/icobacter py/ori Serumgastrin-17 Serum pepsinogen

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Infliximab in pediatric inflammatory bowel disease rapidly decreases fecal calprotectin levels

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World Journal of Gastroenterology 2011年第47期17卷 5166-5171页

作者： Anssi Hmlinen Taina sipponen Kaija-Leena Kolho Hospital for Children and Adolescents Helsinki University Central Hospital University of Helsinki Division of Gastroenterology Helsinki University Central Hospital

AIM: To study the response to infliximab in pediatric inflammatory bowel disease (IBD), as reflected in fecal calprotectin levels. METHODS: Thirty-six pediatric patients with IBD [23 Crohn's disease (CD), 13 ulcerative colitis (UC); median age 14 years] were treated with infliximab. Fecal calprotectin was measured at baseline, and 2 and 6 wk after therapy, and compared to blood inflammatory markers. Maintenance medication was unaltered until the third infusion but glucocorticoids were tapered off if the patient was doing well. RESULTS: At introduction of infliximab, median fecal calprotectin level was 1150 μg/g (range 54-6032 μg/g). By week 2, the fecal calprotectin level had declined to amedian 261 μg/g (p patients, fecal calprotectin was normal (provement in the fecal calprotectin level (median 345 μg/g). In 22% of the patients, fecal calprotectin levels increased by week 6 to pretreatment levels or above, suggesting no response (or a loss of early response). Thus, in CD, the proportion of non-responsive patients by week 6 seemed lower, because only 9% showed no improvement in their fecal calprotectin level when compared to the respective figure of 46% of the UC patients (p protectin levels reflecting intestinal inflammation normalized rapidly in one third of pediatric patients suggesting complete mucosal healing.

关键词： Crohn's disease Ulcerative colitis Surrogatemarkers pediatrics Monoclonal antibodies Infliximab

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Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome

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World Journal of Gastroenterology 2009年第48期15卷 6068-6074页

作者： Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen pentti sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela Institute of Biomedicine PharmacologyUniversity of Helsinki Valio Ltd Research Centre Tampere Health Centre and Department of Medicine Tampere City Hospital Department of pathology Jorvi HospitalHelsinki University Central Hospital VTT Technical Research Centre of Finland Foundation for Nutrition Research

AIM： To investigate the pathophysiology of irritable bowel syndrome （IBS） by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls. METHODS： Fifteen IBS patients fulfilling the Rome II criteria, and nine healthy volunteers were included in the study. A combined lipidomics （UpLC/MS） and metabolomics （GC × GC-TOF） approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon. RESULTS： Overall, lipid levels were elevated in patients with IBS. The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines. Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides, glycosphingolipids, and di-and triacylglycerols. Among the meo tabolites, the cyclic ester 2（3H）-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects （p = 0.03）. CONCLUSION： IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile. Especially, there was an increase in several lipid species such as lysophospholipids and ceramides.

关键词： Functional gastrointestinal diseases Irritable bowel syndrome Histopathology

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Serum immune-activation potency and response to anti-TNF-α therapy in Crohn's disease

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World Journal of Gastroenterology 2010年第46期16卷 5845-5851页

作者： Hanne Rintamki Taina sipponen Harri M Salo Outi Vaarala Kaija-Leena Kolho Division of Gastroenterology Hospital for Children and Adolescents and Helsinki University Central HospitalUniversity of Helsinki Department of Medicine Division of GastroenterologyHelsinki University Central HospitalUniversity of Helsinki Immune Response Unit Department of Vaccination and Immune ProtectionNational Institute for Health and Welfare

AIM:To study whether immune-activation stage in serum of adult Crohn's disease (CD) patients correlates with disease activity and with treatment response to antitumor necrosis factor-α (TNF-α) ***:Serum samples were obtained from 15 adult CD patients introduced to anti-TNF-α *** individual stage of immune activation was studied applying our new in vitro assay,in which target cells (donor derived peripheral blood mononuclear cells) were cultured with patient serum and the T-cell activation induced by the patient serum was studied using a panel of markers for effector [interferon γ (IFNγ),interleukin (IL)-5] and regulatory T-cells [forkhead transcription factor 3 (FOXp3) and glucocorticoid-induced tumour necrosis factor receptor (GITR)].The endoscopic disease activity was assessed with the Crohn's disease endoscopic index of severity (CDEIS) before and 3 mo after therapy with an anti-TNF-α ***:Low induction of FOXp3 and GITR in target cells cultured in the presence of patient serum was associated with high disease activity *** assessed before therapy (r=-0.621,p=0.013 and r=-0.625,p=0.013,respectively).FOXp3 expression correlated inversely with pre-treatment erythrocyte sedimentation rate (r=-0.548,p=0.034).Low serum induced FOXp3 (r=-0.600,p=0.018) and GITR (r=-0.589,p=0.021) expression and low IFNγ secretion from target cells (r =-0.538,p=0.039) associated with treatment response detected as a decrease in ***:The immune-activation potency in the patient serum prior to anti-TNF-α therapy reflected intestinal inflammation and the therapeutic response.

关键词： Crohn’s disease endoscopic index of severity Forkhead transcription factor 3 Glucocorticoid-induced tumour necrosis factor receptor Infliximab Inflammatory bowel disease

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Low circulating levels of gastrin-17 in patients with Barrett's esophagus

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World Journal of Gastroenterology 2005年第38期11卷 5988-5992页

作者： pentti sipponen Matti Vauhkonen Timo Helske Ilpo Kriinen Matti Hrknen Division of pathology Department Internal Medicine Department of Clinical Chemistry

AIM: To examine whether the fasting levels of serum gastrin-17 (G-17) are lower in Barrett's esophagus (BE)patients than in non-Barrett ***: Nineteen patients with BE (presenting with a tubular segment ≥2 cm long in lower esophagus and intestinal metaplasia of incomplete type ('specialized columnar epithelium') in endoscopic biopsies from the tubular segment below the squamocolumnar junction were collected prospectively from outpatients referred to diagnostic gastroscopy. The controls comprised 199 prospectively collected dyspeptic outpatients without BE or any endoscopically visible lesions in the upper GI *** levels of serum G-17 (G-17fast) were assayed with an EIA test using a Mab highly specific to amidated G-17. None of the patients and controls received therapy with ppIs or other antisecretory ***: The mean and median levels of G-17fast in serum were significantly lower (p = 0.001) in BE patients than in controls. The positive likelihood ratios (LR+) of low G-17fast to predict BE in the whole study population at G-17fast levels ＜0.5, ＜1, or ＜1.5 pmol/L were 3.5, 3.0,and 2.8, respectively. Among patients and controls with healthy stomach mucosa, the LR+ were 5.6, 3.8, and 2.6,respectively. In the whole study population, serum G-17 was below 2 pmol/L in 15 of 19 BE patients (79%). The corresponding prevalence was 66 of 199 (33%) in controls (p＜0.001). The G-17fast was 5 pmol/L or more in only one of the 19 BE patients (5%). In controls, 76 of the 199 patients (38%) had such high serum G-17fast levels (p＜0.01).CONCLUSION: Serum levels of G-17fast tend to be lower in native patients with BE than in healthy controls.

关键词： Gastrin-17 Barrett's esophagus Chronic gastritis Atrophic gastritis Diagnostics

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