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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.v.p.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

semantic segmentation of Lumbar vertebrae Using Meijering U-Net(MU-Net)on spine Magnetic Resonance Images

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Computer Modeling in Engineering & sciences 2025年第1期142卷 733-757页

作者： Lakshmi s v v shiloah Elizabeth Darmanayagam sunil Retmin Raj Cyril Department of Computer science and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is one of the most common medical problems in the world and it is experienced by a huge percentage of people *** to its ability to produce a detailed view of the soft tissues,including the spinal cord,nerves,intervertebral discs,and vertebrae,Magnetic Resonance Imaging is thought to be the most effective method for imaging the *** semantic segmentation of vertebrae plays a major role in the diagnostic process of lumbar *** is difficult to semantically partition the vertebrae in Magnetic Resonance Images from the surrounding variety of tissues,including muscles,ligaments,and intervertebral discs.U-Net is a powerful deep-learning architecture to handle the challenges of medical image analysis tasks and achieves high segmentation *** work proposes a modified U-Net architecture namely MU-Net,consisting of the Meijering convolutional layer that incorporates the Meijering filter to perform the semantic segmentation of lumbar vertebrae L1 to L5 and sacral vertebra ***-colour mask images were generated and used as ground truth for training the *** work has been carried out on 1312 images expanded from T1-weighted mid-sagittal MRI images of 515 patients in the Lumbar spine MRI Dataset publicly available from Mendeley *** proposed MU-Net model for the semantic segmentation of the lumbar vertebrae gives better performance with 98.79%of pixel accuracy(pA),98.66%of dice similarity coefficient(DsC),97.36%of Jaccard coefficient,and 92.55%mean Intersection over Union(mean IoU)metrics using the mentioned dataset.

关键词： Computer aided diagnosis(CAD) magnetic resonance imaging(MRI) semantic segmentation lumbar vertebrae deep learning U-Net model

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAURABH R.kIRAN D.sINGH R.vAIsH v.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Effect of wall temperature modulation on the heat transfer characteristics of droplet-train flow inside a rectangular microchannel

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Chinese Journal of Chemical Engineering 2020年第3期28卷 685-697页

作者： vivekanand s.v.B.,raju v.R.k. Department of Mechanical Engineering National Institute of TechnologyWarangalTelangana 506004India

The numerical studies of water–oil two-phase slug flow inside a two-dimensional vertical microchannel subjected to modulated wall temperature boundary conditions have been discussed in the present *** researchers have contributed their efforts in exploring the characteristics of Taylor flows inside microchannel under constant wall heat flux or isothermal wall ***,there is no study available in the literature which discusses the impact of modulated thermal wall boundary conditions on the heat transfer behavior of slug flows inside ***,to bridge this gap,an effort has been made to understand the heat transfer characteristics of the flow under sinusoidal wall temperature ***,a single phase flow and heat transfer study was performed in microchannels,and the results of the fully developed velocity profile and heat transfer rate were validated with benchmark analytical *** an optimal selection of the combination of sinusoidal thermal wall boundary conditions has been made for the two-phase slug flow ***,the effects of amplitude(0 bεb 0.03)and frequency(0 bωb 750πrad·s-1)of the sinusoidal wall temperature profile on the heat transfer have been studied using the optimal combination of the wall boundary *** results of the numerical study using modulated temperature conditions on channel walls showed a significant improvement in the heat transfer over liquid-only flow by approximately 50%as well as over two-phase flow without wall temperature *** non-dimensional temperature contours obtained for different cases of temperature modulation clearly explain the root cause of such improvement in the heat ***,the results based on the hydrodynamics of the flow have also been reported in terms of variation of droplet shapes and film *** influence of Capillary number on the film thickness as well as heat transfer rates has also been *** addition,the measured fil

关键词： Heat transfer Microchannel Modulation surface tension Taylor flow

Thermo-diffusion impact on immiscible flow characteristics of convectively heated vertical two-layered Baffle saturated porous channels in a suspension of nanoparticles:an analytical study

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Applied Mathematics and Mechanics(English Edition) 2023年第2期44卷 307-324页

作者： s.p.v.ANANTH B.N.HANUMAGOWDA s.v.k.vARMA C.s.k.raju I.kHAN p.RANA Department of Mathematics School of Applied SciencesREVA UniversityBangalore 560064India Department of Mathematics GITAM School of ScienceGITAM UniversityBangalore 562163India Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-Majmaah 11952Saudi Arabia school of Mathematical sciences College of Science and TechnologyWenzhou-Kean UniversityWenzhou 325060Zhejiang ProvinceChina

The heat and mass transfer of two immiscible fluids in an inclined channel with thermal diffusion,vicious,and Darcy dissipation is *** first region consists of a clear fluid,and the second one is filled with a nanofluid saturated with a porous *** behaviors of Cu-H_(2)O,In-H_(2)O,and Au-H_(2)O nanofluids are *** transport properties are assumed to be *** coupled non-linear equations of the flow model are transformed into the dimensionless form,and the solutions for the velocity,temperature,and concentration are obtained by the regular perturbation *** are carried out on the flow characteristics for various values of the material *** results show that the velocity and temperature of the fluids enhance with the thermal Grashof number,solutal Grashof number,and Brinkman number while decrease with the porosity parameter and solid volume fraction.

关键词： viscous fluid nanofluid heat and mass transfer thermal diffusion

Convergence of COvID-19 and recurrent stroke:In-hospital mortality risks explored

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World Journal of virology 2025年第1期14卷 5-8页

作者： Basavraj s Nagoba shree v Dhotre Ajay M Gavkare sachin s Mumbre pradnya s Dhotre Department of Microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of Microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Community Medicine Ashwini Rural Medical CollegeSolapur 413001India Department of Biochemistry Ashwini Rural Medical CollegeSolapur 413001India

This editorial comments on the article by Desai et al,which investigates the impact of coronavirus disease 2019(COvID-19)on in-hospital mortality among patients with recurrent stroke using data from the 2020 National Inpatient *** findings reveal significantly higher mortality rates in COvID-19-positive patients compared to non-COvID-19 patients,particularly among middle-aged individuals,males,and ethnic *** editorial explores the underlying mechanisms contributing to these outcomes and discusses the clinical implications for targeted management strategies in high-risk *** results emphasize the need for comprehensive approaches to mitigate the heightened risks faced by recurrent stroke patients during the COvID-19 pandemic.

关键词： Recurrent stroke COvID-19 In-hospital mortality Nationwide analysis stroke admissions Infectious diseases Chronic health conditions Hypercoagulability

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(pkA and pkC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the pkA/pkC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and p/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

New Data on the Mineralogy of Chromite from the Nuggihalli schist Belt,Western Dharwar Craton,karnataka,India:petrogenetic Implications

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Acta Geologica sinica(English Edition) 2011年第1期85卷 107-115页

作者： perumala v.s.raju Elapavalooru v.s.s.k.BABU Roland k.W.MERkLE National Geophysical Research Institute Hyderabad India(Council of Scientific and Industrial Research) Department of Geology University of pretoria PretoriaSouth Africa

The occurrence of rhythmic layering of chromite and host serpentinites in the deformed layered igneous complexes has been noticed in the Nuggihalli schist belt （NsB） in the western Dharwar craton, karnataka, south India. For this study, the chromitite rock samples were collected from Jambur, Tagadur, Bhakatarhalli, Ranganbetta and Byrapur in the NsB. petrography and ore microscopic studies on chromite show intense cataclasis and alteration to ferritchromite. The ferritchromite compositions are characterized by higher Cr number （Cr/[Cr＋AI]）（0.68-0.98） and lower Mg number （Mg/[Mg＋Fe]）（0.33-0.82） ratios in ferritchromite compared to that of parent chromite. The formation process for the ferritchromite is thought to be related to the exchange of Mg, AI, Cr, and Fe between the chromite, surrounding silicates （serpentines, chlorites）, and fluid during serpentinization.

关键词： chromite ferritchromite Nuggihalli schist belt Dharwar Craton India