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Heterogeneity of mature oligodendrocytes in the central nervous system

Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne stratton G.R.Wayne Moore Jack p.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Bubble-Enriched smoothed Finite Element Methods for Nearly-Incompressible solids

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Computer Modeling in Engineering & sciences 2021年第5期127卷 411-436页

作者： Changkye lee sundararajan Natarajan Jack s.Hale Zeike A.Taylor Jurng-Jae Yee stephane p.A.Bordas University Core Research Center for Disaster-Free and safe Ocean City Construction Dong-A UniversityBusan49315Korea Department of Mechanical Engineering Indian Institute of Technology MadrasChennai600036India Faculty of science Technology and CommunicationUniversity of LuxembourgEsch-sur-AlzetteL-4364Luxembourg CIsTIB-Center for Computational Imaging&simulation Technologies in Biomedicine School of EngineeringLeedsLS29JTUK

This work presents a locking-free smoothed finite element method(s-FEM)for the simulation of soft matter modelled by the equations of quasi-incompressible *** proposed method overcomes well-known issues of standard finite element methods(FEM)in the incompressible limit:the over-estimation of stiffness and sensitivity to severely distorted *** concepts of cell-based,edge-based and node-based s-FEMs are extended in this paper to ***,a cubic bubble function is utilized to improve accuracy and *** the bubble function,an additional displacement degree of freedom is added at the centroid of the *** numerical studies are performed demonstrating the stability and validity of the proposed *** obtained results are compared with standard FEM and with analytical solutions to show the effectiveness of the method.

关键词： strain smoothing smoothed finite element method bubble functions hyperelasticity mesh distortion

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Fault detection method with pCA and LDA and its application to induction motor

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Journal of Central south University 2010年第6期17卷 1238-1242页

作者： JUNG D Y lee s M 王洪梅 KIM J H lee s H Daeho Tech Company Limited Department of Electronics Engineering Inha University school of Mechatronics Changwon National University

A feature extraction and fusion algorithm was constructed by combining principal component analysis(pCA) and linear discriminant analysis(LDA) to detect a fault state of the induction *** yielding a feature vector with pCA and LDA from current signal that was measured by an experiment,the reference data were used to produce matching *** a diagnostic step,two matching values that were obtained by pCA and LDA,respectively,were combined by probability model,and a faulted signal was finally *** the proposed diagnosis algorithm brings only merits of pCA and LDA into relief,it shows excellent performance under the noisy *** simulation was executed under various noisy conditions in order to demonstrate the suitability of the proposed algorithm and showed more excellent performance than the case just using conventional pCA or LDA.

关键词： principal component analysis (pCA) linear discriminant analysis (LDA) induction motor fault diagnosis fusionalgorithm

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primary pancreatic gastrointestinal stromal tumor

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Hepatobiliary & pancreatic Diseases International 2021年第4期20卷 391-393页

作者： Whayoung lee Xiaodong Li sonia lee Vishal s Chandan Department of pathology and Laboratory Medicine University of CaliforniaIrvineCA 92868USA Department of Radiological sciences University of CaliforniaIrvineCA 92868USA

Gastrointestinal stromal tumor (GIsT) arises from the interstitial cells of Cajal (ICC) and is the most common mesenchymal tumor of the gastrointestinal tract,accounting for approximately 1%-2%of all malignant gastroi... 详细信息

关键词： gastrointestinal stomach tumor

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Merging bound states in the continuum in an open acoustic resonator

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science China(physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem s.pilipchuk sibo Huang Chen shen Almas F.sadreev Yong Li Andrey E.Miroshnichenko school of physics and Electronic sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of physics Department of Mechanical Engineering Rowan University school of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano sergei A.Kirov Jesús M.Hernández-Guijo Department of pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIs) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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Accounting for the uncertainties in the estimation of average shear wave velocity using Vs-N correlations

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Frontiers of structural and Civil Engineering 2021年第5期15卷 1199-1208页

作者： Jithin p ZACHARIAH Ravi s JAKKA Department of Earthquake Engineering Indian Institute of Technology RoorkeeRoorkee 247667India

site-specific seismic hazard analysis is crucial for designing earthquake resistance structures,particularly in seismically active *** wave velocity(V_(s))is a key parameter in such analysis,although the economy and other factors restrict its direct field measurement in many *** V_(s)-spT-N correlations are routinely incorporated in seismic hazard analysis to estimate the value of V_(s).However,many uncertainties question the reliability of these estimated V_(s)*** paper comes up with a statistical approach to take care of such uncertainties involved in V_(s)*** measured spT-N values from all the critical boreholes were converted into statistical parameters and passed through various correlations to estimate V_(s)at different *** effect of different soil layers in the boreholes on the V_(s)estimation was also taken into ***,the average shear wave velocity of the top 30 m soil coverV_(s30))is estimated after accounting for various epistemic and aleatoric *** scattering nature of the V_(s)values estimated using different V_(s)-N correlations was reduced significantly with the application of the *** results further clearly demonstrated the potential of the approach to eliminate various uncertainties involved in the estimation of V_(s)30 using general and soil-specific correlations.

关键词： uncertainties V_(s)-N correlations V_(s30) spT data statistical methodology

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Emissions of Er3+ and Yb3+ co-doped srZrO3 nanocrystals under near-infrared and near-ultraviolet excitations

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Journal of Advanced Ceramics 2020年第4期9卷 413-423页

作者： Hyeontae Lim Juyeong Lim soyoung Jang Y.s.lee Department of physics Soongsil UniversitySeoul06978Republic of Korea

In this study,the upconversion(UC)emissions of Er3+and Yb3+co-doped srZrO3 nanocrystals(NCs)were investigated in terms of the thermal annealing temperature and concentration of Er3+ions and compared with the emissions under a near-ultraviolet(near-UV)*** NCs were synthesized by the combustion method,and the as-synthesized NCs were post-annealed at high *** X-ray diffraction patterns revealed that the grain sizes and crystallinity degrees of the samples increased with increasing annealing *** photoluminescence spectra of our samples exhibited strong green and very weak red emissions with the near-UV excitation,originating from the f-f transitions in the Er3+***,under near-infrared(near-IR)excitation,we identified sizable visible emissions at 525,547,and 660 nm in our NCs,which indicated that the UC process successfully occurred in our *** UC emissions were maximized in the NCs with an Er3+concentration of 0.02 and thermal annealing at 1000°*** found that the intensity ratios of red to green emissions increased with increasing annealing *** discussed the differences in the emissions between near-UV and near-IR excitations.

关键词： Er3+and Yb3+co-doped srZrO3 upconversion downshifting nanocrystals combustion method annealing temperature

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Nonlinear mixing-based terahertz emission in inclined rippled density plasmas

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Chinese physics B 2023年第6期32卷 384-390页

作者： K Gopal A p singh s Divya Rajdhani College Department of Physics&ElectronicsUniversity of DelhiNew DelhiIndia Computational plasma Dynamics Laboratory Rajdhani CollegeDepartment of Physics&ElectronicsUniversity of DelhiNew DelhiIndia

We propose to investigate the THz field generation using nonlinear mixing mechanism of laser beat wave with inclined rippled density *** laser pulses with frequencies(ω_(1),ω_(2)) and wave vectors(k_(1),k_(2)) co-propagate and resultant laser beat wave forms at beat frequency(ω_(1)-ω_(2)).Laser beat wave imparts a nonlinear force on the ambient electrons and pushes them outward with nonlinear velocity v_(NL).Coupling of induced density perturbation and nonlinear velocity v_(NL)generates nonlinear currents at laser beat frequency that further generates electromagnetic field E_((ω_(1)-ω_(2))) in terahertz(THz)*** the present scheme,density ripples are introduced at an angle with respect to laser propagation and flat Gaussian index(f) is introduced in laser field profile that transform curved top of Gaussian field envelope into flat top field *** combined effect of flat laser pulses with inclined density ripples in plasmas shows 10-fold enhancement in THz field amplitude when flat-Gaussian index(f) varies from 1 to ***,the THz field intensifies when density ripples inclination increases upto a certain angle and then decreases.

关键词： terahertz inclined ripple flat laser laser plasma interaction

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plasma density measurement and downstream etching of silicon and silicon oxide in Ar/NF3 mixture remote plasma source

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plasma science and Technology 2019年第6期21卷 52-57页

作者： H J YEOM D H CHOI Y s lee J H KIM D J sEONG s J YOU H C lee Korea Research Institute of standards and science(KRIss) Daejeon 34113 Republic of Korea Department of physics Chungnam National University Daejeon 34134 Republic of Korea

In this study,plasma density measurements were performed near the plume region of the remote plasma source (Rps) in Ar/NF3 gas mixtures using a microwave cutoff *** measured plasma density is in the range of 1010-1011 cm-3 in the discharge conditions with Rps powers of 2-4 kW and gas pressures of 0.87-4 *** plasma density decreased with increasing gas pressures and Rps powers under various Ar/NF3 mixing *** decrease in the plasma density measured at the fixed measurement position (plume region) can be understood by the reduction of the electron energy relaxation length with increases in the gas pressures and mixing ratio of NF3/(Ar/NF3).We also performed downstream etching of silicon and silicon oxide films in this *** etch rate of the silicon films significantly increases while the silicon oxide is slightly etched with the gas pressures and *** was also found that the etch rate strongly depends on the wafer position on the processing chamber electrode,and that the etch selectivity reached 96-131 in the discharge conditions of RF powers (3730-4180 W) and gas pressures (3.6-4 Torr).

关键词： remote plasma source electron density cutoff probe downstream etch

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