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Small extracellular vesicles from hypoxia-preconditioned bone marrow mesenchymal stem cells attenuate spinal cord injury via miR-146a-5p-mediated regulation of macrophage polarization

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Neural Regeneration Research 2024年第10期19卷 2259-2269页

作者： Zeyan Liang Zhelun Yang Haishu Xie jian rao Xiongjie Xu Yike Lin Chunhua Wang Chunmei Chen Department of Neurosurgery Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Neurosurgical Institute FuzhouFujian ProvinceChina

Spinal cord injury is a disabling condition with limited treatment *** studies have provided evidence suggesting that small extracellular vesicles(SEVs)secreted by bone marrow mesenchymal stem cells(MSCs)help mediate the beneficial effects conferred by MSC transplantation following spinal cord ***,hypoxia-preconditioned bone marrow mesenchymal stem cell-derived SEVs(HSEVs)exhibit increased therapeutic *** thus explored the role of HSEVs in macrophage immune regulation after spinal cord injury in rats and their significance in spinal cord *** or HSEVs were isolated from bone marrow MSC supernatants by density gradient *** administration to rats via tail vein injection after spinal cord injury reduced the lesion area and attenuated spinal cord *** regulate macrophage polarization towards the M2 phenotype in vivo and in *** RNA sequencing and bioinformatics analyses of SEVs and HSEVs revealed that mi R-146a-5p is a potent mediator of macrophage polarization that targets interleukin-1 receptor-associated kinase *** mi R-146a-5p expression in HSEVs partially attenuated macrophage *** data suggest that HSEVs attenuate spinal cord inflammation and injury in rats by transporting mi R-146a-5p,which alters macrophage *** study provides new insights into the application of HSEVs as a therapeutic tool for spinal cord injury.

关键词： bone marrow mesenchymal stem cells hypoxia preconditioning interleukin-1 receptor-associated kinase 1 macrophages mesenchymal stem cells small extracellular vesicles spinal cord injury

Dimethylamine oxalate manipulating CspbI_(3) perovskite film crystallization process for high efficiency carbon electrode based perovskite solar cells

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journal of Energy Chemistry 2024年第6期93卷 221-228,I0006页

作者： Wenran Wang Xin peng jianxin Zhang jiage Lin Rong Huang Guizhi Zhang Huishi Guo Zhenxiao pan Xinhua Zhong Huashang rao Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642GuangdongChina College of Chemistry and Civil Engineering Shaoguan UniversityShaoguan 512005GuangdongChina Guangdong provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region Shaoguan UniversityShaoguan 512005GuangdongChina

Crystallization process determines the quality of perovskite films and the performances of resultant perovskite solar cells(pSCs).Dimethylamine oxalate has been proven as a multifunctional modulator,and is explored as an efficient additive in manipulating the crystallization process of CspbI_(3) perovskite *** one hand,oxalate serves as the precipitator that facilitates the nucleation process of *** larger size of intermediate is conductive to the larger size and smaller grain boundaries of resultant *** the other hand,in subsequent annealing process,the phase conversion and growth process of transient perovskite can be decelerated due to the strong interactions of oxalate with both dimethylamine cation(DMA^(+))and pb^(2+).Due to the optimized crystallization kinetics,the morphology and quality of CspbI_(3) perovskite films are comprehensively improved with lower defect concentrations,and charge recombination loss is effectively *** from the optimized crystal quality of perovskite films,the carbon electrode-based CspbI_(3) pSCs exhibit a champion efficiency of 18.48%.This represents one of the highest levels among all hole transport layer-free inorganic perovskite solar cells.

关键词： Solar cells perovskite CspbI_(3) Carbon electrodes Oxalate

Novel miR-490-3p/hnRNpA1-b/pKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the pI3K/AKT pathway

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World journal of Gastrointestinal Oncology 2024年第5期16卷 2038-2059页

作者： Xiang-Hui Wan Guo-Bing jin Qun Yang ji-Long Hu Zhi-Liang Liu jun rao Can Wen peng-Ling Li Xi-Mei Yang Bo Huang Xiao-Zhong Wang jiangxi Medical College Nanchang UniversityNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina jiangxi Key Laboratory of Translational Research for Cancer Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Abdominal Surgery Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of pathology Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Science and Education Section Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Children’s HospitalNanchang 330006Jiangxi ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina jiangxi province Key Laboratory of Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Heterogeneous ribonucleoprotein A1(hnRNpA1)has been reported to enhance the Warburg effect and promote colon cancer(CC)cell proliferation,but the role and mechanism of the miR-490-3p/hnRNpA1-b/pKM2 axis in CC have not yet been *** To investigate the role and mechanism of a novel miR-490-3p/hnRNpA1-b/pKM2 axis in enhancing the Warburg effect and promoting CC cell proliferation through the pI3K/AKT *** paraffin-embedded pathological sections from 220 CC patients were collected and subjected to immunohistochemical analysis to determine the expression of *** relationship between the expression values and the clinicopathological features of the patients was *** in mRNA expression were analyzed using quantitative real-time polymerase chain reaction,while differences in protein expression were analyzed using western *** proliferation was evaluated using the cell counting kit-8 and 5-ethynyl-2’-deoxyuridine assays,and cell cycle and apoptosis were detected using flow cytometric *** targeted binding of miR-490-3p to hnRNpA1-b was validated using a dual luciferase reporter *** Warburg effect was evaluated by glucose uptake and lactic acid production *** The expression of hnRNpA1-b was significantly increased in CC tissues and cells compared to normal controls(ppression of the hnRNpA1-b antigen in different stages of CC,including stage I,II-III,and ***,the clinicopathologic characterization revealed a significant correlation between hnRNpA1-b expression and clinical stage as well as T ***1-b was found to enhance the Warburg effect through the pI3K/AKT pathway,thereby promoting proliferation of HCT116 and SW620 ***,the proliferation of HCT116 and SW620 cells was inhibited when miR-490-3p targeted and bound to hnRNpA1-b,effectively blocking the Warburg ***

关键词： Heterogeneous ribonucleoprotein A1-b MiR-490-3p Colon cancer Alternative splicing Warburg effect

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轴向磁场混合永磁记忆电机电磁转矩精确分离

东南大学学报（自然科学版） 2024年第3期54卷 730-737页

作者：杨公德饶飞林明耀福州大学电气工程与自动化学院福州350108 东南大学电气工程学院南京210096

为了解决传统记忆电机转矩密度较低,电枢绕组与励磁绕组空间位置冲突等问题,结合轴向磁场永磁电机,提出一种新型轴向磁场混合永磁记忆电机.该电机采用定子分离结构,使用NdFeB与AlNiCo混合励磁,实现宽调速范围和高转矩密度.为了分析不同... 详细信息

为了解决传统记忆电机转矩密度较低,电枢绕组与励磁绕组空间位置冲突等问题,结合轴向磁场永磁电机,提出一种新型轴向磁场混合永磁记忆电机.该电机采用定子分离结构,使用NdFeB与AlNiCo混合励磁,实现宽调速范围和高转矩密度.为了分析不同永磁体对新型电机输出转矩的贡献,解决传统冻结磁导率法无法准确分离电磁转矩的问题,提出一种新型冻结磁导率法,并对比分析了2种方法的分离结果.结果表明:在不同磁化状态下,新型转矩分离方法的分离精度始终高于传统转矩分离方法,与有限元计算结果的相对误差始终小于5%;在正向完全充磁状态下,新型转矩分离方法与有限元计算结果的相对误差仅为0.94%.所提转矩分离方法实现了新型记忆电机中电磁转矩的精确分离.

关键词：混合永磁记忆电机定子分离冻结磁导率转矩分离

青藏高原及其周边侏罗纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 1211-1243页

作者：李建国饶馨牟林崔肖辉李鑫罗辉刘培学中国科学院南京地质古生物研究所中国科学院生物演化与环境卓越创新中心南京210008 中国科学院大学南京学院南京211135

侏罗纪是青藏高原构造演化的重要阶段,它结束了古特提斯构造演化,即将迎来印度板块的向北漂移和新特提斯的消减.地层时代是地质历史重建的基础.本文对近年来所取得的一些地层学、古生物新发现和新进展进行了综合和梳理,为青藏高原侏罗... 详细信息

侏罗纪是青藏高原构造演化的重要阶段,它结束了古特提斯构造演化,即将迎来印度板块的向北漂移和新特提斯的消减.地层时代是地质历史重建的基础.本文对近年来所取得的一些地层学、古生物新发现和新进展进行了综合和梳理,为青藏高原侏罗系建立了一个新的多重地层划分对比和时代框架.该框架包括巴颜喀拉、羌塘、拉萨-冈底斯和藏南喜马拉雅四个分区.其中,综合生物地层框架得到了很大的补充和细化,包括了一系列在青藏高原侏罗系中常见并在国际侏罗系划分对比中具有重要作用的化石门类,如海相的菊石、双壳、腕足、放射虫、有孔虫和沟鞭藻以及陆相的孢子花粉和轮藻等.通过菊石标准分子或特征属种,建立了该生物地层框架与国际地层委员会2020年侏罗纪地质年表(GTS 2020)的标准分带的对比.以此为基础,建立了青藏高原主要区块间侏罗系的横向对比.生物群对比揭示,侏罗纪时拉萨-冈底斯区与羌塘区的关系比与藏南喜马拉雅更紧密,它们总体属于东特提斯洋北缘海区同一个特征相似的生物地理区系,不太支持雅鲁藏布江缝合带特提斯是弧后小盆地的观点.综合地层、生物和沉积特征,研究认为,班公湖-怒江特提斯在晚三叠世开始张裂,可能在早侏罗世晚期已有初始洋壳增生形成;中侏罗世晚期班公湖-怒江洋发展至顶峰,随后开始收缩,羌塘地块向南俯冲与拉萨-冈底斯地块发生碰撞和拼合.

关键词：生物地层年代地层特提斯雅鲁藏布缝合带班公湖-怒江缝合带

Studies on LH modulated 8 kDa peptide involved regulation of testosterone production in rat Leydig cells

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Asian journal of Andrology 1999年第4期1卷 191-194页

作者： p.ramaraj.a.j.gannadha rao Department of Diabetes Endocrinology & Metabolism The University of Hope National Medical Centre 15000 East Duarte Road Duarte CA 91007 USADepartment of Biochemistry & Department of Molecular Reproduction Development & Genetics Indian Institute of Science Bangalore-560 0112 India

Aim: To demonstrate the role of the 8 kDa peptide in regulation of testosterone production by mt Leydig cells. Meth-ods: A peptide similar to 8 kDa peptide purified from immature rat Leydig cells was isolated and purified from rat lungcytosol. Immunological and structural similarity between the peptides purified from lung and Leydig cells was estab-lished by Western blot and tryptic map comparison respectively. Results: Addition of the 8 kDa peptide 10, 50, 100;and 150 ug decreased the production of testosterone in Leydig cells dose-dependently. But the addition of the peptide150 ug along with hCG had no effect on hCG-stimulated increase in testosterone production. Conclusion: In vitro ad-dition of the peptide purified from lung cytosol to adult rat Leydig cells resulted in a concentration-dependent decrease inbasal testosterone production although it had no effect on hCG-stimulated testosterone production. (Asian j Androl1999 Dec; 1: 191-194)

关键词： Leydig cells testosterone regulation differentiation steroidogenesis peptides LH

不均衡小样本下多特征优化选择的生命体触电故障识别方法

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电工技术学报 2024年第7期39卷 2060-2071页

作者：高伟饶俊民全圣鑫郭谋发福州大学电气工程与自动化学院福州350108 智能配电网装备福建省高校工程研究中心福州350108

针对现有的剩余电流保护装置无法有效识别触电事故的问题,该文提出了一种不均衡小样本下多特征优化选择的生命体触电故障识别方法。首先通过变分自编码器(VAE)对实验收集到的生命体触电小样本数据进行增殖以实现正负样本均衡;然后在时... 详细信息

针对现有的剩余电流保护装置无法有效识别触电事故的问题,该文提出了一种不均衡小样本下多特征优化选择的生命体触电故障识别方法。首先通过变分自编码器(VAE)对实验收集到的生命体触电小样本数据进行增殖以实现正负样本均衡;然后在时域上提取能够反映波形动态变化特性的23个特征量,并利用高斯核Fisher判别分析(GKFDA)与最大信息系数(MIC)法从中选择最优表达特征组;最后,提出基于遗忘因子的在线顺序极限学习机(FOS-ELM)算法实现生命体触电行为的鉴别。实验结果表明,所提方法利用不均衡小样本触电数据集就可以训练出一个优秀的分类模型,诊断准确率可达98.75%,诊断时间仅为1.33 ms。其优良的性能结合在线增量式学习分类器设计,使得模型具备新知识学习能力,具有极好的工程应用前景。

关键词：剩余电流保护装置生命体触电故障多特征优化选择基于遗忘因子的在线顺序极限学习机(FOS-ELM) 不均衡小样本

Dietary Green Tea Extract and Antioxidants Improve Insulin Secretory Functions of pancreatic β-Cells in Mild and Severe Experimental Rodent Model of Chronic pancreatitis

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Open journal of Endocrine and Metabolic Diseases 2024年第2期14卷 53-72页

作者： Galande Sheethal Ranjeet K. Tokala pavan pondugala Krishna Vemula Vijayalakshmi Venkatesan pothani Suresh Surya Satyanarayana Singh Guduru Venkat rao Duvvur Nageshwar Reddy Mitnala Sasikala Basic Science and Translational Research Division Asian Healthcare Foundation AIG Hospitals Hyderabad India Division of Cell and Molecular Biology National institute of Nutrition Hyderabad India National Animal Resource Facility for Biomedical Research Hyderabad India Department of Biochemistry Osmania University Hyderabad India Department of Surgical Gastroenterology Asian Institute of Gastroenterology Hyderabad India Department of Gastroenterology Asian Institute of Gastroenterology Hyderabad India

Chronic pancreatitis (Cp) is a progressive inflammatory disorder of the pancreas. It is predominantly idiopathic (with an unknown cause) in India and mostly due to alcohol in the West. Diabetes that occur secondary to chronic pancreatitis (T3c Diabetes) is often brittle, and is difficult to attain normoglycemia with conventional treatment requiring multiple doses of insulin. Mild and severe model of Cp was induced in mice by repeated intraperitoneal injections of cerulein and L-arginine respectively with an intent to study islet dysfunction and develop therapeutic strategy in animal models of Cp. Dietary intervention of epigallocatechin-3-gallate (EGCG) was tested in both the models of Cp for its beneficial effects on insulin secretory functions. pancreata collected upon euthanasia were used to study alterations in the morphology of pancreatic parenchyma and inflammation by staining with H&E and fibrotic changes by Masson’s trichrome and picrosirius staining. Insulin secretory functions of islets were evaluated to test the efficacy of the dietary intervention on β-cell functions. Intraperitoneal glucose tolerance test was performed to monitor the glucose homeostasis before and after the dietary intervention. Both the models resulted in Cp with dispersed acini, inflammation and fibrosis. The loss of acini and extent of fibrosis was more in L-arginine model. 2-fold improvement in glucose-stimulated insulin secretory functions of islets was observed with 0.5% EGCG dietary intervention in cerulein model of Cp and 1.6-fold in L-arginine model of Cp. A further improvement in insulin secretion by 3.2-fold was observed with additional dietary supplements like N-acetyl cysteine, curcumin in combination with EGCG. Our results thus demonstrate and highlight the therapeutic potential of dietary green tea (EGCG) supplementation in reversing islet dysfunction and improving glucose homeostasis in experimental chronic pancreatitis in mice.

关键词： Dietary Intervention C57BL6/j Mice Epigallocatechin-3-Gallate N-Acetyl Cysteine Curcumin Chronic pancreatitis Islets Glucose Stimulated Insulin Secretion

初始含水率和降雨能量对黑土团聚体溅蚀特征的影响

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水土保持学报 2024年第2期38卷 68-75页

作者：张转敏王彬饶伟王文刚北京林业大学水土保持学院北京100083 北京林业大学重庆缙云山三峡库区森林生态系统国家定位观测研究站北京100083

[目的]为明晰降雨能量和初始含水率对土壤团聚体溅蚀过程机制的影响。[方法]选取东北典型耕层黑土为研究对象,通过人工模拟降雨试验,探讨不同初始含水率、降雨能量和团聚体初始粒径的团粒溅蚀特征。[结果](1)4种初始粒径黑土团聚体的溅... 详细信息

[目的]为明晰降雨能量和初始含水率对土壤团聚体溅蚀过程机制的影响。[方法]选取东北典型耕层黑土为研究对象,通过人工模拟降雨试验,探讨不同初始含水率、降雨能量和团聚体初始粒径的团粒溅蚀特征。[结果](1)4种初始粒径黑土团聚体的溅蚀量均在初始含水率4%时最大,其中初始粒径25%后则呈增大现象。(2)4种初始粒径黑土团聚体的溅蚀量均随降雨能量的增加而增大。相较于降雨能量305 j/(m^(2)·h)(1 m)条件,当降雨能量增加至909 j/(m^(2)·h)(5 m)时,不同初始粒径团聚体溅蚀量分别增加15.37~20.70(j/(m^(2)·h)(2 m)以上时,不同降雨能量梯度下的溅蚀量存在显著差异。(3)降雨能量是影响溅蚀量的关键因素。降雨能量对溅蚀量的直接效应为0.811,存在显著正向影响,且相关程度最高;初始含水率和团聚体初始粒径的直接效应分别为0.193和0.352,存在显著负向影响。[结论]研究结果可为东北黑土区坡面土壤侵蚀过程机制研究和土壤侵蚀机理模型构建提供科学依据。

关键词：初始含水率降雨能量溅蚀量典型黑土区