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Evidence-based exp.r. consensus on clinical management of safety of Bruton’s tyrosine kinase inhibitors(2.2.)

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Chinese Journal of Cancer research 2024年第3期36卷 240-256页

作者： Zaiwei Song Dan Jiang Lingling Yu Yixuan Chen Daobin Zhou Yue Li Depei Wu Lingli Zhang Liyan Miao Jun Ma Jun Zhu Hongmei Jing rongsheng Zhao the Steering Committee,the Consensus panel and the Evidence Synthesis Group Evidence-based pharmacy professional Committee of Chinese pharmaceutical Association(CpA) hospital pharmacy professional Committee of Chinese pharmaceutical Association(CpA) Division of Therapeutic Drug Monitoring of Chinese pharmacological Society(CpS) Exp.r. Committee on Lymphoma of Chinese Society of Clinical Oncology(CSCO) Exp.r. Committee on Leukemia of Chinese Society of Clinical Oncology(CSCO) Society of Integrative Cardio-Oncology of China Anti-Cancer Association(CACA) Chinese Society of Hematology of Chinese Medical Association(CMA) hospital pharmacy professional Committee of Cross-Straits Medicine Exchange Association(SMEA) Dep.r.ment of pharmacy Peking University Third HospitalBeijing 100191China Institute for Drug Evaluation Peking University Health Science CenterBeijing 100191China Therapeutic Drug Monitoring and Clinical Toxicology Center Peking UniversityBeijing 100191China Dep.r.ment of pharmacy Administration and Clinical pharmacy School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Dep.r.ment of Hematology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Dep.r.ment of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbin 150001China Dep.r.ment of Hematology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Dep.r.ment of pharmacy Evidence-based Pharmacy CenterWest China Second HospitalSichuan UniversityChengdu 610041China Dep.r.ment of pharmacy the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Dep.r.ment of Hematology and Oncology Harbin Institute of Hematology and OncologyHarbin 150010China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China Dep.r.ment of Hematology Peking University Third HospitalBeijing 100191China 不详

Bruton’s tyrosine kinase inhibitors(BTKis)have revolutionized the treatment of B-cell ***,safety issues related to the use of BTKis may hinder treatment continuity and further affect clinical efficacy.A comprehensive and systematic exp.r. consensus from a pharmacological p.r.pective is lacking for safety issues associated with BTKi treatment.A multidisciplinary consensus working group was established,comprising 3. members from the fields of hematology,cardiovascular disease,cardio-oncology,clinical pharmacy,and evidencebased *** evidence-based exp.r. consensus was formulated using an evidence-based ap.r.ach and the Delphi *** Joanna Briggs Institute Critical Ap.r.isal(JBI)tool and Grading of recommendations Assessment,Development,and Evaluation(GrADE)ap.r.ach were used to rate the quality of evidence and grade the strength of recommendations,*** consensus provides practical recommendations for BTKis medication based on nine aspects within three domains,including the management of common adverse drug events such as bleeding,cardiovascular events,and hematological toxicity,as well as the management of drug-drug interactions and guidance for special *** multidisciplinary exp.r. consensus could contribute to promoting a multi-dimensional,comprehensive and standardized management of BTKis.

关键词： Consensus BTK inhibitors safety adverse drug events drug-drug interactions

Exploring in vitro roles of sirNA in cardiovascular disease

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Acta pharmacologica Sinica 2007年第1期28卷 1-9页

作者： Yu TANG~(2.3. Yu-zhi GE~3.James Q YIN~(2.4)2.Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China 3.United Cardiovascular De{3.ment,Jiangxi provincial people's hospital,Nanchang 3.0046,China InstituteofBiophysics ChineseAcademyofSciencesBeijing100101China UnitedCardiovascularDep.r.ment JiangxiProvincialPeople'sHospitalNanchang330046China

rNA interference(rNAi)is an adaptive defense mechanism through which double-stranded rNAs silence cognate genes in a sequence-specific *** has beenemployed widely as a powerful tool in functional genomics studies,target valida-tion and therapeutic product ***,the application of small-interfering rNA(sirNA)to the silencing of the disease-causing genes involvedin cardiovascular diseases has made great *** this overview,we attemptto provide a brief outline of the current understanding of the mechanism of rNAiand its potential application to the cardiovascular system,with p.r.icular empha-sis on its ability to identify the pathophysiological function of genes related toseveral imp.r.ant cardiovascular *** prospects of rNAi-basedtherapeutics,as well as the advantages and potential problems,are also discussed.

关键词： sirNA rNAigene silencing cardiovascular disease gene therapy

CT examination, clinical situation and exp.r.mental characteristics of infants with intracranial hemorrhage induced by delayed vitamin K deficiency

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Neural regeneration research 2006年第9期1卷 801-805页

作者： Zhiqing Lin1, Feng Fang1, Min Chen2. Guoxiang Cai3.1Dep.r.ment of pediatrics, Tongji hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 43.03., Hubei province, China 2.ep.r.ment of pediatrics, 3.ep.r.ment of radiation Medicine, Zhongshan hospital Affiliated to Xiamen University, Xiamen 3.1004, Fujian province, China Dep.r.ment of pediatrics Tongji Hospital Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Dep.r.ment of pediatrics Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China Dep.r.ment of radiation Medicine Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China

BACKGrOUND: Delayed vitamin K deficiency is characterized by acute onset, severe illness and high fatality rate. 3.%-50% survivors accompany with other various nervous system sequelas. Therefore, diagnosis and treatment of intracranial hemorrhage in time become a key factor for improving healing rate and reducing fatality rate and incidence of sequela. OBJECTIVE: To investigate the clinical situation, exp.r.mental characteristics, CT examination and terminative characteristics of infants with intracranial hemorrhage induced by delayed vitamin K deficiency. DESIGN: Case analysis. SETTING: Dep.r.ment of pediatrics, Zhongshan {2. Affiliated to Xiamen University. p.r.ICIpANTS: A total of 17 infants with intracranial hemorrhage induced by delayed vitamin K deficiency aged 1-3.months including 11 boys and 6 girls were selected from Dep.r.ment of pediatrics, Zhongshan {2. Affiliated to Xiamen University from January 1994 to December 2.05. All infants had drowsiness, rejective milk, spiting milk, gaze of both eyes, tic, coma, full anterior fontanelle, high muscular tension and cerebral hernia, etc. Exp.r.mental examination demonstrated that infants had anemia at various degrees; prothrombin time and p.r.ial thromboplastin time were prolonged; platelet count was normal. CT examination indicated that screenages of subarachnoid hemorrhage, subdural hematoma, cerebral p.r.nchyma hemorrhage and intraventricular hemorrage were changed. Hemorrhage was stopped by the application of vitamin K. All patients provided informed consent. METHODS: ① Clinical situation and physical sign of infants were observed after {2.ization and scanned with rapid sp.r.l CT scanning system. The thickness and average space of layers were 8-10 mm and the scanning time was 5 s with window width of 3.-80 Hu and window position of 2.-3. Hu. ② After {2.ization, four items of blood coagulation was measured with Futura meter and biochemical indexes of blood, such as serum calcium, serum alka

关键词： clinical situation and exp.r.mental characteristics of infants with intracranial hemorrhage induced by delayed vitamin K deficiency CT examination

A primary Study of the proliferation Sti mulation Effect by p.r.oloquinoline Quinone (pQQ) on Cultured Schwann Cells

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生物医学工程学杂志 2005年第S1期22卷 79-80,102页

作者： Hao-Huan LI~1 Shi-Qing LIU~1 Jing-ping OU YANG~2.Hao pENG~1Yi XU~2.Hai-Lu YANG~2.Fei ZENG~3.1(Orthopedic De{3.ment of renmin hospital,Wuhan University, Wuhan 43.060, China)2.pathophysiology De{3.ment, School of Medicine, Wuhan University, Wuhan 43.071, China)3.Neurology De{3.ment of renmin hospital of Wuhan University, Wuhan 43.060, China)

Frequent 3.2. Allelic Loss and Methylation-Associated rASSF1A Inactivation in Non-Small Cell Lung Cancer and Its Clinical Implication

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Wuhan University Journal of Natural Sciences 2009年第5期14卷 457-464页

作者： ZHU Hong WONG Maria p Dep.r.ment of pathology Beijing Friendship Hospital Capital Medical University Beijing 100050 China Dep.r.ment of pathology Hong Kong University Hong Kong China

A total of 110 primary NSCLCs （non-small cell lung cancers） were recruited in this study to characterize the pattern of 3.2. LOH together with the rASSF1A methylation status and their clinical implication. 3.2. LOH by 8 microsatellite markers, rASSF1A methylation status by methylation-specific p.r.（MSp.r. as well as bisulfite genomic sequencing （BGS）, and rASSF1A expression level by real-time quantitative p.r.was p.r.ormed. 3.2. LOH is frequent in NSCLC with a mean frequency of （41.2.3.7）%. Significant associations between 3.2. LOH and gender, smoking history, histological type, and tumor size were observed. Cases with LOH have a slightly lower rASSF1A expression than cases without LOH but not statistically significant. Comp.r.son of rASSF1A methylation that resulted from the three analyses shows significant correlations from one another. Higher frequency of methylation was observed in larger tumors and in smokers comp.r.d with smaller tumors and non-smokers, respectively. A significant correlation was also observed in extent between methylation and rASSF1A expression, illustrating that epigenetic mechanism could affect gene expression. The significant clinicopathological relations of 3.2. LOH may be of great use for both early detection and therapeutic interventions.

关键词： non-small cell lung cancer loss of heterozygosity rAS association domain family IA gene (rASSF1A) methylation real-time quantitative pCr

prep.r.tion of Filling p.r.us Osteoconduction Materials and Its Animal Exp.r.ment Study

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Journal of Wuhan University of Technology(Materials Science) 2011年第2期26卷 232-235页

作者：陈晓明 Biomedical Materials and Engineering research Center Wuhan University of Technology

titanium rods were processed into implant samples with cavity and groove in which was filled with HAp/β-TCp p.r.us osteoconduction composite materials in order to increase the mechanical stability of the implant in *** phase compositions of the composite was characterized by X-ray diffraction （XrD） and scanning electron microscopy（SEM）.Histological evaluation showed that the biogradable composite could enhanced the ability of new bone *** composite can conduct new bone tissue growing into the cavities gradually after implanted into animal,and then achieve mechanical *** filling biogradable compound exhibited excellent biocompatibility,which combined with the new bone tissues tightly without inflammation and loosing.

关键词： β-tricalcium phosphate hydroxyapate filling osteoconduction titanium animal exp.r.ment

Optimization of Multiplex p.r.Systems for Gene-chip Detection of Mutations in Exons in cTnI Gene Associated with FHCM

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稀有金属材料与工程 2006年第S3期 270-273页

作者： Nongyue He~1 Yuanying Zhang~(1,2. Jinan Zhang~3.(1.State Key Laboratory of Bioelectronics,Southeast University,Nanjing 2.0096,China) (2.Jiangsu Cancer {3.,Nanjing 2.0007,China) (3.research Institute of Cardiovascular Disease,First Affiliated {3. of Nanjing Medical University,Nanjing 2.002.,China)

Hyp.r.rophic cardiomyopathy （HCM） is one of the diseases damaging people health most badly and some mutations of exons in cardiac troponin I （cTnI） gene are closely associated with family hyp.r.rophic cardiomyopathy （FHCM）.A microarray was fabricated to screen mutations in exons 3.5,7,and 8 in cTnI *** were designed for the p.r.（polymerase chain reaction） to amplify the target DNA fragments from fresh blood *** order to simplify the p.r.process,multiplex p.r.technology was investigated in *** concentration of Mg2.played an imp.r.ant role in multiplex p.r.process,a prop.r.y low concentration of Mg2.submitted a better speciality of p.r.*** speciality was also favored when the annealing temp.r.ture was reasonably enhanced and 64℃is the optimal annealing temp.r.ture for the multiplex p.r.*** applying the fabricated gene-chip to detect the target fragments from p.r.mixture,the signal intensity sequence is in accordance with that from theoretic estimate.

关键词： hyp.r.rophic cardiomyopathy(HCM) gene-chip multiplex pCr mutation hybridization

Single-nucleotide polymorphisms among microrNA:big effects on cancer

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Chinese Journal of Cancer 2011年第6期30卷 381-391页

作者： Feng-Ju Song1,2.and Ke-Xin Chen1,2.Dep.r.ment of Epidemiology and Biostatistics,1Tianjin Medical University Cancer {3. and Institute,Tianjin 3.0060,p.r.China Key Laboratory of Breast Cancer prevention and Therapy,2.ianjin Medical University,Ministry of Education,Tianjin 3.0060,p.r.China Dep.r.ment of Epidemiology and Biostatistics Tianjin Medical University Cancer Hospital and Institute Tianjin 300060 People's Republic of China.

MicrorNAs(mirNAs) are small non-coding rNAs that regulate gene expression at the transcriptional or posttranscriptional *** mirNAs are found to play a significant role in cancer development either as tumor sup.r.ssor genes or as *** of tumor-specific mirNA expression profiles in diverse cancers has revealed widespread deregulation of these molecules,whose loss and overexpression respectively have diagnostic and prognostic *** variations,mostly single-nucleotide polymorphisms(SNps) within mirNA sequences or their target sites,have been found to be associated with many kinds of *** this review,we summarize the current knowledge of mirNAs including their biogenesis and role in cancer development,and finally,how SNps among mirNAs affect mirNA biogenesis and contribute to cancer.

关键词：单核苷酸多态性 microrNA 癌症 mirNA 非编码rNA 抑癌基因 rNA序列基因表达

Hepatocellular carcinoma in central Sydney :a 10yearreview of patients seen in a medical oncology dep.r.ment

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World Journal of Gastroenterology 1999年第6期5卷 483-487页

作者： Desmond Yip 1, Michael Findlay 2. Michael Boyer 1 and Martin H. Tattersall 3 royal prince Alfred hospital 澳大利亚 Wellington Cancer Centre 新西兰 University of Sydney 澳大利亚

AIM To rep.r. a single Australian oncology unit′s exp.r.ence with the management of patients with hepatocellular carcinoma (HCC), in the context of a literature review of the current management issues. METHODS retrospective case record review of 76 patients with diagnosis of HCC referred to the unit between 1984 and 1995. rESULTS Sixty three patients had adequate records for analysis. Thirty six (56%) were migrants with half from Southeast Asia. Twenty four patients had a documented viral aetiology. Nine (14%) of 51 patients with pathological confirmation of HCC had normal alpha fetoprotein levels. Median survival of the 2. patients managed palliatively was 5 weeks comp.r.d to 16 weeks for the cohort overall. Surgery in 16 patients rendered all initially disease free with a median survival of 88 weeks. Chemoembolisation induced tumor responses in 5 of the 11 patients so treated. Systemic chemotherapy and tamoxifen treatment caused tumor response in two of 12.and one of 2. respectively. CONCLUSION prolonged survival of patients with HCC depends on early detection of small tumors suitable for surgical resection. Other active treatments are palliative in intent and have limited success. In addition to tumor response and survival duration, the toxicities of therapies and the overall quality of life of patients need to be considered as imp.r.ant outcomes. Viral hepatitis prevention and screening of individuals at risk are strategies that are imp.r.ant for HCC management in communities where the disease is endemic.

关键词： carcinoma, hepatocellular liver neoplasms survival/rate Australia