Exploring in vitro roles of siRNA in cardiovascular disease
Exploring in vitro roles of siRNA in cardiovascular disease作者机构：Institute of Biophysics Chinese Academy of Sciences Beijing China United Cardiovascular Department Jiangxi Provincial People's Hospital Nanchang China
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2007年第28卷第1期
页 面：1-9页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：the Hundred Talents Program of the Chinese Academy of Sciences the High-Tech Project Foundation(863 project)(No_2002BA711A01-22)
主 题：siRNA RNAigene silencing cardiovascular disease gene therapy
摘 要：RNA interference(RNAi)is an adaptive defense mechanism through which double-stranded RNAs silence cognate genes in a sequence-specific *** has beenemployed widely as a powerful tool in functional genomics studies,target valida-tion and therapeutic product ***,the application of small-interfering RNA(siRNA)to the silencing of the disease-causing genes involvedin cardiovascular diseases has made great *** this overview,we attemptto provide a brief outline of the current understanding of the mechanism of RNAiand its potential application to the cardiovascular system,with particular empha-sis on its ability to identify the pathophysiological function of genes related toseveral important cardiovascular *** prospects of RNAi-basedtherapeutics,as well as the advantages and potential problems,are also discussed.
同方期刊数据库