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Crosstalk between androgen signaling and the chemokine receptor CXCR4:a novel strategy to promote myelin regeneration

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neural Regeneration Research 2025年第9期20卷 2581-2582页

作者： Marianne Bardy-Lagarde Narimène Asbelaoui Abdel Mouman Ghoumari UMR1195 “Diseases and Hormones of the Nervous System”Inserm and University Paris-SaclayKremlin-BicêtreFrance

Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

关键词： myelin al. CXCR4

The g-factor measurement as an ultimate test for nuclear chirality

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Frontiers of physics 2024年第3期19卷 1-10页

作者： Ernest Grodner Michał Kowalczyk Julian Srebrny Leszek próchniak Chrystian Droste Jan Kownacki Maciej Kisieliński Krzysztof Starosta Takeshi Koike National Centre for Nuclear Research 05-540ŚwierkPoland Heavy Ion Laboratory University of WarsawPasteura 5a02-093 WarsawPoland Faculty of physics University of WarsawPasteura 502-093 WarsawPoland Simon Fraser University 8888 University Drive BurnabyB.C.Canada V5A 1S6 Department of physics Tohoku UniversitySendaiMiyagi 980-8577Japan

We present results of a series of experiments aimed at finding the most direct fingerprints of a phenomenon of nuclear chirality. These experiments brought a detailed knowledge of the so called partner bands in 132La, 128Cs and 126Cs including absolute values of E2 and M1 transition probabilities obtained through the DSA (Doppler Shift Attenuation) method. Considering the indirect character of observables such as energies and transition rates we proposed measurement of the g-factor of a chosen state as a direct, ultimate test of chirality. Our experiment on the bandhead of partner bands in 128Cs showed feasibility of this approach. Measured value of the g-factor which suggests non-chiral character of this state leads to another puzzle in the chirality studies — how the chirality emerges with increasing spin of levels along a partner band.

关键词： nuclear chirality electromagnetic transitions electromagnetic moments level lifetimes

Intestinal glucagon-like peptide-1:A new player associated with impaired counterregulatory responses to hypoglycaemia in type 1 diabetic mice

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World Journal of Diabetes 2024年第8期15卷 1764-1777页

作者： Fang-Xin Jin Yan Wang Min-ne Li Ru-Jiang Li Jun-Tang Guo Department of Histology and Embryology Key Laboratory of Universities in Shandong ProvinceShandong Second Medical UniversityWeifang 261053Shandong ProvinceChina Department of pathological physiology Shandong Second Medical UniversityWeifang 261053Shandong ProvinceChina

BACKGROUND Impaired hypoglycaemic counterregulation has emerged as a critical concern for diabetic patients who may be hesitant to medically lower their blood glucose levels due to the fear of potential hypoglycaemic ***,the pathogenesis of hypoglycaemic counterregulation is still ***-like peptide-1(GLp-1)and its analogues have been used as adjunctive therapies for type 1 diabetes mellitus(T1DM).The role of GLp-1 in counterregulatory dysfunction during hypoglycaemia in patients with T1DM has not been *** To explore the impact of intestinal GLp-1 on impaired hypoglycaemic counterregulation in type 1 diabetic *** T1DM was induced in C57BL/6J mice using streptozotocin,followed by intraperitoneal insulin injections to create T1DM models with either a single episode of hypoglycaemia or recurrent episodes of hypoglycaemia(DH5).Immunofluorescence,Western blot,and enzyme-linked immunosorbent assay were employed to evaluate the influence of intestinal GLp-1 on the sympathetic-adrenal reflex and glucagon(GCG)*** GLp-1 receptor agonist GLp-1(7-36)or the antagonist exendin(9-39)were infused into the terminal ileum or injected intraperitoneally to further investigate the role of intestinal GLp-1 in hypoglycaemic counterregulation in the model *** The expression levels of intestinal GLp-1 and its receptor(GLp-1R)were significantly increased in DH5 *** instances of excess of intestinal GLp-1 weakens the sympathetic-adrenal reflex,leading to dysfunction of adrenal counterregulation during ***5 mice showed increased pancreaticδ-cell mass,cAMp levels inδcells,and plasma somatostatin concentrations,while cAMp levels in pancreaticαcells and plasma GCG levels ***,GLp-1R expression in islet cells and plasma active GLp-1 levels were significantly increased in the DH5 *** experiments involving terminal ileal infusion and intraperitoneal injection in the model mice demonstra

关键词： Glucagon-like peptide-1 Impaired hypoglycaemic counterregulation Type 1 diabetes Intestine pancreas

Crosstalk between androgen signaling and the chemokine receptor CXCR4:a novel strategy to promote myelin regeneration

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neural Regeneration Research 2025年第09期 2581-2582页

作者： Marianne Bardy-Lagarde Narimène Asbelaoui Abdel Mouman Ghoumari UMR1195 "Diseases and Hormones of the Nervous System"Inserm and University Paris-Saclay

Multiple sclerosis(MS) is the most common chronic disease of the central nervous system(CNS) in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.

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The Life and political Leadership of Gra?a Machel

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心理传记与质性心理学

心理传记与质性心理学 2024年第1期 126-154页

作者： Claude-Hélène Mayer University of Johannesburg South Africa

This article focuses on the life and political leadership of an extraordinary woman leader, Gra?a Machel. Gra?a Machel was born in very poor circumstances in rural Mozambique, became a fighter against colonialism, and married to presidents: firstly, she married Samora Machel, later she married nelson Mandela. At the same time, she followed her own political career, always promoting a political agenda of education, peace and distribution of wealth. Her political leadership is an extraordinary example for leaders in Southern Africa and the world. This psychobiography contributes to expanding the psychobiographies on extraordinary women in political leadership in Southern Africa. Its aim is to present new insights into the life of Gra?a Machel and her political leadership as a woman leader in pan-African contexts from a psychobio-graphical perspective.

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Acute coalescent mastoiditis in a 16-month-old child due to Streptococcus pneumoniae infection

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Journal of Acute Disease 2024年第1期13卷 36-39页

作者： Magdalena pszczołowska Monika Morawska-Kochman Katarzyna Resler Katarzyna pękalska Tomasz Zatoński Department and Clinic of Otolaryngology Head and Neck SurgeryWrocław Medical UniversityBorowska 213WrocławPoland Department of General Radiology Interventional Radiology and NeuroradiologyWrocław Medical UniversityBorowska 213WrocławPoland

Rationale:Acute otitis media is a common disease in early childhood,and is usually caused by Streptococcus pneumoniae(***).Acute mastoiditis is a complication of acute otitis media and can involve not only the mucoperiosteum of the middle ear but can also spread to the periosteum by destroying the mastoid bone(acute coalescent mastoiditis).In addition,the infection can extend through the surrounding bones or the emissary veins beyond the mastoid’s air cells,leading to subperiosteal ***’s Concern:A 16-month-old female patient was hospitalized due to the purulent discharge of the left ear and the symptoms of right mastoiditis(swelling and redness of the skin).Diagnosis:Bilateral acute coalescent mastoiditis caused by *** *** computer tomography revealed bilateral bone destruction of the mastoid and abscesses found behind the auricle on both ***:The patient underwent intravenous antibiotic therapy and surgical ***:The patient was discharged 14 days after hospitalization with an improved ***:Improperly treated acute coalescent mastoiditis can lead to extracranial and intracranial complications,sometimes serious and even *** are prevalent in children under 2 years,in whom the disease progresses more rapidly and *** vaccination with a 13-valent vaccine may not result in sufficient immunity against ***,a predominant pathogen in children affected by acute coalescent mastoiditis.

关键词： Acute otitis media Acute coalescent mastoiditis Streptococcus pneumoniae Children Case report

Effects of prandtl and Jacob Numbers and Dimensionless Thermal Conductivity on Velocity profiles in Media (porous and Liquid)

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Journal of Modern physics 2024年第10期15卷 1603-1614页

作者： Momath Ndiaye Madialène Sene Goumbo Ndiaye Department of Hydraulics Rural Engineering Machinery and Renewable Energy UFR Fundamental and Engineering Sciences University of Sine Saloum El Hadj Ibrahima NIASS Kaolack Senegal

In this present study, we analyzed the effects of prandtl and Jacob numbers and dimensionless thermal conductivity on the velocity profiles in media (porous and liquid). The transfers in the porous medium and the liquid film are described respectively by the improved Wooding model and the classical boundary layer equations. The mesh of the digital domain is considered uniform in the transverse and longitudinal directions. The advection and diffusion terms are discretized with a back-centered and centered scheme respectively. The coupled systems of algebraic equations thus obtained are solved numerically using an iterative line-by-line relaxation method of the Gauss-Seidel type. The results show that the parameters relating to the thermal problem (the dimensionless thermal conductivity, the prandtl (pr) and Jacob (Ja) numbers) have no influence on the dimensionless speed, although the thermal and hydrodynamic problems are coupled. Via the heat balance equation. The results obtained show that the parameters relating to the thermal problem have no influence on the dimensionless speed, although the thermal and hydrodynamic problems are coupled via the heat balance equation. So, at first approximation with the chosen constants, we can solve the hydrodynamic problem independently of the thermal problem.

关键词： Condensation Implicit Finite Difference Thin Film porous Material Model Wooding Vertical Wall

potential of contemporary earth-sheltered buildings to achieve plus Energy status in various European climates during the heating season

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Building Simulation 2024年第1期17卷 41-52页

作者： Aleksandar nesovic nebojsa Jurisevic Robert Kowalik lvana Terzic Faculty of Engineering University of KragujevacSestre Janjic 634000 KragujevacSerbia Faculty of Environmental Geomatic and Energy EngineeringKielce University of TechnologyTysigclecia Panstwa Polskiego725-314 KielcePoland

This study investigates the potential of contemporary Earth-Sheltered Buildings to contribute to sustainable societies by achieving plus Energy Building status during the heating *** buildings analyzed are intended to house a four-member family(102.5 m^(2)).The house is equipped with a ground source heat pump,geothermal vertical probes,floor heating panels,an energy recovery ventilator,and building-integrated photovoltaic panels installed on the exposed building *** numerical analysis(using Energyplus software)was carried out for nine European sites covering five different climatic zones(namely:southern,Atlantic,continental,alpine,and northern climate)and three latitude belts spanning Europe from south to *** above 65°N(northern and alpine climate)could not achieve plus Energy status with 20% efficient *** 15% efficient BIpVs,the building above 59°N(northern climate)was incapable of achieving this as *** the monthly time step,the buildings in the southern and Atlantic climates with 15% efficient BipVs were able to produce an energy surplus every month,as was the building in theAlps with 20% efficientBIpVs.

关键词： civil engineering earth-sheltered buildings renewable energy sustainable societies plus Energy Buildings Energy plus software

昆虫生理中短神经肽F的功能研究进展（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期 389-410页

作者： Marcin CHOLEWI?ski Szymon CHOWA?ski Jan LUBAWY Arkadiusz URBA?ski Karolina WALKOWIAK-NOWICKA pawe? MARCINIAK 亚当密茨凯维奇大学生物学院动物生理学和发育生物学系

短神经肽F(sNpF)肽家族是参与调控昆虫体内各种生理过程的多功能神经激素。它们广泛分布于生物体中，但前体分子中的异构体数量因物种而异，从一个到四个不等。sNpF受体（sNpFR）属于G蛋白偶联受体家族，在多种昆虫目中已有表征，并被... 详细信息

短神经肽F(sNpF)肽家族是参与调控昆虫体内各种生理过程的多功能神经激素。它们广泛分布于生物体中，但前体分子中的异构体数量因物种而异，从一个到四个不等。sNpF受体（sNpFR）属于G蛋白偶联受体家族，在多种昆虫目中已有表征，并被证明是哺乳动物泌乳素释放肽受体（prpR）的同源物。sNpF信号通路通过与其他神经激素（例如类胰岛素肽、SIFamide和色素分散因子（pDFs））的相互作用以调控多种生理过程。其主要生理功能涉及摄食的调节，但观察到的效应因物种而异。sNpF还与觅食行为和嗅觉系统的调节相关。其对摄食及能量代谢的影响还可能间接影响其他重要过程，例如繁殖和发育。此外，这些神经激素还参与昆虫的运动活动和昼夜节律的调节。本文回顾并总结了昆虫中sNpF系统的现阶段研究进展。

关键词：昆虫神经肽无脊椎动物神经生物学短神经肽F(sNpF) 摄食神经激素