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Comparison of mismatch repair and immune checkpoint protein profile with histopathological parameters in p.ncreatic,periampullary/ampullary,and choledochal adenocarcinomas

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 875-882页

作者： Arzu Hazal Aydın nesrin Turhan Department of pathology Aksaray University Aksaray Training and Research HospitalAksaray 68200Turkey Department of pathology University of Health Sciences Ankara City HospitalAnkara 06800Turkey

BACKGROUnD p.ncreatic,periampullary/ampullary,and choledochal adenocarcinomas are aggressive malignancies with a poor *** checkpoint blockade is a promising treatment option for several tumor types.H long terminal repeatassociating 2(HHLA2),which is analogous to programmed death-ligand 1(pDL1),is a recently discovered member of the B7/cluster of differentiation 28 family and is expressed in many *** To analyze the expression of HHLA2 and its association with the pathologic biomarkers that predict sensitivity to *** ninety-two adenocarcinoma cases located in the p.ncreas,ampulla,and distal common bile duct were *** study assessed 106 p.ncreaticoduodenectomy and distal/total p.ncreatectomy samples that were delivered to Ankara City Hospital between 2019 and *** was conducted to examine the expression of DnA mismatch repair(MMR),pD-L1,and HHLA2 *** patients with high HHLA2 expression had a higher mean age than those with low *** HHLA2 expression was associated with high perineural ***2 expression was low in pathological stage T3(pT)3 cases and high in pathological stage T1,T2,and T4 *** was no correlation between HHLA2 expression and the expression of MMR proteins and *** Evaluation of HHLA2 expression in microsatellite stable and pD-L1-negative tumors may be useful for predicting the resp.nse of individuals to immunotherapy and may serve as a novel therapeutic target for immunotherapy in advanced-stage disease.

关键词： H long terminal repeat-associating 2 programmed death-ligand 1 Adenocarcinoma p.ncreas Ampulla of Vater Distal common bile duct

CL2ES-KDBC:A novel Covariance Embedded Selection Based on Kernel Distributed Bayes Classifier for Detection of Cyber-Attacks in IoT Systems

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Computers, Materials & Continua 2024年第3期78卷 3511-3528页

作者： Talal Albalawi p.Ganeshkumar Computer Science Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia

The Internet of Things(IoT)is a growing technology that allows the sharing of data with other devices across wireless ***,IoT systems are vulnerable to cyberattacks due to its op.nnes The proposed work intends to implement a new security framework for detecting the most specific and harmful intrusions in IoT *** this framework,a Covariance Linear Learning Embedding Selection(CL2ES)methodology is used at first to extract the features highly associated with the IoT ***,the Kernel Distributed Bayes Classifier(KDBC)is created to forecast attacks based on the probability distribution value *** addition,a unique Mongolian Gazellas Optimization(MGO)algorithm is used to optimize the weight value for the learning of the *** effectiveness of the proposed CL2ES-KDBC framework has been assessed using several IoT cyber-attack datasets,The obtained results are then compared with current classification methods regarding accuracy(97%),precision(96.5%),and other *** analysis of the CL2ES-KDBC system on IoT intrusion datasets is performed,which provides valuable insight into its performance,efficiency,and suitability for securing IoT networks.

关键词： IoT security attack detection covariance linear learning embedding selection kernel distributed bayes classifier mongolian gazellas optimization

presynaptic endoplasmic reticulum architecture and hereditary spastic paraplegia

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neural Regeneration Research 2024年第3期19卷 485-486页

作者： Juan Josépérez-Moreno Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen Del Rocío/CSIC/Universidad de Sevillaand Departamento de Biología CelularFacultad de BiologíaUniversidad de SevillaSevilleSpain

Hereditary spastic paraplegia(HSp)is a clinically and genetically heterogeneous neurodegenerative disorder,characterized primarily by progressive spasticity and weakness in the lower *** ients can also experience peripheral neuropathy,cognitive impairment,and other neurological *** date,more than 80 genes have been implicated in HSp,encompassing various cellular comp.nents,although mutations in genes encoding endoplasmic reticulum(ER)-shap.ng proteins are the most prevalent(parodi et al.,2017).ER-shap.ng proteins are generally known for regulating the tubulation and curvation of the ER,but most of them show additional functions,including fusion of ER tubules,microtubule-severing,ER autophagy,lipid droplet synthesis,contact sites with other organelles(Öztürk et al.,2020).This highlights the complexity of studying the role of these proteins and the link between ER function and HSp.

关键词： reticulum endoplasmic

Investigating Stability properties for Transition Metal Carbonate precursors Using Universal Cluster Exp.nsion Technique(UnCLE)as Cathodes for Li-Ion Batteries

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材料科学与工程（中英文A版） 2024年第1期14卷 26-33页

作者： Mogahabo Tebogo Morukuladi n.L.Lethole M.C.Masedi n.n.ngoepe p.E.ngoepe Materials Modelling Centre University of LimpopoPrivate Bag x1106Sovenga 0727South Africa Department of physics University of Fort HareAlice 5700South Africa

The universal cluster exp.nsion technique was used in this study to determine the binary phase diagrams for the transition metal carbonate precursors MCO3(M:Mn,ni,Co).The use of mixed cathode materials in lithium-ion batteries such as nMC(ni,Mn and Co)formulations,is a strategic approach to optimize performance,enhance safety and address cost and environmental considerations in the rapidly evolving field of energy *** study focuses on the cost issue related to lithium ion batteries by investigating the manganese rich nMC since manganese is more abundant and *** doped MnCO3 with nickel and doped MnCO3 with cobalt then ran cluster exp.nsion calculations to generate binary *** binary phase diagrams generated indicated that dop.ng MnCO3 with nickel favours the Mn-rich side,while dop.ng MnCO3 with cobalt favours 50%Mn-rich and 50%*** further extracted the most stable structures from both binary diagrams and determined their electronic,mechanical and vibrational stabilities using DFT(density functional theory)calculations within the LDA(local gradient approximation)with Hubbard parameter(U).The electronic properties revealed that both materials are semiconductors due to their narrow energy band gap obtained while the mechanical properties showed that structures are mechanically stable since their necessary conditions for trigonal and triclinic systems were satisfied.

关键词： Binary phase diagrams mechanical properties electronic conductivity phonon dispersion curves.

A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres M.Angélica Michea Ákos Végvári Marion Arce Valentina pérez Marcela Alcota Alicia Morales Rolando Vernal Mauricio Budini Roman A.Zubarev Fermín E.González Laboratory of Experimental Immunology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Department of Conservative Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Division of Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and Molecular pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is implicated in the pathogenesis of numerous chronic-inflammatory diseases,yet its association with progressive periodontitis remains *** investigate the involvement and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically monitored over twelve weeks via weekly clinical evaluations and gingival crevicular fluid(GCF)collection was performed for further *** metrics,proteomic data,in silico methods,and bioinformatics tools were combined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses validated key ***,a single-cell RnA sequencing(scRnA-seq)dataset(GSE164241)for gingival tissues was analyzed to elucidate cellular dynamics during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** samples from progressing and non-progressing periodontal sites showed quantitative and qualitatively distinct proteomic *** addition,specific biological processes and molecular functions during progressive periodontitis were revealed and a set of hub proteins,including SnCA,CA1,HBB,SLC4A1,and AnK1 was strongly associated with the clinical progression status of ***,we found specific proteins-drivers or suppressors-associated with ferroptosis(SnCA,FTH1,HSpB1,CD44,and GCLC),revealing the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitative proteomic data with scRnA-seq analysis suggested the susceptibility of fibroblasts to *** analyses reveal proteins and processes linked to ferroptosis for the first time in periodontal patients,which offer new insights into the molecular mechanisms of progressive periodontal *** findings may le

关键词： finding progression faster

Immune resp.nse to inactivated bacterial vector carrying the recombinant K39 antigen of Leishmania infantum in mice

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Asian pacific Journal of Tropical Biomedicine 2024年第5期14卷 199-206页

作者： Lucelina S.Araújo Bruno B.Silva Eduarda n.F.n.Santos Arnaldo S.Bezerra Samuel S.Frota Assis R.Montenegro Eridan O.p.T.Florean Maurício Fvan Tilburg Maria Izabel F.Guedes Laboratory of Biotechnology and Molecular Biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil Faculty of Veterinary Medicine State University of CearáFortalezaBrazil

Objective:To evaluate the immunological resp.nse elicited by an inactivated bacterial vector carrying the K39 antigen of Leishmania infantum,and a purified ***:Mice were subjected to the following treatments:(1)purified recombinant K39(rK39)protein at a 20μg dose with complete Freund’s adjuvant;(2)Inactivated Escherichia coli(BL21 DE3)carrying the K39 protein at an equivalent total protein content of 200μg;(3)Inactivated bacteria lacking the K39 protein;(4)non-immunized control *** monitoring was *** groups were challenged by intraperitoneal injection of 10^(7) Leishmania infantum *** euthanasia,the liver and spleen were collected to analyze the levels of TnF,IFn-γ,IL-12,IL-4,and ***:Mice immunized with purified rK39 or the inactivated bacterial vector carrying the K39 antigen of Leishmania infantum showed a long-lasting immune resp.nse with high levels of polyclonal antibodies specifically recognizing the recombinant *** IgG1 subclass was the predominant immunoglobulin;however,the induction of IgG2a and the profile of cytokines produced were indicative of the induction of a mixed-type ***:The inactivated bacterial vector carrying the K39 antigen,as well as the purified antigen can induce a long-lasting immune resp.nse in immunized mice,predominantly favouring a Th2 profile resp.nse.

关键词： Visceral leishmaniasis K39 Inactivated bacterial vector Vaccine Immune resp.nse Th1 Th2 Leishmania infantum

nonlinear-Optical Analogies in nuclear-Like Soliton Reactions:Selection Rules,nonlinear Tunneling and Sub-Barrier Fusion–Fission

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Chinese physics Letters 2024年第8期41卷 1-7页

作者： T.L.Belyaeva V.n.Serkin Universidad Autonoma del Estado de Mexico Av.Instituto Literario 100C.P.50000TolucaMexico Benemerita Universidad Autonoma de puebla Av.4 Sur 104C.P.72001PueblaMexico

The main goal of our study is to reveal unexpected but intriguing analogies arising between optical solitons and nuclear physics,which still remain hidden from *** consider the main cornerstones of the concept of nonlinear optics of nuclear reactions and the well-dressed repulsive-core *** the base of this model,we reveal the most intriguing properties of the nonlinear tunneling of nucleus-like solitons and the soliton selfinduced sub-barrier transparency *** describe novel interesting and stimulating analogies between the interaction of nucleus-like solitons on the repulsive barrier and nuclear sub-barrier *** main finding of this study concerns the conservation of total number of nucleons(or the baryon number)in nuclear-like soliton *** show that inelastic interactions among well-dressed repulsive-core solitons arise only when a“cloud”of“dressing”spectral side-bands appears in the frequency spectra of the *** property of nucleus-like solitons is directly related to the nuclear density distribution described by the dimensionless small shape-squareness *** the Fourier spectra of nucleus-like solitons are similar to the nuclear form *** show that the nuclear-like reactions between well-dressed solitons are realized by“exchange”between“particle-like”side bands in their spectra.

关键词： solitons soliton nonlinear

A novel diurnal and seasonal variation analysis of BTEX in Bengaluru urban area

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Research in Cold and Arid Regions 2024年第1期16卷 14-19页

作者： H.n.Sowmya M.Dinamani G.p.Shivashankara H.K.Ramaraju B.S.Surendra Vijaya V.Shanbhag R.prajwal Department of Civil Engineering Dayananda Sagar College of EngineeringBangalore 560078India Department of Chemistry Dayananda Sagar College of EngineeringBangalore 560078India Department of physics GFGCVijayanagarBengaluru 560040India

In the urban atmosphere of Bengaluru, various volatile organic compounds(VOCs), particularly Benzene,Toluene, Ethylbenzene, and Xylene(BTEX), have shown an increasing trend in concentration. The present research was conducted during summer and monsoon seasons, focusing on Kadubeesanahalli, a high-traffic area within the Bengaluru Metropolitan City. Hourly sample data was collected using a BTEX analyzer(Model GC955-600) and subsequently transformed into daily, monthly, and seasonal values. The study revealed distinct patterns in benzene concentrations. Benzene levels were lowest during the early morning hours, specifically from 1:00 *** 7:00 a.m.. Concentrations then increased from 7:00 a.m. to 9:00 a.m. and again from 4:00 p.m. to 11:00 p.m.,corresp.nding to the morning and evening peak traffic hours. However, between 10:00 a.m. and 4:00 p.m., the concentration decreased due to reduced traffic levels. These diurnal variations in benzene concentration are influenced by meteorological parameters. Comparing the two seasons, higher concentrations of Benzene, EthylBenzene, and Mp-xylene were observed during the summer season. This increase is attributed to the elevated temperatures during summer, which promote the vaporization of BTEX compounds. Conversely, lower BTEX concentrations were recorded during the monsoon season due to the wet deposition process. The observed positive correlation(r > 0.5) among BTEX parameters strongly suggests a common source, most likely originating from vehicular emissions.

关键词： BTEX Summer variation Meteorological parameters Correlation

Aberrant adult neurogenesis in intractable epilepsy:can GABAergic progenitor transplantation normalize this process?

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neural Regeneration Research 2024年第7期19卷 1419-1420页

作者： Muhammad n.Arshad Janice R.naegele Department of Biology Wesleyan UniversityMiddletownCTUSA Department of neuroscience Tufts University School of MedicineBostonMAUSA

Temporal lobe epilepsy(TLE) is a common type of focal epilepsy characterized by seizure foci within the temporal *** surgical resection of the foci is an established and effective approach for controlling seizures,both temporal lobes cannot be removed,due to their prominent roles in learning and ***,seizures induce changes to the temporal lobes that contribute to hyperexcitability,including mossy fiber sprouting,astrogliosis.

关键词： epilepsy progenitor seizures