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夜间血压降低幅度的减少和持续夜间高血压是继发性高血压的特有标志

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 28-28页

作者： Seeman t. palyzová D. Du■ek J. Janda J. 郭战宏 Department of pediatrics University Hospital Motol Charles University Prague V'Uvalu 84 15006 Prague 5 Czech Republic Dr.

Objective: to investigate with the use of ambulatory blood pressure (Bp) monitoring whether nocturnal Bp dip and nighttime Bp values are different in children with untreated primary and secondary hypertension. Study design: Ambulatory Bp monitoring studies from 145 children with untreated hypertension were retrospectively analyzed. Forty-five children had primary hypertension and 100 children had secondary hyperten sion. Results: Children with secondary hypertension had lower nocturnal Bp dip for systolic and diastolic Bp in comparison to children with primary hypertension (8% ± 5% vs 14% ± 4% for systolic and 14% ± 7% vs 22% ± 5% for diastolic Bp, p th). Eleven percent of children with primary hypertension were classified as nondipper (Bp dip tolic Bp and no child for diastolic Bp; on the contrary, in children with secondary hypertension, 65% were nondippers for systolic and 21% for diastolic Bp. Nocturnal systolic and diastolic Bp loads were significantly greater in children with secondary hypertension than in those with primary hypertension. Conclusions: Reduced nocturnal Bp dip and sustained nighttime Bp elevation are specific markers of secondary hypertension in children with untreated hypertension. Children with blunted nocturnal Bp dip or sustained nighttime hypertension should be thoroughly investigated searching for the underlying cause of hypertension.

关键词：继发性高血压夜间高血压血压降低原发性高血压夜间收缩压监测结果高血压患者回顾性分析舒张压非杓型

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手助腹腔镜在卵巢癌中的应用

世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 42-42页

作者： Krivak t.C Elkas J.C Rose G.S 朱国栋

the traditional approach to patients with ovarian cancer is cytoreductive surg ery and surgical staging through a vertical midline laparotomy. While laparoscop y has become an integral part of gynecologic surgery, debulking procedures have not been feasible to date with standard minimally invasive techniques. twenty-f ive patients with ovarian carcinoma un-derwent surgical staging and cytoreducti on using hand-assisted laparoscopy. We review the surgical technique and clinic al outcomes. twenty-five patients were managed during this study time frame wit h hand-assisted laparoscopy. Six patients had apparent advanced stage ovarian c ancer at the time of referral, and 17 patients had apparent early-stage ovarian cancer. Of the 19 patients with presumed early-stage disease, 5 patients were upstaged based on retroperitoneal lymph node involvement, 3 with disease to othe r pelvic structures, and 2 patients had microscopic disease in the omentum. twen ty-two patients had their surgeries completed via hand-assisted laparoscopy, a nd three cases required conversion to laparotomy for completion of debulking sur gery. Complication rates were low with three complications requiring reoperation or hospitalization. the mean hospital stay was 1.8 days for the 22 patients who had a successful hand-assisted laparoscopic evaluation. Operating times were v ariable and ranged from 81 to 365 min. Hand-as-sisted laparoscopy may be emplo yed in the initial management of early and advanced stage ovarian carcinoma. thi s approach allows for thorough evaluation of peritoneal and retroperitoneal stru ctures and surgical cytoreduction while retaining the advantages of minimally in vasive surgery.

关键词：手助腹腔镜肿瘤细胞减灭术早期卵巢癌晚期卵巢癌外科手术技术手术时间微转移灶首次治疗腹正中线术后并发症

巨脑性白质脑病伴皮层下囊肿:一个黎巴嫩家系的研究和文献回顾(法国)

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 6-6页

作者： Koussa S. Roukoz H. Rizk t. Mégarbané A. 方伯言 Htel-Dieu de France Université Saint-Jos- eph Beyrouth Lebanon

Introduction. Megalencephalic leukoencephalopathy with subcortical cysts is a rare disease with autosomal recessive inheritance. Materials and methods. two br others born from a consanguineous marriage, presenting with the phenotype of the disease, their parents, brothers and sisters were examined. Magnetic resonance imaging of the brain was performed for the two patients. Sequence analysis of Ml C1 (GenBank mRNA accession no. NM 015166) was performed for the patients using i ntronic primers. pCR restriction fragment length polymorphism analysis was done in patients, their parents and in 100 lebanese controls in order to exclude gene ***. the clinical features were characteristic of the disease, consisting of an early-onset macrocephaly followed by slowly progressive ataxia , pyramidal tract involvement and epileptic seizures. In one patient, the clinic al manifestations were aggravated by a trivial brain trauma. In his brother and in one female cousin, a status epilepticus was precipitated by a febrile syndrom e. the diffuse cerebral white matter lesions and the subcortical temporo-polar and frontal cysts, best seen on MRI,allowed making the *** genet ics revealed a new mutation involving the MlC1 gene (263G→t, exon 3). As a cons equence, it affects the second transmembrane domain predict (G88v) of the MlC pr otein (protein sequence Np 055981). the mutation was confirmed by pCR restrictio n fragment length polymorphism analysis. Conclusion. Megalencephalic leucoenceph alopathy with subcortical cysts may be individualized on clinical and radiologic al basis and confirmed by molecular genetics. In this lebanese family, a new mut ation of the MlC1 gene is reported.

关键词：白质脑病巨脑文献回顾脑白质癫痫持续状态近亲婚配共济失调基因多态性锥体束囊性变

应用酚磺乙胺预防脑室旁出血患儿的发育结果——一个随机对照试验

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 24-24页

作者： Schulte J. Osborne J. Benson J. W. t. 郭战宏 Bath U. for Research in paediatrics Royal United Hospital Combe Park Bath BA1 3NG United KingdomProf.

Objective: to compare neurodevelopmental outcome of survivors of the multicent re trial of etamsylate (the iRNN for ethamsylate) for prevention of periventricu lar haemorrhage in very low birthweight infants. Design: Double blind, single ob server, prospective follow up of placebo controlled study. Setting: Six neonatal intensive care units in the United Kingdom. Neurodevelopmental outcome was asse ssed in health premises or children’s homes. Subjects: 268 of 276 survivors of the original study were seen between 3.5 and 4.2 years of age. All were inborn and weighed 1500 g or less at birth. Intervention: Etamsylate 12.5 mg/kg or pl acebo six hourly from within one hour of delivery for four days. Main outcome me asures: McCarthy scales of children’s abilities, standardised neurological exam ination, full physical examination, functional assessment, seven letter Stycar v ision test, and audiometry. Results: there was no difference between the groups in neuromotor outcome (cerebral palsy) or in the general cognitive index (GCI) o f the McCarthy scales (mean GCI was 93.3 for the etamsylate group (n = 133) and 89.7 for the placebo group (n = 131); p = 0.10). there were more children wit h GCI v 19; p = 0.047) or ≤50 (3 v 11; p = 0.03) in the placebo group . Fewer children in the etamsylate group had squints (17 v 30; p = 0.042) or re quired surgery for patent ductus arteriosus (1 v 8; p = 0.036). Conclusions: Et amsylate was not associated with a reduction in cerebral palsy. Severe cognitive impairment was reduced, but more children died and the improvement may be becau se fewer survived with low GCI.

关键词：酚磺乙胺随机对照试验安慰剂对照存活者听力测定多中心试验极低体重儿全面体格检查神经发育认知损害

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高石灰石含量水泥的耐久性和适用性

高石灰石含量水泥的耐久性和适用性

用于工业的具有高频开关性能的1200v IGBt模块

2015中国水泥技术年会暨第十七届全国水泥技术交流大会

作者： C.Müller S.palm C.-A.Graubner Ing.t.proske Dipl.-Ing.S.Hainer M.Sc.M.Rezvani W.Neufert Dipl.-Ing.I.Reuken 孟刘邦张洪滔 Research Institute of the Cement Industry tU Darmstadt Spenner Zement GmbH&Co.KG

本研究项目的目的是为了在实验室和工厂生产和测试一种水泥,该水泥的石灰石含量超过欧洲标准197-1所允许的最大值,考虑到硫酸盐的影响,选取石灰石含量在30%0%之间。对于石灰石作为主要成分的水泥的性能,我们测试了其熟料的减少对混凝土... 详细信息

本研究项目的目的是为了在实验室和工厂生产和测试一种水泥,该水泥的石灰石含量超过欧洲标准197-1所允许的最大值,考虑到硫酸盐的影响,选取石灰石含量在30%0%之间。对于石灰石作为主要成分的水泥的性能,我们测试了其熟料的减少对混凝土强度发展和耐久性的影响。本文主要研究水泥中石灰石替代熟料对以上两性能的影响程度,该程度可以在实验室和实际环境中通过优化颗粒大小和组成分布以及改变混凝土工艺来进行估算。而就目前的现状来说;对于高石灰石含量水泥(石灰石最低质量分数50%)的生产以及在混凝土(加适量外加剂的低含水率混凝土)制备中的应用其工艺过程和方法都很复杂而不易控制,如果这些工艺方法能被应用在实际状况下,那么,我们有可能获得能够满足允许要求的混凝土耐久性的相关参数。然而,在实际的施工过程中这些工艺过程的操作都是很粗糙的,对于能否达到要求还得进一步去认证。另外,这些混凝土的蠕变和收缩的问题也需要进一步的研究,同时,石灰石质量的好坏对混凝土冻融测试的影响也需要更深一层的检验。我们通过高效地使用高石灰石含量可以高效利用波特兰水泥熟料,从而能够进一步提高生态平衡,就生态平衡来说,使用高石灰石含量的水泥制备的低含水率的混凝土,在同样的效果下(指抗压强度和耐久性),其全球变暖潜力比使用硅酸盐水泥II/A-ll或来自vDZ-EpD的普通水泥制备的混凝土低25%。

关键词：水泥测试石灰石含量耐久性适用性

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电力电子 2005年第5期3卷 62-64页

作者： N.lwomura Y.Onozawa Y.Cobayashi t.Miyasaka Y.Seki Fuji Hitachi power Semiconductor Co. Ltd

带有平面门极和场止结构的新型IGBt器件已应用到最新研发的1200v模块上。与沟槽门极相比,平面门极更适合高速应用。实验结果:在20kHz载波频率下,新的IGBt模块比沟槽门极IGBt模块降低大约20%的功率损耗。

关键词： IGBt模块开关性能高频工业 IGBt器件功率损耗门极

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溅射氧化铁薄膜的Hall效应

物理学报 1988年第10期 1613-1618页

作者：尤广建余梅罗惠临北京大学物理系 Department of Electrical & Computer Engineering University of California San Dicgo USA

在磁场垂直于薄膜表面,磁感应强度B由0—1.4t变化的条件下,测量了溅射氧化铁薄膜的Hall效应。从实验数据得到了Fe3O4薄膜和γ-Fe2O3薄膜的寻常Hall系数R0和非常Hall系数Rs,计算出这两种薄膜的Hall迁移率μH分别是2.35和1.56（cm）2/v·s... 详细信息

在磁场垂直于薄膜表面,磁感应强度B由0—1.4t变化的条件下,测量了溅射氧化铁薄膜的Hall效应。从实验数据得到了Fe3O4薄膜和γ-Fe2O3薄膜的寻常Hall系数R0和非常Hall系数Rs,计算出这两种薄膜的Hall迁移率μH分别是2.35和1.56（cm）2/v·s。这个结果适合于大极化子导电机制的条件（υ≥1（cm）2/v·s）。对于非常 Hall效应,应用 Berger的侧向跳跃模型进行了比较。观察到了这两种薄膜具有负的磁阻。

关键词：氧化铁薄膜 Hall Fe 大极化子跳跃模型溅射真空沉积

饮酒对经皮腔内冠状动脉成形术和支架植入术后再狭窄率的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第2期1卷 40-40页

作者： Niroomand F. Hauer O. tiefenbacher C.p. 张明娟 Universitt Heidelberg Innere Medizin III Bergheimer Stra sse 58 D-69115 Heidelberg Germany Dr.

Objective: to disclose possible influences of alcoholic beverages on restenosi s rate in men with coronary artery disease treated with percutaneous translumina l coronary angioplasty (ptCA) and stent implantation. Design: Retrospective coho rt study. patients: 225 consecutive male patients underwent ptCA and stent impla ntation. All patients had a control angiography and were contacted for a questio nnaire regarding their drinking habits. Main outcome measures: Mean late loss of luminal diameter, rate of coronary restenosis of 50%or more within the stented segment, and rate of repeat angioplasty. Results: 53 patients (with 80 stents) consumedlcohol a week and 172(with 266 stents) consumed more (50-700 g a week). Baseline characteristics were similar in both groups except for a hi gher prevalence of reduced cardiac function and multivessel disease and a lower high density lipoprotein cholesterol concentration among patients who consumed l ittle or no alcohol. patients who consumed ≥50 g alcohol a week had a lower mea n late loss of the luminal diameter (1.1 (0.79)mm v 1.45 (0.82) mm, p=0.002), a lower rate of coronary restenosis within the stented segment (33.7%v 48.8%, p= 0.001), and a lower rate of repeat angioplasty(23.3%v 42.5%, p=0.002). In mult ivariate analysis, only alcohol consumption and diabetes were independent and si gnificant discriminators for late loss of luminal diameter (p=0.005 and p=0.01, respectively), restenosis(odds ratio 0.54 and 2.08, respectively), and repeat an gioplasty(odds ratio 0.39 and 2.18, respectively). Conclusion: Alcohol intake is associated with reduced restenosis after ptCA and stent implantation.

关键词：支架植入术再狭窄率管腔直径血管成形术血管疾病回顾性队列研究高密度脂蛋白饮酒量造影术饮食习惯

甲状腺乳头状癌BRAF v600E、tERt和REt分子检测及与临床病理特征的关系

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临床与实验病理学杂志 2023年第6期39卷 661-667页

作者：尚轶钒黄思夏王佳鹤王玉姣陈伶俐张慧娟李烨王蕾吕新全郑州大学第一附属医院病理科郑州450052

目的探讨甲状腺乳头状癌(papillary thyroid carcinoma,ptC)中三种驱动基因BRAF v600E、tERt和REt与临床病理特征的关系。方法收集4678例ptC,2637例患者行BRAF v600E和tERt启动子检测(C250t和C228t位点),另2041例患者行BRAF v600E和REt检测,并分析以上3种基因与临床病理特征的关系。结果ptC中BRAF v600E、tERt及REt基因阳性检出率分别为88.9%(4161/4678)、0.5%(12/2637)、3.7%(75/2041)。BRAF v600E突变仅与被膜侵犯及桥本甲状腺炎伴随相关(ptERt启动子突变与患者年龄、肿瘤最大径、肿瘤数量、淋巴结转移、tNM分期均有关(pt基因融合与患者性别、肿瘤最大径、淋巴结转移、桥本甲状腺炎伴随有关(pv600E突变伴CCDC6-REt(Exon1-Exon12)基因重排变异,1例BRAF v600E突变伴NCOA4-REt(Exon6-Exon12/partial Exon7-Exon12)基因重排变异,10例BRAF v600E伴tERt启动子双突变。BRAF v600E伴tERt双突变在>55岁、较大肿瘤、多癌灶、有淋巴结转移或晚期患者中更易发生(pv600E在ptC中突变率极高,提示可作为ptC诊断的重要分子学依据;tERt及REt基因改变可反映肿瘤侵袭性生物学行为并提示预后不佳,两者均可伴有BRAF v600E突变,且BRAF v600E和tERt双突变提示更差的临床预后,因此联合多基因检测可更全面评估患者预后风险,为疾病预后分层及临床个性化治疗策略提供分子基础。

关键词：甲状腺乳头状癌 BRAF v600E tERt REt 多基因改变