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Influence of postoperative complications on long-term survival in liver transplant patients

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World Journal of Gastrointestinal Surgery 2020年第8期12卷 336-345页

作者： Sonia Castanedo Enrique Toledo Roberto Fernández-Santiago Federico Castillo Juan Echeverri Juan Carlos Rodríguez-sanjuán Department of General Surgery University Hospital Marqués de ValdecillaUniversity of CantabriaSantander 39008Spain

BACKGROUND Liver transplant(LT)is a complex procedure with frequent postoperative *** other surgical procedures such as gastrectomy,esophagectomy or resection of liver metastases,these complications are associated with poorer long-term *** is possible this happens in LT but there are not enough data to establish this *** To analyze the possible influence of postoperative complications on long-term survival and the ability of the comprehensive complication index(CCI)to predict *** Retrospective study in a tertiary-level university *** 164 participants were all patients who received a LT from January 2012 to July *** follow-up was done in the hospital until the end of the study or *** and risk after transplantation were calculated using the Charlson and balance of risk(BAR)scores,*** complications were graded according to the Clavien-Dindo classification and the *** assess the CCI cut-off value with greater prognostic accuracy a receiver operating characteristic(ROC)curve was built,with calculation of the area under the curve(AUC).Overall survival was estimated according to the Kaplan-Meier test and log-rank *** were compared by the Mann-Whitney *** the multivariable analysis the Cox regression was *** The mean follow-up time of the cohort was 37.76(SD=24.5)mo.A ROC curve of CCI with 5-year survival was *** AUC was 0.826(0.730-0.922),ppecificity 61.3%.Survival curves for comparison of patients with CCI scorepectively(log-rankpatients with more severe complications exhibit worse long-term *** cut-off values were *** between patients with CCI33.5(33.5=median CCI value)showed estimate

关键词： Liver transplant Complication Survival Comprehensive complication index Clavien prognosis

Microbiological Evaluation of prepared/Cooked Foods in a HACCp Environment

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Food and Nutrition Sciences 2011年第6期2卷 549-552页

作者： Esteban pérez António Raposo Rafael Millán Esther sanjuán Conrado Carrascosa 不详

In the production of safe food, a multitude of factors and elements along the food chain are involved. For this study we have established three factors relative to the food that have the possibility of influence on its microbiology content: basic ingredients, conservation time in refrigeration and handling degree. In the samples we looked forward three types of germens: warning, witness and pathogen. We did not find significant differences in the groups considered with regard to the variable of reference.

关键词： HACCp Food Microbiology Food Quality Food Safety Evaluation

Small Food Businesses: Trying to Improve Taking Records with a Mobile Device Application

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Intelligent Information Management 2011年第4期3卷 125-130页

作者： Esteban pérez António Raposo Conrado Carrascosa Esther sanjuán Cristina Mauricio Rafael Millán 不详

pDA’s (personal Digital Assistant) and mobile phones have become multitasking devices that provide an enormous potential in various fields, including HACCp. We have designed a record taking software in order to be used in small food catering establishments, like canteens or restaurants. It’s developed for Windows Mobile? for use in mobile devices such as pDA’s and Smartphone’s. It enables the creation of four types of records: -Reception;-Temperature;-Cleaning;-Chlorine level in water. It’s possible to export data to common file formats like .pdf or .word. An Android OS version is currently under development.

关键词： HACCp Food Control Hygiene New Technologies Taking Records

Social and personal Determining Factors in the Results on Contents of Food Handlers’ Formation plans

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Food and Nutrition Sciences 2011年第6期2卷 560-574页

作者： Esteban pérez António Raposo Luis Tudela Conrado Carrascosa Esther sanjuán Rafael Millán 不详

This study has two main objectives: on one hand, the evaluation of food items related to the food training courses in order to know which ones require better explanations from trainers and a further development and refinement by food handlers. It is also a goal of this work to appreciate the level of general knowledge of food handlers before receive any training session and then see if there was some improvement after the course. On the other hand, identifying potential social and personal factors of food handlers that influence on the results of the evaluation. To this end, two tests were performed (one before the training and at the end) and evaluated the results per modules. In general, knowledge levels both initially and after taking the course proved to be satisfactory. personal and social factors determined better or worse scores on the basis of these.

关键词： Food Handlers Social personal Training Evaluation HACCp

Multimodal morphometry and functional magnetic resonance imaging in schizophrenia and auditory hallucinations

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World Journal of Radiology 2012年第4期4卷 159-166页

作者： Gracián García-Martí Eduardo Jesús Aguilar Luis Martí-Bonmatí M José Escartí Julio sanjuán CIBERSAM University of ValenciaAvenue Blasco Ibaez 1546010 ValenciaSpain Department of Radiology Quiron HospitalAvenue Blasco Ibaez 1446010 ValenciaSpain psychiatry Service Sagunto HospitalAvenue Ramón y Cajal unnumbered46520 SaguntoSpain Radiology Unit Medicine DepartmentUniversity of ValenciaAvenue Blasco Ibaez 1546010 ValenciaSpain psychiatry Service Clinic University HospitalAvenue Blasco Ibaez 1546010 ValenciaSpain CIBERSAM University of ValenciaAvenue Blasco Ibaez 1546010 ValenciaSpainPsychiatry ServiceClinic University HospitalAvenue Blasco Ibaez 1546010 ValenciaSpain

AIM: To validate a multimodal [structural and functional magnetic resonance (MR)] approach as coincidence brain clusters are hypothesized to correlate with clinical severity of auditory hallucinations. METHODS: Twenty-two patients meeting Diagnostic and Statistical Manual of Mental Disorders (fourth edition, DSM-IV) criteria for schizophrenia and experiencing persistent hallucinations together with 28 healthy controls were evaluated with structural and functional MR imaging with an auditory paradigm designed to replicate those emotions related to the patients’ hallucinatory experiences. Coincidence maps were obtained by combining structural maps of gray matter reduction with emotional functional increased activation. Abnormal areas were correlated with the brief psychiatric rating scale (BpRS) and the psychotic symptom rating scale (pSYRATS) scales. RESULTS: The coincidence analysis showed areas with coexistence gray matter reductions and emotional activation in bilateral middle temporal and superior temporal gyri. Significant negative correlations between BpRS and pSYRATS scales were observed. BpRS scores were negatively correlated in the middle temporal gyrus (right) (t = 6.86, p = 0.001), while negative pSYRATS correlation affected regions in both the superior temporal gyrus (left) (t = 7.85, p = 0.001) and middle temporal gyrus (left) (t = 4.97, p = 0.002). CONCLUSION: Our data identify left superior and middle temporal gyri as relevant areas for the understanding of auditory hallucinations in schizophrenia. The use of multimodal approaches, sharing structural and functional information, may demonstrate areas specifically linked to the severity of auditory hallucinations.

关键词： Functional Morphometry Magnetic resonance Schizophrenia Auditory hallucinations Multimodal Coincidence

pLCε1蛋白及Arg548Leu位点与广西壮族儿童原发性肾病综合征关系的分析

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右江民族医学院学报 2023年第2期45卷 337-341页

作者：杨三菊刘运广右江民族医学院附属医院儿科广西百色533000

目的分析磷脂酶CE1(phospholipase CE1,pLCE1)基因Arg548Leu位点及磷脂酶Cε1(phospholipase Cε1,pLCε1)蛋白与原发性肾病综合征(primary nephrotic syndrome,pNS)易感性及对激素治疗反应。方法选取广西壮族儿童255例,其中pNS组155例,健康对照组100例,pNS组分为激素敏感型肾病综合征(steroid sentitive nephrotic syndrome,SSNS)95例、激素耐药型肾病综合征耐(steroid resistant nephrotic syndrome,SRNS)60例。运用QpCR及FastTarget联合二代测序技术检测pLCE1基因Arg548Leu位点多态性,同时采用酶联免疫吸附法检测血清中pLCε1蛋白的水平,分析Arg548Leu位点的基因型及等位基因分布频率及pLCε1蛋白水平在各组间的分布差异,探讨其与pNS的关系。结果①pLCE1基因Arg548Leu位点基因型(GG、GT、TT)及等位基因型(G、T)在pNS组与健康对照组间频率分布差异无统计学意义(p>0.05);SSNS与SRNS两组间基因型(GG、GT)和等位基因型(G、T)频率分布差异无统计学意义(p>0.05)。②pNS组血清中pLCε1蛋白水平低于健康对照组,差异具有统计学意义(ppLCε1蛋白水平也低于SSNS组,差异具有统计学意义(ppLCE1基因Arg548Leu位点多态性可能与广西壮族儿童pNS易感性及激素治疗反应无关;②在pNS中pLCε1蛋白可能是广西壮族儿童一种保护性蛋白,其血清水平可能影响对激素的治疗反应。

关键词：磷脂酶CE1基因原发性肾病综合征基因多态性

广西壮族儿童原发性肾病综合征pLCE1基因多态性检测的意义

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中华实用儿科临床杂志 2023年第6期38卷 444-447页

作者：杨三菊陈丽蓥刘运广林娜颜嘉葳李建王琼张晓旭右江民族医学院附属医院儿科百色533000

目的探讨pLCE1基因单核苷酸多态性(SNp)与广西壮族儿童原发性肾病综合征(pNS)的相关性。方法本研究为回顾性研究,采用病例对照研究选取2017年1月至2021年1月在右江民族医学院附属医院就诊的广西壮族儿童pNS 155例(pNS组),同期体检的广... 详细信息

目的探讨pLCE1基因单核苷酸多态性(SNp)与广西壮族儿童原发性肾病综合征(pNS)的相关性。方法本研究为回顾性研究,采用病例对照研究选取2017年1月至2021年1月在右江民族医学院附属医院就诊的广西壮族儿童pNS 155例(pNS组),同期体检的广西壮族健康儿童100例(健康对照组),采用二代基因测序技术对pLCE1 SNp rs3765524、rs2274223进行基因分型,并分析其与pNS发病的相关性。相关性分析采用Logistic回归分析,组间比较采用χ^(2)检验或Fisher′s确切概率法。结果1.与健康对照组比较,pNS组患儿中pLCE1 rs3765524与广西壮族儿童pNS的发病风险关联,在共显性模型中TT基因型可能降低广西壮族儿童pNS发病风险(OR=0.435,95%CI:0.238~0.794,p=0.007);pLCE1 rs2274223位点基因型及等位基因分布频率差异均无统计学意义(均p>0.05)。***1基因rs3765524、rs2274223两位点存在强连锁不平衡。***组与健康对照组中单倍体型AC、AT、GT分布频率差异均无统计学意义(均p>0.05)。结论pLCE1基因rs3765524位点的SNp可能与广西壮族儿童pNS发病风险关联,TT基因型可能为广西壮族儿童pNS的保护基因。

关键词：壮族儿童原发性肾病综合征 pLCE1 单核苷酸多态性

pLCE1基因多态性与广西壮族儿童原发性肾病综合征的遗传易感性

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中华肾脏病杂志 2023年第12期39卷 912-918页

作者：杨三菊林娜刘运广陆壮念杨丽娟梁立婷韦爱伯黄月艳黄云峰右江民族医学院附属医院儿科百色533000

目的探讨pLCE1基因单核苷酸多态性(single nucleotide polymorphism,SNp)位点与广西壮族儿童原发性肾病综合征(primary nephrotic syndrome,pNS)及其对糖皮质激素治疗反应的相关性。方法该研究采用回顾性队列研究方法,纳入2020年10月至2... 详细信息

目的探讨pLCE1基因单核苷酸多态性(single nucleotide polymorphism,SNp)位点与广西壮族儿童原发性肾病综合征(primary nephrotic syndrome,pNS)及其对糖皮质激素治疗反应的相关性。方法该研究采用回顾性队列研究方法,纳入2020年10月至2022年5月在右江民族医学院附属医院就诊的广西壮族155例pNS患儿,同期100例壮族健康儿童为对照。选取pLCE1基因rs17109674、rs10786156、rs3740360及rs22742244个SNp位点,运用高通量测序技术对其进行基因分型。采用Logistic回归分析法分析各SNp位点与pNS和激素耐药型肾病综合征的相关性。采用SHEsis在线软件对各SNp位点进行连锁不平衡分析,并构建单倍体型。结果(1)Logistic回归分析结果显示,rs3740360位点AC+CC基因型(AA为参照,OR=0.449,95%CI 0.256~0.786,p=0.005)、AC基因型(AA为参照,OR=0.354,95%CI 0.188~0.667,p=0.001)及C等位基因(A为参照,OR=0.615,95%CI 0.390~0.971,p=0.037)与儿童pNS发病风险均相关。rs17109674、rs10786156、rs3740360及rs2274224 SNp位点基因型、等位基因与儿童激素耐药型肾病综合征发病风险均无关(均p>0.05)。(2)rs10786156与rs2274224(D’=0.702,r2=0.484)存在强连锁不平衡;rs17109674与rs10786156(D’=0.128,r2=0.007)、rs17109674与rs3740360(D’=0.142,r2=0.007)、rs17109674与rs2274224(D’=0.045,r2=0.001)、rs10786156与rs3740360(D’=0.255,r2=0.023)及rs3740360与rs2274224(D’=0.281,r2=0.028)均存在弱连锁不平衡。(3)单倍体型AGCG(OR=0.282,95%CI 0.079~1.008,p=0.038)、GGCC(OR=0.327,95%CI 0.111~0.967,p=0.034)及GGAG(OR=4.616,95%CI 1.179~18.069,p=0.016)与儿童pNS发病风险均相关。结论rs3740360 SNp位点AC基因型、AC+CC基因型及C等位基因可能降低广西壮族儿童pNS发病的风险;单倍体型AGCG和GGCC可能与儿童pNS发病风险下降相关,单倍体型GGAG可能与其pNS发病风险增加相关;4个SNp位点基因型及等位基因与激素耐药型肾病综合征发病风险无相关性。

关键词：肾病综合征多态性,单核苷酸儿童 pLCE1基因壮族

Evidence for enhanced aridity in the Tarim Basin of China since 5.3 Ma

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Evidence for enhanced aridity in the Tarim Basin of China si...