在精神分裂症和听觉的幻觉的多模式的 morphometry 和功能的磁性的回声成像

作     者：Gracián García-Martí Eduardo Jesús Aguilar Luis Martí-Bonmatí M José Escartí Julio Sanjuán 

作者机构：CIBERSAMUniversity of ValenciaAvenue Blasco Ibaez 1546010 ValenciaSpain Department of RadiologyQuiron HospitalAvenue Blasco Ibaez 1446010 ValenciaSpain Psychiatry ServiceSagunto HospitalAvenue Ramón y Cajal unnumbered46520 SaguntoSpain Radiology UnitMedicine DepartmentUniversity of ValenciaAvenue Blasco Ibaez 1546010 ValenciaSpain Psychiatry ServiceClinic University HospitalAvenue Blasco Ibaez 1546010 ValenciaSpain CIBERSAMUniversity of ValenciaAvenue Blasco Ibaez 1546010 ValenciaSpainPsychiatry ServiceClinic University HospitalAvenue Blasco Ibaez 1546010 ValenciaSpain 

出 版 物：《World Journal of Radiology》 (世界放射学杂志（英文版）（电子版）)

年 卷 期：2012年第4卷第4期

页      面：159-166页

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：Supported by The research network CIBERSAM 

主　　题：Functional Morphometry Magnetic resonance Schizophrenia Auditory hallucinations Multimodal Coincidence 

摘      要：AIM:To validate a multimodal[structural and functional magnetic resonance(MR)]approach as coincidence brain clusters are hypothesized to correlate with clinical severity of auditory hallucinations.METHODS:Twenty-two patients meeting Diagnostic and Statistical Manual of Mental Disorders(fourth edition,DSM-Ⅳ)criteria for schizophrenia and experiencing persistent hallucinations together with 28 healthy controls were evaluated with structural and functional MR imaging with an auditory paradigm designed to replicate those emotions related to the patients’hallucinatory experiences.Coincidence maps were obtained by combining structural maps of gray matter reduction with emotional functional increased activation.Abnormal areas were correlated with the brief psychiatric rating scale(BPRS)and the psychotic symptom rating scale(PSYRATS)scales.RESULTS:The coincidence analysis showed areas with coexistence gray matter reductions and emotional activation in bilateral middle temporal and superior temporal gyri.Significant negative correlations between BPRS and PSYRATS scales were observed.BPRS scores were negatively correlated in the middle temporal gyrus(right)(t=6.86,P=0.001),while negative PSYRATS correlation affected regions in both the superior temporal gyrus(left)(t=7.85,P=0.001)and middle temporal gyrus(left)(t=4.97,P=0.002).CONCLUSION:Our data identify left superior and middle temporal gyri as relevant areas for the understanding of auditory hallucinations in schizophrenia.The use of multimodal approaches,sharing structural and functional information,may demonstrate areas specifically linked to the severity of auditory hallucinations.