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一种新的选择性堵水措施：水敏性亚稳定体系的应用

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国外石油动态 2008年第14期 34-44页

作者： Istvan lakatos

该项目的目的是要开发一种新的化学体系，该体系一接触水就可形成一种堵塞相。目前开发的最新的化学体系分别是均质的水敏性溶液和水包油乳状液。这两种体系被水稀释后形成稳定的宏观乳液。在高含水的油藏中亚稳定体系转变成稳定的体系... 详细信息

该项目的目的是要开发一种新的化学体系，该体系一接触水就可形成一种堵塞相。目前开发的最新的化学体系分别是均质的水敏性溶液和水包油乳状液。这两种体系被水稀释后形成稳定的宏观乳液。在高含水的油藏中亚稳定体系转变成稳定的体系，在转变过程中水的粘度升高和通过孔洞的分散粒子被束缚从而限制水的流动。将有机硅、表面活性剂和天然原油作为一种分散剂进行测试。化学体系的流动特性可在天然砂岩体系中进行研究，相结构、相变以及粒径可通过光谱法和流变学方法进行分析。岩心实验表明，在饱和的砂岩岩层中所有的亚稳定体系都可以将水的流量减小80％-90％。假设用硅树脂作为后置液，水的流动阻力将十分大，但同时地层污染也不可忽视。亚稳定体系是一种有效的单步渗透率调整液。在成熟的气田和储藏设施中亚稳定体系是一种有效的堵水方式。该技术的独特之处是其只在水饱和油藏产生流动阻力；只在该技术失败时产生流动阻力。通过注油或注气可以消除流动隔层。

关键词：稳定体系堵水措施水敏性应用化学体系水包油乳状液流动特性流动阻力

Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: phenotype-genotype correlations

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World Journal of Gastroenterology 2005年第10期11卷 1489-1495页

作者： peter laszlo lakatos laszlo lakatos Ferenc Szalay Claudia Willheim-polli Christoph (O|¨)sterreicher Zsolt Tulassay Tamas Molnar Walter Reinisch Janos papp Gyula Mozsik Hungarian IBD Study Group peter Ferenci 1st Department of Medicine laszlo lakatos Department of Internal Medicine 4 2nd Department of Medicine Semmelweis University 2nd Department of MedicineSemmelweis UniversityBudapest:Laszlo PronaiAnnamaria NemethPal Miheller Erzsebet Hospital 1st Department of MedicineBudapest: Agota KovacsLaszlo Bene Szent Janos Hospital 1st Department of Medicine:Gyorgy Szekely University of pecs 1st Department of MedicinePecs:Beata Gasztonyi University of Szeged 1st Department of MedicineSzeged:Ferenc NagyJanos Lonovics Semmelweis Hospital 1st Department of MedicineMiskolc:Laszlo Ujszaszy University of Debrecen 2nd Department of MedicineDebrecen:Istvan AltorjaiKaroly Palatka Kenezi Gy. County Hospital 2nd Department of MedicineDebrecen: Gyula G. Kiss County Hospital 2nd Department of MedicineZalaegerszeg Ferenc Tarnok Markusovszky Hospital2nd Department of MedicineSzombathely:Zoltan Dobronte Csolnoky F. County Hospital 1st Department of MedicineVeszprem:Zsuzsanna ErdelyiTunde PandurGabor Mester

AIM: To determine common NOD2/CARD15 mutations and TlR4 D299G polymorphism in Hungarian patients with ***: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing highperformance liquid chromatography (confirmed by direct sequencing). TlR4 D299G was tested by ***: NOD2/CARD15 mutations were found in 185patients (35.1%) and in 33 controls (16.5%, p＜0.0001).SNp8/R702W (10.8% vs 6%, p = 0.02), SNp13/3020insC (19.4% vs 5%, p＜0.0001) and exon4 R703C (2.1% vs 0%, p = 0.02) mutations were more frequent in CD, while the frequency of SNp12/G908R was not increased. The frequency of TlR4 D299G was not different (CD: 9.9% vscontrols: 12.0%). Variant NOD2/CARD15 allele was associated with an increased risk for CD (ORhet = 1.71,95%CI = 1.12-2.6, p= 0.0001, ORtwo-riskalleles = 25.2,95%CI = 4.37- , p＜0.0001), early disease onset (carrier:26.4 years vs non-carrier: 29.8 years, p = 0.0006), ileal disease (81.9% vs 69.5%, OR = 1.99, 95%CI = 1.29-3.08,p = 0.02, presence of NOD2/CARD15 and TlR4: 86.7% vs64.8%), stricturing behavior (OR = 1.69, 95%CI = 1.13-2.55,p = 0.026) and increased need for resection (OR=1.71,95%CI: 1.13-2.62, p= 0.01), but not with duration, extraintestinal manifestations, familial disease or smoking. TlR4exhibited a modifier effect: age of onset in wt/TlR4 D299G carriers: 27.4 years vs NOD2mut/TlR D299G: 23 years (p= 0.06), in NOD2mut/wt: 26.7 ***: These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease,stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TlR4 D299G polymorphism was not different from controls, NOD2/TlR4mutation carriers tended to present at earlier age.

关键词：基因型基因多态性 NOD2/CARD15 基因突变克罗恩病肠炎

prevalence, significance and predictive value of antiphospholipid antibodies in Crohn's disease

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World Journal of Gastroenterology 2015年第22期21卷 6952-6964页

作者： Nora Sipeki laszlo Davida Eszter palyu Istvan Altorjay Jolan Harsfalvi peter Antal Szalmas Zoltan Szabo Gabor Veres Zakera Shums Gary l Norman peter l lakatos Maria papp Division of Gastroenterology Department of Internal Medicine Faculty of Medicine University of Debrecen Clinical Research Center Faculty of MedicineUniversity of Debrecen Department of laboratory Medicine Faculty of Medicine University of Debrecen Division of Emergency Medicine Department of Internal Medicine Faculty of Medicine University of Debrecen 1~(st) Department of Medicine Semmelweis University Inova Diagnostics Inc. San Diego California

AIM: To assess the prevalence and stability of different antiphospholipid antibodies(AplAs) and their association with disease phenotype and progression in inflammatory bowel diseases(IBD) ***: About 458 consecutive patients [Crohn's disease(CD): 271 and ulcerative colitis(UC): 187] were enrolled into a follow-up cohort study in a tertiary IBD referral center in Hungary. Detailed clinical phenotypes were determined at enrollment by reviewing the patients' medical charts. Disease activity, medical treatment and data about evolvement of complications or surgical interventions were determined prospectively during the follow-up. Disease course(development f complicated disease phenotype and need for surgery),occurrence of thrombotic events, actual state of diseaseactivity according to clinical, laboratory and endoscopic scores and accurate treatment regime were recorded during the follow-up,(median, 57.4 and 61.6 mo for CD and UC). Sera of IBD patients and 103 healthy controls(HC) were tested on individual anti-β2-Glycoprotein-I(anti-β2-GpI IgA/M/G), anti-cardiolipin(ACA IgA/M/G)and anti-phosphatidylserine/prothrombin(anti-pS/pT IgA/M/G) antibodies and also anti-Saccharomyces cerevisiae antibodies(ASCA IgA/G) by enzyme-linked immunosorbent assay(ElISA). In a subgroup of CD(n = 198) and UC patients(n = 103), obtaining consecutive samples over various arbitrary timepoints during the disease course, we evaluated the intraindividual stability of the AplA status. Additionally,we provide an overview of studies, performed so far, in which significance of AplAs in IBD were ***: patients with CD had significantly higher prevalence of both ACA(23.4%) and anti-pS/pT(20.4%) antibodies than UC(4.8%, p p = 0.004) and HC(2.9%, p p = NS). No difference was found for the prevalence of anti-β2-GpI between different groups(7.2%-9.7%). In CD, no association was found between AplA and ASCA status of the *** of a

关键词： Crohn's disease Ulcerative colitis Diseaseprogression Antiphospholipid antibodies Anti-β2-Glycoprotein-I antibodies Anti-phosphatidylserine/prothrombin Anti-cardiolipin antibodies Thrombosis

基于水力条件评估的轴流转浆式水轮机组主轴密封修复

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国外大电机 2014年第2期 54-56页

作者： K lakatos 贾伟不详哈尔滨大电机研究所

本文的目的是使人们关注在轴流转浆式水轮机组改造过程中可能发生的潜在危险。在匈牙利蒂萨勒克水电站改造过程中，该水轮机主轴密封出现破损。在查找原因过程中，假设由于水轮机内部流速的不断增加，导致轮毂间隙压力低于大气压力，因... 详细信息

本文的目的是使人们关注在轴流转浆式水轮机组改造过程中可能发生的潜在危险。在匈牙利蒂萨勒克水电站改造过程中，该水轮机主轴密封出现破损。在查找原因过程中，假设由于水轮机内部流速的不断增加，导致轮毂间隙压力低于大气压力，因此改造之前一直圆满运行的主轴密封出现了不稳定供水和空运行的情况，一段时间以后就会烧损主轴密封。首先，通过一维流体模型计算得出水轮机流动条件和轮毂间隙压力，之后使用二维方法进行细化。通过数据采集系统和小排水泵运行观察也充分证实了上述结论的正确性。当水轮机的流量超过某一极限值时，排水泵依然保持止转，这说明没有水从主轴密封中流过。此时外部供水系统开始工作，水轮机正常运行。

关键词：水轮机组主轴密封轴流转浆式水力条件修复评估改造过程大气压力

SiO2-Al2O3-Na2O-K2O-CaO-MgO系统中技术玻璃成分范围内的粘度温度关系

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玻璃 1978年第3期 39-49页

作者： T.lakatos l.G.Johansson B.Simmingsk(?)ld 瑞典魏克晓玻璃研究所瑞典魏克晓玻璃研究所瑞典魏克晓玻璃研究所

本研究的目的是为玻璃工业提供一种技术钠钙玻璃在一定的成分变化范围内计算粘度的方法。经与斯堪的纳维亚各国机制玻璃工业的代表们讨论后,决定取SiO2、Na2O、K2O、CaO、MgO和Al2O3

关键词：低温粘度方程式富尔玻璃成分方程流变仪粘度计 CaO 成分范围温度关系 Na Al

Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort

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World Journal of Gastroenterology 2013年第14期19卷 2217-2226页

作者： Barbara Dorottya lovasz laszlo lakatos Agnes Horvath Istvan Szita Tunde pandur Michael Mandel Zsuzsanna Vegh petra Anna Golovics Gabor Mester Mihaly Balogh Csaba Molnar Erzsebet Komaromi lajos Sandor Kiss peter laszlo lakatos First Department of Medicine Semmelweis University Department of Medicine Csolnoky F Province Hospital Department of pediatrics Csolnoky F Province Hospital Department of Medicine Grof Eszterhazy Hospital Department of Infectious Diseases Magyar Imre Hospital Department of Gastroenterology Municipal Hospital

AIM:To investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and ***:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD *** phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate ***:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).There was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during ***,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of ***,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier *** year of diagnosis(p = 0.04),ileal location(p perianal disease(p p = 0.038) and need for steroids(p presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(p = 0.01),but not with age at ***:long-term evolution of disease behavior was not different in pediatric-a

关键词： Crohn’s disease Age at diagnosis Disease behavior Disease course

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科学研究纲领方法论

世界科学译刊 1980年第9期 46-51页

作者： I.lakatos 纪树立教育部

西方现代科学哲学发展到70年代,无论是鲍波尔的证伪主义,或者是库恩的科学'规范'论,都暴露了愈来愈多的矛盾。在各种解决矛盾的尝试中,英国科学哲学家拉卡托斯的'研究纲领'方法论引起了极大的注意。下面两篇译文可以大体反映出它的基本... 详细信息

西方现代科学哲学发展到70年代,无论是鲍波尔的证伪主义,或者是库恩的科学'规范'论,都暴露了愈来愈多的矛盾。在各种解决矛盾的尝试中,英国科学哲学家拉卡托斯的'研究纲领'方法论引起了极大的注意。下面两篇译文可以大体反映出它的基本内容。按照这种方法论,科学总是以'研究纲领'的形式发展的。纲领是严密的理论系统,有相对稳定的'硬核',有柔韧多变的'保护层',还有一套解决疑难的机制。它可以通过'反面启发'规定不应当做什么,以保卫硬核,免于反常现象的冲击;另一方面,它叉可以通过'正面启发'规定应当做什么,从而不断提出解决反常的方案,构造各种模型,以排斥或消溶一切反常。因此,科学理论不象鲍波尔所描述的那样脆弱,一个反例就会遭到'证伪'。研究纲领只要处于前进期,就有足够的'启发力'实现'进步的问题转换',即不断提出问题和解决问题。同时,科学发展也不象库恩所设想的那样,从一种'规范'到另一'规范'的更替犹如宗教转向,其间没有任何连续性可寻。当研究纲领愈来愈应付不了各种问题,出现退化的问题转换,最后就要让位于新生的竞争对手。这是一个自然的新陈代谢过程,是一个不断趋于真理的合乎理性的过程。《科学研究纲领方法论》是根据他的《证伪和科学研究纲领方法论》(载 The Methodology ofScientific Research programmes, Cambridge, 1978)一文摘编,比较全面地介绍了他这种方法论的基本思想。《判决性实验在科学申的地位》(原载 Studies in History and philosophy of Science,4(4),1974)一文着重阐述了他对鲍波尔证伪主义的批判。拉卡托斯(Imre lakatos,1922～1974)原籍匈牙利,曾为匈共党员并任职教育部,1950年被捕,1956年逃离,后入英国籍,一直在伦敦经济学院任教授。他对科学哲学、特别是数学哲学的工作,对世界哲学界和科学界都有相当影响。著书除上引,还有《证明和反驳:数学发现的逻辑》(1976年)、《数学、科学和认识论》(1977年)等。

关键词：牛顿理论问题转换科学研究纲领方法论辅助假说判决性实验普劳特证伪主义科学哲学库恩正面研究纲领拉卡托斯约定主义形而上学物理学家

Is early limited surgery associated with a more benign disease course in Crohn's disease?

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World Journal of Gastroenterology 2013年第43期19卷 7701-7710页

作者： petra Anna Golovics laszlo lakatos Attila Nagy Tunde pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya lovasz Michael Mandel Gabor Veres lajos S Kiss Zsuzsanna Vegh peter laszlo lakatos First Department of Medicine Semmelweis UniversityH-1083 BudapestHungary Department of Medicine Csolnoky F Province HospitalH-8200 VeszpremHungary Department of Surgery Csolnoky F Province HospitalH-8200 VeszpremHungary Department of Medicine Grof Eszterhazy HospitalH-8500 PapaHungary Department of Infectious Diseases Magyar Imre HospitalH-8400 AjkaHungary Department of Gastroenterology Municipal HospitalH-8100 VarpalotaHungary First Department of pediatrics Semmelweis UniversityH-1083 BudapestHungary

AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,***-up data were collected until December 31,*** patients included had at least 1year of follow-up *** with indeterminate colitis at diagnosis were excluded from the ***:Overall,73 patients(14.4%)required resective surgery within 1 year of *** exposure and need for biological therapy were lower in patients with early limited surgery(pp=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(pperation was also lower in patients with early limited resective surgery(p=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(p=0.04)***,this advantage was not observed after matching on propensity scores(plogrank=0.656,pBreslow=0.498).CONClUSION:long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ.

关键词： Crohn’s disease Early surgery Disease course Disease behavior Treatment strategy

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判决性实验在科学中的作用

世界科学译刊 1980年第9期 51-54页

作者： I.lakatos 金吾伦

我们究竟是怎样从实验中学习科学理论的?学习的又是什么样的科学理论?'判决性实验'一词表明,我们从某些实验中可以学得更多。按照严格的归纳主义,如能从一个实验中归纳出某种重要的自然定律,这就是基本实验(不是'判决性'实验)。但有些... 详细信息

我们究竟是怎样从实验中学习科学理论的?学习的又是什么样的科学理论?'判决性实验'一词表明,我们从某些实验中可以学得更多。按照严格的归纳主义,如能从一个实验中归纳出某种重要的自然定律,这就是基本实验(不是'判决性'实验)。但有些逻辑学家认为归纳概括无效,

关键词：判决性实验波尔证伪主义科学哲学