Increased nociceptin/orphanin FQ plasma levels in hepatocellular carcinoma

作     者：FerencSzalay AndreaHorvath PeterL.Lakatos AnikoFolhoffer KingaDunkel DalmaHegedus KornéliaTekes MónikaBHantos 

作者机构：1~(st) Department of Medicine of Semmelweis UniversityBudapestHungary Department of Pharmacodynamics of Semmelweis UniversityBudapestHungary Neurochemical Research Unit of Hungarian Academy of SciencesBudapestHungary 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第1期

页      面：42-45页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Adult Aged Aged, 80 and over Carcinoma, Hepatocellular Female Humans Liver Cirrhosis Liver Neoplasms Male Middle Aged Opioid Peptides Radioimmunoassay 

摘      要：AIM:The heptadecapeptide nociceptin alias orphanin FQ is the endogenous agonist of opioid receptor-likel receptor. It is involved in modulation of pain and *** blood level was reported in patients with acute and chronic pain, and in Wilson *** accidental observation led us to investigate nociceptin in hepatocellular carcinoma. METHODS:Plasma nociceptin level was measured by radioimmunoassay,aprotinin was used as protease inhibitor. Hepatocellular carcinoma was diagnosed by laboratory, ultrasound,other imaging,and confirmed by fine needle *** were compared to healthy controls and patients with other chronic liver diseases. RESULTS:Although nociceptin levels were elevated in patients with Wilson disease (14.0±2.7 pg/mL,n=26), primary biliary cirrhosis (12.1±3.2 pg/mL,n=21) and liver cirrhosis (12.8±4.0 pg/mL,n=15) compared to the healthy controls (9.2±1.8 pg/mL,n=29, P0.001 for each),in patients with hepatocellular carcinoma a ten-fold increase was found (105.9±14.4 pg/mL,n=29,P0.0001).High plasma levels were found in each hepatocellular carcinoma patient including those with normal alpha fetoprotein and those with pain (104.9±14.9 pg/mL,n=12) and without (107.7±14.5 pg/mL,n=6). CONCLUSION:A very high nociceptin plasma level seems to be an indicator for hepatocellular *** research is needed to clarify the mechanism and clinical significance of this novel finding.