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Mitigation of indomethacin-induced gastric mucosal lesions by a potent specific type V phosphodiesterase inhibitor

World Journal of Gastroenterology 2009年第40期15卷 5091-5096页

作者： Kemal Karakaya Volkan Hanci Sibel Bektas Murat Can Hamdi B ucan Ali Ugur Emre Oge Tasc1lar Is1l Ozkocak Turan Mustafa Comert Oktay Irkorucu Guldeniz Karadeniz Cakmak Department of General Surgery Zonguldak Karaelmas UniversityMedical Faculty Department of Anesthe-siology Zonguldak Karaelmas UniversityMedical Faculty Department of Pathology Zonguldak Karaelmas UniversityMedical Faculty Department of Biochemistry Zonguldak Karaelmas UniversityMedical Faculty

AIM: To investigate the gastroprotective effect of vardenafil against indomethacin-induced gastric damage. METHODS: Forty-eight female Wistar albino rats were randomly divided into 6 groups. Group 1 received saline only. Group 2 (indomethacin) received indomethacin. Rats in group 3 and 4 were pretreated with different doses of famotidine. Group 5 and 6 were pretreated with different doses of vardenafil. Rats in groups 3 to 6 received 25 mg/kg indomethacin 30 min after pretreatment. The animals were sacrificed 6 h later and their stomachs were opened. Gastric lesions were counted and measured. The stomach of each animal was divided in two parts for histopathological examinations and nitric oxide (NO) and malondialdehyde (MDA) assays, respectively. RESULTS: There were no gastric mucosal lesion in the saline group but all rats in the indomethacin group had gastric mucosal ulcerations (ulcer count; 6.25 ± 3.49, and mean ulcer area; 21.00 ± 12.35). Ulcer counts werediminished with famotidine 5 mg/kg (4.12 ± 2.47, P > 0.05), 20 mg/kg (2.37 ± 4.43, P < 0.05), vardenaf il 2 mg/kg (4.37 ± 3.06), and vardenafil 10 mg/kg (1.25 ± 1.38, P < 0.05) compared to the indomethacin group. Gastric mucosal lesion areas were diminished with famotidine 5 mg/kg (8.62 ± 2.97, P < 0.001), famotidine 20 mg/kg (0.94 ± 2.06, P < 0.001), vardenafil 2 mg/kg (6.62 ± 5.87, P < 0.001), and vardenafil 10 mg/kg (0.75 ± 0.88, P < 0.001) compared to the indomethacin group. MDA levels were signif icantly higher in indometh-acin group (28.48 ± 14.51), compared to the famotidine 5 mg/kg (6,21 ± 1.88, P < 0.05), famotidine 20 mg/kg (5.88 ± 1.60. P < 0.05), vardenaf il 2 mg/kg (15.87 ± 3.93, P < 0.05), and vardenafil 10 mg/kg (10.97 ± 4.50, P < 0.05). NO concentration in gastric tissues of the fa-motidine groups were significantly increased (P < 0.05), but the NO increases in the vardenafil groups were not statistically significant. Histopathology revealed dimin-ished gastric damage for pretreatment groups co

关键词： Vardenafil Gastric ulceration Indomethacin Gastroprotection Rats

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Competitive Advantages and Clustering of SMEs： An Analysis of Clustering Effect on Competition in Small-Scale Enterprises in Istanbul

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Journal of Modern Accounting and Auditing 2011年第9期7卷 994-1003页

作者： Yildiz Yilmaz Guzey ozlem Tasseven Izmir University Turkey Dogus University Turkey

According to Michael Porter＇s Diamond Model, a business cluster is defined as geographic concentration of inter-connected companies and institutions working in a common industry. In addition, clusters encompass an array of collaborating and competing services and providers that create a specialized infrastructure, which supports the cluster＇s industry. The economic cluster model, represents a synergy, a dynamic relationship and a network between not only the companies that comprise a cluster but also the successful partnering of the stakeholders. Today in all over the world, successful clusters have established a greater competitive advantage and wealth creation for their regions when compared to companies not in a cluster. Given this success more policy makers and regions are considering fostering cluster development as building blocks of regional economies. Research is planned and performed for understanding the clustering in SMEs （small and medium enterprises） industrial estate in Istanbul if it gives a competitive advantage to the cluster members or not. It is performed to determine and satisfy the lack of knowledge about the small and medium enterprises＇ issues, technologic systems, production quality standards, capacity usage ratios, interactions with other firms, habits of following the technologic improvements and clustering effects on the members.

关键词： clusters small and medium enterprises (SMEs) clustering

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Transfer of single dose of intravitreal injection of ranibizumab and bevacizumab into milk of sheep

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1069-1075页

作者： Tugba Cakmak Argun ozlem Yalcin Tok Levent Tok Gulsen Yilmaz Fatma Meric Yilmaz Alime Gunes Mehmet Argun Osman Butuner Department of Ophthalmology Hatay Dortyol State Hospital Faculty of Medicine Ophthalmology Suleyman Demirel University Ministry of Health Ankara HospitalBiochemistry Biochemistry Department Faculty of MedicineYildirim Beyazit University The Management of Veterinary Service

AIM： To investigate whether single-dose intravitreal injections of bevacizumab and ranibizumab transfer into milk. METHODS： This study included lactating 12 sheep and a single 3-month old suckling lamb of each sheep. Two groups consisting of 6 sheep and their lambs were constituted; the ranibizumab group and the bevacizumab group before the administration of intravitreal injections, blood and milk samples were obtained from all sheep and, following the injections, blood and milk samples of all sheep and blood samples of all lambs were collected at regular time points. Serum and milk concentrations of bevacizumab and ranibizumab were measured using an enzyme-linked immunosorbent assay（ELISA） kit. The limit of determination was 0.9 ng/m L for bevacizumab and 0.62 ng/m L for ***： At 6h after intravitreal injections, bevacizumab concentration was above the limit of determination in the blood of all sheep. At 3wk, when the study was terminated, bevacizumab concentrations were high in 4 sheep. Even though bevacizumab concentrations in milk showed fluctuations, the drug transferred into the milk of all sheep at detectable concentrations. Ranibizumab drug concentrations in the blood and milk of sheep and those in the blood of lambs were below the limit of determination by the ELISA ***： This sheep model study demonstrate that intravitreal injection of ranibizumab, which did not transfer into the milk of sheep and suckling lambs, is safer than bevacizumab during lactation period.

关键词： bevacizumab ranibizumab lactation milk vascular endothelial growth factor

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Does vitamin D affect disease severity in patients with ankylosing spondylitis？

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Chinese Medical Journal 2012年第14期125卷 2511-2515页

作者： Bekir Durmus Zuhal Altay ozlem Baysal Yuksel Ersoy Department of Physical Medicine & Rehabilitation InonuUniversity Faculty of Medicine Malatya Turkey

Background Vitamin D has been found to have a role in the function of the immune system. There have been a lot of studies investigating a relation between vitamin D and disease activity in ankylosing spondylitis （AS）. However, there have not been any studies arranging AS in groups according to vitamin D levels and determining any differences among these patients in terms of disease activity, functional status, quality of life, and other clinical parameters. The aim of this study is to compare 25-hydroxy-vitamin D3 （25（OH）D3） levels in AS patients with those in normal healthy subjects and to determine the relationship between 25（OH）D3 levels and AS disease activity, functional status, and quality of life. Methods Ninety-nine consecutive patients and 42 healthy volunteers were included in this study. After a comparison between the patient group and the control group, the patient group was divided into normal, insufficient and deficient subgroups according to the plasma 25（OH）D3 levels for another comparison. Results The differences in the 25（OH）D3 level between the patient and the control groups were statistically insignificant. The number of AS patients whose 25（OH）D3 levels were classified as normal, insufficient, and deficient were 34, 29, and 36, respectively. Erythrocyte sedimentation rate （ESR）, C-reactive protein （CRP）, and Bath AS Disease Activity Index （BASDAI） scores were higher in the low （including insufficient and deficient） 25（OH）D3 level subgroups （P 〈0.05）. The Bath AS Functional Index （BASFI） and AS Quality of Life （ASQoL） scores were significantly different between the normal and the deficient subgroups （P 〈0.05）. Pain, BASDAI, ESR, and CRP were inversely correlated to the 25（OH）D3 levels （P 〈0.05）. Conclusions The plasma 25（OH）D3 levels may decrease in AS patients and this may negatively affect disease activity, functional status and quality of life.

关键词： ankylosing spondylitis 25(OH)D3, diease activity, functional status, quality of life

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Tumor budding as a potential prognostic marker in determining the behavior of primary liver cancers

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World Journal of Hepatology 2023年第6期15卷 775-785页

作者： Betul Unal Mennan Yigitcan Celik Elif Ocak Gedik Cumhur Ibrahim Bassorgun Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

Hepatocellular(HCC)and intrahepatic cholangiocarcinoma(ICC),the most common primary tumors of the liver,are among the most important causes of cancer deaths *** patients with primary liver tumors are frequently diagnosed at an advanced stage and have high mortality,many efforts have been made to identify new markers to determine their behavior and treatment,similar to those in other solid organ ***,morphological assessment of tumor budding(TB)has been revealed as a promising prognostic finding to predict tumor behavior and survival across several different tumor ***,the TB score in colorectal cancer has been revealed as an important parameter in pathology report protocols to determine the course of the *** the liver,despite enormous data showing that many mechanisms involved in TB are associated with tumor behavior in both HCC and ICC,studies focusing on the role of TB in predicting the behavior and prognosis of these tumors have started to be investigated very *** purpose of this review is to present data about TB in primary tumors of the liver,pointing out the potential role of this parameter in determining the course of the disease,and emphasize the need to increase the number of further studies focusing on the evaluation of this parameter with an overview of the mechanisms involved in TB.

关键词： Tumor budding Hepatocellular carcinoma Cholangiocarcinoma Prognosis Liver cancer Epithelial-mesenchymal transition

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Comparison of the Effects of Physiotherapy Group Exercise and Basketball on Quality of Life of Obese Children

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Open Journal of Therapy and Rehabilitation 2017年第1期5卷 1-10页

作者： Zehra Guchan Topcu ozlem Ulger Department of Physiotherapy and Rehabilitation Faculty of Health SciencesEastern Mediterranean UniversityFamagustaCyprus Department of Physiotherapy and Rehabilitation Faculty of Health SciencesHacettepe UniversityAnkaraTurkey

Aim: To compare the effects of group exercises under physiotherapist control and basketball program on the quality of life of obese children. Methods: 45 obese children aged 10 years were randomly included to the physiotherapy (n=14), basketball (n:15), and control group (n:16). The children were assessed before and after 12-week study duration. The Pediatric Quality of Life Inventory (PedsQL) was used to determine and compare their quality of life (QoL). Results: No difference was found when the subheadings of the PedsQL were compared among the groups (p>0.05). When the changes were investigated within the groups, only significant increase was determined in the physical and emotional subheadings of the physiotherapy group (pConclusion: Although no change was determined in the quality of life, physiotherapy group exercise was found to be more successful to affect physical and emotional status of obese children.

关键词： Physiotherapy Basketball Quality of Life Obese Children

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Incidental Collision Tumor of Hepatocellular Carcinoma and Neuroendocrine Carcinoma

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Journal of Clinical and Translational Hepatology 2018年第3期6卷 339-344页

作者： Düriye Betül Yilmaz Zeynep Bayramoglu Gülsah Ünay Erdem Ayik Cumhur Ibrahim Bassorgun Gülsüm ozlem Elpek Department of Pathology Akdeniz University Medical SchoolKonyaalti/AntalyaTurkey

The composite tumors of the liver are very rare,including the coexistence of HCC(hepatocellular carcinoma)with NEC(neuroendocrine carcinoma).The rare occurrence of these tumors necessitates more reported cases in order to fully understand their clinical characteristics,behaviors and *** is described an incidental collision tumor of HCC-NEC,along with a review of the literature focusing on their clinicopathological findings and *** tumor presented here was found incidentally in the hepatectomy specimen of a 56-yearold man who had undergone liver transplantation for rapidly progressive liver failure because of alcoholic hepatitis and *** and laboratory examinations did not demonstrate tumor-related *** macroscopic examination,two sharply defined and distinctive areas(1.7 cm and 0.6 cm dimension respectively)were detected among the cirrhotic *** characteristic histopathological features and immunohistochemical findings allowed a diagnosis of HCCNEC to be *** was no evidence of recurrence and metastasis after 10months following *** present case and review revealed that these tumors are frequently found in older ages and *** serum markers are valuable in the discrimination of malignant tumors,their absence cannot completely rule out composite *** requires a comprehensive histopathological evaluation together with *** NEC component might influence the treatment strategy and eventually the outcome of the *** conclusion,the rare occurrence of HCC-NEC and the lack of diagnostic clinical signs and symptoms do not exclude their consideration in the differential diagnosis of liver tumors,especially in patients with the chronic liver disease.

关键词： Liver neoplasm Hepatocel ular carcinoma Neuroendocrine carcinoma

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Post-Varicella Disciform Keratitis: Case Report

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Open Journal of Ophthalmology 2012年第3期2卷 83-84页

作者： ozlem G. Sahin The World Eye Center Department of Uveitis Ankara Turkey

The purpose of this study is to report a rare condition of post-varicella disciform keratitis in a 4-year-old child. It is a prospective study of the follow-up of a 4 year-old girl who was diagnosed as post-varicella stromal disciform keratitis related to high serum antibody titers five months after the skin lesions. Rapid response to topical steroids, topical and oral antivirals have been observed in 6 weeks of treatment. There was no recurrence in the 6 months of follow-up. Total resolution of the disciform stromal keratitis in a short period of time was disclosed with an effective treatment of both topical and oral antivirals and topical steroids.

关键词： Acyclovir Disciform Keratitis Trifluridine Varicella Zoster

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An adult case of celiac sprue triggered after an ileal resection for perforated Meckel's diverticulum

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World Journal of Gastroenterology 2009年第32期15卷 4075-4076页

作者： Firdevs Topal Sabiye Akbulut Ismail Cagatay Topcu Yasemin Dolek ozlem Yonem Department of Gastroenterology Cumhuriyet University Cumhuriyet Universitesi Hastanesi 58140 Sivas Turkey Department of Gastroenterology ankiri State HospitalCankiri Devlet Hastanesi18200 CankiriTurkey Department of Gastroenterology Kartal Kosuyolu High Speciality Education and Research HospitalKartal Kosuyolu Devlet Hastanesi34846 IstanbulTurkey Department of Surgery Cankiri State HospitalCankiri Devlet Hastanesi18200 CankiriTurkey Department of Pathology Cankiri State HospitalCankiri Devlet Hastanesi18200 CankiriTurkey

Celiac disease can be triggered by upper abdominal surgery, such as vagotomy, oesophagectomy, pancreatico-duodenectomy, and gastrojejunal anastomosis. Here we report a case of a 24 year-old woman who developed celiac disease after an ileal resection for perforated Meckel's diverticula. This is the first reported celiac case that has been triggered, not by upper abdominal surgery, but after ileal resection for Meckel's diverticula.

关键词： Celiac disease Meckel's diverticula Ilealresection

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Effect of basic life support training on the knowledge and skills of first aid of first year medical students

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Journal of Acute Disease 2021年第4期10卷 169-172,I0002-I0005页

作者： Esra Karaman Nazire Avcu ozlem Guneysel Department of Emergency Medicine Faculty of MedicineMaltepe UniversityIstanbulTurkey

Objective:To determine the timing of first aid training in the medical school curriculum and the training method with the 8-hour first aid training given to the first-grade students of the faculty of ***:The study was conducted prospectively with 168 first year medical students at Faculty of Medicine,Maltepe University in October *** 8-hour course plan consisting of theoretical and practical applications was *** courses included cardiopulmonary resuscitation,basic life supports,epileptic seizures,heatstroke,aspiration,and drowning issues,while practical applications included cardiopulmonary resuscitation techniques,basic life support scenarios,Heimlich’s Maneuver and the coma *** were sent a link consisting of 17 questions created with Google forms at the beginning and the end of the *** knowledge was measured with the posttest,and pre-and post-training results were ***:A significant increase was found in the rate of correct answers compared to the pre-training *** the rate of correct post-test answers increased significantly in all questions;the increase in the questions related to the subjects supported by practical applications was more *** was found that more incorrect answers were given to questions about environmental ***:It is possible to improve the public recognition of first aid,even with one day of theoretical and practical ***,adding first aid practical courses to the first-year medical school curriculum and raising awareness at an earlier age will play an essential role in medical education.

关键词： Medical education First aid Basic life support Medical school curriculum

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