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Diffusion Weighted MRI: A Practical and Quick Approach to Evaluate Brain Death

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2015年第2期4卷 113-123页

作者： Ihsan Nuri Akpinar Bediha Aygun Nuri Cagatay Cimsit ozlem turkoglu Department of Radiology Medical Faculty Marmara Univeristy Istanbul Turkey Department of Radiology Haydarpasa Numune Education and Research Hospital Istanbul Turkey Department of Radiology Dr. Lutfi Kirdar Kartal Education and Research Hospital Istanbul Turkey

It is significantly important to define brain death with greater precision in terms of timing and accuracy. While in the past determination of brain death is simply based on conventional angiography, now with major technological advances the Diffusion-weighted MRI is a new method sensitive to cerebral ischemia which gives on the molecular level the deeply ischemic nature of the changes. Its value in brain death has been shown in various studies. In our study, we did a comparative overview of diffusion-weighted imaging (DWI) with and magnetic resonance angiography (MRA) considering the contribution of ADC measurements from brain parenchyma, in the patients diagnosed with brain death by clinical criteria. We studied 16 brain deaths in serial studies, in which there is a prominent difference between the white and gray matter ADC values on diffusion MRI. In the postmortem brains, ADC values comparing with the normal brain parenchyma, were reduced 65% in white matter and 42% in gray matter. Also, the patients’ ADC values of gray and white matter were significantly lower than those of irreversible brain-ischemia patients’ in ADC values. In comparison to most of the other studies, in our study population studied is large, in which is a comprehensive study that results consistent with the literature. As a result we propose that in the definition of brain death Diffusion MRI and ADC measurements are reliable to show diffuse ishemic changes of brain parenchyma.

关键词： DWI MRI Brain Death Transplantation

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Solutions of Three-Dimensional Separable Non-Central Potential

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Chinese Physics Letters 2008年第4期25卷 1172-1174页

作者： ozlem Yesiltas Gazi University Faculty of Arts and Sciences Department of Physics 06500 Ankara Turkey

We show that a wide class of non-central potentials can be analysed via the improved picture of the Nikiforov- Uvarov method [Physica Scripta 75 （2007） 686]. It has been shown that using the alternative approach, po... 详细信息

关键词： supernova explosion proto-neutron star shock wave

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Ionic liquid-based transparent membrane-coupled human lung epithelium-on-a-chip demonstrating PM0.5 pollution effect under breathing mechanostress

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Bio-Design and Manufacturing 2024年第5期7卷 624-636页

作者： Bilgesu Kaya ozlem Yesil-Celiktas Department of Bioengineering Faculty of EngineeringEge UniversityIzmir 35100Türkiye Translational Pulmonary Research Center(EgeSAM) Ege UniversityIzmir 35100Türkiye

The plausibility of human exposure to particulate matter(PM)has witnessed an increase within the last several *** of different sizes has been discovered in the atmosphere given the role of dust transport in weather and climate *** a regulator,the lung epithelium orchestrates the innate response to local ***,we developed a lung epithelium-ona-chip platform consisting of easily moldable polydimethylsiloxane layers along with a thin,flexible,and transparent ionic liquid-based poly(hydroxyethyl)methacrylate gel *** epithelium was formed through the culture of human lung epithelial cells(Calu-3)on this *** mechanical stress at the air–liquid interface during inhalation/exhalation was recapitulated using an Arduino-based servo motor system,which applied a uniaxial tensile strength from the two sides of the chip with 10%strain and a frequency of 0.2 ***,the administration of silica nanoparticles(PM0.5)with an average size of 463 nm to the on-chip platform under static,dynamic,and dynamic+mechanical stress(DMS)conditions demonstrated the effect of environmental pollutants on lung *** viability and release of lactate dehydrogenase were determined along with proinflammatory response through the quantification of tumor necrosis factor-α,which indicated alterations in the epithelium.

关键词： Ionic liquid-based membrane Lung Epithelial barrier Mechanostress Organ-on-chip Silica particles

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A cross-layer fault tolerance management module for wireless sensor networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第9期13卷 660-673页

作者： ozlem KARACA Radosveta SOKULLU Izmir Vocational School Dokuz Eylul UniversityIzmir 35160Turkey Department of Electrical and Electronics Engineering Ege UniversityIzmir 35100Turkey

It is a well-established fact that wireless sensor networks (WSNs) are very power constraint networks, but besides this, they are inherently more fault-prone than any other type of wireless network and their protocol design is very application specific. Major reasons for the faults are the unpredictable wireless communication channel, battery depletion, as well as fragility and mobility of the nodes. Furthermore, as traditional protocol design methods have proved inadequate, the cross-layer design (CLD) approach, which allows for interactions between different layers, providing more flexible and energy-efficient functionality, has emerged as a viable solution for WSNs. In this study we define a fault tolerance management module suitable to the requirements, limitations, and specifics of WSNs, encompassing methods for fault detection, fault prevention, fault management, and recovery. The suggested solution is in line with the CLD approach, which is an important factor in increasing the network performance. Through simulations the functionality of the network is evaluated, based on packet loss, delay, and energy consumption, and is compared with a similar solution not including fault management. The results achieved support the idea that the introduction of a unified approach to fault management improves the network performance as a whole.

关键词： Wireless sensor networks (WSNs) Cross-layer frameworks Protocol design Fault management

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Tata-box-binding protein-associated factor 15 as a new potential marker in gastrointestinal tumors

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World Journal of Gastroenterology 2024年第28期30卷 3367-3372页

作者： Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Türkiye

In this editorial,the roles of tata-box-binding protein-associated factor 15(TAF15)in oncogenesis,tumor behavior,and as a therapeutic target in cancers in the context of gastrointestinal(GI)tumors are discussed concerning the publication by Guo et ***15 is a member of the FET protein family with a comprehensive range of cellular ***,evidence has shown that TAF15 is involved in many diseases,including ***15 contributes to carcinogenesis and tumor behavior in many ***,its relationship with the mitogen-activated protein kinases(MAPK)signaling pathway makes TAF15 a new target for ***,the fact that there is few studies investigating the expression of TAF15 constitutes a potential limitation in GI system,the association of TAF15 expression with aggressive tumor behavior and,similar to other organ tumors,the influence of TAF15 on the MAPK signaling pathway emphasize that this protein could serve as a new molecular biomarker to predict tumor behavior and target therapeutic intervention in GI *** conclusion,more studies should be performed to better understand the prognostic and therapeutic role of TAF15 in GI tumors,especially in tumors resistant to therapy.

关键词： Gastrointestinal cancer Tata-box-binding protein-associated factor 15 Cell proliferation Cell migration Prognosis

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Indoor^(222)Rn Levels and Effective Dose Estimation of Academic Staff in izmir-Turkey

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Biomedical and Environmental Sciences 2014年第4期27卷 259-267页

作者： TURKAN ALKAN ozlem KARADENIZ Department of Medical Physics Institute of Health SciencesDokuz Eyliil University Department of Physics Faculty of SciencesDokuz Eyliil University

Objective To investigate the annual effective doses from indoor radon received by academic staff in the Faculty building. Methods Measurements of indoor radon concentrations were performed in the Arts and Sciences Faculty of Dokuz Eylul University for two surveys of about 1 month duration respectively using the SSNTD （Solid State Nuclear Track Detectors） method with LR115 detectors. Time integrated measurements comprised different locations inside the faculty building： classrooms, toilets, canteen and offices. Homes of academic staff were also tested for radon. Results The aritthmetic mean radon concentration is 161 Bq m-3 with a range between 40 and 335 Bq m-3 in the Faculty. Six offices and three classrooms have a radon concentration above 200 Bq m-3. The results show that the radon concentration in classrooms is generally higher than in offices. Based on the measured indoor radon data, the annual effective doses received by staff in the Faculty were estimated to range from 0.79 to 4.27 mSv, according to UNSCEAR methodology. The annual effective doses received by staff ranged from 0.78 to 4.20 mSv in homes. On average, the Faculty contributed 56% to the annual effective dose. Conclusion Reported values for radon concentrations and corresponding doses are within the ICRP recommended limits for workplaces.

关键词： Indoor radon Solid state nuclear track detectors School Annual effective dose

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Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update

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World Journal of Clinical Cases 2021年第19期9卷 4890-4917页

作者： Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

Hepatocellular carcinoma(HCC)is the most common type of cancer among primary malignant tumors of the liver and is a consequential cause of cancerrelated deaths *** recent years,uncovering the molecular mechanisms involved in the development and behavior of this tumor has led to the identification of multiple potential treatment *** the vast amount of data on this topic,HCC remains a challenging tumor to treat due to its aggressive behavior and complex molecular ***,the number of studies aiming to elucidate the mechanisms involved in both carcinogenesis and tumor progression in HCC continues to *** this context,the close association of HCC with viral hepatitis has led to numerous studies focusing on the direct or indirect involvement of viruses in the mechanisms contributing to tumor development and *** line with these efforts,this review was undertaken to highlight the current understanding of the molecular mechanisms by which hepatitis B virus(HBV)and hepatitis C virus(HCV)participate in oncogenesis and tumor progression in HCC and summarize new *** evidence indicates that HBV DNA integration promotes genomic instability,resulting in the overexpression of genes related to cancer development,metastasis,and angiogenesis or inactivation of tumor suppressor *** addition,genetic variations in HBV itself,especially preS2 deletions,may play a role in malignant *** dysregulation caused by both viruses might also contribute to tumor formation and metastasis by modifying the methylation of DNA and histones or altering the expression of ***,viral proteins of both HBV and HCV can affect pathways that are important anticancer *** effects of these two viruses on the Hippo-Yap-Taz pathway in HCC development and behavior need to be ***,comprehensive studies are also needed to determine these viruses'interaction with integrins,farnesoid X,and the

关键词： Hepatitis B virus Hepatitis C virus Hepatocellular carcinoma Carcinogenesis Molecular pathways Viral hepatitis

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Effectiveness of vedolizumab treatment in two different anti-tumor necrosis factor alpha refractory pouchitis: A case report

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World Journal of Clinical Cases 2019年第16期7卷 2316-2321页

作者： ozlem Ozer Cakir Department of Gastroenterology and Hepatology Alanya Alaaddin Keykubat University School of Medicine

BACKGROUND Refractory pouchitis is a common cause of pouch failure,which may require surgical excision of the pouch or permanent *** aimed to show the effect of vedolizumab on treatment of the patient with refractory *** SUMMARY A 32-year-old male with pancolonic ulcerative colitis since the age of 25 with primary failure of infliximab and mesalamine and intolerance of azathioprine,underwent a total proctocolectomy with ileal pouch-anal anastomosis in *** developed chronic diarrhea in 2014,which was watery,30 per day and accompanied with blood and mucus affecting his quality of *** Vedolizumab is safe and effective in the management of anti-tumor necrosis factor alpha refractory pouchitis.

关键词： Anti-tumor necrosis factor alpha Refractory pouchitis Vedolizumab Ulcerative colitis

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Neuropilins and liver

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World Journal of Gastroenterology 2015年第23期21卷 7065-7073页

作者： Gulsum ozlem Elpek Department of Pathology Medica School Akdeniz University Antalya 07070 Turkey

Neuropilins(NRPs) are highly conserved transmembrane glycoproteins that possess pleiotropic functions. Neuropilin-1(NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively. The contribution of NRPs to tumor angiogenesis has been highlighted in previous studies, leading to the development of NRP antagonists as novel anti-angiogenesis therapies. However, more recent studies have demonstrated that NRPs have a much broader spectrum of activity in the integration of different pathways in physiological and pathological conditions. A few studies investigated the role of NRPs in both malignant and non-neoplastic liver diseases. In normal liver, NRP1 is expressed in hepatic stellate cells and liver sinusoidal endothelial cells. NRP1 expression in hepatocytes has been associated with malignant transformation and may play an important role in tumor behavior. A contribution of NRPs in sinusoidal remodeling during liver regeneration has been also noted. Studies in chronic liver diseases have indicated that, besides its influence on angiogenesis, NRP1 might contribute to the progression of liver fibrosis owing to its effects on other growth factors, including transforming growth factor β1. As a result, NRP1 has been identified as a promising therapeutic target for future antifibrotic therapies based on the simultaneous blockade of multiple growth factor signaling pathways. In this review, the structure of NRPs and their interactions with various ligands and associated cell surface receptors are described briefly. The current understanding of the roles of the NRPs in liver diseases including tumors, regeneration and fibrogenesis, are also summarized.

关键词： Neuropilins Neuropilin-1 Neuropilin-2 Angiogenesis Liver fibrosis Vascular endothelial growth factor Transforming growth factor β1

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Clinical characteristics of Caroli’s disease

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World Journal of Gastroenterology 2007年第13期13卷 1930-1933页

作者： ozlem Yonem Yusuf Bayraktar Hacettepe University Faculty of Medicine Department of Gastroenterology Sihhiye 06100 Ankara Turkey Hacettepe University Faculty of Medicine Department of Gastroenterology Sihhiye 06100 Ankara Turkeyr MD Series Editor

Caroli's disease is a rare congenital condition chara- cterized by non-obstructive saccular or fusiform dilatation of larger intrahepatic bile ducts. Cholangitis, liver cirrhosis, and cholangiocarcinoma are its potential complications. The diagnosis of Caroli's disease depends on demonstrating that the cystic lesions are in continuity with the biliary tree which can be showed by ultrasonography, computerized tomography, endoscopic retrograde cholangiopancreatography, percutaneous transhepatic cholangiography or magnetic resonance cholangiopancreatography. Treatment of Caroli's disease relies on the location of the biliary abnormalities. While localized forms confined to one lobe can be treated with surgery, liver transplantation is the only effective modality for diffuse forms. Although a rare disorder; Caroli's disease should always be considered in the differential diagnosis of chronic cholestasis of unknown cause.

关键词： Caroli's disease Liver transplantation Endoscopic retrograde cholangiopancreatography

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