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World Journal of Clinical Cases 2019年第16期7卷 2316-2321页

作者： ozlem Ozer Cakir Department of Gastroenterology and Hepatology Alanya Alaaddin Keykubat University School of Medicine

BACKGROUND Refractory pouchitis is a common cause of pouch failure,which may require surgical excision of the pouch or permanent *** aimed to show the effect of vedolizumab on treatment of the patient with refractory *** SUMMARY A 32-year-old male with pancolonic ulcerative colitis since the age of 25 with primary failure of infliximab and mesalamine and intolerance of azathioprine,underwent a total proctocolectomy with ileal pouch-anal anastomosis in *** developed chronic diarrhea in 2014,which was watery,30 per day and accompanied with blood and mucus affecting his quality of *** Vedolizumab is safe and effective in the management of anti-tumor necrosis factor alpha refractory pouchitis.

关键词： Anti-tumor necrosis factor alpha Refractory pouchitis Vedolizumab Ulcerative colitis

Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update

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World Journal of Clinical Cases 2021年第19期9卷 4890-4917页

作者： Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

Hepatocellular carcinoma(HCC)is the most common type of cancer among primary malignant tumors of the liver and is a consequential cause of cancerrelated deaths *** recent years,uncovering the molecular mechanisms involved in the development and behavior of this tumor has led to the identification of multiple potential treatment *** the vast amount of data on this topic,HCC remains a challenging tumor to treat due to its aggressive behavior and complex molecular ***,the number of studies aiming to elucidate the mechanisms involved in both carcinogenesis and tumor progression in HCC continues to *** this context,the close association of HCC with viral hepatitis has led to numerous studies focusing on the direct or indirect involvement of viruses in the mechanisms contributing to tumor development and *** line with these efforts,this review was undertaken to highlight the current understanding of the molecular mechanisms by which hepatitis B virus(HBV)and hepatitis C virus(HCV)participate in oncogenesis and tumor progression in HCC and summarize new *** evidence indicates that HBV DNA integration promotes genomic instability,resulting in the overexpression of genes related to cancer development,metastasis,and angiogenesis or inactivation of tumor suppressor *** addition,genetic variations in HBV itself,especially preS2 deletions,may play a role in malignant *** dysregulation caused by both viruses might also contribute to tumor formation and metastasis by modifying the methylation of DNA and histones or altering the expression of ***,viral proteins of both HBV and HCV can affect pathways that are important anticancer *** effects of these two viruses on the Hippo-Yap-Taz pathway in HCC development and behavior need to be ***,comprehensive studies are also needed to determine these viruses'interaction with integrins,farnesoid X,and the

关键词： Hepatitis B virus Hepatitis C virus Hepatocellular carcinoma Carcinogenesis Molecular pathways Viral hepatitis

Orosomucoid in liver diseases

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World Journal of Gastroenterology 2021年第45期27卷 7739-7747页

作者： Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

In this editorial,the roles of orosomucoid(ORM)in the diagnoses and follow-up assessments of both nonneoplastic diseases and liver tumors are discussed with respect to the publication by Zhu et al presented in the previous issue of World Journal of Gastroenterology(2020;26(8):840-817).ORM,or alpha-1 acid glycoprotein(AGP),is an acute-phase protein that constitutes 1%to 3%of plasma proteins in humans and is mainly synthesized in the *** exists in serum as two variants:ORM1 and *** the variants share 89.6%sequence identity and have similar biological properties,ORM1 constitutes the main component of serum *** interesting feature of ORM is that its biological effects differ according to variations in glycosylation *** variable feature makes ORM an attractive target for diagnosing and monitoring many diseases,including those of the *** findings suggest that a sharp decrease in ORM level is an important marker for HBV-associated acute liver failure(ALF),and ORM1 plays an important role in liver *** viral hepatitis,increases in both ORM and its fucosylated forms and the correlation of these increases with fibrosis progression suggest that this glycoprotein can be used with other markers as a noninvasive method in the follow-up assessment of *** addition,similar findings regarding the level of the asialylated form of ORM,called asialo-AGP(AsAGP),have been reported in a follow-up assessment of fibrosis in chronic liver *** increase in ORM in serum has also been shown to improve hepatocellular carcinoma(HCC)diagnosis performance when combined with other *** addition,determination of the ORM level has been useful in the diagnosis of HCC with AFP concentrations less than 500 ng/*** monitoring patients with AFP-negative HCC,a unique trifucosylated tetra-antennary glycan of ORM may also be used as a new potential *** fact that there are very few studies investigating the expression of this glycopro

关键词： Orosomucoid Alpha-1-acid glycoprotein Viral hepatitis cirrhosis Hepatocellular carcinoma Downregulation

Tumor budding as a potential prognostic marker in determining the behavior of primary liver cancers

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World Journal of Hepatology 2023年第6期15卷 775-785页

作者： Betul Unal Mennan Yigitcan Celik Elif Ocak Gedik Cumhur Ibrahim Bassorgun Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

Hepatocellular(HCC)and intrahepatic cholangiocarcinoma(ICC),the most common primary tumors of the liver,are among the most important causes of cancer deaths *** patients with primary liver tumors are frequently diagnosed at an advanced stage and have high mortality,many efforts have been made to identify new markers to determine their behavior and treatment,similar to those in other solid organ ***,morphological assessment of tumor budding(TB)has been revealed as a promising prognostic finding to predict tumor behavior and survival across several different tumor ***,the TB score in colorectal cancer has been revealed as an important parameter in pathology report protocols to determine the course of the *** the liver,despite enormous data showing that many mechanisms involved in TB are associated with tumor behavior in both HCC and ICC,studies focusing on the role of TB in predicting the behavior and prognosis of these tumors have started to be investigated very *** purpose of this review is to present data about TB in primary tumors of the liver,pointing out the potential role of this parameter in determining the course of the disease,and emphasize the need to increase the number of further studies focusing on the evaluation of this parameter with an overview of the mechanisms involved in TB.

关键词： Tumor budding Hepatocellular carcinoma Cholangiocarcinoma Prognosis Liver cancer Epithelial-mesenchymal transition

The fatty acid compositions of predator Piocoris luridus （Heteroptera： Lygaeidae） and its host Monosteria unicostata （Heteroptera： Tingidae） reared on almond

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Insect Science 2007年第6期14卷 461-466页

作者： ozlem CAKMAK MEHMET BASHAN HALIL BOLU Department of Biology Education Faculty Department of Biology Science and Art Faculty Department of Plant Protection AgricultureFaculty Dicle University 21280 Diyarbakir Turkey

The changes in fatty acid compositions during nutritional interaction among almond Amygdalus communis Linnaeus （Rosales： Rosaceae）（host plant）, lacebug Monosteria unicostata （Mulsant and Rey）（Heteroptera： Tingidae） and its predator Piocoris luridus Fieber （Heteroptera： Lygaeidae） were determined by gas chromatography and gas chromatography-mass spectrometry analyses. The fatty acid profiles of phospholipids and triacylglycerols were substantially different. Unlike the general observations for virtually most terrestrial insects, arachidonic and eicosapentaenoic acids were detected in high proportions of phospholipid fractions in both insects, especially in P. luridus. Also the almond tissues provide very little oleic acid to the herbivore diet, yet both insect species developed high proportions of this component. Our data reveals instances of specific accumulation of fatty acid biosynthesis, elongation/desaturation, and not incorporating selected fatty acids into cellular lipids.

关键词： Arachidonic acid insect fatty acid Monosteria unicostata Piocoris luridus,phospholipids triacylglycerols

Leucocyte-and platelet-rich fibrin as a rescue therapy for small-to-medium-sized complex wounds of the lower extremities

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Burns & Trauma 2019年第1期7卷 98-106页

作者： Kadri Ozer ozlem Colak Aydin State Hospital PlasticReconstructive and Aesthetic Surgery Clinic09100 AydinTurkey Istanbul Okmeydani Training and Research Hospital PlasticReconstructive and Aesthetic Surgery Clinic34384 IstanbulTurkey

Background:Generally,advanced wound care resources are applied for complex wounds that pose a challenge to the medical and nursing *** this report,the use of leukocyte-and platelet-rich fibrin(L-PRF)is emphasized for complex wounds as an alternative,simple,inexpensive,time-saving process that does not require hospitalization and has a healing potential over that of bare soft tissue,including bone,tendon,and *** aim of this study is to extend the use of L-PRF in small-to-moderate-sized complex wounds of lower extremities in which L-PRF maintains the sensitive structures ***:Between January 2016 and December 2017,17 small-to-moderate-sized complex wounds of lower extremities treated with L-PRF were recruited from the plastic and reconstructive surgery clinic in Aydin State Hospital,*** treatment was administered twice per week in the outpatient *** on the size and extension of the complex wound,two to five blood samples were collected into 8.5 ml dry,glass vacuum tubes with no anticoagulant,and samples were immediately centrifuged at 1630×g for 5 min to obtain *** healing was defined as the day of complete wound ***:The median values of the initial wound size and wound duration were 12 cm^(2)(interquartile range,6 to 23 cm^(2))and 8 months before first admission(interquartile range,4 to 18 months),*** wounds showed significant improvements after L-PRF therapy and full closure after a median of 18months,with an interquartile range of 11 to 34 months of L-PRF *** were recurrences of wounds during the first 6 months after *** adverse events were ***:Our results add to the growing evidence that L-PRF treatments protect and maintain bare soft tissue structures viable,facilitate the formation of granulation tissue and epithelization,and remarkably reduce the need for additional soft tissue surgeries in small-to-medium-sized complex wounds.

关键词： Leukocyte-and platelet-rich fibrin Complex wound Bare bone Bare tendon

ELECTRORHEOLOGY AND CREEP-RECOVERY BEHAVIOR OF CONDUCTING POLYTHIOPHENE/POLY(OXYMETHYLENE)-BLEND SUSPENSIONS

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Chinese Journal of Polymer Science 2012年第1期30卷 16-25页

作者： ozlem Erol H.Ibrahim Unal Bekir Sari Smart Materials Research Lab Chemistry Department Gazi UniversityAnkaraTurkey

Electrorheological properties and creep-recovery behavior of polythiophene/polyoxymethylene-blend having PT（50%）/POM（50%） composition were *** size,conductivity and dielectric values were measured to be 24.77μm,3.85×10^（-5） S·m^（-1） and 26.75,*** ratio was measured to be 64%at the end of 16 *** effects of dispersed particle volume fraction,external electric field strength,shear rate,frequency and temperature on ER properties and storage modulus of PT/POM-blend/silicone oil（SO） suspensions were *** were observed in the electric field viscosities of the suspensions and thus they were classified as a smart *** thinning non-Newtonian viscoelastic behavior was determined for PT/POM-blend/SO ***,time-dependent deformation was examined by creep-recovery tests and recoverable viscoelastic deformation established.

关键词： Conducting polythiophene/poly(oxymethylene) Blends Electrorheogical fluids Creep-recovery behavior

Does vitamin D affect disease severity in patients with ankylosing spondylitis？

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Chinese Medical Journal 2012年第14期125卷 2511-2515页

作者： Bekir Durmus Zuhal Altay ozlem Baysal Yuksel Ersoy Department of Physical Medicine & Rehabilitation InonuUniversity Faculty of Medicine Malatya Turkey

Background Vitamin D has been found to have a role in the function of the immune system. There have been a lot of studies investigating a relation between vitamin D and disease activity in ankylosing spondylitis （AS）. However, there have not been any studies arranging AS in groups according to vitamin D levels and determining any differences among these patients in terms of disease activity, functional status, quality of life, and other clinical parameters. The aim of this study is to compare 25-hydroxy-vitamin D3 （25（OH）D3） levels in AS patients with those in normal healthy subjects and to determine the relationship between 25（OH）D3 levels and AS disease activity, functional status, and quality of life. Methods Ninety-nine consecutive patients and 42 healthy volunteers were included in this study. After a comparison between the patient group and the control group, the patient group was divided into normal, insufficient and deficient subgroups according to the plasma 25（OH）D3 levels for another comparison. Results The differences in the 25（OH）D3 level between the patient and the control groups were statistically insignificant. The number of AS patients whose 25（OH）D3 levels were classified as normal, insufficient, and deficient were 34, 29, and 36, respectively. Erythrocyte sedimentation rate （ESR）, C-reactive protein （CRP）, and Bath AS Disease Activity Index （BASDAI） scores were higher in the low （including insufficient and deficient） 25（OH）D3 level subgroups （P 〈0.05）. The Bath AS Functional Index （BASFI） and AS Quality of Life （ASQoL） scores were significantly different between the normal and the deficient subgroups （P 〈0.05）. Pain, BASDAI, ESR, and CRP were inversely correlated to the 25（OH）D3 levels （P 〈0.05）. Conclusions The plasma 25（OH）D3 levels may decrease in AS patients and this may negatively affect disease activity, functional status and quality of life.

关键词： ankylosing spondylitis 25(OH)D3, diease activity, functional status, quality of life

A numerical framework for the approximate solution of fractional tumor-obesity model

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International Journal of Modeling, Simulation, and Scientific Computing 2019年第1期10卷 106-118页

作者： Sadia Arshad Dumitru Baleanu ozlem Defterli Shumaila Department of Mathematics COMSATS University Islamabad LahorePunjab 54000Pakistan Department of Mathematics and Computer Sciences Cankaya University Ankara 06530Turkey

In this paper,we have proposed the efficient numerical methods to solve a tumor-obesity model which involves two types of the fractional operators namely Caputo and CaputoFabrizio(CF).Stability and convergence of the proposed schemes using Caputo and CF fractional operators are *** simulations are carried out to investigate the effect of low and high caloric diet on tumor dynamics of the generalized *** perform the numerical simulations of the tumor-obesity model for different fractional order by varying immune response rate to compare the dynamics of the Caputo and CF fractional operators.

关键词： Tumor-obesity model numerical approximation stability and convergence analysis

Possible agent for COVID-19 treatment:Rifampicin

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World Journal of Virology 2022年第5期11卷 391-393页

作者： ozlem Celik Aydin Sonay Aydın Sureyya Barun Department of Medical Pharmacology Erzincan UniversityMengucek Gazi Education and Research HospitalErzincan 24100Turkey Department of Pharmacology Gazi UniversityAnkara 06500Turkey Department of Radiology Erzincan UniversityErzincan 24100Turkey

Rifampicin is a promising drug for the treatment of coronavirus disease 2019 based on its antiviral properties and recent in silico *** silico studies can serve as a foundation for further studies.

关键词： Rifampicin COVID-19 Treatment In silico Drug-drug interaction Therapeutic potential