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Assessment of the potential interactions between favipiravir and radiocontrast agents

World Journal of Radiology 2024年第5期16卷 128-135页

作者： Sonay aydin ozlem Celik aydin Mesut Furkan Yazar Huseyin Aydemir Mecit Kantarci Sureyya Barun Department of Radiology Erzincan Binali Yıldırım UniversityFaculty of MedicineErzincan 24100Türkiye Department of Pharmacology Gazi UniversityFaculty of MedicineErzincan 24100Türkiye Department of Radiology Bilecik Education and Reseach HospitalBilecik 11230Türkiye Department of Radiology Atatürk UniversityFaculty of MedicineErzurum 25030Türkiye

BACKGROUND In cases of coronavirus disease 2019(COVID-19),favipiravir is commonly included to the therapy *** interactions between favipiravir and other COVID-19 therapy drugs are frequently ***,no research on possible drug interactions between Favipiravir and radiocontrast agents,which have become almost crucial in diagnostic processes while not being part of the treatment,has been *** To determine potential medication interactions between Favipiravir and radiocontrast *** The study comprised patients who were taking Favipiravir for COVID-19 therapy and underwent a contrast-enhanced computed tomography(CT)or magnetic resonance imaging(MRI)test while taking the *** computerized patient files of the cases included in the study,as well as the pharmacovigilance forms in the designated hospital,were evaluated for this *** The study included the evaluation of data from 1046 *** study sample's mean age was 47.23±9.48 *** mean age of cases with drug interactions was statistically significant greater than that of cases with no drug interactions(P=0.003).When evaluated with logistic regression analysis,a 1-year raises in age increases the risk of developing drug interactions by 1.63 times(P=0.023).There was no statistically significant difference in the occurrence of medication interactions between the sexes(P=0.090).Possible medication interactions were discovered in 42 cases(4%).CONCLUSION The findings of this study revealed that the most notable findings as a result of the combined use of contrast agents and favipiravir were increased creatinine and transaminase values,as well as an increase in the frequency of nausea and *** majority of drug interactions discovered were modest enough that they were not reflected in the *** interactions become more common as people get older.

关键词： Favipiravir Iohexol Gadoxetic acid Meglumine gadoterate Drug interactions

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Defining the awareness and attitude of the clinicians through pharmacovigilance in Turkey

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World Journal of Clinical Cases 2023年第20期11卷 4865-4873页

作者： ozlem Celik aydin Sonay aydin Hakki Zafer Guney Department of Medical Pharmacology Gazi University Faculty of MedicineAnkara 06500Turkey

BACKGROUND Pharmacovigilance(PV)is the activities and scientific studies conducted to detect,evaluate,understand or prevent adverse reactions and other drug-related *** To define the awareness and experiences of the clinicians on PV and adverse drug reactions(ADRs)in *** The study was cross-sectional and *** were obtained through a *** questionnaire was sent via *** survey was sent to 2030 physicians and 670 *** The most appropriate definition of PV was correctly defined by 53.9%of the *** most important goal of PV was correctly defined by 54.9%of the participants,and 27.3%of the participants were aware of the Turkish Pharmacovigilance *** physicians had better PV knowledge than surgical physicians.A total of 80.9%of the physicians who encountered ADRs,filled in the ADR notification form,and 8.8%received training on how to fill in the *** knowledge of the clinicians was not *** half of the physicians encountered ADRs,the rates of seeing and filling in the ADR form were *** Few of the physicians followed the current information about *** results provide more comprehensive data on PV practices and ADR reporting at a national level.

关键词： Pharmacovigilance Physicians Knowledge level Attitude Behavior Adverse drug reaction

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Interobserver variation in histopathological assessment of Helicobacter pylori gastritis

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World Journal of Gastroenterology 2003年第10期9卷 2232-2235页

作者： ozlem aydin Reyhan Egilmez Tuba Karabacak Arzu Kanik Department of Pathology and Biostatistics Medical SchoolMersin UniversityMersin-IcelTurkey

AIM:Because the presence or absence of H pylori infection has important implications for therapeutic decisions based on histological assessment,the reproducibility of Sydney system is *** study was designed to test the reproducibility of features of Helicobacter pylori gastritis, using the updated Sydney classification. METHODS:Gastric biopsies of 40 randomly selected cases of H pylori gastritis were scored semiquantitatively by three *** analysed induded chronic inflammation, inflammatory activity,atrophy,intestinal metaplasia,H pylori, surface epithelial damage.κ values below 0.5 represented poor,those between 0.5 and 0.75 good and values over 0.75 excellent interobserver agreement. RESULTS:The best interobserver agreement(κ=0.62)was present for intestinal *** agreement was the poorest for evaluating atrophy(κ=0.31). CONCLUSION:Although the results of this study were in accordance with some previous studies,an excellent agreement could not be reached for any features of H pylori *** low degree of concordance is assumed to be due to the personal evaluation differences in grading the features,the lack of standardized diagnostic criteria,and the ignorance to reach a consensus about the methods to be used in grading the features of H pylori gastritis before initiating the study.

关键词： Helicobacter pylori Adult Aged Biopsy numerical data Female Gastritis Helicobacter Infections Humans Male Middle Aged Observer Variation Pyloric Antrum Random Allocation

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Role of natural products and intestinal flora on type 2 diabetes mellitus treatment

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World Journal of Clinical Cases 2023年第1期11卷 65-72页

作者： ozlem Celik aydin Sonay Aydın Sureyya Barun Department of Medical Pharmacology Erzincan Mengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of Radiology Erzincan Binali Yıldırım UniversityMengücek Gazi Training and Research HospitalErzincan 24100Turkey Department of Medical Pharmacology Gazi University Faculty of MedicineAnkara 06500Turkey

Diabetes mellitus(DM)is a complicated,globally expanding disease that is influenced by hereditary and environmental *** in modern society’s food choices,physical inactivity,and obesity are significant factors in the development of type 2 DM(T2DM).The association between changes in intestinal flora and numerous disorders,including obesity,diabetes,and cardiovascular diseases,has been studied in recent *** purpose of this review is to analyze the mechanisms underlying the alteration of the diabetic patients’intestinal flora,as well as their therapeutic *** included is a summary of the antidiabetic benefits of natural compounds demonstrated by *** short-chain fatty acids theory,the bile acid theory,and the endotoxin theory are all potential methods by which intestinal flora contributes to the establishment and progression of *** to an intestinal flora imbalance,abnormalities in shortchain fatty acids and secondary bile acids have been found in diabetic ***,metabolic endotoxemia with altering flora induces a systemic inflammatory response by stimulating the immune system via bacterial *** agenda for diabetes treatment includes the use of short-chain fatty acids,probiotics,prebiotics in the diet,fecal bacteria transplantation,and *** studies have proven the antidiabetic benefits of numerous bioactive substances,including Flavonoids,Alkaloids,Saponin,and ***,further research is required to contribute to the treatment of diabetes.

关键词： Diabetes mellitus Intestinal flora Natural products Endotoxemia Bioactive compounds Probiotics

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Possible agent for COVID-19 treatment:Rifampicin

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World Journal of Virology 2022年第5期11卷 391-393页

作者： ozlem Celik aydin Sonay Aydın Sureyya Barun Department of Medical Pharmacology Erzincan UniversityMengucek Gazi Education and Research HospitalErzincan 24100Turkey Department of Pharmacology Gazi UniversityAnkara 06500Turkey Department of Radiology Erzincan UniversityErzincan 24100Turkey

Rifampicin is a promising drug for the treatment of coronavirus disease 2019 based on its antiviral properties and recent in silico *** silico studies can serve as a foundation for further studies.

关键词： Rifampicin COVID-19 Treatment In silico Drug-drug interaction Therapeutic potential

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Ionic liquid-based transparent membrane-coupled human lung epithelium-on-a-chip demonstrating PM0.5 pollution effect under breathing mechanostress

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Bio-Design and Manufacturing 2024年第5期7卷 624-636页

作者： Bilgesu Kaya ozlem Yesil-Celiktas Department of Bioengineering Faculty of EngineeringEge UniversityIzmir 35100Türkiye Translational Pulmonary Research Center(EgeSAM) Ege UniversityIzmir 35100Türkiye

The plausibility of human exposure to particulate matter(PM)has witnessed an increase within the last several *** of different sizes has been discovered in the atmosphere given the role of dust transport in weather and climate *** a regulator,the lung epithelium orchestrates the innate response to local ***,we developed a lung epithelium-ona-chip platform consisting of easily moldable polydimethylsiloxane layers along with a thin,flexible,and transparent ionic liquid-based poly(hydroxyethyl)methacrylate gel *** epithelium was formed through the culture of human lung epithelial cells(Calu-3)on this *** mechanical stress at the air–liquid interface during inhalation/exhalation was recapitulated using an Arduino-based servo motor system,which applied a uniaxial tensile strength from the two sides of the chip with 10%strain and a frequency of 0.2 ***,the administration of silica nanoparticles(PM0.5)with an average size of 463 nm to the on-chip platform under static,dynamic,and dynamic+mechanical stress(DMS)conditions demonstrated the effect of environmental pollutants on lung *** viability and release of lactate dehydrogenase were determined along with proinflammatory response through the quantification of tumor necrosis factor-α,which indicated alterations in the epithelium.

关键词： Ionic liquid-based membrane Lung Epithelial barrier Mechanostress Organ-on-chip Silica particles

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Tata-box-binding protein-associated factor 15 as a new potential marker in gastrointestinal tumors

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World Journal of Gastroenterology 2024年第28期30卷 3367-3372页

作者： Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Türkiye

In this editorial,the roles of tata-box-binding protein-associated factor 15(TAF15)in oncogenesis,tumor behavior,and as a therapeutic target in cancers in the context of gastrointestinal(GI)tumors are discussed concerning the publication by Guo et ***15 is a member of the FET protein family with a comprehensive range of cellular ***,evidence has shown that TAF15 is involved in many diseases,including ***15 contributes to carcinogenesis and tumor behavior in many ***,its relationship with the mitogen-activated protein kinases(MAPK)signaling pathway makes TAF15 a new target for ***,the fact that there is few studies investigating the expression of TAF15 constitutes a potential limitation in GI system,the association of TAF15 expression with aggressive tumor behavior and,similar to other organ tumors,the influence of TAF15 on the MAPK signaling pathway emphasize that this protein could serve as a new molecular biomarker to predict tumor behavior and target therapeutic intervention in GI *** conclusion,more studies should be performed to better understand the prognostic and therapeutic role of TAF15 in GI tumors,especially in tumors resistant to therapy.

关键词： Gastrointestinal cancer Tata-box-binding protein-associated factor 15 Cell proliferation Cell migration Prognosis

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Is sarcopenia effective on survival in patients with metastatic gastric cancer?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1861-1868页

作者： ozlem Dogan Hayriye Sahinli Yakup Duzkopru Tuba Akdag Abdulkadir Kocanoglu Department of Medical Oncology Adıyaman University Training and Research HospitalAdiyaman 02100Turkey Department of Medical Oncology Ankara Etlik City HospitalAnkara 06170Turkey Department of Radiology University of Health SciencesDiskapi Yildirim Beyazit Training and Research HospitalAnkara 06000Turkey Department of Medical Oncology Ankara Ataturk Sanatoryum Training and Research HospitalAnkara 06170Turkey

BACKGROUND Sarcopenia is a progressively diminishing state characterized by the reduction of muscle mass and density,which is frequently observed in malignancies of solid *** To assess how sarcopenia affects the overall survival of individuals who have been diagnosed with metastatic gastric *** The study retrospectively included individuals who had been diagnosed with metastatic gastric cancer between January 2008 and December *** was identified through the calculation of the average Hounsfield units(HUAC)using computed tomography(CT)images taken at the time of diagnosis in *** A total of 118 patients with metastatic gastric cancer were *** was detected in 29 patients(24.6%).The median survival of all patients was 8(1-43)*** median survival of patients with sarcopenia was 2 mo,while it was 10 mo for those without sarcopenia(P<0.001).A significant relationship was found between sarcopenia and *** Sarcopenia has been observed to impact survival outcomes in various types of solid tumor *** patients can be identified in a short time,easily and inexpensively,by HUAC measurements from CT images used for diagnosis,and survival could be promoted with nutritional support.

关键词： Hounsfield units Sarcopenia Gastric cancer Survival Psoas muscle mass Muscle density

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Gastric polypoid lesions:Analysis of 150 endoscopic polypectomy specimens from 91 patients

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World Journal of Gastroenterology 2003年第10期9卷 2236-2239页

作者： Rasim Gencosmanoglu Ebru Sen-Oran ozlem Kurtkaya-Yapicier Erol Avsar aydin Sav Nurdan Tozun the Unit of Surgery Institute of GastroenterologySchool of MedicineMarmara UniversityIstanbulTurkey Department of Pathology School of MedicineMarmara UniversityIstanbulTurkey the Unit of Gastroenterology Institute of GastroenterologySchool of MedicineMarmara UniversityIstanbulTurkey

AIM:To analyze gastric polypoid lesions in our patient- population with respect to histopathologic features and demographic,clinical,and endoscopic characteristics of patients. METHODS:Clinical records and histopathologic reports of patients with gastric polypoid lesions were analyzed *** lesions had been totally removed by either endoscopic polypectomy or hot biopsy *** histopathologic slides were re-evaluated by the same histopathologist. RESULTS:One-hundred and fifty gastric polypoid lesions were identified in 91 *** were 53(58 %)women and 38(42 %)men with a median age of 53(range,31 to 82)*** most frequent presenting symptom was dyspepsia that was observed in 35(38.5 %)patients. Symptoms were mostly related to various associated gastric abnormalities such as chronic gastritis or H pylori infection rather than polypoid lesion *** lesions were commonly located in the antrum followed by *** of 150 lesions,80(53 %)had the largest dimensions less than or equal to 5 mm and only 7 were *** frequencies of hyperplastic polyps,foveolar hyperplasia,and fundic gland polyps were 46 %,18 %,and 14 % respectively. We also detected gastritis varioliformis in 12 specimens, lymphoid follicles in 9,4 adenomatous polyps in 4,polypoid lesions with edematous mucosa in 4,inflammatory polyps in 3,and carcinoid tumor in *** changes were observed within two hyperplastic polyps and low grade dysplasia in one *** evaluation of the surrounding gastric mucosa demonstrated chronic gastritis in 72(79 %)patients and H pylori infection in 45(49 %). CONCLUSION:Hyperplastic polyps are the mbst frequently encountered subtype of gastric polypoid *** are usually associated with chronic gastritis or H pylori *** to the previous belief,they may harbour adenomatous changes or dysplastic foci. Therefore,endoscopic polypectomy seems as a safe and fast procedure for both diagnosis a

关键词： Adult Aged Aged, 80 and over Dyspepsia Endoscopy, Digestive System Female Humans Hyperplasia Male Middle Aged Polyps Stomach Neoplasms

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Prognostic significance of tumor budding,desmoplastic reaction,and lymphocytic infiltration in patients with gastric adenocarcinoma

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 9-25页

作者： Aysen Yavuz Kubra Simsek Anil Alpsoy Busra Altunay Elif Ocak Gedik Betul Unal Cumhur Ibrahim Bassorgun Ali Murat Tatli Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Türkiye Department of Medical Oncology Akdeniz University Medical SchoolAntalya 07070Türkiye

BACKGROUND Recent studies have shown that the tumor microenvironment significantly influences the behavior of solid *** this context,Accumulated data suggests that pathological evaluation of tumor budding(TB),desmoplastic reaction(DR),and tumor-infiltrating lymphocytes(TILs)may be crucial in determining tumor behavior in the gastrointestinal *** gastric adenocarcinoma(GAC),although some results suggest that TB and TILs may be effective in determining the course of the disease,the data do not ***,very few studies have investigated the relationship between DR and *** present,the associations between tumor TB,DR and TILs in GAC patients have not been *** To establish the relationships between TB,DR,and TILs in patients with GAC and to assess their influence on *** Our study group comprised 130 patients diagnosed with *** definition of TB was established based on the International TB Consensus *** DR was categorized into three groups according to the level of tumor stroma *** assessment of TILs was conducted using a semiquantitative approach,employing a cutoff value of 5%.The statistical analysis of the whole group and 100 patients with an intestinal subtype of GAC was performed using SPSS version *** A significant correlation between peritumoral budding(PTB)and intratumoral budding(ITB)was noted(r=0.943).Tumors with high PTBs and ITBs had a greater incidence of immature DRs and low TILs(P<0.01).PTB and ITB were associated with histological subtype,lymph node metastasis(LNM),and stage(P<0.01).ITB,PTB,LNM,DR,and stage were significant risk factors associated with poor *** multivariate Cox regression analysis identified ITB,PTB,and LNM as independent prognostic variables(P<0.05).In intestinal-type adenocarcinomas,a positive correlation between PTB and ITB was noted(r=0.972).While univariate analysis revealed that LNM,stage,PTB,ITB,and DR were strong parameters for pred

关键词： Gastric cancer Tumor budding Desmoplastic stroma Tumor-infiltrating lymphocytes Prognosis

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