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Effects of resveratrol and methylprednisolone on biochemical,neurobehavioral and histopathological recovery after experimental spinal cord injury

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Acta Pharmacologica Sinica 2006年第10期27卷 1317-1325页

作者： ozkan aries Suleyman CAYLI Eyup ALTINOZ Iclal GURSES Neslihan YUCEL Ayhan KOCAK Saim YOLOGLU Yusuf TURKOZ Department of Neurosurgery Department of Biochemistry Department of Pathology Department of Emergency Medicine Department of Biostatistics Inonu UniversitySchool of Medicine44280 MalatyaTurkey

Aim:To investigate the neuroprotective effect of resveratrol in an experimentalspinal cord injury(SCI)model in ***:Male Wistar albino rats weighing200-250 g were randomized into six ***-drop trauma was performedfor *** 1 underwent laminectomy *** 2 underwent laminectomyfollowed by *** 3,4,5,and 6 underwent laminectomy followed by SCIand received resveratrol(100 mg/kg),methylprednisolone(MP)(30 mg/kg),resveratrol(100 mg/kg)plus MP(30 mg/kg),and ethanol(2%),*** were divided into two subgroups for biochemical analysis(killed at 24 h aftersurgery)and for neurobehavioral and histopathological evaluation(killed at 6weeks after surgery).Posttraumatic neurological recovery after surgery was re-corded ***:Groups 3 and 5 revealed significantly lower malon-dialdehyde,nitric oxide,xanthine oxidase,and higher glutathione levels than group4(P<0.05).Neurological recovery rates were significantly better in groups 3 and5 than group 4(P<0.05).When spinal trauma size ratios were compared,there wasno significant difference between treatment ***:Resveratroltreatment revealed better biochemical recovery in the acute stage of trauma thanMP *** resveratrol and combined treatment revealed betterneurobehavioral recovery than MP treatment;resveratrol,MP,and combined treat-ment modalities improved histopathological recovery at the same level in the finalstage of the *** studies involving different doses of resveratroland different doses combinations with MP could promise better results as eachdrug has a different anti-oxidative mechanism of action.

关键词： lipid peroxidation resveratrol spinal cord

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