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Mechanism of Surface-Enhanced Raman Scattering and Its Application to Highly Sensitive Protein Detection

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Mechanism of Surface-Enhanced Raman Scattering and Its Appli...

Molecular Resonance Dependence on Surface-enhanced Raman Scattering plus Background Luminescence from Single Ag Nanoaggregates

第十五届全国分子光谱学术报告会

作者： ozaki y Itoh T yoshida K Kitahama y School of Science and Technology Kwansei Gakuin University Health Technology Research Center National Institute of Advanced Industrial Science and Technology (AIST) Health Technology Research Center National Institute of Advanced Industrial Science and Technology (AIST)

＜正＞Surface-enhanced resonance Raman scattering（SERRS） has recently attracted great interest in an-alytical science due to enormous enhancement factors that have

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Molecular Resonance Dependence on Surface-enhanced Raman Sca...

Dipolar Surface Plasmon Resonance Sensitive Surface Enhanced Raman Scattering of Single Ag Nano-aggregates

第三十五届国际光谱会议

作者： K.yoshida T.Itoh V.Biju M.Ishikawa y.ozaki Department of Chemistry School of Science and Technology Kwansei Gakuin University SandaHyogo 669-1337Japan Nano-Bioanalysis Team Health Technology Research Center National Institute of Advanced Industrial Science and Technology (AIST)TakamatsuKagawa 761-0395Japan

Surface-enhanced Raman scattering (SERS) from isolated Ag nanoaggregates is promising in ultra-sensitive detection because of Raman scattering enhancement by a factor of *** there are several unsolved central issues in SERS spectroscopy of isolated single Ag *** of the issues is aggregate-by-aggregate variation of SERS and background luminescence spectra [1].In previous work we

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光散射学报 2005年第3期17卷 299-302页

作者： T.Itoh K.Hashimoto y.Kikkawa A.Ikehata y.ozaki Department of Chemistry School of Science and TechnologyKwansei-Gakuin University2-1GakuenSanda 669-1337Japan

We investigated polarization dependences of surface enhanced resonance Raman scattering(SERRS)and surface plasmon resonance(SPR)to identify the SERRS yielding SPR *** also studied SERRS excitation spectra for single A... 详细信息

关键词： (SPR) investigated SERRS

超重和肥胖的全球趋势及其与心血管疾病发生率之间的关系

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中华高血压杂志 2014年第12期22卷 1117-1117页

作者：刘莉叶鹏 yatsuya H Li y Hilawe EH Ota A Wang C Chiang C Zhang y Uemura M Osako A ozaki y Aoyama A Circ J

虽然超重和肥胖的全球发病率逐日上升,但在不同地区、国家和性别中的发病趋势仍存在差异。据世界卫生组织报道,全球多个地区由体质量指数（body mass index,BMI）≥25kg/m2定义的超重/肥胖发生率几乎接近一半人口,有的甚至超过了一半,... 详细信息

虽然超重和肥胖的全球发病率逐日上升,但在不同地区、国家和性别中的发病趋势仍存在差异。据世界卫生组织报道,全球多个地区由体质量指数（body mass index,BMI）≥25kg/m2定义的超重/肥胖发生率几乎接近一半人口,有的甚至超过了一半,如美洲（61.1%）,欧洲（54.8%）和东地中海地区（46.0%）,然而,在非洲（26.9%）,东南亚（13.7%）和西太平洋地区（25．4％），超重／肥胖发生率较低。

关键词：肥胖发生率疾病发生率超重心血管世界卫生组织西太平洋地区体质量指数发病趋势

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： Victor V.Chizhikov Igor y.Iskusnykh Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关键词： epithelium Figure center

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幽门螺杆菌空胞毒素对血小板功能的影响

中国微循环 2009年第3期13卷 191-193页

作者：林香春佐藤金夫尾崎由基男北京世纪坛医院消化科北京100038 日本山梨大学医学部临床检查部

目的探讨幽门螺杆菌(H pylori)空胞毒素(VacA)对血小板功能的影响。方法健康志愿者全血分离血小板,用不同浓度的VacA刺激血小板,用热灭活VacA作为对照组,观察血小板表面P-选择素的表达;采用低剂量vWF和Botrocetin刺激上述两组血小板,观... 详细信息

目的探讨幽门螺杆菌(H pylori)空胞毒素(VacA)对血小板功能的影响。方法健康志愿者全血分离血小板,用不同浓度的VacA刺激血小板,用热灭活VacA作为对照组,观察血小板表面P-选择素的表达;采用低剂量vWF和Botrocetin刺激上述两组血小板,观察VacA对血小板凝集功能的影响。结果与对照组比较,VacA可以引起血小板表面P-选择素表达增加;增强血小板对vWF和Botrocetin刺激的凝集反应。结论VacA直接作用于血小板并引起血小板的活化。

关键词：幽门螺杆菌空胞毒素血小板

由靶向破骨细胞前体细胞的癌细胞诱导的新破骨细胞生成途径

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中国口腔颌面外科杂志 2019年第1期17卷 96-96页

作者： Wada A Tsuchiya M ozaki-Honda y 赵泽亮

肿瘤浸润到骨中诱导骨溶解的确切机制仍不清楚。主要假设是肿瘤细胞产生核因子K-B配体(RANKL)、肿瘤坏死因子仅(TNF-OL)或其他激活成骨细胞、骨细胞或骨髓基质中RANKL表达的分子的受体激活剂。

关键词：破骨细胞生成细胞诱导前体细胞靶向核因子K-B 肿瘤坏死因子 RANKL 肿瘤浸润

Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

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Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： Meifeng Zheng Borui Zhang Sonata S y yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

Rate-, state-, and pressure-dependent friction model based on the elastoplastic theory

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Friction 2020年第4期8卷 768-783页

作者： Shingo ozaki Takeru MATSUURA Satoru MAEGAWA Division of System Research Yokohama National UniversityTokiwadai 79-5Hodogaya-kuYokohama 240-8501Japan Department of Electrical and Mechanical Engineering Nagoya Institute of TechnologyGokiso-choShowa-kuNagoya 466-8555Japan

Adhesion is one of essences with respect to rubber friction because the magnitude of the friction force is closely related to the magnitude of adhesion on a real contact area. However, the real contact area during sliding depends on the state and history of the contact surface. Therefore, the friction force occasionally exhibits rate-, state-, and pressure dependency. In this study, to rationally describe friction and simulate boundary value problems, a rate-, state-, and pressure-dependent friction model based on the elastoplastic theory was formulated. First, the evolution law for the friction coefficient was prescribed. Next, a nonlinear sliding surface (frictional criterion) was adopted, and several other evolution laws for internal state variables were prescribed. Subsequently, the typical response characteristics of the proposed friction model were demonstrated, and its validity was verified by comparing the obtained results with those of experiments conducted considering the contact surface between a rough rubber hemisphere and smooth acrylic plate.

关键词： adhesion friction model elastoplastic theory contact surface stick-slip