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SARS-CoV-2 infection rates after different vaccination schemes:An online survey in Turkey

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Asian Pacific Journal of Tropical Medicine 2022年第4期15卷 171-178页

作者： oya baydar Toprak Sennur Ozen Berker Ozturk Burcu Ozturk Ebru Ozturk Mehmet Kitapci Nurdan Kokturk Chest Diseases Department Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Delta HospitalIstanbulTurkey Chest Diseases Department Aksaray Training and Research HospitalAksarayTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Hacettepe UniversityAnkaraTurkey Department of Nuclear Medicine Integra Medical Imaging CenterAnkaraTurkey

Objective:To identify effects of various nationwide vaccination protocols on the evolution of new SARS-CoV-2 infections among adult population and to evaluate the safety of mRNA(BioNTech/Pfizer)***:Totally 10735 adult volunteers that received at least one dose of BioNTech/Pfizer or triple doses of CoronaVac participated in this cross-sectional-online survey between 1 and 10 September *** information was collected covering a 5-month period from April 2021 to September *** about people who were vaccinated with only single and double dose CoronaVac were not included in this ***:At least one side effect after single and double dose of BioNTech/Pfizer and triple doses of CoronaVac were observed in 42.1%,42.5%and 10.9%,*** most common side effects were shoulder/arm pain,weakness/fatigue,muscle/joint pain and *** side effects were the most frequent in single BioNTech/Pfizer,while it was the least in triple *** rate of positive PCR tests before vaccination was 17.6%,and decreased to 3.0%after *** rates of positive SARS CoV-2-PCR were 18.8%,3.5%,3.1%,0.5%and 4.6%in single BioNTech/Pfizer,double BioNTech/Pfizer,double CoronaVac+single BioNTech/Pfizer,double CoronaVac+double BioNTech/Pfizer and triple CoronaVac,*** 1.8%of PCR positive COVID-19 cases needed intensive unit care in the pre-vaccination period,intensive care unit was required in 0%,1.5%,2.4%,0%and 4.2%after single BioNTech/Pfizer,double BioNTech/Pfizer,double CoronaVac+single BioNTech/Pfizer,double CoronaVac+double BioNTech/Pfizer and triple CoronaVac,*** rate after vaccination was 0.4%.Conclusions:The rarity of COVID-19 infection after vaccination suggests that efficacy of vaccines is *** the other hand,the data underscore the critical importance of continued public health mitigation.

关键词： mRNA vaccine COVID-19 SARS-CoV-2 Vaccine schemes Reinfection Positivity rate after vaccination

The predictors of long-COVID in the cohort of Turkish Thoracic Society-TURCOVID multicenter registry:One year follow-up results

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Asian Pacific Journal of Tropical Medicine 2022年第9期15卷 400-409页

作者： Serap Argun Baris oya baydar Toprak Pelin Duru Cetinkaya Fusun Fakili Nurdan Kokturk Seval Kul Ozgecan Kayalar Yildiz Tutuncu Emel Azak Mutlu Kuluozturk Pinar Aysert Yildiz Pelin Pinar Deniz Oguz Kilinc Ilknur Basyigit Hasim Boyaci Ismail Hanta Neslihan Kose Gulseren Sagcan Caglar Cuhadaroglu Hacer Kuzu Okur Hasan Selcuk Ozger Begum Ergan Mehtap Hafizoglu Abdullah Sayiner Esra Nurlu Temel Onder Ozturk Tansu Ulukavak Ciftci Ipek Kivilcim Oguzulgen Vildan Avkan Oguz Firat Bayraktar Ozlem Ataoglu Merve Ercelik Pinar Yildiz Gulhan Aysegul Tomruk Erdem Muge Meltem Tor oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Koc University Research Center for Translational Medicine(KUTTAM) Koc University School of MedicineIstanbulTurkey Department of Immunology Koc University Research Center for Translational Medicine(KUTTAM)Koc University School of MedicineIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeli Turkey Department of Pulmonary Medicine Faculty of MedicineFirat UniversityElazigTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineEge UniversityIzmirTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Internal Medicine Faculty of MedicineDokuz Eylul UniversityIzmirTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZongu

Objective:To evaluate long-term effects of COVID-19,and to determine the risk factors in long-COVID in a cohort of the Turkish Thoracic Society(TTS)-TURCOVID multicenter ***:Thirteen centers participated with 831 patients;504 patients were enrolled after *** study was designed in three-steps:(1)Phone questionnaire;(2)retrospective evaluation of the medical records;(3)face-to-face ***:In the first step,93.5%of the patients were hospitalized;61.7%had a history of pneumonia at the time of diagnosis.A total of 27.1%reported clinical symptoms at the end of the first ***(17.00%),fatigue(6.30%),and weakness(5.00%)were the most prevalent long-term *** incidence of long-term symptoms was increased by 2.91 fold(95%CI 1.04-8.13,P=0.041)in the presence of chronic obstructive pulmonary disease and by 1.84 fold(95%CI 1.10-3.10,P=0.021)in the presence of pneumonia at initial diagnosis,3.92 fold(95%CI 2.29-6.72,P=0.001)of dyspnea and 1.69 fold(95%CI 1.02-2.80,P=0.040)fatigue persists in the early-post-treatment period and 2.88 fold(95%CI 1.52-5.46,P=0.001)in the presence of emergency service admission in the post COVID *** step 2,retrospective analysis of 231 patients revealed that 1.4%of the chest X-rays had not significantly improved at the end of the first year,while computed tomography(CT)scan detected fibrosis in 3.4%.In step 3,138(27.4%)patients admitted to face-to-face visit at the end of first year;at least one symptom persisted in 49.27%*** most common symptoms were dyspnea(27.60%),psychiatric symptoms(18.10%),and fatigue(17.40%).Thorax CT revealed fibrosis in 2.4%***:COVID-19 symptoms can last for extended lengths of time,and severity of the disease as well as the presence of comorbidities might contribute to increased ***-term clinical issues should be regularly evaluated after COVID-19.

关键词： Long COVID-19 Dyspnea Fatigue Comorbidity

Post-discharge mortality in the first wave of COVID-19 in Turkey

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Asian Pacific Journal of Tropical Medicine 2022年第11期15卷 479-484页

作者： Fusun Fakili Pelin Duru Cetinkaya oya baydar Serap Argun Baris Nurdan Kokturk Seval Kul Oguz Karcioglu Pinar Aysert Yildiz Ilim Irmak Yonca Sekibag Emel Azak Sait Mulamahmutoglu Caglar Cuhadaroglu Bugra Kerget Burcu Baran Ketencioglu Hasan Selcuk Ozger Gulcihan Ozkan Zeynep Ture Merve Ercelik Tansu Ulukavak Ciftci Ozlem Alici Esra Nurlu Temel Ozlem Ataoglu Neslihan Kose Muge Meltem Tor Gulsah Gunluoglu Sedat Altin Onder Ozturk Pinar Yildiz Gulhan Ilknur Basyigit Hasim Boyaci I Kivilcim Oguzulgen Sermin Borekci Bilun Gemicioglu Ismail Hanta Hacer Kuzu Okur Gulseren Sagcan Metin Akgun Ali Fuat Kalyoncu oya Itil Hasan Bayram Department of Pulmonary Medicine Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine University of Health SciencesAdana City Training and Research HospitalFaculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineCukurova UniversityAdanaTurkey Department of Pulmonary Medicine Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Faculty of MedicineGazi UniversityAnkaraTurkey Department of Biostatistics Faculty of MedicineGaziantep UniversityGaziantepTurkey Department of Pulmonary Medicine Halil Sivgin Cubuk State HospitalAnkaraTurkey Department of Infectious Disease Faculty of MedicineGazi UniversityAnkaraTurkey Department of Pulmonary Medicine Faculty of MedicineHacettepe UniversityAnkaraTurkey Department of Pulmonary Medicine Cerrahpasa Faculty of MedicineIstanbul University−CerrahpasaIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineKocaeli UniversityKocaeliTurkey Department of Pulmonary Medicine Altunizade Acibadem HospitalIstanbulTurkey Department of Pulmonary Medicine Faculty of MedicineAtaturk UniversityErzurumTurkey Department of Pulmonary Medicine Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Maslak Acibadem HospitalIstanbulTurkey Department of Infectious Disease and Clinical Microbiology Faculty of MedicineErciyes UniversityKayseriTurkey Department of Pulmonary Medicine Faculty of MedicineDuzce UniversityDuzceTurkey Department of Infectious Disease Faculty of MedicineTurkiye Gazetesi Private HospitalIstanbulTurkey Department of Infectious Diseases and Clinical Microbiology Faculty of MedicineSuleyman Demirel UniversityIspartaTurkey Department of Pulmonary Medicine Bilecik Training and Research HospitalBilecikTurkey Department of Pulmonary Medicine Faculty of MedicineZonguldak Bulent Ecevit UniversityZonguldakTurkey Department of Pulmonary Medicine Universi

Objective:To determine post-discharge mortality and associated factors of the first-wave multicenter Turkish Thoracic Society(TTD)-TURCOVID ***:In this retrospective cohort study,we analyzed the data of 18 of 26 centers included in the first TTD-TURCOVID study,and 1112 cases diagnosed with COVID-19 between 11 March and 31 July 2020 participated in the *** causes of death after COVID-19 discharge were ***:The mean age of the patients was(51.07±16.93)years,with 57.6%male *** the cohort group,89.1%of COVID-19 treatment locations were hospital wards,3.6%were intensive care units(ICUs),and 7.2%were community *** the longterm follow-up,the in-hospital mortality rate was 3.6%(95%CI 2.6-4.8),the post-discharge mortality rate was 2.8%(95%CI 1.9-3.9),and the total mortality was 6.3%(95%CI 5.0-7.8).After discharge,63.3%of mortality overall occurred during the first six *** rates in post-discharge follow-ups were 12.7%(95%CI 8.0-30.6)in cancer patients,10.8%(95%CI 6.3-22.9)in chronic obstructive pulmonary disease patients,11.1%(95%CI 4.4-22.7)in heart failure patients,7.8(95%CI 3.8-14.3)in atherosclerotic heart disease patients,and 2.3%(95%CI 0.8-5.6)in diabetes mellitus *** smokers/ex-smokers,the all-mortality rates were higher than in ***:This multicenter study showed that patients over 65 years of age,males,former/active smoker,ICU stay,lung,heart disease,and malignancy should be followed up for at least the first six months after discharge due to COVID-19.

关键词： COVID-19 Post-discharge Mortality Comorbidity

A note on generalized Lie derivations of prime rings

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Frontiers of Mathematics in China 2017年第1期12卷 247-260页

作者： Nihan baydar YARBIL Nurcan ARGAC Department of Mathematics Science Faculty Ege University 35100 Bornova Izmir Turkey

Let R be a prime ring of characteristic not 2, A be an additive subgroup of R, and F, T, D, K： A →R be additive maps such that F（[x, y]） = F（x）y - yg（x） - T（y）x ＋ xD（y） for all x, y ∈ A. Our aim is to deal with this functional identity when A is R itself or a noncentral Lie ideal of R. Eventually, we are able to describe the forms of the mappings F, T, D, and K in case A = R with deg（R）〉 3 and also in the case A is a noncentral Lie ideal and deg（R）〉 9. These enable us in return to characterize the forms of both generalized Lie derivations, D-Lie derivations and Lie centralizers of R under some mild assumptions. Finally, we give a generalization of Lie homomorphisms on Lie ideals.

关键词： Prime ring derivation generalized derivation generalized Lie derivation functional identity generalized polynomial identity

Determination of Hesperidin and Limonin Levels as Part of the Defense Mechanism of Some Lemon Varieties [Citrus limon （L,） Burm f.] against Mal Secco Disease [Phoma tracheiphila （Petri） Kanc,et Ghik,]

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Journal of Agricultural Science and Technology(A) 2011年第2X期1卷 149-155页

作者： K. baydar N. K. Koc E. Kafkas Subtropical Fruits Research and Experimental Center Cukurova University Balcah Adana 01330 Turkey University of Cukurova Biotechnology Research and Experimental Center Balcah Adana 01330 Turkey

In this paper, it was aimed to identified and quantified hesperidin and limonin compounds using HPLC （High Performance Liquid Chromatography） techniques against to developing of mal secco disease caused by Phoma tracheiphila. Six citrus lemon varieties （Meyer, Kiitdiken, Enterdonato, Yediveren, Sweet lemon and Euroka） were infected by P. tracheiphila and artificial inoculation were applied in vivo conditions. Before and after inoculation, leaf, branch and stem samples were taken from each lemon varieties. The results show that the amount of hesperidin and limonin concentration was increased after the inoculations at various levels based on the lemon cultivars. Various concentrations （1, 5, 10, 25, 50, 75, 100 ppm） of hesperidin and limonin compounds were also tested under in vitro conditions to compare response of P. tracheiphila development. According to the results, hesperidin and limonin compounds play an important role against to P. tracheiphila development and Sweet Lemon variety was found to be the most resistance both observation and HPLC results.

关键词： HPLC Phoma tracheiphila Citrus limon hesperidin limonin.

A new approach for development of vaccine against visceral leishmaniasis: Lipophosphoglycan and polyacrylic acid conjugates

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 877-886页

作者： Adil M.Allahverdiyev Rabia Cakir Koc Melahat Bagirova Serhat Elcicek Serap Yesilkir baydar Olga Nehir Oztel Emrah Sefik Abamor Sezen Canim Ates Murat Topuzogullari Sevil Isoglu Dincer Zeynep Akdeste Yildiz Technical University Department of Bioengineering Firat University Department of Bioengineering Yeni Yuzyil University Biomedical Engineering Abdullah Gul University Material Science and Nanotechnology Department

Objective: To determine the antileishmanial vaccine effectiveness of lipophosphoglycan(LPG) and polyacrylic acids(PAA) conjugates on in vivo mice ***: LPG molecule was isolated and purified from large-scale Leishmania donovani parasite culture. Protection efficacies of LPG alone, in combination with Freund's adjuvant, in a physical mixture and in conjugate(consisting of various LPG concentrations) with PAA, were comparatively determined by various techniques, such as cultivation with the micro-culture method, assessment of in vitro infection rates of peritoneal macrophages, determination of parasite load in liver with Leishman-Donovan Units, and detection of cytokine ***: Obtained results demonstrated that the highest vaccine-mediated immune protection was provided by LPG-PAA conjugate due to all parameters investigated. According to the Leishman-Donovan Units results, the sharpest decline in parasite load was seen with a ratio of 81.17% when 35 mg LPG containing conjugate was applied. This value was 44.93% for the control group immunized only with LPG. Moreover, decreases in parasite load were 53.37%, 55.2% and 65.8% for the groups immunized with 10 mg LPG containing LPG-PAA conjugate, a physical mixture of the LPG–PAA, and a mixture of LPG + Freund's adjuvant, respectively. Furthermore, cytokine results supported that Th1 mediated protection occurred when mice were immunized with LPG-PAA ***: It has been demonstrated in this study that conjugate of LPG and PAA has an antileishmanial vaccine effect against visceral leishmaniasis. In this respect, the present study may lead to new vaccine approaches based on high immunogenic LPG molecule and adjuvant polymers in fighting against Leishmania infection.

关键词： Leishmania Lipophosphoglycan Vaccine Polymer Polyacrylic acid