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CD44 and CD221 directed magnetic cubosomes for the targeted delivery of helenalin to rhabdomyosarcoma cells

Nano Research 2023年第2期16卷 2915-2926页

作者： Hakmin Mun Yuriy Chaban Tanveer A.Tabish Nanasaheb Thorat Nathan Cowieson CDavid owen Helen E.Townley Nuffield Department of Women’s and Reproductive health University of OxfordOxford OX39DUUK Electron Bio-Imaging Centre Diamond Light SourceDidcot OX110DEUK Radcliffe Department of Medicine University of OxfordOxford OX37BNUK B21 Diamond Light SourceDidcot OX110DEUK Department of Engineering Science University of OxfordOxford OX13PJUK

Confining chemotherapy to tumour sites by means of active targeting nanoparticles(NPs)may increase the treatment effectuality while reducing potential side *** are one of the next-generation drug delivery nanocarriers by virtue of their biocompatibility and bioadhesion,sizeable payload encapsulation and high ***,an active tumour targeting system towards rhabdomyosarcoma(RMS)cells was *** were loaded with helenalin(a secondary metabolite from Arnica plants),which we have previously shown to induce apoptosis in RMS *** functionalization of the cubosomes was accomplished to enable binding to membrane receptors and translocation under a magnetic *** cells overexpress CD44 and CD221 on their membrane surface and,therefore,hyaluronic acid(HA,a ligand for CD44)and antibodies(Abs)against CD221 were coupled to cubosomes via electrostatic attraction and the thiol-Michael reaction,*** of the cubic phase NPs was achieved by embedding superparamagnetic iron oxide NPs(SPIONPs)into the cubic ***-function and multi-function cubosomes had Im3m cubic phase structures with well-organized lattice *** with 2%HA or anti-CD221 half Abs and/or 1%SPIONPs showed significantly higher uptake into RMS cells compared to unfunctionalized ***44 and CD221 directed magnetic(triple-function)cubosomes were capable of internalizing into RMS cells in an energy-independent ***-laden triple functionalized cubosomes showed limited impact on the viability of control fibroblast cells,while they induced a high degree cytotoxicity against RMS *** tumour cell death was observed in both two-dimensional(2D)culture and three-dimensional(3D)tumour spheroids.

关键词： cubosome active targeting rhabdomyosarcoma helenalin nanoparticle functionalization

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Modelling internal air systems ingas turbine engines

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航空动力学报 2007年第4期22卷 505-520页

作者： J Michael owen Department of Mechanical Engineering University of Bath

Rotating-disc systems can be used to model,experimentally and computationally,the flow and heat transfer that occur inside the internal cooling-air systems of gas turbine *** rotating-disc systems have been used successfully to simplify and understand some of the complex flows that occur in internal-air systems,and designers have used this insight to improve the cooling effectiveness,thereby increasing the engine efficiency and reducing the *** this review paper,three important cases are considered:hot-gas ingress;the pre-swirl system;and buoyancy-induced ***,or ingestion,occurs when hot gas from the mainstream gas path is ingested into the wheel-space between the turbine disc and its adjacent *** seals are fitted at the periphery of the system,and sealing flow is used to reduce or prevent ***,too much sealing air reduces the engine efficiency,and too little can cause serious overheating,resulting in damage to the turbine rim and blade *** the flow is three-dimensional and unsteady,there are encouraging signs that simple ‘orifice models’ could be used to estimate the amount of ingress into the *** a pre-swirl system,the cooling air for the gas-turbine blades is swirled by stationary nozzles,and the air is delivered to the blades via receiver holes in the rotating turbine *** the air reduces its temperature relative to the rotating blades,and the designer needs to calculate the air temperature and pressure drop in the *** designer also needs to calculate the effect of this swirling flow on the heat transfer from the turbine disc to the air,as this has a significant effect on the temperature distribution and stresses in the *** experimental and computational studies have given a better understanding of the flow and heat transfer in these ***-induced flow occurs in the cavity between two co-rotating compressor discs when the temperature of the discs is higher than

关键词：燃气涡轮机车空气动力学数学模型旋转式圆盘系统

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Landsat 8 and Alos DEM geological mapping reveals the architecture of the giant Mesoproterozoic Kunene Complex anorthosite suite(Angola/Namibia)

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Geoscience Frontiers 2023年第5期14卷 308-328页

作者： Jeremie Lehmann Alan M.Brower Trishya M.owen-Smith Grant M.Bybee Ben Hayes Department of Geology University of JohannesburgSouth Africa Jurumani Solutions Midrand 1685South Africa School of Geosciences University of the Witwatersrand2050 JohannesburgSouth Africa

The quasi-monomineralic composition and huge spatial extent of massif-type anorthosites make detecting lithological regions and boundaries *** use processed Landsat 8 OLI multispectral images and ALOS digital elevation models integrated with field and petrographic observations to characterize the architecture of the≥17,000 km2 Mesoproterozoic Kunene Complex(KC)anorthosite suite in Angola and *** of false colour composite bands 6,4 and 1 and band ratios 4/2(ferric minerals),6/5(ferrous minerals)and 6/7(OH-bearing minerals),as well as assessment of the PCA and MNF matrices of eigenvectors and eigenvalues from Landsat 8 data using available spectral libraries,have substantially improved the interpretation of the Kunene Complex rock types and *** dataset shows that the reflectance signature of KC anorthositic rocks is primarily a function of the degree of metasomatism,which is most significant in olivine-poor rock *** weathering intensity of the olivine-bearing anorthosite substrate is another control on the remote sensing *** remote sensing and field-based approach has enabled us to divide the KC anorthosite suite into six distinct spectral and architecture domains and at least four distinct magmatic plutons when considering available high-precision geochronological *** northernmost pluton(ca.1380 Ma)of massive,olivine-bearing anorthosite shows distinct remote sensing signatures in the band ratio and MNF images marked by the dominance of OH-bearing and subordinate ferric *** central pluton(1412–1400 Ma)is composed of NNE-to N-striking steeply dipping interlayered olivine-bearing and olivinepoor anorthosite,which correspond to ridges of dark-coloured,low albedo rocks with subordinate slightly oxidised ferrous mineral spectral signatures,and valleys of low albedo and OH-bearing mineral spectral signatures.A NNE-striking tectonic zone along a linear belt of KC granite gneiss separates the northern and central plu

关键词： Remote sensing Structural geology LANDSAT 8 Alos DEM Lineaments Proterozoic massif-type anorthosite

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Widespread glacier advances across the Tian Shan during Marine Isotope Stage 3 not supported by climate-glaciation simulations

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Fundamental Research 2023年第1期3卷 102-110页

作者： Qing Yan Lewis A.owen Chuncheng Guo Zhongshi Zhang Jinzhe Zhang Huijun Wang Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Meteorological Disaster/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China Department of Marine Earthand Atmospheric ScienceNorth Carolina State UniversityRaleighNC 27695United States NORCE Norwegian Research Centre Bjerknes Centre for Climate ResearchBergenNorway Department of Atmospheric Science School of Environmental StudiesChina University of GeosciencesWuhan 430074China

Whether there were more extensive glaciations during the Marine Isotope Stage(MIS)3 relative to MIS 2 across the Tian Shan in Central Asia is intensely debated because of the uncertainty in chronological data and fully understanding the driving *** help resolve the ongoing debate,we assess the climate sensitivity of the glaciers and reconstruct the extent of glaciation during MIS 2 and 3 across the Tian Shan,using a glacier-resolving(250×250 m)ice sheet model asynchronously coupled with a global climate *** results demonstrate that the equilibrium-line altitude(ELA)over the Tian Shan decreases by∼180 m for every 1°C cooling under a modern precipitation regime,but precipitation reduction greatly lowers the sensitivity of the glaciers to temperature decrease(e.g.,the effect of 2°C cooling is broadly offset by a 50%decrease in precipitation).Under the modeled colder/drier-than-present climate,the model predicts an ELA depression(∆ELA)of∼75 m(162 m)over the Tian Shan during MIS 3 interstadials(stadials).The extent of MIS 3 glaciation is much smaller than that during MIS 2(i.e.,∆ELA=∼726 m).The more extensive glaciation during MIS 2 is largely attributed to the enhanced summer ***,through a site-to-site model-data comparison,we find that the closest match between the modeled glacier margin and the locations of the glacial deposits previously argued to be MIS 3 is generally achieved under MIS 2 climatic *** results suggest more extensive glacier advances over the Tian Shan during MIS 2 than MIS 3 on a regional scale,although MIS 3 glaciation may still occur in individual glacier *** pattern suggests general synchronicity with the timing of maximum Northern Hemisphere ice sheets during the last glacial,which should be further tested in a multimodel framework in the future.

关键词： Glacier modeling Glacier sensitivity MIS 3 MIS 2 Tian Shan Paleoclimate modeling

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Polymer graph neural networks for multitask property learning

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npj Computational Materials 2023年第1期9卷 1420-1429页

作者： owen Queen Gavin A.McCarver Saitheeraj Thatigotla Brendan P.Abolins Cameron L.Brown Vasileios Maroulas Konstantinos D.Vogiatzis Department of Mathematics University of TennesseeKnoxvilleTN 37996-1320USA Department of Electrical Engineering and Computer Science University of TennesseeKnoxvilleTN 37996-2250USA Department of Chemistry University of TennesseeKnoxvilleTN 37996-1600USA Eastman Chemical Company KingsportTN 37660USA

The prediction of a variety of polymer properties from their monomer composition has been a challenge for material informatics,and their development can lead to a more effective exploration of the material *** this work,POLYMERGNN,a multitask machine learning architecture that relies on polymeric features and graph neural networks has been developed towards this *** provides accurate estimates for polymer properties based on a database of complex and heterogeneous polyesters(linear/branched,homopolymers/copolymers)with experimentally refined *** POLYMERGNN,each polyester is represented as a set of monomer units,which are introduced as molecular graphs.A virtual screening of a large,computationally generated database with materials of variable composition was performed,a task that demonstrates the applicability of the POLYMERGNN on future studies that target the exploration of the polymer ***,a discussion on the explainability of the models is provided.

关键词： properties space polyester

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THE UNIQUE CHINESE FLAVORS OF LABA FESTIVAL

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China News Release 2022年第1期 74-76页

作者： owen Fishwick 不详

Laba porridge is a traditional dish associated with Laba Festival—a historical Chinese festival dating back to the Northern Song Dynasty(960-1127)that celebrates the enlightenment of the *** porridge is traditionally served on the eighth day of the twelfth month of the Chinese calendar,and has warmed the bellies of Chinese people in the coldest months of the year for more than a 1,000 years.

关键词： traditionally dating Buddha

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Prime gradient noise

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Computational Visual Media 2021年第3期7卷 349-362页

作者： Sheldon Taylor owen Sharpe Jiju Peethambaran Graphics&Spatial Computing Lab Dept.of Math&CSSaint Mary’s UniversityHailifaxNSCanadaB3H3C3

Procedural noise functions are fundamental tools in computer graphics used for synthesizing virtual geometry and texture ***,a procedural noise function should be compact,aperiodic,parameterized,and randomly *** lattice noise functions such as Perlin noise,however,exhibit periodicity due to the axial correlation induced while hashing the lattice vertices to the *** this paper,we introduce a parameterized lattice noise called prime gradient noise(PGN)that minimizes discernible periodicity in the noise while enhancing the algorithmic *** utilizes prime gradients,a set of random unit vectors constructed from subsets of prime numbers plotted in polar coordinate *** map axial indices of lattice vertices to prime gradients,PGN employs Szudzik pairing,a bijection F:N2→*** of Szudzik pairing functions are used in higher *** the core of PGN is the ability to parameterize noise generation though prime sequence offsetting which facilitates the creation of fractal noise with varying levels of heterogeneity ranging from homogeneous to hybrid multifractals.A comparative spectral analysis of the proposed noise with other noises including lattice noises show that PGN significantly reduces axial correlation and hence,periodicity in the noise *** demonstrate the utility of the proposed noise function with several examples in procedural modeling,parameterized pattern synthesis,and solid texturing.

关键词： procedural noise procedural texture Perlin noise prime numbers

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The Specimen Data Refinery:A Canonical Workflow Framework and FAIR Digital Object Approach to Speeding up Digital Mobilisation of Natural History Collections

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Data Intelligence 2022年第2期4卷 320-341页

作者： Alex Hardisty Paul Brack Carole Goble Laurence Livermore Ben Scott Quentin Groom Stuart owen Stian Soiland-Reyes School of Computer Science and Informatics Cardiff UniversityCardiff CF243AAUK The Department of Computer Science The University of ManchesterManchester M139PLUK The Natural History Museum London SW75BDUK Meise Botanic Garden 1860 MeiseBelgium Informatics Institute Faculty of ScienceUniversity of Amsterdam1090 GH AmsterdamThe Netherlands

A key limiting factor in organising and using information from physical specimens curated in natural science collections is making that information computable,with institutional digitization tending to focus more on imaging the specimens themselves than on efficiently capturing computable data about *** data are traditionally manually transcribed today with high cost and low throughput,rendering such a task constrained for many collection-holding institutions at current funding *** show how computer vision,optical character recognition,handwriting recognition,named entity recognition and language translation technologies can be implemented into canonical workflow component libraries with findable,accessible,interoperable,and reusable(FAIR)*** libraries are being developed in a cloudbased workflow plaform-the Specimen Data Refinery'(SDR)-founded on Galaxy workflow engine,Common Workflow Language,Research Object Crates(RO-Crate)and WorkflowHub *** SDR can be applied to specimens'labels and other artefacts,offering the prospect of greatly accelerated and more accurate data capture in computable *** kinds of FAIR Digital Objects(FDO)are created by packaging outputs of SDR workflows and workflow components as digital objects with metadata,a persistent identifier,and a specific type *** first kind of FDO are computable Digital Specimen(DS)objects that can be consumed/produced by workflows,and other applications.A single DS is the input data structure submitted to a workflow that is modified by each workflow component in turn to produce a refined DS at the *** Specimen Data Refinery provides a library of such components that can be used individually,or in *** cofunction,each library component describes the fields it requires from the DS and the fields it will in turn populate or *** second kind of FDO,RO-Crates gather and archive the diverse set of digital and real-world resources,configurations,a

关键词： Digital Specimen Workflow FAIR Digital Object RO-Crate

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Detecting the ?ngerprints of observed climate change on surface ozone variability

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Science Bulletin 2019年第6期64卷 359-360页

作者： owen R.Cooper Cooperative Institute for Research in Environmental Sciences University of Colorado NOAA Earth System Research Laboratory

At the surface, tropospheric ozone is an air pollutant that adversely impacts human health, natural vegetation and crop yield and quality. This important trace gas also plays key roles as a greenhouse gas, and as the primary source of the hydroxyl (OH) radical, which determines the lifetime of many other trace gases in the atmosphere. Tropospheric ozone has a variety of sources including photochemical production from anthropogenic and naturally occurring precursor gases, and transport from the stratosphere. As a result of 让s high reactivity and its wide range of sources,*sozone lifetime can vary from minutes in the polluted boundary layer to several weeks in the mid- and upper troposphere.

关键词： tropospheric ozone greenhouse gas polluted boundary layer

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The presence and influence of glacier surging around the Geladandong ice caps,North East Tibetan Plateau

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Advances in Climate Change Research 2021年第3期12卷 299-312页

作者： owen KING Atanu BHATTACHARYA Tobias BOLCH Department of Geography and Sustainable Development University of St AndrewsSt AndrewsKY169ALUK Department of Remote Sensing and GIS JIS UniversityKolkata700109India

Many glaciers and ice caps on the Tibetan Plateau have retreated and lost mass in recent years in response to temperature increases,providing clear evidence of the impact of climate change on the *** is increasing evidence that many of the glaciers on the Tibetan Plateau have also shown periodically dynamic behaviour in the form of glacier surging and some even catastrophic collapse *** this study,we examine the prevalence of glacier surging at the Geladandong ice caps,North East Tibetan Plateau,to better understand the role of surge events in the evolution of glacier mass loss *** glacier surface elevation change data over the period 1969—2018 and glacier surface velocity data from the ITS_LIVE dataset,we find that 19 outlet glaciers of the ice caps are of *** multi-temporal measurements of glacier mass balance show that surge-type glacier mass budgets vary depending on the portion of the surge-cycle captured by geodetic *** the regional level,pre-and post-surge glacier mass loss variability does not bias regional mass budget estimates,but enhanced,or suppressed,mass loss estimates are likely when small groups of glaciers are *** results emphasise the importance of accurate surge-type glacier inventories and the need to maximise geodetic data coverage over glacierised regions known to contain surge-type glaciers.

关键词： Glacier surge Remote sensing Corona KH-4 Glacier mass balance ASTER Tibetan Plateau Glacier velocity

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