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An Integrative Collaborative Proj.ct Approach to Climate-Change Resilience and Urban/Regional Sustainability for the Mexico-Lerma-Cutzamala Hydrological Region

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Open j.urnal of Civil Engineering 2022年第1期12卷 101-138页

作者： Timothy j. Downs morgan Ruelle Nigel Brissett Ravi Hanumantha Marisa Mazari-Hiriart Rob Krueger Edward R. Carr International Development Community & Environment (IDCE) Department Clark University Worcester USA Institute of Ecology National Autonomous University of Mexico (UNAM) Ciudad Universitaria Coyoacán Mexico Environmental & Sustainability Studies Worcester Polytechnic Institute (WPI) Worcester USA Humanitarian Response and Development Lab (HURDL) George Perkins Marsh Institute Clark University Worcester USA

In a rapidly urbanizing world, the social, economic, and ecological complexities of cities require conceptual and operational innovations to enhance climate resilience and sustainability. We describe our Integrative Collaborative Proj.ct (ICP) approach to co-create climate resilience in the Mexico-Lerma-Cutzamala Hydrological Region (MLCHR). In recent years, it has suffered from frequent natural disasters, and under climate change scenarios, the intensity and frequency of extreme events, including severe floods, droughts, heat waves and landslides are expected to increase. ICPs are framed as socio-technical capacity building enterprises, with networks operating at multiple scales. The approach differs from other integrative efforts, which tend to be top-down with scant civil society co-ownership, and focus on limited aspects like indicators/assessment, or institutional capacity building. We reimagine all operational stages, from creative thinking, through ethos and concept, assessment, planning, proj.ct design, implementation and management, and monitoring and evaluation. The design of ICPs is informed by six integrative domains: 1) proj.ct ethos, concept, and framing;2) sectors, topics, and issues;3) spatial and temporal scales;4) stakeholder interests, relationships and capacities;5) knowledge types, models and methods;and 6) socio-technical capacities and networks. Empirically, the approach is based on participatory development practices, pilot proj.ct work tackling sustainable water and sanitation in Mexico, and a synthesis of rich experiential knowledge spanning 20 years. The theoretical basis considers a pragmatic knowledge frame, socio-technical transitions literature, and education for social transformation. We describe forward-looking operational details of the Pilot ICP for the Mexico-Lerma-Cutzamala Hydrological Region, with our three-university partnership as catalyst, and a new breed of socio-technical enterprise organization as a key partner, engaging

关键词： Climate-Change Resilience Sustainable Development Urban Regional Mexico City

Spatiotemporal microRNA profile in peripheral nerve regeneration:miR-138 targets vimentin and inhibits Schwann cell migration and proliferation

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Neural Regeneration Research 2018年第7期13卷 1253-1262页

作者： Travis B.Sullivan Litchfield C.Robert Patrick A.Teebagy Shannon E.morgan Evan W.Beatty Bryan j.Cicuto Peter K.Nowd Kimberly M.Rieger-Christ David j.Bryan Department of Translational Research Lahey Hospital & Medical Center Tissue Engineering Laboratory Lahey Hospital & Medical Center Department of Plastic and Reconstructive Surgery Lahey Hospital & Medical Center

While the peripheral nervous system has regenerative ability,restoration of sufficient function remains a *** has been shown to be localized in axonal growth fronts and associated with nerve regeneration,including myelination,neuroplasticity,kinase signaling in nerve axoplasm,and cell migration;however,the mechanisms regulating its expression within Schwann cell（SC） remain *** aim of this study was to profile the spatial and temporal expression profile of micro RNA（mi RNA） in a regenerating rat sciatic nerve after transection,and explore the potential role of mi R-138-5 p targeting vimentin in SC proliferation and migration.A rat sciatic nerve transection model,utilizing a polyethylene nerve guide,was used to investigate mi RNA expression at 7,14,30,60,and 90 days during nerve *** levels of mi RNA expression were determined using microarray analysis and subsequently validated with quantitative real-time polymerase chain *** vitro assays were conducted with cultured Schwann cells transfected with mi RNA mimics and assessed for migratory and proliferative *** top seven dysregulated mi RNAs reported in this study have been implicated in cell migration elsewhere,and GO and KEGG analyses predicted activities essential to wound *** of one of these,mi RNA-138-5 p,into SCs reduced cell migration and *** R-138-5 p has been shown to directly target vimentin in cancer cells,and the luciferase assay performed here in rat Schwann cells confirmed *** results detail a role of mi R-138-5 p in rat peripheral nerve regeneration and expand on reports of it as an important regulator in the peripheral nervous system.

关键词： non-coding RNA neural regeneration nerve guide sciatic nerve transection peripheral nerve inj.ry wound healing Gene Ontology processes Kyoto Encyclopedia of Genes and Genomes pathways microarray luciferase assay

Effect of feeding broilers diets differing in susceptible phytate content

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Animal Nutrition 2016年第1期2卷 33-39页

作者： Natalie K.morgan Carrie L.Walk Michael R.Bedford Dawn V.Scholey Emily j.Burton School of Animal Rural and Environmental Science Nottingham Trent University AB Vista Feed Ingredients

Measurements of total phytate phosphorus content of diets may be deceptive as they do not indicate substrate availability for phytase; it may be that measurements of phytate susceptible to phytase effects are a more accurate measure of phosphorus(P) availability to the bird. To verify this hypothesis, an experiment was conducted to compare diets formulated to contain either high or low susceptible phytate, supplemented with either 0 or 500 FTU/kg phytase. Susceptible phytate was determined by exposing the feed samples to conditions that mimicked the average pH of the proximal gastrointestinal tract(pH 4.5) and the optimum temperature for phytase activity(37℃) and then measuring phytate dissolved. Ross 308 birds(n = 240) were fed one of 4 dietary treatments in a 2 x 2 factorial design; 2 diets with high(8.54 g/kg, 57.90% of total phytate) or low(5.77 g/kg, 46.33% of total phytate) susceptible phytate, containing 0 or 500 FTU/kg phytase. Diets were fed to broilers(12 replicate pens of 5 birds per pen) from d 0 to 28 post hatch. Birds fed diets high in susceptible phytate had greater phytate hydrolysis in the gizzard(P j.j.num(P j.j.num and ileum(P < 0.05) and resulting greater tibia and femur Ca and P(P < 0.05) content than those fed the low susceptible diets. All the susceptible phytate was fully degraded in the tract in the absence of added phytase, suggesting the assay used in this study was able to successfully estimate the amount of total dietary phytate that was susceptible to the effects of phytase when used at standard levels. No interactions were observed between susceptible phytate and phytase on phytate hydrolysis. Hydrolysis of phytate was greate

关键词： Broiler Phytate Digestibility Phytase Phosphorus

工作找寻的强度、成本与结果——基于硕士毕业生就业市场的分析

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教育发展研究 2015年第5期35卷 18-24页

作者：李锋亮赵延东 W.j.morgan 清华大学教育研究所副教授北京100084 中国科技发展战略研究院研究员北京100038 诺丁汉大学教育学院

本文实证考察了硕士毕业生在工作找寻过程中求职次数的多少以及在工作找寻过程中花费的总成本与他们最终工作找寻结果之间的关系。实证结果发现:毕业生求职的次数越多,越有可能求职成功,也能够找到起薪显著更高的工作。但毕业生在求职... 详细信息

本文实证考察了硕士毕业生在工作找寻过程中求职次数的多少以及在工作找寻过程中花费的总成本与他们最终工作找寻结果之间的关系。实证结果发现:毕业生求职的次数越多,越有可能求职成功,也能够找到起薪显著更高的工作。但毕业生在求职上花费的更多却既不能帮助他们提高工作找寻成功的概率,也不能帮助他们找到起薪更高的工作。基于此,本文建议毕业生在找寻工作中不要盲目花费,应掌握求职策略、确定求职目标,有针对性地去求职。

关键词：工作找寻努力强度成本起薪

Performance and calibration of quark/gluon-j.t taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuj. X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j.F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of j.ts originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rej.cting j.ts from gluon over j.ts from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the j.t,and the other combines several j.t substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the j.t *** in tagging efficiency between data and simulation are provided for j.ts with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS j.T QUARK GLUON TAGGING

抗苯丙氨酸羟化酶单克隆抗体的提纯和轻、重链的N端顺序

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生物化学杂志 1991年第2期7卷 129-134页

作者：徐秀璋 F.j.morgan 中国科学院生物物理所北京100080 墨尔本ST.Vincent医学研究所

利用DEAE-52离子交换层析和FPLC的Mono Q离子交换柱,从鼠的腹水液中提纯抗苯丙氨酸羟化酶单克隆抗体,再利用FPLC的Superose 12凝胶柱分离它们的轻链和重链。经SDS-凝胶电泳,氨基酸组成分析和N端顺序测定,确定轻链的分子量约为24 kD,约含... 详细信息

利用DEAE-52离子交换层析和FPLC的Mono Q离子交换柱,从鼠的腹水液中提纯抗苯丙氨酸羟化酶单克隆抗体,再利用FPLC的Superose 12凝胶柱分离它们的轻链和重链。经SDS-凝胶电泳,氨基酸组成分析和N端顺序测定,确定轻链的分子量约为24 kD,约含有215个残基,轻链的N端的顺序是:D-V-V-M-T-Q-T-P-L-S-L-P-V-S-L-G-D-Q-A-S-I-S-C-R-S-D?-Q-N(D)-,并确认该轻链为鼠KaPPa轻链Ⅱ型。重链的分子量约为52 kD,它的末端被焦谷氨酰封闭。

关键词： IgGPH7 轻链重链 N端顺序

利用FPLC提纯抗苯丙氨酸羟化酶抗体的Fab及其轻链和重链的分离

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生物化学杂志 1990年第5期6卷 394-399页

作者：徐秀璋 F.j.morgan 中国科学院生物物理所墨尔本St.Vincent医学研究所

IgGPH_7经木瓜蛋白酶消解产生Fab和Fc,在FPLC仪上,分别用MonoQ,Superose_(12),MonoS柱提纯Fab。提纯的Fab经还原和烷基化后,再用琥珀酸酐修饰,然后用Mono Q柱分离得到轻链和重链。最后通过SDS凝胶电泳和N端顺序测定,以鉴定它的纯度和轻... 详细信息

IgGPH_7经木瓜蛋白酶消解产生Fab和Fc,在FPLC仪上,分别用MonoQ,Superose_(12),MonoS柱提纯Fab。提纯的Fab经还原和烷基化后,再用琥珀酸酐修饰,然后用Mono Q柱分离得到轻链和重链。最后通过SDS凝胶电泳和N端顺序测定,以鉴定它的纯度和轻、重链。

关键词： IgGPH7 Fab 轻链重链纯化

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尿中少量有机硷的快速检查方法

药学进展 1961年第Z1期 84-85页

作者： P. j. morgan 李涵

本法叙述了生物体液中小量有机硷的快速检定方法。这种方法对于纸上层析法特别适宜。并列出了咖啡,咖啡因,可卡因、尼古丁等几种不同有机硷的一些试验结果。此法已进一步用于检定尿中或其他体液中可能遇到的不正常的有机硷,其浓度约为1P... 详细信息

本法叙述了生物体液中小量有机硷的快速检定方法。这种方法对于纸上层析法特别适宜。并列出了咖啡,咖啡因,可卡因、尼古丁等几种不同有机硷的一些试验结果。此法已进一步用于检定尿中或其他体液中可能遇到的不正常的有机硷,其浓度约为1P.P.M,这种方法简单并且仅需要小型的装置,同时在作者的实验室中已经广泛地试用三年了。这种方法实质上是两步提取,先用一种不混合的有机溶剂从尿中提取有机硷,然后将

关键词：纸上层析生物体液检定方法有机溶剂试验结果

Case report:simultaneous femtosecond laser astigmatic keratotomy and toric intraocular lens implantation in femtosecond laser-assisted cataract surgery in a patient with surgically induced high corneal astigmatism

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Annals of Eye Science 2022年第4期7卷 69-76页

作者： Yan Guo Heather Edwards Mark Woodward Tyrone Curtis Gresham Kayla morgan Hampton Roads Eye Associates Riverside Medical GroupHamptonVAUSA Hampton Surgical Center Riverside Medical GroupHamptonVAUSA

Background:Femtosecond laser astigmatic keratotomy(FSAK)and toric intraocular lens(IOL)implantation have been studied individually for comparison to treat astigmatism at cataract *** report a case of surgically induced high corneal astigmatism by laser thermal keratoplasty(LTK)in a patient with cataract who was successfully treated with simultaneous combination of FSAK and toric IOL implantation with femtosecond laser-assisted cataract surgery(FLACS).This is the first report of both procedures combined simultaneously,with or without history of *** Description:A 68-year-old male presented with a history of LTK with two enhancements each eye in 2004,with subsequent surgically induced high corneal astigmatism,and with age-related nuclear cataract of both *** master demonstrated+7.71 diopters of astigmatism at 163 degree right eye and+3.29 diopters of astigmatism at 4 degree left *** extensive discussion of the risks and benefits,the patient agreed to undergo FLACS with FSAK with two 61 degrees of relaxation incisions(RIs)and toric IOL(Alcon SN6AT9)right eye;FLACS with toric IOL(Alcon SN6AT7)alone left *** 2-year follow-up,uncorrected visual acuity was 20/30 right eye,20/25 left *** best corrected visual acuity was 20/25(+0.25+1.00 axis 21)right eye and 20/20(plano+0.25 axis 90)left eye;his best corrected near visual acuity was j.+with add+2.50 diopters right eye and left ***:Patients with age-related cataract and LTK induced high corneal astigmatism can hardly be sufficiently treated with FSAK or toric IOL alone at the time of cataract *** effective way is to combine large FSAK and toric IOL of the highest cylindrical power of T9,in our case,simultaneously,which can achieve an excellent long term visual outcome.

关键词： High corneal astigmatism[induced by laser thermal keratoplasty(LTK)] femtosecond laser astigmatic keratotomy(FSAK) toric intraocular lens implantation(IOL implantation) femtosecond laser-assisted cataract surgery(FLACS) case report