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A Self-Healing Optoacoustic Patch with High Damage Threshold and Conversion Efficiency for Biomedical Applications

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Nano-Micro Letters 2024年第7期16卷 31-45页

作者： tao Zhang Cheng-Hui Li Wenbo Li Zhen Wang Zhongya Gu Jiapu Li Junru Yuan Jun ou-Yang Xiaofei Yang Benpeng Zhu School of Integrated Circuit Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093People’s Republic of China National Institute of Dental and Craniofacial Research(NIDCR) National Institutes of Health(NIH)35A Convent DriveBethesdaMD 20892USA Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People’s Republic of China

Compared with traditional piezoelectric ultrasonic devices,optoacoustic devices have unique advantages such as a simple preparation process,anti-electromagnetic interference,and wireless long-distance power supply.However,current optoacoustic devices remain limited due to a low damage threshold and energy conversion efficiency,which seriously hinder their widespread applications.In this study,using a self-healing polydimethylsiloxane(PDMS,Fe-Hpdca-PDMS)and carbon nanotube composite,a flexible optoacoustic patch is developed,which possesses the self-healing capability at room temperature,and can even recover from damage induced by cutting or laser irradiation.Moreover,this patch can generate high-intensity ultrasound(>25 MPa)without the focusing structure.The laser damage threshold is greater than 183.44 mJ cm^(-2),and the optoacoustic energy conversion efficiency reaches a major achievement at 10.66×10^(-3),compared with other carbon-based nanomaterials and PDMS composites.This patch is also been successfully examined in the application of acoustic flow,thrombolysis,and wireless energy harvesting.All findings in this study provides new insight into designing and fabricating of novel ultrasound devices for biomedical applications.

关键词： Optoacoustic Self-healing PDMS Acoustic flow Thrombolytic Wireless energy harvesting

Proposal for valleytronic materials:Ferrovalley metal and valley gapless semiconductor

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Frontiers of physics 2024年第2期19卷 131-139页

作者： san-Dong Guo Yu-Ling tao Guangzhao Wang Shaobo Chen Dong Huang Yee Sin Ang School of Electronic Engineering Xi’an University of Posts and TelecommunicationsXi’an 710121China Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information EngineeringYangtze Normal UniversityChongqing 408100China College of Electronic and Information Engineering Anshun UniversityAnshun 561000China Science Mathematics and Technology(SMT)Singapore University of Technology and Design(SUTD)8 Somapah RoadSingapore 487372Singapore

Valleytronic materials can provide new degrees of freedom to future electronic devices.In this work,the concepts of the ferrovalley metal(FVM)and valley gapless semiconductor(VGS)are proposed,which can be achieved in valleytronic bilayer systems by electric field engineering.In valleytronic bilayer systems,the interaction between out-of-plane ferroelectricity and A-type antiferromagnetism can induce layer-polarized anomalous valley Hall(LP-AVH)effect.The K and−K valleys of FVM are both metallic,and electron and hole carriers simultaneously exist.In the extreme case,the FVM can become VGS by analogizing spin gapless semiconductor(SGS).Moreover,it is proposed that the valley splitting enhancement and valley polarization reversal can be achieved by electric field engineering in valleytronic bilayer systems.Taking the bilayer RuBr_(2)as an example,our proposal is confirmed by the first-principle calculations.The FVM and VGS can be achieved in bilayer RuBr_(2)by applying electric field.With appropriate electric field range,increasing electric field can enhance valley splitting,and the valley polarization can be reversed by flipping electric field direction.To effectively tune valley properties by electric field in bilayer systems,the parent monolayer should possess out-of-plane magnetization,and have large valley splitting.our results shed light on the possible role of electric field in tuning valleytronic bilayer systems,and provide a way to design the ferrovalley-related material by electric field.

关键词： valleytronics electric field bilayer

Megafossils of Betulaceae from the Oligocene of Qaidam Basin and their paleoenvironmental and phytogeographic implications

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Plant Diversity 2024年第1期46卷 101-115页

作者： tao Yang Jia-Hao Cai Yan-Zhi Dai Hong-Yu Chen Lei Han Li Zhang Wei-Yu Liang Xu-Jun Li Wen-Jia Li Jing-Yu Wu san-Ping Xie De-Fei Yan School of Earth Sciences and Key Laboratory of Mineral Resources in Western China(Gansu Province) Lanzhou UniversityLanzhou 730000China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China Center for Research and Education on Biological Evolution and Environments School of Earth Sciences and EngineeringNanjing UniversityNanjing 210023China

Understanding the paleoenvironment and phytogeographical history of the Tibetan Plateau,China relies on discovering new plant fossils.The Qaidam Basin has long been regarded as an ideal‘field laboratory’to investigate the paleoclimate and paleobiological evolution of the northern Tibetan Plateau.However,fossil angiosperms from the Qaidam Basin are rare,and our knowledge of its paleovegetation is poor.Here,we report fossil leaves and fruits of Betulaceae found from the Oligocene Shangganchaigou Formation of northwestern Qaidam Basin(Huatugou area).Comparative morphological analysis led us to assign the fruits to the Betula subgenus Betula and the leaves to Carpinus grandis.These findings,together with other reported fossil plants from the same locality,reveal a close floristic linkage between the Qaidam Basin and Europe during the Oligocene.The northern pathway of this floristic exchange may have crossed through the Qaidam Basin during the late Paleogene.This floristic linkage may have been facilitated by the continuous narrowing of the Turgai Strait and stronger westerlies,which transported moisture and provided favorable climatic conditions.Indeed,fossil plants collected from the Qaidam Basin suggest that during the Oligocene this region had warm and humid deciduous broad-leaf forest,which differs from the region’s modern vegetation and indicates that the Qaidam Basin may have been a suitable region for these plants to flourish and spread during the Oligocene.

关键词： Paleoenvironment Biogeography Betulaceous fossil Qaidam basin Tibetan Plateau Oligocene

Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity

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Acta Pharmaceutica Sinica B 2024年第1期14卷 350-364页

作者： Yongshun Zhang Lan Yang Yangsen ou Rui Hu Guangsheng Du Shuang Luo Fuhua Wu Hairui Wang Zhiqiang Xie Yu Zhang Chunting He Cheng Ma tao Gong Ling Zhang Zhirong Zhang Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10(PTEN)gene in cancer cells may be associated with immunosuppressive tumor microenvironment(TME)and poor response to immune checkpoint blockade(ICB)therapy.Therefore,efficiently restoring PTEN gene expression in cancer cells is critical to improving the responding rate to ICB therapy.Here,we screened an adeno-associated virus(AAV)capsid for efficient PTEN gene delivery into B16F10 tumor cells.We demonstrated that intratumorally injected AAV6-PTEN successfully restored the tumor cell PTEN gene expression and effectively inhibited tumor progression by inducing tumor cell immunogenic cell death(ICD)and increasing immune cell infiltration.Moreover,we developed an anti-PD-1 loaded phospholipid-based phase separation gel(PPSG),which formed an in situ depot and sustainably release anti-PD-1 drugs within 42 days in vivo.In order to effectively inhibit the recurrence of melanoma,we further applied a triple therapy based on AAV6-PTEN,PPSG^(@anti-PD-1)and CpG,and showed that this triple therapy strategy enhanced the synergistic antitumor immune effect and also induced robust immune memory,which completely rejected tumor recurrence.We anticipate that this triple therapy could be used as a new tumor combination therapy with stronger immune activation capacity and tumor inhibition efficacy.

关键词： Triple therapy Adeno-associated virus PTEN PPSG@anti-PD-1 CpG Immunogenic cell death Antitumor immune response Immune memory

基于特征图像组合与改进ResNet-18的电能质量扰动识别方法

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中国电机工程学报 2024年第7期44卷 2531-2544,I0003页

作者：张逸欧杰宇金涛毕贵红福州大学电气工程与自动化学院福建省福州市350108 昆明理工大学电力工程学院云南省昆明市650500

针对传统电能质量扰动(power quality disturbance,PQD)识别体系中单一图像特征信息受限与算法识别能力不足等问题,依据特征融合的思想,提出一种基于特征图像组合与改进ResNet-18的PQD识别方法。首先,对PQD信号进行变分模态分解(variati... 详细信息

针对传统电能质量扰动(power quality disturbance,PQD)识别体系中单一图像特征信息受限与算法识别能力不足等问题,依据特征融合的思想,提出一种基于特征图像组合与改进ResNet-18的PQD识别方法。首先,对PQD信号进行变分模态分解(variational mode decomposition,VMD)得到一系列固有模态函数(intrinsic mode functions,IMFs)与残差分量;其次,将IMFs、残差分量、原始扰动信号与Subtract分量纵向拼接成分量矩阵,利用信号-图像转化方法生成特征分量彩色图;再次,对原始扰动信号进行连续小波变换(continuous wavelet transform,CWT)生成小波时-频图;最后,将特征分量彩色图与小波时-频图组合输入改进的六通道ResNet-18中训练学习并完成扰动识别。通过仿真对PQD识别方法进行分析并将其与目前常用识别体系进行比较。结果表明,所提方法具有较好的抗噪性能并且能够更好地提取PQD特征信息,达到更高的识别准确率。

关键词：电能质量扰动变分模态分解特征分量彩色图小波时-频图残差网络

公立医院运营管理视角下采购预算管理对策研究

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中国卫生经济 2024年第3期43卷 82-84页

作者：宋颖欧涛罗艳重庆医科大学附属第一医院计划财务处重庆400017

针对公立医院预算管理改革背景及实施过程中存在的问题,文章从运营管理视角探讨如何加强采购预算管理,提高预算资金使用效率和效果,降本增效、防范风险,以促进医院高质量发展。研究认为应努力实现采购预算管理与公立医院发展顶层设计相... 详细信息

针对公立医院预算管理改革背景及实施过程中存在的问题,文章从运营管理视角探讨如何加强采购预算管理,提高预算资金使用效率和效果,降本增效、防范风险,以促进医院高质量发展。研究认为应努力实现采购预算管理与公立医院发展顶层设计相衔接,探索采购项目资金预算与项目进程管理的协同方式,将采购预算刚性约束与动态调整相统一,建立多维度、全流程的采购预算项目绩效评价体系。

关键词：公立医院运营管理采购预算

Probing the dynamic thermodynamic resolution and biological activity of Cu(Ⅱ) and Pd(Ⅱ) complexes with Schiff base ligand derived from proline

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Chinese Chemical Letters 2024年第4期35卷 99-105页

作者： tao Yu Vadim A.Soloshonok Zhekai Xiao Hong Liu Jiang Wang State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesBeijing 100049China Department of Organic Chemistry Ⅰ Faculty of ChemistryUniversity of the Basque Country UPV/EHUSan Sebastian 20018Spain IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China Lingang Laboratory Shanghai 200031China

Schiff base metal complexes are of great importance in pharmaceutical science owing to their unique chemical properties, which enable them to exhibit diverse biological activities such as anti-bacterial,anti-oxidant, anti-inflammatory, and anti-tumor properties. Furthermore, Schiff base metal complexes can serve as reagents and catalysts in chemical reactions. This review aims to provide an overview of our recently published studies on Cu(Ⅱ) and Pd(Ⅱ) complexes derived from proline Schiff base ligands. We also discuss the potential applications of these metal complexes in the fields of antibacterial and chiral resolution.

关键词： Schiff bases Biological activity Tailor-made amino acids Asymmetric synthesis Chiral tridentate ligands Square-planar Cu(Ⅱ)-complexes Square-planar Pd(Ⅱ)-complexes

长三角新闻工作者ChatGPT使用意愿的影响因素——基于创新扩散理论

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现代传播（中国传媒大学学报） 2024年第3期46卷 13-22页

作者：严三九陶冠男上海大学新闻传播学院

我国新闻采编流程数字化改造中,算力规模持续扩张。就围绕新闻工作者应用生成式AI移动采编意愿是否增强这个问题,基于创新扩散理论、技术接受模型,研究影响新闻工作者使用ChatGPT新闻生产的意愿,在长江三角区新闻者群体中收集357份问卷... 详细信息

我国新闻采编流程数字化改造中,算力规模持续扩张。就围绕新闻工作者应用生成式AI移动采编意愿是否增强这个问题,基于创新扩散理论、技术接受模型,研究影响新闻工作者使用ChatGPT新闻生产的意愿,在长江三角区新闻者群体中收集357份问卷,从相对优势、兼容性、复杂性和社会影响以及感知有用性对新闻工作者ChatGPT使用意愿的影响因素开展实证研究,推进新闻采编行业数字化、实时化、数据化转型。研究表明,前四项变量对感知有用性与使用意愿有显著影响,感知有用性对使用意愿有显著影响,不同变量之间均具有显著相关性。

关键词： ChatGPT 使用意愿影响因素创新扩散理论技术接受模型

稀疏约束与时间一致的背景感知相关滤波目标跟踪

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小型微型计算机系统 2024年第3期45卷 657-663页

作者：陶洋唐函欧双江周婉怡重庆邮电大学通信与信息工程学院重庆400065

背景感知滤波算法通过循环移位采集真实负样本,有效解决了边界效应.但在复杂场景例如遮挡、快速移动、背景干扰等,其较大的采样区域导致过多背景在杂波干扰,从而影响跟踪效果.针对这一问题,本文首先提取灰度HOG特征与颜色CN特征来提高... 详细信息

背景感知滤波算法通过循环移位采集真实负样本,有效解决了边界效应.但在复杂场景例如遮挡、快速移动、背景干扰等,其较大的采样区域导致过多背景在杂波干扰,从而影响跟踪效果.针对这一问题,本文首先提取灰度HOG特征与颜色CN特征来提高目标外观模型,在基准目标函数基础上引入L1稀疏正则约束形成弹性网络以自适应筛选关键特征,增强滤波器在复杂背景下的判别能力.同时针对BACF在跟踪过程中目标快速变化,本文引入时间正则项提高滤波器抑制畸变的能力.最后,本文提出了一种独立的尺度滤波器算法,准确提供目标尺度大小.实验仿真结果表明,在公开数据集OTB-2013和OTB-2015上,本文算法较基准算法有很大提升,能够较好应对不同复杂场景下的跟踪难题.

关键词：背景感知稀疏约束相关滤波目标跟踪