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Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats

World Journal of Gastroenterology 2009年第11期15卷 1373-1380页

作者： Salim S al-Rejaie Abdulaziz M aleisa Abdulaziz A al-Yahya Saleh A Bakheet Abdulmalik alsheikh Amal G Fatani othman a al-shabanah Mohamed M Sayed-Ahmed Department of Pharmacology College of PharmacyKing Saud UniversityPO Box 2457Kingdom of Saudi Arabia Department of Pathology College of MedicineKing Saud UniversityPO Box 2457 Kingdom of Saudi Arabia

AIM:To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis. METHODS:A total of 60 male Wistar albino rats were divided into six groups with 10 animals in each *** in group 1(control group)received a single intraperitoneal(i.p.)injection of normal saline. Animals in group 2(carnitine-supplemented group) were given L-carnitine(200 mg/kg per day)in drinking water for 8 *** in group 3(carnitine-depleted group)were given D-carnitine(200 mg/kg per day)and mildronate(200 mg/kg per day)in drinking water for 8 *** in group 4(DENA group)were injected with a single dose of DENA(200 mg/kg,i.p.)and 2 wk later received a single dose of carbon tetrachloride(2 mL/kg) by gavage as 1:1 dilution in corn *** in group 5(DENA-carnitine depleted group)received the same treatment as group 3 and group *** in group 6 (DENA-carnitine supplemented group)received the same treatment as group 2 and group ***:Administration of DENA resulted in a significant increase in alanine transaminase(alT), gamma-glutamyl transferase(G-GT),alkaline phosphatase(alP),total bilirubin,thiobarbituric acid reactive substances(TBARS)and total nitrate/ nitrite(NOx)and a significant decrease in reduced glutathione(GSH),glutathione peroxidase(GSHPx), catalase(CAT)and total carnitine content in liver *** the carnitine-depleted rat model,DENA induced a dramatic increase in serum alT,G-GT,alP and total bilirubin,as well as a progressive reduction in total carnitine content in liver ***, L-carnitine supplementation resulted in a complete reversal of the increase in liver enzymes,TBARS and NOx,and a decrease in total carnitine,GSH,GSHPx, and CAT induced by DENA,compared with the control *** examination of liver tissues confirmed the biochemical data,where L-carnitine prevented DENA-induced hepatic carcinogenesis while D-carnitine-mildronate aggravated DENA-

关键词： Carnitine deficiency D-carnitine L-carnitine Diethylnitrosamine Hepatic carcinogenesis

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Reproductive,cytological and biochemical toxicity of Yohimbe in male swiss albino mice

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Asian Journal of Andrology 2006年第4期8卷 469-476,517页

作者： AbdulhakeemA.AI-Majed AbdulazizA.AI-Yahya A.M.AI-Bekairi othmanA.al-shabanah ShoebQureshi Department of Pharmacology College of PharmacyKing Saud UniversityPO Box 2457Riyadh 11451Saudi Arabia

Aim:To study the effect of Corynanthe Yohimbe(Yohimbe)on germ cells in Swiss albino ***:Adult male mice were orally(gavage)treated with different doses(188,375 and 750 mg/[***])of aqueous suspension of Yohimbe for 90 *** following parameters were evaluated:(i)reproductive organ weight,(ii)motility and count of sperm,(iii)study on rate of pregnancy and mean implants,(iv)spermatozoa morphology,(v)cytology of the testes chromosomes,and(vi)biochemical study on estimation of proteins,RNA,DNA,malondialdehyde,nonprotein sulfhydryl(NP-SH)and ***:The treatment caused significant increase in the weight of seminal vesicles,motility and count of spermatozoa,pre-and *** fertility was *** results are confirmed by our data on spermatozoa abnormalities and chromosomal *** data on biochemical param- eters showed increase of malondialdehyde and depletion of NP-SH,proteins,RNA and DNA in the testicular cells. Conclusion:Our results elucidated the role of free radical species in cytological and reproductive changes,possibly, under the influence of yohimbine(principal constituent of Yohimbe)on neurotransmitters,including norephinephrine. These data warrant careful use of Yohimbe.(Asian J Androl 2006 Jul;8:469-476)

关键词： Yohimbe cytological reproduction mice germ cell sperm

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