Reproductive,cytological and biochemical toxicity of Yohimbe in male swiss albino mice

作     者：AbdulhakeemA.AI-Majed AbdulazizA.AI-Yahya A.M.AI-Bekairi OthmanA.Al-Shabanah ShoebQureshi 

作者机构：Department of PharmacologyCollege of PharmacyKing Saud UniversityPO Box 2457Riyadh 11451Saudi Arabia 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2006年第8卷第4期

页      面：469-476,517页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The authors are thankful to King Abdulaziz City for Science and Technology  Riyadh  Kingdom of Saudi Arabia  for sanction of grant to conduct research on herbal drugs (PROJECT AR-21-41) 

主　　题：Yohimbe cytological reproduction mice germ cell sperm 

摘      要：Aim:To study the effect of Corynanthe Yohimbe(Yohimbe)on germ cells in Swiss albino ***:Adult male mice were orally(gavage)treated with different doses(188,375 and 750 mg/[***])of aqueous suspension of Yohimbe for 90 *** following parameters were evaluated:(i)reproductive organ weight,(ii)motility and count of sperm,(iii)study on rate of pregnancy and mean implants,(iv)spermatozoa morphology,(v)cytology of the testes chromosomes,and(vi)biochemical study on estimation of proteins,RNA,DNA,malondialdehyde,nonprotein sulfhydryl(NP-SH)and ***:The treatment caused significant increase in the weight of seminal vesicles,motility and count of spermatozoa,pre-and *** fertility was *** results are confirmed by our data on spermatozoa abnormalities and chromosomal *** data on biochemical param- eters showed increase of malondialdehyde and depletion of NP-SH,proteins,RNA and DNA in the testicular cells. Conclusion:Our results elucidated the role of free radical species in cytological and reproductive changes,possibly, under the influence of yohimbine(principal constituent of Yohimbe)on neurotransmitters,including norephinephrine. These data warrant careful use of Yohimbe.(Asian J Androl 2006 Jul;8:469-476)