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World Journal of Clinical Cases 2024年第34期12卷 6721-6727页

作者： Yu Igata Masashi Kudo Motohiro Kojima Shota kami Keishiro Aoki Tomoyuki Satake Tatsushi Kobayashi Motokazu Sugimoto Shin Kobayashi Masaru Konishi Naoto Gotohda Department of hepatobiliary and Pancreatic Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research and Clinical Trial Center National Cancer CenterKashiwa 277-8577Japan Department of hepatobiliary and Pancreatic Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Diagnostic Radiology National Cancer Center Hospital EastChiba 277-8577Japan

BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine and cisplatin plus durvalumab(GCD)regimen was recently approved as first-line therapy for patients with advanced ***,post-GCD conversion surgery has not been previously ***,we describe a case of advanced intrahepatic cholangiocarcinoma(ICC)successfully treated with radical surgery after *** SUMMARY A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD,followed by durvalumab maintenance treatment,with mild adverse *** response was ***,a conversion surgery with extended left hepatectomy and bile duct resection was *** resection margins were negative,and the pathological diagnosis was compatible with small duct type *** patient remained disease-free for 8 months without adjuvant *** We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.

关键词： Conversion surgery Intrahepatic cholangiocarcinoma Small duct type Immunotherapy Case report

Optimum heating of Thick-Walled Pressure Components Assuming a Quasi-steady State of Temperature Distribution

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Journal of Thermal Science 2016年第4期25卷 380-388页

作者： Piotr Dzierwa Marcin Trojan Dawid Taler Katarzyna kamińska Jan Taler Institute of Thermal Power Engineering Cracow University of Technology Institute of Thermal Engineering and Air Protection Faculty of Environmental Engineering Department of hydraulic Engineering and Geotechnics Agricultural University of Cracow

As a result of the development of wind farms,the gas- steam blocks,which shall quickly ensure energy supply in case the wind velocity is too low,are introduced to the energy *** shorten the start-up time of the gas-steam and conventional blocks,the structure of the basic components of the blocks are changed,*** reducing the diameter of the boiler,the thickness of its wall is also *** attempts were also made to revise the currently binding TRD 301 regulations,replacing them by the EN 12952-3 European Standard,to reduce the allowable heating and cooling rates of thick walled boiler *** basic assumption,on which the boiler regulations allowing to calculate the allowable temperature change rates of pressure components were based,was the quasi- steady state of the temperature field in the simple shaped component,such as a slab,cylindrical or spherical wall.

关键词： pressure component thermal stress quasi-steady state optimum heating

Observations on the Spermatogenic Cycle of the Grass Snake,Natrix natrix (Serpentes:Colubridae) in Northern Iran

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Asian herpetological Research 2011年第1期2卷 55-59页

作者： Afshin FAGhIRI Abdolhossein ShIRAVI Vida hOJATI haji Gholi kami Department of Biology Islamic Azad UniversityDamghan BranchDamghanIran Department of Biology Faculty of ScienceGolestan UniversityGorganIran

The Grass Snake, Natrix natrix, is one of the non-venomous oviparous snakes of the family Colubridae, found in Mazandaran, a northern province of Iran. In order to study the spermatogenic cycle of this species in the area, sampling was done from April to November, and twenty-six male snakes were collected by hand during daylight hours. Testes were extracted from the specimens, and were fixed and prepared for histological examination. The results indicated that the spermatogenesis started in early June, November. The mean body length of the specimens was reached its height in August and September, and ended in measured 636.21 mm, and the mean volume of testes was 524.54 rnm3 and 569.06 mm3 for the right and left ones, respectively, and the mean weight of the testes was 0.051 g Spermatogenesis in this species is aestival and sperms are stored for use in the year following production.

关键词： spermatogenesis Grass snake Natrix natrix northern Iran

New Karyological and Morphometric Data on Poorly Known Bufo surdus and Bufo luristanicus in Comparison with Data of Diploid Green Toads of the Bufo viridis Complex from South of Iran

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Asian herpetological Research 2014年第3期5卷 168-178页

作者： Fatemeh FAKhARZAEh Jamshid DARVISh haji Gholi kami Fereshteh GhASEMZADEh Eskandar RASTEGAR-POUYANI Department of Biology Faculty of Sciences Ferdowsi University of Mashhad Department of Biology Faculty of Sciences Shahid Chamran University of Ahvaz Department of Biology Faculty of Sciences Golestan University Department of Biology Faculty of Sciences Hakim Sabzevari university

Previous studies on the Bufo viridis complex, which is distributed broadly across Iran, are incomplete and restricted to a few regions or a few samples. In this paper a new detailed study on the B. viridis complex in southern of Iran （from West to East） is presented. The analysis of 18 morphometric characters with univariate and multivariate methods reveals significant differences between three members of the B. viridis complex namely B. variabilis, B. luristanicus, and B. surdus distributed in southern part of Iran. Our result help to resolve an old taxonomic problem about B. surdus subgroup （taxa closely related to B. surdus） confirming that B. luristanicus and B. surdus are distinct species. Moreover, for the first time we report and describe karyotype details of B. luristanicus and B. surdus which confirmed that they are diploid. Karyological studies demonstrate that all toads from three mentioned species have 2n = 22 chromosomes. These chromosomes are arranged into two groups. First group has six large chromosomes and the second group is composed of five small chromosomes. These chromosomes are metacentric or submetacentric. The number of submetacentric chromosomes is different in three mentioned species of B. viridis complex. Neither sexual heteromorphism, nor secondary constriction was observed in any pairs of chromosomes.

关键词： Bufo viridis complex taxonomy Bufo surdus Bufo luristanicus Bufo variabilis karyotype morphometry,Iran

Mapping cultural ecosystem services in mountain forests using mobile phone data

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Journal of Mountain Science 2023年第12期20卷 3437-3449页

作者： CIESIELSKI Mariusz kamiNSKA Agnieszka Department of Geomatics Forest Research InstituteSękocin StaryBraci leśnej 305-090Poland

The aim of the work was to determine the spatial distribution of activity in the forest on the area of the Forest Promotional Complex“Sudety Zachodnie”using mobile phone *** study identified the sites with the highest(hot spot)and lowest(cold spot)***,stand,demographic,topographic and spatial factors affecting the distribution of activity were also *** approaches were applied in our research:global and local Moran’s coefficients,and a machine learning technique,Boosted Regression *** results show that 11,503,320 visits to forest areas were recorded in the“Sudety Zachodnie”in *** most popular season for activities was winter,and the least popular was *** global and local Moran’s I coefficients,three small hot clusters of activity and one large cold cluster were *** with high values with similar neighbours(hot-spots)were most often visited forest areas,averaging almost 200,000 visits over *** fewer visits were recorded in cold-spots,the average number of visits to these areas was about 4,*** value of global Moran’s I was equal to 0.54 and proved significant positive spatial *** of Boosted Regression Trees modeling of visits in forest,using tree stand habitat and spatial factors accurately explained 76%of randomly selected input *** variables that had the greatest effect on the distribution of activities were the density of hiking and biking trails and diversity of *** methodology presented in this article allows delineation of Cultural Ecosystem Services hot spots in forest areas based on mobile phone *** also allows the identification of factors that may influence the distribution of visits in *** data are important for managing forest areas and adapting forest management to the needs of society while maintaining ecosystem stability.

关键词： Ecosystem services Big data Traffic research Monitoring Forests

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高粱抗炭疽病资源鉴定及抗性基因发掘

高粱抗炭疽病资源鉴定及抗性基因发掘

^(13)C-methacetin breath test reproducibility study reveals persistent CYP1A2 stimulation on repeat examinations

中国植物病理学会2024年学术年会

作者：余志凡张继伟李金洋夏敬阳韩君如赵菲菲常新雅 Yam Bahadur kami 王文明四川农业大学西南作物基因资源发掘与利用国家重点实验室

高粱[Sorghum bicolor (L.) Moench]是世界第五大粮食作物,也是中国最重要的酿造原料。由疏纹刺盘孢(Colletotrichum sublineola)引起的高粱炭疽病已成为我国高粱产业第一大真菌病害,严重影响高粱及下游产业的经济效益。挖掘高粱抗炭疽... 详细信息

高粱[Sorghum bicolor (L.) Moench]是世界第五大粮食作物,也是中国最重要的酿造原料。由疏纹刺盘孢(Colletotrichum sublineola)引起的高粱炭疽病已成为我国高粱产业第一大真菌病害,严重影响高粱及下游产业的经济效益。挖掘高粱抗炭疽病基因资源,培育抗病品种是解决这一问题的根本途径。在实验室前期研究中,通过室内接种和田间自然发病实验,对382份资源材料进行炭疽病抗性评估,从中鉴定到7份高抗材料、22份抗病材料、304份感病材料、34份中感材料和15份高感材料。通过全基因组关联分析和表达谱验证,成功定位到一个主效NLR基因SbAr1。SbAr1在炭疽菌侵染进程中被显著诱导,单倍型分析表明该基因与炭疽病抗性共分离,西南糯高粱品种全部为感病单倍型。进一步对SbAr1的结构分析发现,相较于粳高粱BTx623和甜高粱Rio,GJh1中SbAr1的一个SNP突变导致编码提前终止,使其缺失了相应的LRR结构域。利用酵母双杂交实验,筛选SbAr1互作蛋白,将所得到的蛋白进行GO富集分析发现,互作蛋白主要在免疫防御、植物胁迫和生长发育等信号通路中富集。其中Sobic.001G006400、14-3-3a和14-3-3c被筛选到的频次较高,很可能是SbAr1互作靶标蛋白。下一步笔者将在此基础上,构建SbAr1基因敲除和过表达,检测SbAr1在高粱炭疽病抗性中的作用,采用分子和生化试验阐明SbAr1与靶标蛋白的互作机制,从而解析SbAr1调控高粱炭疽病抗性的机制。另外,笔者将通过杂交和反复回交,将具有编码完整蛋白结构的SbAr1导入西南糯高粱品种中,以评估其在西南糯红高粱抗病育种中的应用价值。笔者的实验结果将为高粱抗病育种提供新的抗性基因资源和理论支撑。

关键词：高粱炭疽病资源鉴定抗性基因挖掘 NLR

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World Journal of Gastroenterology 2011年第45期17卷 4979-4986页

作者： Anna Kasicka-Jonderko Anna Nita Krzysztof Jonderko Magdalena kamińska Barbara Bońska-Fajfrowska Department of Basic Biomedical Science School of Pharmacy Medical University of Silesia

AIM: To find the most reproducible quantitative parameter of a standard 13C-methacetin breath test (13C-MBT). METhODS: Twenty healthy volunteers (10 female, 10 male) underwent the 13C-MBT after intake of 75 mg 13C-methacetin p.o. on three occasions. Short-and medium-term reproducibility was assessed with paired examinations taken at an interval of 2 and 18 d (medians), respectively. RESULTS: The reproducibility of the 1-h cumulative 13C recovery (AUC0-60), characterized by a coefficient of variation of 10%, appeared to be considerably better than the reproducibility of the maximum momentary 13C recovery or the time of reaching it. Remarkably, as opposed to the short gap between consecutive examinations, the capacity of the liver to handle 13C-methacetin increased slightly but statistically significantly when a repeat dose was administered after two to three *** the AUC0-60, the magnitude of this fixed bias amounted to 7.5%. Neither the time gap between the repeat examinations nor the gender of the subjects affected the 13C-MBT reproducibility. CONCLUSION: 13C-MBT is most reproducibly quantified by the cumulative 13C recovery, but the exactitude thereof may be modestly affected by persistent stimulation of CYP1A2 on repeat examinations.

关键词： 13C-Methacetin Breath test Isotope application in medicine Liver Reproducibility

A Sputtering Deposition of Al Enhances the Output Reproducibility in a Conducting Rubber Force Sensor

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Journal of Sensor Technology 2016年第3期6卷 46-55页

作者： Masato Ohmukai Yasushi kami Department of Electrical and Computer Engineering Akashi College of Technology Akashi Hyogo Japan

Compressive force sensors or pressure sensors are indispensable to tactile sensors in humanoid robots. It is investigated that low-cost electro-conducting rubber sheets are applied to the force sensor, of which the biggest problem is its poor reproducibility. It was found that the aluminum deposition by a vacuum evaporation method shows excellent characteristics but suffers deterioration by a radiation heating effect. The aluminum electrode was deposited by a sputtering method, known to have an advantage of a low-temperature method, and the reproducibility of the output was improved.

关键词： Conducting Rubber Force Sensor Electrode Magnetron Sputtering Reproducibility

first records of tropiocolotes steudneri peters, 1869 and hemidactylus flaviviridis riippell, 1840 (sauria: gekkonidae)from fars province, iran

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Asian herpetological Research 2010年第1期1卷 61-63页

作者： Ali Gholamifard Ali Gholamhosseini Nasrullah Rastegar-Pouyani hamid Reza Esmaeili haji-Gholi kami department of biology college of sciences shiraz university shiraz 71454 iran department of biology faculty of sciences razi university kermanshah 671491ran department of biology faculty of sciences golestan university gorgan 336 iran

Steudner’s dwarf gecko,Tropiocolotes steudneri(Peters,1869) and the yellow-bellied house gecko,hemidactylus flaviviridis Rüppell,1840 were recorded for the first time from Fars Province in southern *** a herpetofaunal survey in November 2006,a single subadult specimen of *** was collected from Deh Kohneh in southwestern *** November 2007 and May 2008,two specimens of *** were collected from Ghaleh Seied in western Fars,*** collection locations of the two new records are well outside the known distribution ranges of the two species in Iran.

关键词： lizard new record distribution Iranian Plateau gecko

缓控释氮肥一次性施用对舟山地区小麦产量和氮肥利用率的影响

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浙江农业科学 2024年第6期65卷 1325-1328页

作者：费维方红玲张浩顾卡咪杨梢娜岱山县农业农村局浙江岱山316200 舟山市农业技术推广中心浙江舟山316021

为了探究缓释氮肥对冬小麦生产的影响,以扬麦16为材料,于2020—2022年在浙江省岱山县进行田间试验,研究不同释放期缓释氮肥对小麦产量、氮素累积量、氮肥表观利用率、农学效率及偏生产力的影响。结果显示,与常规施肥相比,2种释放期的缓... 详细信息

为了探究缓释氮肥对冬小麦生产的影响,以扬麦16为材料,于2020—2022年在浙江省岱山县进行田间试验,研究不同释放期缓释氮肥对小麦产量、氮素累积量、氮肥表观利用率、农学效率及偏生产力的影响。结果显示,与常规施肥相比,2种释放期的缓控释氮肥均显著提高了小麦产量。在2020—2021年,缓控释氮肥较常规施肥显著提高了小麦氮素吸收量,而2021—2022年小麦季CF、CRU60和CRU90处理间的小麦总吸氮量无显著差异;与CF处理相比,缓控释氮肥处理的小麦氮肥表观利用率、农学效率和偏生产力分别提高3.4~6.0百分点、10.4%~19.8%和3.9%~7.5%。综上,在小麦生产上一次基施缓释期90 d的缓控释氮肥可以达到增效、省工、节本的效果。

关键词：小麦产量氮素累积量氮肥利用率

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