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World Journal of Gastroenterology 2008年第27期14卷 4407-4409页

作者： Sergio Zepeda-Gómez Jesús camacho Edgar Oviedo-Cárdenas Carmen Lome-Maldonado Department of Gastrointestinal Endoscopy Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" Department of Pathology Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"

Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype of the non-Hodgkin’s lymphoma (NHL) accounting for about 40% of all NHLs. This is a case report about the endoscopic appearance of a DLBCL with infiltration to the stomach in a 39-year-old female. She had a 6-mo history of lumbar and left upper quadrant pain with intermittent episodes of melena. A computer tomograghy (CT) scan showed mural thickening of the gastric antrum. Endoscopic examination revealed multiple gastric ulcers. Definite diagnosis could be made by endoscopic biopsies and the patient had a good response to chemotherapy. This response correlated well with a further endoscopic follow-up. A follow-up endoscopic examination could be considered to evaluate a good response to chemotherapy in DLBCL patients with secondary gastric dissemination.

关键词： Diffuse large B-cell lymphoma Non-Hodgkin's lymphoma Gastric infiltration

From nuclear submarines to graduate medical education: applying David Marquet's intent-based leadership model

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Military Medical Research 2018年第1期5卷 90-91页

作者： Camilo Fernandez-Salvador Rebecca Oney Sungjin A.Song Macario camacho Department of Otolaryngology Tripler Army Medical Center Otolaryngology-Head and Neck Surgery Tripler Army Medical Center

*** Marquet,a decorated Navy Captain,transformed an under performing submarine crew by empowering his subordinates to be leaders and reach their full *** called this intent-based leadership(IBL).What would happen if Marquet’s model were implemented in Graduate Medical Education(GME)?In this letter to the editor,we summarize the potential of the IBL model in graduate medical education as opposed to the traditional leaderfollower *** harnesses human productivity toward the shared goals of GME,which are patient care and trainee *** shift in mindset could lead both teachers and trainees to focus more on the real reason that we undertake GME and change behaviors for the *** suggest that IBL can and should be adopted in GME and propose that both patients and providers will benefit from this action.

关键词： David Marquet Leadership Graduate medical education Intent-based leadership

短链葡聚糖-姜黄素纳米乳液的制备及结构表征

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农业工程学报 2019年第1期35卷 303-309页

作者：冯涛曾小兰王珂 osvaldo Campanella 上海应用技术大学香料香精技术与工程学院上海201418 江南大学食品学院无锡214000 普度大学食品科学系惠斯特勒碳水化合物研究中心美国西拉斐特43845

利用短链葡聚糖(short glucan chains,SGC)的螺旋空间结构来包埋姜黄素(curcumin,CUR)。通过使用高剪切分散乳化机高速剪切溶液5 min,用纳米均质机在50 MPa压力下高压均质经剪切后的乳液2次制备成纳米乳液以提高其包埋率和载药量。XRD (... 详细信息

利用短链葡聚糖(short glucan chains,SGC)的螺旋空间结构来包埋姜黄素(curcumin,CUR)。通过使用高剪切分散乳化机高速剪切溶液5 min,用纳米均质机在50 MPa压力下高压均质经剪切后的乳液2次制备成纳米乳液以提高其包埋率和载药量。XRD (x-ray diffraction)和TGA (thermogravimetric analysis)很好的验证了包合物的形成,通过TGA、SEM (scanning electron microscopy)、激光粒径分析仪等各种表征分析得出短链葡聚糖-姜黄素纳米乳液制备成功,所制得的乳液对姜黄素的包埋率和载药量都高于短链葡聚糖-姜黄素包合物,分别达到了71.11%和12.07%,说明制备成纳米乳液对姜黄素的包埋率和载药量都有了明显的提高。所制备的纳米乳液的粒径小于300 nm,粒径分布均一,Zeta电位观测表明所制得的乳液的稳定性有所提高。为提高食品及医药领域姜黄素的生物利用率提供了一定的参考意义。

关键词：乳液纳米包合材料微观结构蜡质玉米淀粉短链葡聚糖普鲁兰酶姜黄素纳米乳液

Exergames： neuroplastic hypothesis about cognitive improvement and biological effects on physical function of institutionalized older persons

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Neural Regeneration Research 2016年第2期11卷 201-204页

作者： Renato Sobral Monteiro-Junior Cesar Augusto Otero Vaghetti osvaldo Jose M. Nascimento Jerson Laks Andrea Camaz Deslandes Physical Education and Sport Department of the Universidade Estadual de Montes Claros Minas GeraisBrazil Post Graduation Program(PhD)in Medicine(Neurology-Neuroscience) Universidade Federal FluminenseNiteroiBrazil Neuroscience Laboratory of Exercise Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Higher School of Physical Education Universidade Federal de PelotasPelotasBrazil Neurology Department Universidade Federal FluminenseNiteroiBrazil Programa de Pos-graduacao em Biomedicina Translacional-Biotrans Universidade UnigranrioBrazil Institute of Psychiatry UniversidadeFederal do Rio de JaneiroRio de JaneiroBrazil Centro de Estudos e Pesquisa do Envelhecimento Instituto Vital BrasilRio de JaneiroBrazil Institute of Physical Education and Sport Universdiade do Estado do Rio de JaneiroRio de JaneiroBrazil

Exergames can be considered a dual task because the games are performed by a man-videogame interface, requiring cognitive and motor functions simultaneously. Although the literature has shown improvements of cognitive and physical functions due to exergames, the intrinsic mechanisms involved in these functional changes have still not been elucidated. The aims of the present study were（1） to demonstrate the known biological mechanisms of physical exercise regarding muscle adaptation and establish a relationship with exergames; and（2） to present a neurobiological hypothesis about the neuroplastic effects of exergames on the cognitive function of institutionalized older persons. These hypotheses are discussed.

关键词： virtual reality elderly nursing-home physical activity cognition neuroplasticity

Estrogen and progesterone receptor isoforms expression in the stomach of Mongolian gerbils

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World Journal of Gastroenterology 2008年第37期14卷 5701-5706页

作者： Milena Saqui-Salces Teresa Neri-Gómez Armando Gamboa-Dominguez Guillermo Ruiz-Palacios Ignacio camacho-Arroyo Facultad de Química Departamento de Biología Universidad Nacional Autónoma de MéxicoMéxico DF 04510 México Departamento de Patología INCMNSZMéxico DF14000 México Departamento de Infectología INCMNSZMéxico DF 14000 México

AIM: We studied the estrogen receptor (ER) and progesterone receptor (PR) isoforms expression in gastric antrum and corpus of female gerbils and their regulation by estradiol (E2) and progesterone (P4). METHODS: Ovariectomized adult female gerbils were subcutaneously treated with E2, and E2 + P4. Uteri and stomachs were removed, the latter were cut along the greater curvature, and antrum and corpus were excised. Proteins were immunoblotted using antibodies that recognize ER-alpha, ER-beta, and PR-A and PR-B receptor isoforms. Tissues from rats treated in the same way were used as controls. RESULTS: Specific bands were detected for ER-alpha (68 KDa), and PR isoforms (85 and 120 KDa for PR-A and PR-B isoforms, respectively) in uteri, gastric antrum and corpus. We could not detect ER-beta isoform. PR isoforms were not regulated by E2 or P4 in uterus and gastric tissues of gerbils. ER-alpha isoform content was significantly down-regulated by E2 in the corpus, but not affected by hormones in uterus and gastric antrum. CONCLUSION: The presence of ER-alpha and PR isoforms in gerbils stomach suggests that E2 and P4 actions in this organ are in part mediated by their nuclear receptors.

关键词： Estrogen receptor Progesterone receptor isoforms Gerbil Stomach Sex steroid hormones

Classification of Some Nilpotent Class of Leibniz Superalgebras

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Acta Mathematica Sinica,English Series 2010年第5期26卷 799-816页

作者： Luisa M.camacho José R.GóMEZ Rosa M.NAVARRO Bakhrom A.OMIROV Dpto. Matemática Aplicada I Universidad de Sevilla Dpto. de Matemáticas Universidad de Extremadura Institute of Mathemátics and Information Technologues Uzbekistan Academy of Science

The aim of this work is to present the description of Leibniz superalgebras up to isomorphism with characteristic sequence （n｜m - 1, 1） and nilindex n ＋ m.

关键词： Lie superalgebras Leibniz superalgebras nilindex charasteristic sequence

Biliary acute pancreatitis:a review

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World Journal of Gastroenterology 2000年第2期6卷 157-168页

作者： osvaldo M.Tiscomia Susana Hamamura Enriqueta S.deLehmann Graciela Otero Hipolito Waisman Patricia Tiscornia-Wasserman Simmy Bank "Programade Estudios Pancreáticos" Hospital de ClínicasUniversidad de Bs.As.Argentina Centro de Investigaciones Pancreáticas"(CIP)Hospital de ClínicasUniv.de Buenos AiresArgentina Research Member of CONICETBuenos AiresArgentina "Programade Estudios Pancreáticos" Hospital de ClínicasUniversidad de Bs.As.Argentina "Centro de Investigaciones Pancreáticas"(CIP)Hospital de ClínicasUniv.de Buenos AiresArgentina "Programa de Estudios Pancreáticos" Hospital de ClínicasUniversidad de Bs.As.Argentina "Centro de Investigaciones Pancreáticas"(CIP)Hospital de ClínicasUniv.de Buenos AiresArgentina Chief of Cytology Department of PathologyLong Island Jewish Medical Center (LIJ) NYUSA Chief Department of Gastroenterology Long Island Jewish Medical Center (LIJ) NYUSA

INTRODUCTIONIt is axiomatic that the most effective and soundlybased plan of treatment of any disorder is one aimedat the mechanism or mechanisms responsible for *** basic notion,coupled withrecent reports in which,su... 详细信息

关键词： cholelithiasis/physiopathology pancreatitis/physiopathology bile reflux common bile duct sphincterotomy endoscopic

Geometrical quasi-ballistic effects on thermal transport in nanostructured devices

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Nano Research 2021年第4期14卷 945-952页

作者： Sami Alajlouni Albert Beardo Lluc Sendra Amirkoushyar Ziabari Javier Bafaluy Juan camacho Yi Xuan F.Xavier Alvarez Ali Shakouri Birck Nanotechnology Center Purdue UniversityWest LafayetteIndiana 47907USA Department of electrical and computer engineering Purdue UniversityWest LafayetteIndiana 47907USA Department of physics Universitat Autonoma de BarcelonaBellaterra 08193CataloniaSpain Oak Ridge National Laboratory Oak RidgeTennessee 37831USA R&D Staff Scientist ImagingSignals and Machine LearningTennessee 37831USA

We employ thermoreflectance thermal imaging to directly measure the steady-state two-dimensional(2D)temperature field generated by nanostructured heat sources deposited on silicon substrate with different geometrical configurations and characteristic sizes down to *** analysis of the results using Fourier's law not only breaks down as size scales down,but it alsofails to capture the impact of the geometry of the heat *** substrate effective Fourier thermal conductivities fitted to wire-shaped and circular-shaped structures with identical characteristic lengths are found to display up to 40%***,a hydrcxjynamic heat transport model reproduces the observed temperature fields for all device sizes and shapes using just intrinsic Si parameters,i.e.,a geometry and size-independent thermal conductivity and nonlocal length *** hydrodynamic model provides insight into the observed thermal response and of the contradictory Fourier *** discuss the substantial Silicon hydrodynamic behavior at room temperature and contrast it to InGaAs,which shows less hydrodynamic effects due to dominant phonon-impurity scattering.

关键词： phonon hydrodynamics nanoscale heat transfer quasi-ballistic transport silicon

Mössbauer Spectroscopic Characterization of Fe Occupation of Columns in the Nb₂₈O₇₀ Structure

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World Journal of Condensed Matter Physics 2023年第3期13卷 105-110页

作者： osvaldo F. Schilling Departamento de Fisica UFSC Florianópolis Brazil

In search of an experimental route to produce linear arrays of spins without the use of nanotechnological tools, we have doped Nb28O70 with small amounts of transition metal oxides (TM;in this case Fe2O3) or rare-earth oxides3, and investigated the location of the alien metal (Fe in this case) in the structure. Previous AC magnetic susceptibility measurements at low temperatures have been consistent with the formation of arrays of TM magnetic moments along the widely spaced columns parallel to the crystallographic b-axis in the Nb28O70 structure. To obtain further details about the TM distribution, the previous investigation has been extended now to include a room-temperature Mössbauer spectroscopic analysis of the Fe-doped material. The data are consistent with the presence of low-spin Fe3+ ions in both octahedral and tetrahedral coordinations of oxygens, and confirm (as suggested in the previous work) that Fe also interchanges positions with Nb ions located at tetrahedrally coordinated sites in the columns of the structure.

关键词： Mössbauer Spectroscopy Niobium Oxides Spin Arrays

Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide

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World Journal of Gastroenterology 2022年第26期28卷 3177-3200页

作者： María Belén Novoa Díaz Pedro Carriere Graciela Gigola Ariel osvaldo Zwenger Natalia Calvo Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Centro de Estudios Clínicos SAGA CEC SAGASantiago de Chile 8320000Chile

BACKGROUND Parathyroid hormone-related peptide(PTHrP)plays a key role in the development and progression of many *** found that in colorectal cancer(CRC)HCT116 cells,the binding of PTHrP to its receptor PTHR type 1(PTHR1)activates events associated with an aggressive *** HCT116 cell xenografts,PTHrP modulates the expression of molecular markers linked to tumor *** evidence suggests that the Met receptor is involved in the development and evolution of *** on these data,we hypothesized that the signaling pathway trigged by PTHrP could be involved in the transactivation of Met and consequently in the aggressive behavior of CRC *** To elucidate the relationship among PTHR1,PTHrP,and Met in CRC *** For in vitro assays,HCT116 and Caco-2 cells derived from human CRC were incubated in the absence or presence of PTHrP(1-34)(10-8 M).Where indicated,cells were pre-incubated with specific kinase inhibitors or dimethylsulfoxide,the vehicle of the *** protein levels were evaluated by Western blot ***-time polymerase chain reaction(RT-qPCR)was carried out to determine the changes in gene *** healing assay and morpho logical monitoring were performed to evaluate cell migration and changes related to the epithelialmesenchymal transition(EMT),*** number of viable HCT116 cells was counted by trypan blue dye exclusion test to evaluate the effects of irinotecan(CPT-11),oxaliplatin(OXA),or doxorubicin(DOXO)with or without *** in vivo tests,HCT116 cell xenografts on 6-wk-old male N:NIH(S)_nu mice received daily intratumoral injections of PTHrP(40μg/kg)in 100μL phosphate-buffered saline(PBS)or the vehicle(PBS)as a control during 20 *** slaughter was carried out and the tumors were removed,weighed,and fixed in a 4%formaldehyde solution for subsequent treatment by *** evaluate the expression of molecular markers in human tumor samples,we studied 23 specimens ob

关键词： PTHrP MET receptor tyrosine kinase Parathyroid hormone receptor type 1 Colorectal cancer Drug resistance