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Protein-assisted conjugated polymer microarray: Fabrication and sensing applications

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Chinese Science Bulletin 2013年第33期58卷 4039-4044页

作者： lü FengTing FENG Xuli lIU liBing WANG Shu Key laboratory of Organic Solids Institute of ChemistryChinese Academy of Sciences

A new strategy is performed to fabricate conjugated polymer microarray with the assistance of protein in this *** water-soluble cationic conjugated polymer employed in the present work is capable of absorbing light at 510 nm,which makes it compatible with a variety of commercial microarray *** is demonstrated that the protein-assisted conjugated polymer microarray exhibits higher fluorescence signal and better stability in comparison with the case without *** conjugated polymer microarray can be used for sensitive detection of picric acid(PA).A major advantage of our approach is its simplicity and chemical linking is not required between the conjugated polymer and microarray *** the simplicity of the preparation of the conjugated polymer microarray,it is anticipated that novel sensing platforms will be constructed by employing this versatile method.

关键词：共轭聚合物微阵列蛋白质传感制备应用聚合物芯片荧光信号

A FlEXIBlE PRECONDITIONED ARNOlDI METHOD FOR SHIFTED lINEAR SYSTEMS

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Journal of Computational Mathematics 2007年第5期25卷 522-530页

作者： G.-D. Gu X.-l. Zhou lei lin Department of Applied Mathematics Shanghai University of Finance and Economics Shanghai 200433 China Department of Mathematics Shanghai University Shanghai 200436 China

We are interested in the numerical solution of the large nonsymmetric shifted linear system, （A ＋ αI）x -= b, for many different values of the shift a in a wide range. We apply the Saad＇s flexible preconditioning technique to the solution of the shifted systems. Such flexible preconditioning with a few parameters could probably cover all the shifted systems with the shift in a wide range. Numerical experiments report the effectiveness of our approach on some problems.

关键词： Shifted linear systems 65F10 65Y20. Arnoldi method Flexible preconditioning

Multiple linear Regression Application on the Inter-Network Settlement of Internet

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The Journal of China Universities of Posts and Telecommunications 2006年第2期13卷 103-107页

作者： YANG Qing-feng ZHANG Qi-xiang lǖ Ting-jie School of Management and Economics Beijing University of Posts and Telecommunications Beijing 100876 P.R. China

This paper develops an analytical framework to explain the lnternet interconnection settlement issues. The paper shows that multiple linear regression can be used in assessing the network value of lnternet Backbone Providers （ IBPs）. By using the exchange rate of each network, we can define a rate of network value, which reflects the contribution of each network to interconnection and the interconnected network resource usage by each of the network.

关键词： multiple linear regression network value internet settlement

Peridynamic State-Based Models and the Embedded-Atom Model

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Communications in Computational Physics 2014年第1期15卷 179-205页

作者： Pablo Seleson Michael l.Parks Max Gunzburger Institute for Computational Engineering and Sciences 201 East 24th StStop C0200AustinTexas 78712-1229USA. Sandia National laboratories Computing Research CenterP.O.Box 5800MS 1320AlbuquerqueNM 87185-1320USA. Department of Scientific Computing 400 Dirac Science LibraryFlorida State UniversityTallahasseeFL 32306-4120USA.

We investigate connections between nonlocal continuum models and molecular dynamics.A continuous upscaling of molecular dynamics models of the form of the embedded-atom model is presented,providing means for simulating molecular dynamics systems at greatly reduced *** are presented for structured and structureless material models,supported by computational *** nonlocal continuum models are shown to be instances of the state-based peridynamics *** relating multibody peridynamic models and upscaled nonlocal continuum models are derived.

关键词： Peridynamics multibody potentials embedded-atom molecular dynamics.

Perspectives for the association between olfactory disturbances and depression in Parkinson's disease

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Neural Regeneration Research 2019年第4期14卷 591-592页

作者： Jessica l.Ilkiw Marcelo M.S.lima Neurophysiology laboratory Department of PhysiologyFederal University of Paraná

Non-motor disturbances in Parkinson’s disease:Globally,population aged 60 or over is growing and considering the World Bank predictions for the next 20 years it is expected that the number of Parkinson’s disease(PD)cases will double at the end of this period thus,reaching an impressive 13–39 million patients *** scenario is potentially associated with a significant global negative impact on public health systems particularly in countries with increased ageing populations such as the European countries,Asia and *** pathophysiology of PD involves the progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta(SNpc)that triggers denervation of the nigrostriatal pathway and consequent significant reduction of dopamine in the dorsal *** process leads to a critical motor impairment scenario characterized by bradykinesia,rigidity,resting tremor,and postural instability(Emamzadeh and Surguchov,2018).However,several other non-motor disturbances develop earlier,thus,being considered as prodromal signs of the *** this sense,the literature is increasingly emphasizing the importance of investigating mood and olfactory disruptions as high sensitive benchmarks of the early-phase *** fact,the need for innovative early-phase diagnostic tools,as well as the elucidation of the pathophysiological mechanisms of such disturbances,is essential priority in the field of investigation of ***,in the year of 2015,a woman was known for an intriguing ability of“smell PD”.Her husband had lived with the disease for twenty years and during this process she noticed that his odor slowly changed to a musky ***,this woman could associate this particular smell with PD after meeting different people with this distinct odor in a charity for PD *** fact,this clever observation is aligned with studies showing that hyposmia is found decades before the motor *** type of anecdotal story,

关键词： Parkinson olfactory disturbances association

Recruitment of older adults into randomized controlled trials:Issues and lessons learned from two community-based exercise interventions in Shanghai

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Journal of Sport and Health Science 2016年第3期5卷 308-314页

作者： lingyan Huang Jiaojiao lü Nan Chen Yu liu Key laboratory of Exercise and Health Sciences of Ministry of Education Shanghai University of Sport Department of Rehabilitation Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Background: With the increasing need for high-quality exercise interventions in China, relatively little is known about issues and challenges related to recruitment of older Chinese adults into exercise-based disease prevention interventions. This study aims to describe the recruitment process and outcomes of 2 exercise interventions conducted in Shanghai, ***: Recruitment information was ascertained from 2 community-based randomized controlled trials for 2 exercise interventions, the first designed to improve health outcomes for older women with knee osteoarthritis and the second to study changes in cognitive function in adults with mild cognitive impairment. Results were summarized in terms of recruitment sources, number screened, screening-to-enrollment ratios, and ***: Recruitment was primarily achieved through working with local residential divisions(i.e., neighborhood associations and residential committees). Both studies achieved their planned target number of older adults(45 and 46, respectively) within a 1-year time frame, with a screening-to-randomized ratio of 5:1 and demonstrated excellent retention rates(range 87%–93%) at 6 months. The recruitment cost for the 2studies averaged RMB 189(about USD 30) per initial recruit and RMB 738(about USD 119) per participant randomized. Some major issues encountered during the recruitment process included(1) the use of community neighborhoods to support the conduct of the projects,(2) access to participants, and(3) ***: Analysis of the 2 randomized controlled trials has provided valuable insights into the recruitment process and identified resources that can help better planning and recruitment for future interventions. Recommendations aimed at increasing the success of future recruitment efforts are provided.

关键词： Community stakeholders Exercise intervention Older adults Participant access Randomized controlled trial Recruitment

Algorithm for retrieving surface pressure from hyper-spectral measurements in oxygen A-band

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Chinese Science Bulletin 2014年第14期59卷 1492-1498页

作者： Hailei liu Minzheng Duan Daren l Yan Zhang Institute of Atmospheric Physics Chinese Academy of Sciences Chengdu University of Information Technology Beijing Institute of Remote Sensing Information Application

An algorithm for retrieving the surface pressure from oxygen A-band measurements in the future Chinese CO2satellite(CarbonSpec/TanSat)was *** ful physical radiative transfer model,vector radiative transfe model based on successive order of scattering,which i based on the successive order of scattering approach,wa used to simulate the measurements of CarbonSpec/TanSat as well as the kernel matrix in the inversion algorithm,and then the surface pressure and other related atmospheric parameters such as aerosol optical depth(AOD),surface albedo,and temperature were derived through optima estimation *** of the algorithm to surface albedo,solar zenith angle(SZA),viewing zenith angle(VZA),aerosol type,and AOD were investigated,and the results showed that the absolute error of retrieved surface pressure increases with decreasing surface albedo o increasing SZA and *** accuracy of\4 hPa ove bright surfaces(surface albedo C0.15)could be derived fo various SZAs and viewing ***,the algorithm can simultaneously retrieve the surface albedo AOD,and its vertical distribution indicated by scale

关键词：表面压力求逆算法光谱测量波段氧气检索气溶胶光学厚度地表反照率

Effect of sintering temperature on the preparation of Cu-Ti3 SiC2 metal matrix composite

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Progress in Natural Science:Materials International 2013年第1期23卷 70-76页

作者： Tungwai l.Ngai Wei Zheng Yuanyuan li National Engineering Research Center of Near-net-shape Forming Technology for Metallic Materials South China University of Technology

Ti3SiC2 has the potential to replace graphite as reinforcing particles in Cu matrix composites for applications in brush,electrical contacts and electrode *** this paper the fabrication of Cu-Ti3SiC2 metal matrix composites prepared by warm compaction powder metallurgy forming and spark plasma sintering(SPS) was *** stability of Ti3SiC2 at different sintering temperatures was also *** present experimental results indicate that the reinforcing particles in Cu-Ti3SiC2 composites are not stable at and above 800℃.The decomposition of Ti3SiC2 will lead to the formation of TiC and/or other carbides and *** purity is the major concern,the processing and servicing temperatures of the Cu-Ti3SiC2 composite should be limited to 750℃ or *** composites prepared by warm compaction forming and SPS sintering at 750℃ have lower density when compared with the composites prepared by SPS sintering at 950℃,but their electrical resistivity values are very close to each other and even lower.

关键词： Warm compaction Spark plasma sintering Electrical conductivity Mechanical property Impurity

Adaptive Bayesian Inference for Discontinuous Inverse Problems,Application to Hyperbolic Conservation laws

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Communications in Computational Physics 2014年第6期16卷 1-34页

作者： Alexandre Birolleau Gaël Poëtte Didier lucor CEA DAMDIFF-91297 ArpajonFrance. UPMC Univ Paris 06 UMR 7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance. CNRS UMR 7190Institut Jean Le Rond d’AlembertF-75005 ParisFrance.

Various works from the literature aimed at accelerating Bayesian inference in inverse *** spectral methods have been recently proposed as surrogate approximations of the forward uncertainty propagation model over the support of the prior *** representations are efficient because they allow affordable simulation of a large number of samples from the posterior ***,they do not perform well when the forward model exhibits strong nonlinear behavior with respect to its *** this work,we first relate the fast(exponential)l2-convergence of the forward approximation to the fast(exponential)convergence(in terms of Kullback-leibler divergence)of the approximate *** particular,we prove that in case the prior distribution is uniform,the posterior is at least twice as fast as the convergence rate of the forward model in those *** Bayesian inference strategy is developed in the framework of a stochastic spectral projection *** predicted convergence rates are then demonstrated for simple nonlinear inverse problems of varying *** then propose an efficient numerical approach for the Bayesian solution of inverse problems presenting strongly nonlinear or discontinuous system *** comes with the improvement of the forward model that is adaptively approximated by an iterative generalized Polynomial Chaos-based *** numerical approximations and predicted convergence rates of the former approach are compared to the new iterative numerical method for nonlinear time-dependent test cases of varying dimension and complexity,which are relevant regarding our hydrodynamics motivations and therefore regarding hyperbolic conservation laws and the apparition of discontinuities in finite time.

关键词： Stochastic inverse problems Bayesian inference iterative generalized Polynomial Chaos compressible gas dynamics.