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Operation of a Batch Stripping Distillation Column

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Chinese Journal of Chemical Engineering 2001年第2期9卷 141-144页

作者：许松林 JoseEspinosa HectorE.Salomone oscara.iribarren NationalEngineeringResearchCenterforDistillationTechnology TianjinUniversityTianjin300072China InstituteforDevelopmentandDesignINGAR ConicetSantaFeArgentina

A stripping batch distillation column is preferred when the amount of the light component in the feed is small and the products are to be recovered at high purity. The operation modes of a batch stripping are believed to be the same as those of a rectifier. However, the control system of a stripper is different. In this paper, we explore three different control methods with Hysys (Hyprotech Ltd. 1997) for a batch stripper. The main difference is the control scheme for reboiler liquid level: (a) controlled by reflux flow; (b) controlled by reboiler heat duty; (c) controlled by bottom product flow. The main characteristics of operating a batch stripper with different control scheme are presented in this paper. Guidelines are provided for the startup of a batch stripper, the effects of somecontrol tuning parameters on the column performance are discussed.

关键词： batch stripper control operation

Chemokines and Chemokine Receptors:Their Manifold Roles in Homeostasis and Disease

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Cellular & Molecular Immunology 2004年第2期1卷 95-104页

作者： Pablo iribarren Laboratory of Molecular Immunoregulation Center for Cancer ResearchNational Cancer Institute at FrederickFrederickMarylandUSA

Chemokines are a superfamily of small proteins that bind to G protein-coupled receptors on target cells and were originally discovered as mediators of directional migration of immune cells to sites of inflammation and *** recent years,it has become clear that the function of chemokines extends well beyond the role in leukocyte *** participate in organ development,angiogenesis/angiostasis,leukocyte trafficking and homing,tumorigenesis and metastasis,as well as in immune responses to microbial ***, chemokines and their receptors are important targets for modulation of host responses in pathophysiologicai conditions and for therapeutic intervention of human *** & Molecular Immunology.2004;1(2): 95-104.

关键词： chemokine receptor development leukocyte homing angiogenesis metastasis

The Essential Role of Phosphoinositide 3-Kinases(PI3Ks)in Regulating Pro-Inflammatory Responses and the Progression of Cancer

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Cellular & Molecular Immunology 2005年第4期2卷 241-252页

作者： Keqiang Chen Pablo iribarren Wanghua Gong Ji-Ming Wang School of Agriculture and Biology Shanghai Jiaotong University Shanghai 201101 China Laboratory of Molecular Immunoregulation Center for Cancer Research National Cancer Institute-Frederick Frederick MD 21702 USA Basic Research Program SAIC-Frederick National Cancer Institute at Frederick Frederick MD 21702 USA Laboratory of Molecular Immunoregulation Center for Cancer Research National Cancer Institute at Frederick Building 560 Room 31-40 Frederick MD 21702-1201 USA

Phosphoinositide 3-Kinases （PI3Ks） are proteins coupled to a variety of cell surface receptors and play a key role in signal transduction cascade regulating fundamental cellular functions such as transcription, proliferation, and survival. PI3Ks also are important in disease processes such as inflammation and cancer. The aim of this review is to outline current understandings of the PI3K family, mechanism of their activation, their role in inflammatory responses and the development of malignant tumors.

关键词： PI3K signal transduction inflammation malignant tumor

Tuning optical properties of ITO films grown by rf sputtering:Effects of oblique angle deposition and thermal annealing

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Transactions of Nonferrous Metals Society of China 2019年第12期29卷 2566-2576页

作者： L.G.DAZA M.ACOSTA R.CASTRO-RODRÍGUEZ A.iribarren Department of Applied Physics CINVESTAV-IPNUnity Mérida.97310 MéridaYucatánMéxico Materials Science Laboratory Faculty of EngineeringUniversity of YucatanCP 97130 MéridaYuc.México Instituto de Ciencia y Tecnología de Materiales Universidad de La HabanaZapata s/n esq.GVedadoPlazaLa Habana 10400Cuba

Indium tin oxide(ITO)thin films were prepared using the technique of rf-sputtering with oblique angle deposition(OAD).The films were as-deposited and thermally treated at 250℃.The combination of substrate inclination and annealing was used for modifying morphological and structural properties that lead to changes of the optical *** resulting films show morphology of tilted nanocolumn,fissures among columns,and structural *** as-deposited films are structurally disordered with an amorphous component and the annealed films are crystallized and more ordered and the film diffractograms correspond to the cubic structure of *** refractive index could be modified up to 0.3 in as-deposited films and up to 0.15 in annealed films as functions of the inclination angle of the ***,the band gap energy increases up to about 0.4 eV due to the reduction of the microstrain *** is found that the microstrain distribution,which is related to lattice distortions,defects and the presence of fissures in the films,is the main feature that can be engineered through morphological modifications for achieving the adjustment of the optical properties.

关键词： oblique angle deposition ITO thin films nanocolumnar morphology microstrain distribution optical properties

CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

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Cellular & Molecular Immunology 2019年第12期16卷 940-942页

作者： Joana Vitallé Iñigo Terrén Ane Orrantia Raquel Pérez-Garay Francesc Vidal JoséA.iribarren Carmen Rodríguez Ana M.López Lirola Enrique Bernal Olatz Zenarruzabeitia Francisco Borrego Immunopathology Group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Hospital Universitari de Tarragona Joan XXIII IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades Infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain Hospital Universitario de Canarias Santa Cruz de TenerifeSpain Department of Clinical Medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Natural killer(NK)cell-mediated antibody-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HIV)responses.1–3 CD300a is a surface receptor highly expressed on NK cells that has the capacity to inhibit NK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has been related to several viral infections and is able to diminish the NK cell killing of pseudorabies-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 In addition,CD300a expression on B and CD4+T lymphocytes is altered during HIV-1 infection,and combined antiretroviral therapy(cART)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on NK cells during HIV-1 infection is still *** have determined the surface expression of CD300a on different NK cell subsets and the capacity of this receptor to inhibit CD16-induced NK cell effector functions in healthy and HIV-1 infected individuals.

关键词： CD16 CD30 ADCC

Effect of substrate rotation speed on structure and properties of Al-doped ZnO thin films prepared by rf-sputtering

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Transactions of Nonferrous Metals Society of China 2017年第9期27卷 2055-2062页

作者： E.A.MARTíN-TOVAR L.G.DAZA A.J.R.LóPEZ-ARREGUíN A.iribarren R.CASTRO-RODRIGUEZ Departamento de Física Aplicada CINVESTAV-IPNUnidad Mérida Institut Supérieur de l’Aéronautique et de l’Espace (ISAE) Instituto de Ciencia y Tecnología de Materiales (IMRE) Universidad de La Habana

Al-doped ZnO(AZO)thin films were deposited on glass substrates by rf-sputtering at room *** effects of substrate rotation speed(ωS)on the morphological,structural,optical and electrical properties were *** transversal images show that the substrate rotation produces dense columnar structures which were found to be better defined under substrate *** images show that the surface particles of the samples formed under substrate rotation are smaller and denser than those of a stationary one,leading to smaller grain *** results show that all films have hexagonal wurtzite structure and preferred c-axis orientation with a tensile stress along the *** average optical transmittance was above90%in UV-Vis *** lowest resistivity value(8.5×10?3Ω·cm)was achieved atωS=0r/min,with a carrier concentration of1.8×1020cm?3,and a Hall mobility of4.19cm2/(V·s).For all other samples,the substrate rotation induced changes in the carrier concentration and Hall mobility which resulted in the increasing of electrical *** results indicate that the morphology,structure,optical and electrical properties of the AZO thin films are strongly affected by the substrate rotation speed.

关键词： AZO thin film rf-magnetron sputtering microstructure optoelectronic properties substrate rotation speed

Prevalence of refractive errors in Villa Maria,Córdoba,Argentina

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Eye Science 2016年第2期31卷 68-77页

作者： Victoria M.Sainchez Rafael iribarren Santiago G.Latino Victor E.Torres Anal L.Gramajo Maria N.Artal Maria B.Yadarola Patricia R.Garay Jose D.Luna Claudio P.Juarez Fundacion VER Centro Privado de Ojos RomagosaCordobaArgentina Department of Ophthalmology Centro Medico San LuisBuenos AiresArgentina CIES(Conicet y UNC) Facultad de Ciencias EconornicasUNCCordobaArgentina

Background:Refractive errors are among the most frequent reasons for demand of eye-care *** on refractive errors prevalence in our country are *** study has the purpose to assess the prevalence of refractive errors in an adult population of Villa Maria,Córdoba,***:The Villa Maria Eye Study is a population-based cross-sectional study conducted in the city of Villa Maria,Córdoba,Argentina from May 2008 to November ***’s aged 40+received a demographic interview and complete ophthalmological *** acuity was obtained with an ETDRS *** auto refraction was *** spherical equivalent was highly correlated between right and left eyes,so only data of right eyes are *** and hyperopia were defined with a±0.50 diopters(D)criterion and astigmatism>1 ***:This study included 646 subjects,aged 40 to 90(mean age:59.6±10.3 years old).Four hundred and sixty two(71.5%)were *** mean spherical equivalent was+0.714±2.41 D(range,-22.00 to+8.25 D)and the power of the cylinder was,on average,-0.869±0.91 D(range,0 to-6.50 D).In this sample,61.6%subjects were hyperopic,and 13.5%were *** prevalence was lower in men(9.8%versus14.9%)but this difference among genders was not statistically *** were 141 subjects(21.8%)with anisometropia greater than 1 D,and 168 subjects(26.0%)with astigmatism greater than 1 ***:The present study shows the prevalence of cycloplegic refractive errors in an adult population of *** prevalence of hyperopia was high,while myopia prevalence was very low.

关键词：屈光不正患病率玛丽亚阿根廷别墅平均年龄近视眼屈光度

G蛋白偶联甲酰化肽受体（FPR）在人恶性胶质瘤的快速生长中的作用:FPR促进胶质瘤细胞的成瘤性

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G蛋白偶联甲酰化肽受体（FPR）在人恶性胶质瘤的快速生长中的作用...

他汀类药物和β阻断剂治疗与冠心病初始表现之间的关系

第三届中国肿瘤学术大会

作者：卞修武周烨乐颖英龚旺华张夏 Pablo iribarren Rosalba Salcedo O.M.Zack Howard WilliamFarrar 王吉民第三军医大学西南医院病理学研究所第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院实验免疫学实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院基础研究计划室第三军医大学西南医院分子免疫调节实验室第三军医大学西南医院分子免疫调节实验室

目的:G蛋白偶联的甲酰化肽受体（FPR）最先被认为是表达于具有吞噬能力的白细胞一种高亲和性受体,与细菌趋化性肽FMLP结合。新近研究发现,FPR也可表达于非造血细胞并能被宿主源性配体所激活。但它在肿瘤细胞的功能性表达和作用尚不清楚... 详细信息

目的:G蛋白偶联的甲酰化肽受体（FPR）最先被认为是表达于具有吞噬能力的白细胞一种高亲和性受体,与细菌趋化性肽FMLP结合。新近研究发现,FPR也可表达于非造血细胞并能被宿主源性配体所激活。但它在肿瘤细胞的功能性表达和作用尚不清楚。本研究探讨FPR在胶质瘤生长和血管生成中的作用。方法:本研究首先采用免疫组织（细胞）化学和RT-PCR方法,检测不同分化程度的人胶质瘤组织和细胞系中FPR基因和蛋白表达;采用FMLP结合（激活）FPR后,用细胞趋化试验检测瘤细胞迁移情况,用Western免疫印迹、电泳运动漂移分析（EMSA）、ELASIA等技术检测细胞检测信号转导通路相关信号分子磷酸化改变、HIF1α和NFkB核转位、DNA-NFkB复合物形成以及VEGF产生。应用荧光显微分光技术检测Ca2+流变化,用流式细胞术检测细胞FPR,小管形成试验观察肿瘤细胞诱导内皮细胞HUVEC小管形成情况。用siRNA干扰胶质瘤细胞FPR的功能性表达,观察受干扰细胞在无胸腺裸小鼠的移植瘤形成和生长情况。结果:在人高度恶性的胶质瘤（WHO Ⅲ级和Ⅳ级）组织中的瘤细胞检测到了FPR表达,但在低级别（WHO Ⅱ级）胶质瘤表达阴性;体外研究结果与原位肿瘤相似,即,仅高度恶性起源的胶质瘤细胞系表达该受体（mRNA和蛋白）。激活胶质瘤细胞FPR后,瘤细胞的趋化运动增强,细胞信号转导MAPKs和PI3K通路激活,包括ERK1/2、JNK和Akt.快速磷酸化;FPR激活还诱导了NFkB核转位、形成了DNA-NFkB复合物,并刺激了HIF-1α核转位,使瘤细胞血管内皮细胞生长因子（VEGF）基因和蛋白表达增多。胶质母细胞瘤瘤细胞培养上清能诱导内皮细胞迁移和小管形成,而这种作用可被抗VEGF抗体阻断,提示FPR激活后瘤细胞所产生的VEGF在启动恶性胶质瘤的血管生成中有重要作用。进一步的体内实验显示,高表达FPR的胶质母细胞瘤细胞系U87接种到元胸腺裸小鼠后成瘤性和生长速率高于低表达FPR的SHG-44细胞。采用siRNA干扰FPR表达和功能后,肿瘤生长明显受抑制,进一步验证了上述结果。此外,本研究还证明,坏死的胶质瘤细胞释放出可激活存活胶质瘤细胞所表达的FPR的因子,提示FPR可能还是肿瘤微环境中FPR激动剂的感受器,以利肿瘤生长。结论:高度恶性的胶质瘤细胞表达功能性FPR,并对该瘤成瘤、生长和血管生成有促进作用密切关系。上述结果对于我们认识恶性胶质瘤侵袭生长和血管生成特性以及基于FPR设计治疗措施可能有重要意义。

关键词：胶质瘤坏死小干扰RNA (siRNA)血管生成趋化作用

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世界核心医学期刊文摘（心脏病学分册） 2007年第11期3卷 2-页

作者： Go A.S. iribarren C. Chandra M. 杜媛 Division of Research Kaiser Permanente of Northern California 2000 Broadway Street Oakland CA 94612-2304 United States Dr.

背景:冠状动脉粥样硬化可经数十年缓慢进展,但其常在临床上表现为突然的不稳定发作。表现为不稳定冠心病(如急性心肌梗死)的患者常与那些表现为相对稳定冠心病(如劳累型心绞痛)的患者有显著不同。

关键词：劳累型心绞痛 β阻断剂他汀类冠心病冠状动脉病药物