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The lymphocyte scavenger receptor CD5 plays a nonredundant role in fungal infection

Cellular & Molecular Immunology 2021年第2期18卷 498-500页

作者： María Velasco-de-Andrés Cristina Català Sergi Casadó-Llombart Inês Simões oscar zaragoza Esther Carreras Francisco Lozano Immunoreceptors of the Innate and Adaptive System Institut d’Investigacions Biomèdiques August Pi i Sunyer08036BarcelonaSpain Mycology Reference Laboratory National Centre for MicrobiologyInstituto de Salud Carlos III28220MajadahondaSpain Servei d’Immunologia Centre de Diagnòstic BiomèdicHospital Clínic de Barcelona08036BarcelonaSpain Departament de Biomedicina Universitat de Barcelona08036BarcelonaSpain

Invasive fungal diseases(IFD)impact morbidity,mortality,hospital stay and healthcare costs in critically ill patients,constituting an unmet medical need.1 Pathogenic fungi rarely cause IFD in immunocompetent individuals but become life-threatening in cases of immunodeficiency,young infants,disrupted mucosal barriers or polyantibiotic therapy,highlighting the role of immune surveillance in IFD control.^(2)

关键词： fungal mortality diseases

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Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia

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World Journal of Clinical Oncology 2014年第4期5卷 753-763页

作者： Kirvis Torres-Poveda Margarita Bahena-Román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales oscar Peralta-zaragoza Vicente Madrid-Marina Chronic Infection and Cancer Division Research Center on Infectious Diseases Instituto Nacional de Salud Pública 62100 Cuernavaca Morelos Mexico

Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(TGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. The effects of immunosuppressive cytokines on innate immune response, T-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and TGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. This review provides a comprehensive picture of the immunological functions of IL-10 and TGF-β1 in response to HPV in humans.

关键词： Cervical cancer Immunosuppression Interleukin-10 Transforming growth factor-β1 Human Papillomavirus

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An inter-laboratory study of DNA-based identity,parentage and species testing in animal forensic genetics

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Forensic Sciences Research 2022年第4期7卷 708-713页

作者： Sreetharan Kanthaswamy Torsten Brendel Luis Cancela Denise A.Andrade de Oliveira Bertram Brenig Carmen Cons Julian A.Crespi Markéta Dajbychová Andreas Feldl Tomohito Itoh Vincenzo Landi Amparo Martinez Malgorzata Natonek-Wisniewska Robert F.Oldt Anna Radko oscar Ramírez Clementina Rodellar Manuel Ruiz-Girón David Schikorski María Elena Turba Guillermo Giovambatista School of Mathematics and Natural Sciences Arizona State University(ASU)at the West CampusGlendaleAZUSA California National Primate Research Center University of CaliforniaDavisCAUSA Evolutionary Biology Graduate Program School of Life SciencesArizona State UniversityTempeAZUSA Eurofins Genomics Europe Applied Genomics GmbH EbersbergGermany IDENTITAS MontevideoUruguay Laboratório de Genética Escola de Veterinária da UFMGBelo HorizonteBrazil Institute of Veterinary Medicine University of GoettingenGoettingenGermany Facultad de Veterinaria Laboratorio de Genética Bioquímica(LAGENBIO)Instituto Agroalimentario de Aragón-IA2(Universidad de Zaragoza-CITA)ZaragozaSpain Facultad de Ciencias Veterinarias UNLP IGEVET-Instituto de Genética Veterinaria(UNLP-CONICET LAPLATA)La PlataArgentina Genomia s.r.o. PlzeňCzech Republic Maebashi Institute of Animal Science Livestock Improvement Association of Japan(LIAJ)MaebashiJapan Department of Veterinary Medicine Animal Breeding and GeneticsUniversity of Bari“Aldo Moro”ValenzanoItaly Department of Genetics Faculty of Veterinary SciencesUniversity of CórdobaCórdobaSpain Department of Animal Molecular Biology National Research Institute of Animal ProductionBalicePoland Vetgenomics SL BarcelonaSpain Laboratorio de Biología Molecular y Genómica Hispalis Biolab S.L.U.SevilleSpain Laboratoire LABOFARM-GENINDEXE LOUDEACCedexFrance Genefast SRL ForlìItaly

The probative value of animal forensic genetic evidence relies on laboratory accuracy and ***-laboratory comparisons allow laboratories to evaluate their performance on specific tests and analyses and to continue to monitor their *** International Society for Animal Genetics(ISAG)administered animal forensic comparison tests(AFCTs)in 2016 and 2018 to assess the limitations and capabilities of laboratories offering forensic identification,parentage and species determination *** AFCTs revealed that analyses of low DNA template concentrations(≤300 pg/μL)constitute a significant challenge that has prevented many laboratories from reporting correct identification and parentage ***,a lack of familiarity with species testing protocols,interpretation guidelines and representative databases prevented over a quarter of the participating laboratories from submitting correct species determination *** laboratories showed improvement in their genotyping accuracy over ***,the use of forensically validated standards,such as a standard forensic short tandem repeat(STR)kit,preferably with an allelic ladder,and stricter guidelines for STR typing,may have prevented some common issues from occurring,such as genotyping inaccuracies,missing data,elevated stutter products and loading *** AFCTs underscore the importance of conducting routine forensic comparison tests to allow laboratories to compare results from each *** should keep improving their scientific and technical capabilities and continuously evaluate their personnel’s proficiency in critical techniques such as low copy number(LCN)analysis and species *** this is the first time that the ISAG has conducted comparison tests for forensic testing,findings from these AFCTs may serve as the foundation for continuous improvements of the overall quality of animal forensic genetic testing.

关键词： Forensic sciences forensic genetics comparison test forensic DNA analysis individual identification parentage test species test

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