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Ligation-assisted endoscopic mucosal resection of gastric heterotopic pancreas

world Journal of Gastroenterology 2009年第22期15卷 2805-2808页

作者： Mouen A Khashab oscar w cummings John M Dewitt Division of Gastroenterology and Hepatology Department of MedicineIndiana University School of Medicine Department of Pathology Indiana University School of Medicine

Heterotopic pancreas is a congenital anomaly characterized by ectopic pancreatic *** of heterotopic pancreas may include expectant observation,endoscopic resection or *** aim of this report was to describe the technique of ligation-assisted endoscopic mucosal resection(EMR) for resection of heterotopic pancreas of the *** patients(both female,mean age 32 years) were referred for management of gastric subepithelial *** ultrasound in both disclosed small hypoechoic masses in the mucosa and *** ligation-assisted EMR was performed in both cases without *** from the resected tumors revealed heterotopic pancreas arising from the *** were free of pancreatic ***-assisted EMR is technically feasible and may be considered for the endoscopic management of heterotopic pancreas.

关键词： Endoscopic mucosal resection Endoscopic ultrasound Heterotopic pancreas

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Substantial hepatic necrosis is prognostic in fulminant liver failure

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world Journal of Gastroenterology 2017年第23期23卷 4303-4310页

作者： Paul Ndekwe Marwan S Ghabril Yong Zang Steven A Mann oscar w cummings Jingmei Lin Department of Pathology and Laboratory Medicine Indiana University School of Medicine Department of Internal Medicine Division of Gastroenterology and HepatologyIndiana University School of Medicine Department of Biostatistics Indiana University School of Medicine

To evaluate if any association existed between the extent of hepatic necrosis in initial liver biopsies and patient ***-seven patients with fulminant liver failure, whose liver biopsy exhibited substantial necrosis, were identified and included in the study. The histological and clinical data was then analyzed in order to assess the relationship between the extent of necrosis and patient survival, with and without liver transplantation. The patients were grouped based on the etiology of hepatic necrosis. Each of the etiology groups were then further stratified according to whether or not they had received a liver transplant post-index biopsy, and whether or not the patient *** core tissue length ranged from 5 to 44 mm with an average of 23 mm. Causes of necrosis included 14 autoimmune hepatitis, 10 drug induced liver injury (DILI), 9 hepatitis virus infection, and 4 unknown origin. Among them, 11 showed submassive (26%-75% of the parenchymal volume) and 26 massive (76%-100%) necrosis. Transplant-free survival was worse in patients with a higher extent of necrosis (40%, 71.4% and 100% in groups with necrosis of 76%-100%, 51%-75% and 26%-50%, respectively). Additionally, transplant-free survival rates were 66.7%, 57.1%, and 25.0% in groups of autoimmune hepatitis, DILI, and viral hepatitis, respectively. Even after liver transplantation, the survival rate in patients as a result of viral hepatitis remained the lowest (80%, 100%, and 40% in groups of autoimmune hepatitis, DILI, and viral hepatitis, respectively).CONCLUSIONAdequate liver biopsy with more than 75% necrosis is associated with significant transplant-free mortality that is critical in predicting survival.

关键词： Submassive necrosis Massive necrosis Fulminant liver failure Liver transplantation Biopsy Histopathology

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Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001

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world Journal of Gastroenterology 2009年第30期15卷 3767-3770页

作者： Omer Khalid Sofyan Radaideh oscar w cummings Michael J O'Brien John R Goldblum Douglas K Rex Department of Medicine Indiana University Medical CenterIndianapolisIN 46202United States Department of Pathology Indiana University Medical CenterIndianapolisIN 46202United States Department of Anatomic Pathology Boston University Medical CenterBostonMA 02118United States Department of Anatomic Pathology Cleveland ClinicClevelandOH 44195United States Division of Gastroenterology/Hepatology Indiana University Medical CenterIndianapolisIN 46202United States

AIM： To evaluate how proximal colon polyps interpreted as hyperplastic polyps in 2001 would be interpreted by expert pathologists in 2007.METHODS： ≥ 5 mm in interpreted pathologists 2007 by 3 GI Forty consecutive proximal colon polyps size, removed in 2001, and originally as hyperplastic polyps by general at Indiana University, were reviewed in pathologists.CONCLUSION： Many polyps interpreted as hyperplastic in 2001 were considered sessile serrated lesions by GI pathologists in 2007, but there is substantial inter-observer variation amongst GI pathologists.

关键词： Colonoscopy Colorectal polyps Hyperplasticpolyps Inter-observer variability Serrated adenomas Sessile serrated polyps

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Integrated sensing and delivery of oxygen for next- generation smart wound dressings

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Microsystems & Nanoengineering 2020年第1期6卷 991-1006页

作者： Manuel Ochoa Rahim Rahimi Jiawei Zhou Hongjie Jiang Chang Keun Yoon Dinesh Maddipatla Binu Baby Narakathu Vaibhav Jain Mark Michael Oscai Thaddeus Joseph Morken Rebeca Hannah Oliveira Gonzalo L.Campana oscar w.cummings Michael A.Zieger Rajiv Sood Massood Z.Atashbar Babak Ziaie School of Electrical and Computer Engineering Purdue UniversityWest Lafayette 47907 INUSA Birck Nanotechnololgy Center 1205W State StreetWest Lafayette 47907 INUSA School of Material Science Engineering Purdue UniversityWest Lafayette 47907 INUSA Electrical and Computer Engineering Department Western Michigan University4601 Campus Drive B-236Kalamazoo 49008 MIUSA School of Mechanical Engineering Purdue UniversityWest Lafayette 47907 INUSA Indiana University School of Medicine 980 West Walnut StreetBuilding R3 Room C634Indianapolis 46202 INUSA Department of Pathology and Laboratory Medicine Indiana University School of MedicineIU Health Pathology Laboratory350W 11th StreetRoom 4054IndianapolisIN 46202USA weldon School of Biomedical Engineering Purdue UniversityWest Lafayette 47907 INUSA Present address:Shenzhen MSU-BIT University ShenzhenChina

Chronic wounds affect over 6.5 million Americans and are notoriously difficult to *** oxygenation of the wound bed is one of the most critical and treatable wound management factors,but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable ***,we developed a low-cost alternative for continuous O 2 delivery and sensing comprising of an inexpensive,paper-based,biocompatible,flexible platform for locally generating and measuring oxygen in a wound *** platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology,inkjet ***,we demonstrate the functionality of the oxygenation patch,capable of increasing oxygen concentration in a gel substrate by 13%(5ppm)in *** platform is able to sense oxygen in a range of 5–26 *** vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.

关键词： patch smart printing

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