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The Adverse Event Profile in Patients Treated with Transferon<sup>TM</sup>(Dialyzable Leukocyte Extracts): A Preliminary Report

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Pharmacology & Pharmacy 2015年第2期6卷 65-74页

作者： Toni Homberg Violeta Sáenz Jorge Galicia-Carreón Iván Lara Edgar Cervantes-Trujano Maria C. Andaluz Erika Vera oscar Pineda Julio Ayala-Balboa Alejandro Estrada-García Sergio Estrada-Parra Mayra Pérez-Tapia Maria C. Jiménez-Martínez Clinical Trials Branch and Clinical Immunology Service Unit of External Services and Clinical Research (USEIC) National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Unit of Pharmacovigilance Unit of External Services and Clinical Research (USEIC) National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Department of Immunology National School of Biological Sciences National Polytechnic Institute Mexico City Mexico Unit of R&D in Bioprocesses (UDIBI) National School of Biological Sciences National Poly-technic Institute Mexico City Mexico Department of Biochemistry Faculty of Medicine National Autonomous University of Mexico Mexico City Mexico

Background: Dialyzable leukocyte extracts (DLE) are heterogeneous mixtures of peptides less than 10 kDa in size that are used as immunomodulatory adjuvants in immune-mediated diseases. TransferonTM is DLE manufactured by National Polytechnic Institute (IPN), and is registered by Mexican health-regulatory authorities as an immunomodulatory drug and commercialized nationally. The proposed mechanism of action of TransferonTM is induction of a Th1 immunoregulatory response. Despite that it is widely used, to date there are no reports of adverse events related to the clinical safety of human DLE or TransferonTM. Objective: To assess the safety of TransferonTM in a large group of patients exposed to DLE as adjuvant treatment. Methods: We included in this study 3844 patients from our Clinical Immunology Service at the Unit of External Services and Clinical Research (USEIC), IPN. Analysis was performed from January 2014 to November 2014, searching for clinical adverse events in patients with immune-mediated diseases and treated with TransferonTM as an adjuvant. Results: In this work we observed clinical nonserious adverse events (AE) in 1.9% of patients treated with TransferonTM (MD 1.9, IQR 1.7 - 2.0). AE were 2.8 times more frequently observed in female than in male patients. The most common AE were headache in 15.7%, followed by rash in 11.4%, increased disease-related symptomatology in 10%, rhinorrhea in 7.1%, cough in 5.7%, and fatigue in 5.7% of patients with AE. 63% of adverse event presentation occurred from day 1 to day 4 of treatment with TransferonTM, and mean time resolution of adverse events was 14 days. In 23 cases, the therapy was stopped because of adverse events and no serious adverse events were observed in this study. Conclusion: TransferonTM induced low frequency of nonserious adverse events during adjuvant treatment. Further monitoring is advisable for different age and disease groups of patients.

关键词： Dialyzable Leukocyte Extracts Adverse Events Monitoring Drug Safety Adjuvant Therapy Immunoregulation Guidelines Transfer Factor Pharmacovigilance

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盛夏方程式

现代装饰 2017年第7期 88-95页

作者： Cristina Celestino Ini Archibong Tadeas Podracky oscar Jaramillo Alain Gilles Mauricio Sanin Michael Geldmacher KARIMOKU NEW STANDARD LAMBERT MENU IDA ELKE 李薇 Kristina Dam Studio

每到夏天,脑海里时常回忆起儿时夏天的样子,呼呼转动的风扇,清凉的竹床,圆圆的西瓜,还有一群精力充沛的小伙伴,似乎那时的夏天不算炎热,似乎那时的盛夏更为欢乐有趣。不论是风扇、竹床,还是西瓜、蒲扇,这些夏天特有的物件让夏天也变得... 详细信息

每到夏天,脑海里时常回忆起儿时夏天的样子,呼呼转动的风扇,清凉的竹床,圆圆的西瓜,还有一群精力充沛的小伙伴,似乎那时的夏天不算炎热,似乎那时的盛夏更为欢乐有趣。不论是风扇、竹床,还是西瓜、蒲扇,这些夏天特有的物件让夏天也变得稍显清凉。记得曾经在网上看到一个有趣问答,问理想的夏天生活状态应该是怎样的？

关键词：小伙伴居家环境吹制视觉处理木质家具清透灵感来源管状结构清凉感金属结构

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Journal of Sport and Health Science 2021年第4期10卷 447-453页

作者： Kate Parker Anna Timperio Jo Salmon Karen Villanueva Helen Brown Irene Esteban-Cornejo Veronica Cabanas-Sánchez José Castro-Pinero David Sánchez-Oliva oscarL.Veiga School of Exercise and Nutrition Sciences Institute for Physical Activity and Nutrition(IPAN)Deakin UniversityGeelongVIC 3220Australia Centre for Urban Research School of Global Urban and Social StudiesRMIT UniversityMelbourneVIC 3000Australia Center for Cognitive and Brain Health Department of PsychologyNortheastern UniversityBostonMA 02115USA PROmoting FITness and Health through physical activity(PROFITH)research group Department of Physical Education and SportsFaculty of Sport SciencesUniversity of GranadaGranada 18010Spain Department of Physical Education Sports and Human MovementAutonomous University of MadridMadrid 28049Spain Research Centre in Physical Activity Health and Leisure(CIAFEL)Faculty of SportUniversity of PortoPorto 4099-002Portugal Department of Physical Education Faculty of Education SciencesUniversity of CadizPuerto Real 11003Spain Biomedical Research and Innovation Institute of Cadiz(INiBICA) Cadiz 11003Spain

Background:Children and adolescents can be distinguished by different typologies(clusters) of physical activity and sedentary *** physical activity and sedentary behaviors change over time within different typologies is not *** study examined longitudinal changes in physical activity and sedentary time among children and adolescents with different baseline typologies of activity-related ***:In this longitudinal study(3 annual time points) of children(n=600,age=9.2±0.4 years(mean±SD),50.3% girls) and adolescents(n=1037,age=13.6±1.7 years,48.4% girls),participants were recruited in Spain in *** class analyses identified typologies based on self-reported screen,educational,social and relaxing sedentary behaviors,active travel,muscle strengthening activity,and sport at *** each typology,linear mixed growth models explored longitudinal changes in accelerometer-derived moderate-to-vigorous physical activity and sedentary time,as well as time by class ***:Three typologies were identified among children( "social screenies",12.8%;"exercisers",61.5%;and "non-sporty active commuters",25.7%) and among adolescents "active screenies",43.5%;"active academics",35.0%;and "non-sporty active commuters",21.5%) at *** time increased within each typology among children and adolescents,with no significant differences between *** changes in physical activity were found in any typology among *** adolescents,physical activity declined within all typologies,with "non-sporty active commuters" declining significantly more than "active screenies" over 3 ***:These results support the need for interveation to promote physical activity and prevent increases in sedentary time during childhood and *** characterized as "non-sporty active commuters" may require specific interventions to maintain their physical activity over time.

关键词： Behavior change Physical activity Sedentary behavior Typologies Youth

Sexist Prejudice of Primary School Children in Different Urban and Rural Contexts of Spain

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Journal of Contemporary Educational Research 2018年第4期2卷 6-9页

作者： oscar Navarro Juana Maria Anguita Angel Luis Gonzalez Francisco Javier Sanchez-Verdejo Department of Pedagogy University of Castilla-La ManchaCiudad RealSpain

At present,a great deal of historical gender prejudice is still visible in *** is essential to eliminate these invisible barriers that impede achieving real equality between men and *** article seeks to provide a vision of the perception of primary school girls and boys regarding the masculine and feminine genders.A questionnaire was given to groups of schoolchildren in different locations,including rural areas and large cities such as Madrid,the capital of *** addition to detect prejudice toward one of the two genders,some of the most often repeated answers were taken into *** several occasions,one of the two sexes,or the two,was linked to intelligence or to the ideal of ***,differences were not observed in all *** are made on the most relevant data regarding the predisposition among children to link girls with more passive attitudes than *** many years,society has fought to achieve real equality between the two ***,there is still a great deal to be done,and the younger generations have the responsibility of succeeding in having the two sexes live together in a more egalitarian *** role of education is to encourage this process.

关键词： prejudices stereotype gender children primary school

Gamma-Irradiated Nylon Roughness as Function of Dose and Time by the Hurst and Fractal Dimension Analysis

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材料科学与工程（中英文版） 2010年第9期4卷 50-58页

作者： Carmina Menchaca Juan Carlos Nava Sofia Valdez oscar Sarmiento-Martinez Jorge Uruchurtu Centro de Investigacion en lngenieria y Ciencias Aplicadas （CllCAp） Universidad Autonoma del Estado de Morelos Cuernavaea Morelos 62209 Mexico

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4天大的斑马鱼幼苗(放大10倍)

飞碟探索 2017年第9期 4-4页

作者： oscar Ruiz

斑马鱼因全身布满多条深蓝色纵纹似斑马而得名。这种鱼的基因和人类有87％的高度同源性，早期发育与人类极为相似，这意味着其实验结果大多数情况下适用于人体，因此，常被用作研究相关疾病基因的模式生物。斑马鱼的繁殖为体外受精模式... 详细信息

斑马鱼因全身布满多条深蓝色纵纹似斑马而得名。这种鱼的基因和人类有87％的高度同源性，早期发育与人类极为相似，这意味着其实验结果大多数情况下适用于人体，因此，常被用作研究相关疾病基因的模式生物。斑马鱼的繁殖为体外受精模式，受精卵两三天就可以孵化。

关键词：斑马鱼大10 幼苗疾病基因早期发育模式生物体外受精深蓝色

Polymer Surface Roughness Determination throughout the Hurst Analysis from Optical Signal Measurements

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材料科学与工程（中英文版） 2010年第11期4卷 26-31页

作者： Antonio Marban oscar Sarmiento-Martinez Darwin Mayorga-Cruz Carmina Menchaca Jorge Uruchurtu Centro de Investigaciones en Ingenieria y Ciencias Aplieadas-CIICAp Av Universidad 1001 Chamilpa Cuernavaca MorelosMexico Universidad Autonoma Metropolitana- UAM Azcapotzalco Avenida del Rosario Azcapotzalco Mexico D.F.

A Bibliometric Analysis of the“NetZero”Process in the Energy Knowledge Domain

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Journal of Environmental Science and Engineering(A) 2023年第5期12卷 193-199页

作者： Carine Tondo Alves Luciano Sergio Hocevar Luis oscar Martins Rodrigo Santiago Coelho Instituto Nacional de Ciência e Tecnologia em Energia&Ambiente INCT E&A-UFBASalvadorBahia 40170-115Brazil Federal University of Reconcavo of Bahia Energy Engineering DepartmentFeira de SantanaBahia44085-132Brazil Federal University of Reconcavo of Bahia Production Engineering Department Feira de SantanaBahia44085-132Brazil SENAI CIMATEC Materials and Fabrication DepartmentSalvadorBahia41650-010Brazil

This work aimed to elucidate the key research findings within the realm of NetZero,specifically within the energy *** advanced data visualization tools,particularly VOSviewer,scientific maps were meticulously crafted to explain the evolving landscape of research in this *** results showed that the nations that most vigorously committed to the NetZero endeavor are the United Kingdom,United States,China,Australia,and Canada,signaling a global consensus on the urgency of addressing climate ***,this study reveals pivotal trends in the field and keywords such as“renewable energy”,“decarbonization”,“netzero”,and“sustainability”have gained remarkable prominence,especially in recent *** conclusion,this work offers a comprehensive overview of the NetZero landscape within the energy field,emphasizing the urgency of international collaboration,and identifies key trends that will likely shape the future of sustainable energy research and policymaking.

关键词： Netzero renewable energy decarbonization sustainability

Market Dynamics in Maize Production in the North Region of Mozambique

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Journal of Agricultural Science and Technology(B) 2022年第2期12卷 55-61页

作者： Sónia Maria Olímpio oscar de Araújo Ibraimo Teleha Chabite District Services of Economic Activities Meconta Provincial Services of Economic ActivitiesNampula 36Mozambique Faculty of Agriculture of Cuamba Catholic University of MozambiqueNiassa 22Mozambique Laboratory of Quality and Food Safety(LQSA) Lúrio Interdisciplinary Study Center(CEIL)Lúrio UniversityStreet No.4250Nampula 364Mozambique

In this article,a radiography of the agricultural sector is presented,specifically in the production of maize in the district of Malema,considering that the product is one of the most produced and consumed crops by the population in the province of *** agriculture productivity is attributed to inadequate access to production technology and inputs and to“weak”markets for agricultural products,due to poor infrastructure and inadequate access of agricultural producers to financial services(example credit).In general,several documents analyze on how small-scale agriculture has lacks of conditions,and factors necessary for high productivity and *** contrast,there is little information that gives an idea of the situation of agricultural maize production and existing agricultural markets and how this production and these markets are changing in Mozambique *** is,for example,a complete absence of references to large-scale investments in agriculture currently agreed with domestic and foreign trading *** to this omission,the author presents a partial analysis of the current context,and,therefore,it is not well explained how the greater investment can be directed to obtain greater use of productive technology and better access to the market,among small-scale *** seeks to analyze in more detail the situation“diagnosis”that is intended to be made on agriculture,specifically in the maize crop,and as a way to identify the specific aspects that can be considered starting points to work in the government intervention,in order to achieve the goals and increase agricultural productivity.

关键词： Maize production system family sector Mozambique