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A Multicenter Cohort Study for XELOX (Capecitabine, Leucovorin plus Oxaliplatin) Therapy as First-Line Treatment in Elderly Patients with Unresectable Colorectal Cancer

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Journal of Cancer Therapy 2015年第2期6卷 153-162页

作者： Tetsu Yamamoto Ryoji Hyakudomi Shinichi Sugimoto Atsuo Tokuka Yoshitoshi Sato Satoshi Nagai Hikota Hayashi Masahikoo Igarashi Kenji Takubo Yoshitsugu tajima Department of Digestive and General Surgery Faculty of Medicine Shimane University Izumo Japan Department of Surgery Shimane Prefectural Central Hospital Izumo Japan Department of Gastroenterological Surgery Matsue Red Cross Hospital Matsue Japan Department of Surgery National Hospital Organization Hamada Medical Center Hamada Japan Department of Surgery Masuda Medical Association Hospital Masuda Japan

Oxaliplatin-based chemotherapy with bevacizumab is now widely used for colorectal cancer patients. This study evaluated the efficacy and tolerability of XELOX (capecitabine + oxaliplatin + leucovorin combined) therapy with or without bevacizumab in elderly patients. One hundred and seven patients, consisting of 52 elderly (>70 years of age) and 55 non-elderly, with unresectable colorectal cancer were enrolled in this multicenter cooperative group study using a database between October 2009 and March 2012. We evaluated the outcomes in terms of the median time to treat failure (TTF), overall response rate (ORR), disease control rate (DCR) and tolerability in both age groups. The median TTF for the XELOX + bevacizumab regimen was 7.1 months in the non-elderly group and 8.1 months in the elderly group (p = 0.838). There was no significant difference in TTF between the two groups. The ORR and DCR in the non-elderly group were 30.8% and 73.1%, respectively. In the elderly group, the ORR was 40.0% and the overall DCR was 90.0%. No severe or uncontrollable adverse events were observed in the two groups. These data indicated that the XELOX chemotherapy with or without bevacizumab has an equivalent efficacy in both groups, without increasing the adverse events even in the elderly population.

关键词： Colorectal Cancer Oxaliplatin Capecitabine Bevacizumab Elderly Patients

亚甲基四氢叶酸还原酶基因C677T多态性与胃癌易感性的关系

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中华流行病学杂志 2002年第4期23卷 289-292页

作者：高长明吴建中丁建华刘燕婷臧宇李苏平苏平胡旭徐天亮 Takezaki Toshiro tajima Kazuo 江苏省肿瘤防治研究所流行病学研究室南京210009 淮安市卫生防疫站日本爱知县がんセンタ一研究所疫学预防部

目的　研究亚甲基四氢叶酸还原酶 (MTHFR)基因C6 77T多态性及其和烟酒嗜好相互作用与胃癌易感性的关系。方法　在上消化道癌高发区江苏省淮安市进行病例对照研究 (胃癌患者10 7例 ,对照人群 2 0 0名 ) ,调查研究对象的生活习惯 ,采用PCR... 详细信息

目的　研究亚甲基四氢叶酸还原酶 (MTHFR)基因C6 77T多态性及其和烟酒嗜好相互作用与胃癌易感性的关系。方法　在上消化道癌高发区江苏省淮安市进行病例对照研究 (胃癌患者10 7例 ,对照人群 2 0 0名 ) ,调查研究对象的生活习惯 ,采用PCR RFLP技术检测研究对象的MTHFR基因型。结果　①胃癌组中MTHFR变异基因型拥有者的比例为 79.4 % ,显著高于对照组的 6 8.5 %(χ2 =4 .15 ,P =0 .0 4 16 )。MTHFR变异基因型拥有者发生胃癌的危险性显著升高 (OR =1.78,95 %CI :0 .99～ 3.2 2 ;性别和年龄调整OR =1.89,95 %CI:1.0 8～ 3.32 )。②在MTHFR变异基因型拥有者中 ,伴有吸烟习惯者发生胃癌的OR为 7.72 (95 %CI:2 .2 3～ 2 6 .79) ,伴有经常饮酒习惯者发生胃癌的OR为 3.0 8(95 %CI :1.30～ 7.2 3)。与不吸烟、不经常饮酒的野生型纯合子MTHFR基因型拥有者相比 ,伴有吸烟和经常饮酒习惯的MTHFR变异基因型拥有者发生胃癌的OR为 13.96 (95 %CI :2 .76～ 70 .4 6 )。结论　MTHFRC6 77T变异基因型与胃癌的易感性有关 ;

关键词：亚甲基四氢叶酸还原酶胃癌易感性 C677T基因基因多态性危险因素基因变异

Intraperitoneal Chemotherapy as a Multimodal Treatment for Gastric Cancer Patients with Peritoneal Metastasis

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Journal of Cancer Therapy 2013年第9期4卷 6-15页

作者： Sachio Fushida Katsunobu Oyama Jun Kinoshita Tomoya Tsukada Kouichi Okamoto Hidehiro tajima Itasu Ninomiya Hirohisa Kitagawa Takashi Fujimura Tetsuo Ohta Department of Gastroenterological Surgery Kanazawa University Hospital Kanazawa Japan

Peritoneal metastasis of gastric cancer is mainly caused by the dispersion of free cancer cells from the serosal surface of the invaded stomach, from surgically transected lymphatic channels, and from tumor cell-containing blood from the primary lesion into the peritoneal cavity. Intraperitoneal chemotherapy (IPC) combined with surgery has performed for the prevention and treatment of peritoneal metastasis in gastric cancer. The efficacy of this technique is influenced by the pharmacokinetic advantage achievable with the anticancer drug, timing of administration, combination with hyperthermia, and tumor volume. The pharmacokinetic advantage for peritoneal cavity exposure relative to peripheral circulation by intraperitoneal delivery for drugs including cisplatin (10-fold advantage), mitomycin C (20- to 30-fold advantage), docetaxel (500-fold advantage), and paclitaxel (1000-fold advantage) has been confirmed. To avoid uneven drug distribution in the peritoneal cavity and the re-growth of residual tumor, it seems to be reasonable to perform IPC perioperatively;however, early perioperative intraperitoneal chemotherapy (EPIC) has a relatively high morbidity rate compared with intraoperative IPC. Hyperthermia has both cytotoxicity of itself and a synergistic effect with anticancer drugs, especially mitomycin C. In the adjuvant setting, patients with either hyperthermic intraperitoneal chemotherapy (HIPEC) or EPIC showed a significant improvement of survival compared to those with surgery alone. In addition, extensive intraoperative peritoneal lavage (EIPL) seems also to be a reasonable method to reduce free cancer cells in the peritoneal cavity. For the treatment of peritoneal metastasis, cytoreductive surgery which achieves R0 or R1 resection followed by IPC has demonstrated a survival benefit, whereas gross residual tumor (R2) treated by IPC has shown poor prognosis. Extensive cytoreductive surgery, such as peritonectomy, followed by IPC achieved long-term survival fo

关键词： Peritoneal Metastasis Gastric Cancer Intraperitoneal Chemotherapy

亚甲基四氢叶酸还原酶基因多态性与胃癌化疗的敏感性关系的研究

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中华流行病学杂志 2004年第12期25卷 1054-1058页

作者：高长明陆建伟 Takezaki Toshiro 吴建中曹海霞陈环球冯继锋 tajima Kazuo 江苏省肿瘤防治研究所南京210009 ■研究所疫学预防部

目的研究亚甲基四氢叶酸还原酶(MTHFR) 因C677T、A1298C多态与胃癌患者对5-FU为基础的化疗敏感性和毒性的关系。方法收集经病理学确诊的晚期胃癌患者75例,病例化疗前均抽静脉血,提取白细胞DNA,用聚合酶链反应-限定性片段长度多态性技... 详细信息

目的研究亚甲基四氢叶酸还原酶(MTHFR) 因C677T、A1298C多态与胃癌患者对5-FU为基础的化疗敏感性和毒性的关系。方法收集经病理学确诊的晚期胃癌患者75例,病例化疗前均抽静脉血,提取白细胞DNA,用聚合酶链反应-限定性片段长度多态性技术检测MTHFR基因型。所有患者经5-FU为基础的化疗方案治疗。结果 (1)在75例晚期胃癌患者中,MTHFR C677TC／C、C／T、T／T基因型者分别为24例(32.0％)、33例(44.0％)和18例(24.0％);MTHFR A1298CA／A、A／C、C／C基因型者分别为52例(69.3％)、22例(29.3％)和1例(1.3％);经化疗后22例患者有效,总有效率29.3％。(2)MTHFR C677T T／T基因型者化疗的有效率为83.3％,显著高于T／C基因型者(15.2％,x2=22.27,P=0.000)和C／C基因型者(8 3％,x2=23.44,P=0.000)。C677T T／T基因型患者化疗敏感性是携带C677T C等位基因者的7.64倍(调整了性别、年龄、以往辅助化疗史及化疗方案,95％CI:3.14-18.62)。MTHFR A1298C A／A基因型者的有效率(36.5％),显著高于携带A1298C C(13.0％)等位基因者(x2=4 19,P=0.041;调整OR=3 75,95％CI:0.94-14.87)。同时携带MTHFR C677T T／T基因型和A1298C A／A基因型者化疗的有效率(86.7％)显著高于其他基因型者(15.0％,Fisher's exact:P=0.000,调整OR=6.57.

关键词： C677T MTHFR 化疗方案患者晚期胃癌携带 C基因基因型多态性治疗

<i>Wrinkled</i>1 (WRI1) Homologs, AP2-Type Transcription Factors Involving Master Regulation of Seed Storage Oil Synthesis in Castor Bean (<i>Ricinus communis</i>L.)

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American Journal of Plant Sciences 2013年第2期4卷 333-339页

作者： Daichi tajima Ayami Kaneko Masatsugu Sakamoto Yumena Ito Nong Thi Hue Masayuki Miyazaki Yushi Ishibashi Takashi Yuasa Mari Iwaya-Inoue Department of Bioresource Sciences Faculty of Agriculture Kyushu University Fu- kuoka Japan Department of Bioresource Sciences Faculty of Agriculture Kyushu University Fu- kuoka Ja-pan Fukuoka Agricultural Re- search Center Chikushino Japan Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University Fukuoka Japan

Among APETALA2 (AP2)-type plant specific transcription factor family, WRINKLED1 (WRI1), has appeared to be a master gene transcriptionally regulating a set of carbon metabolism- and fatty acid synthesis (FAS)-related genes responsible for seed specific triacylglycerols (TAGs) storage in oil plants. B3 type transcription factors, such as ABI3 and FUS3, are known to be involved in seed development, such as seed storage protein synthesis and maturation. Based on the recent whole genome sequence data of castor bean (Ricinus communis L.), putative WRI1 homologs (RcWRI1, RcWRI2) specifically expressed in castor bean seed have been identified by comparing organ specific expression profiles among seed development-related transcription factors, seed storage specific genes (Ricin, RcOleosin) and a set of FAS genes including genes for sucrose synthase (RcSUS2), biotin carboxyl carrier protein (a subunit of acetyl-CoA carboxylase, RcBCCP2) and ketoacyl-acyl carrier protein synthase (RcKAS1). Immunoreactive signals with WRI1, FUS3 and ABI5-related polypeptides were also detected in seed specifically, consistent with the expression profiles of seed development-related genes. The WRI1 binding consensus sites, [CnTnG](n)(7)[CG], designated as the AW-box, were found at the promoter region of RcBCCP2 and RcKAS1. Thus, RcWRI1 possibly play a pivotal role in seed specific TAGs storage during seed development by directly activating FAS -related genes.

关键词： AP2 Castor Bean Fatty Acid Oil Seed Ricinus communis L. Transcription Factor WRI1

Ascertainment Corrected Prevalence Rate (ACPR) of Leukopenia in Workers Exposed to Benzene in Small-Scale Industries Calculated With Capture-Recapture Methods

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Biomedical and Environmental Sciences 1995年第1期8卷 30-34页

作者： XIA ZHAO-LIN JIN XI-PENG LU PEI-LIAN GU XUE-QI RONALD E.LAPORTE AND NAOKO tajima(School of Public Health, Post Box 203, Shanghai Medical University,Shanghai 200032, China Department of Epidemiology, Graduate School of Public Health, University of Pit School of Public Health Shanghai Medical University China.

ACPRs of leukopenia in peripheral blood of workers exposed to benzene in small-scale industries are calculated using capture-recapture methods. The results from two figures with 6-month apart demonstrate that the ACPR in workers exposed to benzene is 36.81(29. 14-44.48)%, significantly higher than that of control 12.71(7.20-18.22)% (P<0.05),with a relative risk of 2.9. The prevalences of 4 cross-sectional investigations in exposure group calculated with routine method are 18.73%, 26.37%, 27.93%, and 36.76% respectively;in controls, 8.38%, 6.85%, 7.94%, and 15.00% respectively and all fall in the range of 95% CI of ACPR. It is suggested that the methods of calculating ACPR by capture-recapture methods is simple, feasible and efficient, with the results more precise than with traditional methods.

关键词： ACPR of Leukopenia in Workers Exposed to Benzene in Small-Scale Industries Calculated With Capture-Recapture Methods

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肺癌危险因素──在日本大坂进行的追踪研究

中华流行病学杂志 1997年第6期18卷 328-330页

作者：富永佑民 ToshiroTakezaki Kazuotajima 爱知县肿瘤研究所 DivisionofEpidemlology AichiCancerCenterResearchInstitute

在日本大坂进行了以人群为基础和环境因素与肺癌关系的追踪研究，研究对象为２４４８９名年龄在４０岁以上的居民。基本调查于１９８５年开始，以调查对象本人所填写的问卷为基础，在已进行的１０年追踪中，有１６１例为新发现的肺癌病... 详细信息

在日本大坂进行了以人群为基础和环境因素与肺癌关系的追踪研究，研究对象为２４４８９名年龄在４０岁以上的居民。基本调查于１９８５年开始，以调查对象本人所填写的问卷为基础，在已进行的１０年追踪中，有１６１例为新发现的肺癌病例。分析了各种环境因素与肺癌的关系，结果发现吸烟与肺癌有病因学联系。

关键词：吸烟危险因素肺肿瘤

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重庆地区人群半定量食物频数问卷的研制

第三军医大学学报 2003年第19期25卷 1701-1705页

作者：周紫垣王文昌孙华明孙立平陈国华 Toshiro Takezaki Kazuo tajima 曹佳第三军医大学军事预防医学院卫生毒理学教研室重庆400038 第三军医大学军事预防医学院卫生统计学教研室重庆400038 Division of pidemiology and Prevention Aichi Cancer Center Research InstituteNagoyaJapan Division of Epidemiology and Prevention Aichi Cancer Center Research InstituteNagoyaJapan

目的　制订适用于对重庆城乡成年人群进行膳食营养概况分析的半定量食物频数问卷 (SQFFQ)。方法　采用 3日食物称量法对重庆城、乡成年人群进行膳食调查 ;采用累积百分贡献率 (CA)和多元回归 (MRA)两种方法分析 3 5种营养素与食物之间关... 详细信息

目的　制订适用于对重庆城乡成年人群进行膳食营养概况分析的半定量食物频数问卷 (SQFFQ)。方法　采用 3日食物称量法对重庆城、乡成年人群进行膳食调查 ;采用累积百分贡献率 (CA)和多元回归 (MRA)两种方法分析 3 5种营养素与食物之间关系 ,分别选出累积百分贡献率达 90 %以上或累积R2 达 0 .90以上的食物进入SQFFQ ;进一步合并城市和农村的SQFFQ ,制订最终能涵盖重庆城乡的SQFFQ。结果　重庆城市和农村地区人群能量、蛋白质、碳水化合物等主要营养素摄入的差异不显著 ,但农村人群脂肪摄入明显高于城市人群。在选入合并SQFFQ的 119种食物中 ,78种为城乡共有 ,2 2种为城市独有 ,6种为农村独有。最终制订的SQFFQ的营养素覆盖率有 3 3种在城、乡都达到了 90 %以上。结论　所制订的SQFFQ能较好地覆盖重庆地区人群的营养谱。

关键词：营养素摄入半定量食物频数问卷(SQFFQ)

亚甲基四氢叶酸还原酶基因1298A→C多态与食管癌易感性关系的病例对照研究

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中华流行病学杂志 2004年第4期25卷 341-345页

作者：高长明 Takezaki Toshiro 吴建中曹海霞刘燕婷丁建华李苏平苏平胡旭开海涛 tajima Kazuo 江苏省肿瘤防治研究所流行病学研究室南京210009 日本爱知县がんセンター研究所疫学预防部淮安市楚州区卫生防疫站

目的研究亚甲基四氢叶酸还原酶(MTHFR)基因1298A→C多态及其和生活习惯相互作用与食管癌易感性的关系.方法在食管癌高发区的淮安市楚州区开展了一项病例对照研究(食管癌患者141例,人群对照228名), 调查研究对象的生活习惯,采用聚合酶链... 详细信息

目的研究亚甲基四氢叶酸还原酶(MTHFR)基因1298A→C多态及其和生活习惯相互作用与食管癌易感性的关系.方法在食管癌高发区的淮安市楚州区开展了一项病例对照研究(食管癌患者141例,人群对照228名), 调查研究对象的生活习惯,采用聚合酶链反应-限制性片段长度多态性技术检测研究对象的MTHFR 1298A→C基因型.结果①食管癌组中MTHFR 1298 AA、AC和CC基因型携带者的比例分别为 63.8%、 34.0%和 2.1%, 与对照组的 71.9%、 28.1%和 0.0%相比,差异有统计学意义( χ2MH= 6.69, P= 0.035).②在MTHFR 1298C等位基因携带者中,伴有吸烟习惯者发生食管癌的调整OR为 3.48(95%CI: 1.57～ 7.71),伴有经常饮酒的习惯者发生食管癌的调整OR为 2.91(95%CI: 1.20～ 7.08),无饮茶习惯者发生食管癌的调整OR为 3.52(95%CI: 1.64～ 7.54).MTHFR 1298AC和CC基因型与吸烟、饮酒和不饮茶在食管癌发生中的相互作用系数r分别为 3.05、 3.69和 6.30.结论 MTHFR 1298AC和CC基因型对吸烟、饮酒和不饮茶增加食管癌发生风险的作用有明显的放大效应.

关键词：亚甲基四氢叶酸还原酶基因 1298A→C多态食管癌易感性病例分析