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Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori Kondo Takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

In-silico clearing approach for deep refractive index tomography by partial reconstruction and wave-backpropagation

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Light(Science & Applications) 2023年第5期12卷 877-893页

作者： osamu Yasuhiko Kozo Takeuchi Central Research Laboratory Hamamatsu Photonics K.K5000 HirakuchiHamakita-kuHamamatsu 434-8601 ShizuokaJapan

Refractive index(RI)is considered to be a fundamental physical and biophysical parameter in biological imaging,as it governs light-matter interactions and light propagation while reflecting cellular *** tomography enables volumetric visualization of RI distribution,allowing biologically relevant analysis of a ***,multiple scattering(MS)and sample-induced aberration(SIA)caused by the inhomogeneity in RI distribution of a thick sample make its visualization *** paper proposes a deep RI tomographic approach to overcome MS and SIA and allow the enhanced reconstruction of thick samples compared to that enabled by conventional linear-model-based RI *** proposed approach consists of partial RI reconstruction using multiple holograms acquired with angular diversity and their backpropagation using the reconstructed partial RI map,which unambiguously reconstructs the next partial *** this operation efficiently reconstructs the entire RI tomogram while suppressing MS and *** visualized a multicellular spheroid of diameter 140μm within minutes of reconstruction,thereby demonstrating the enhanced deep visualization capability and computational efficiency of the proposed method compared to those of conventional RI ***,we quantified the high-RI structures and morphological changes inside multicellular spheroids,indicating that the proposed method can retrieve biologically relevant information from the RI *** from the excellent biological interpretability of RI distributions,the label-free deep visualization capability of the proposed method facilitates a noninvasive understanding of the architecture and time-course morphological changes of thick multicellular specimens.

关键词： properties refractive overcome

Roles of dopaminergic receptors in bladder and erectile function at the spinal level

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Asian Journal of Andrology 2002年第4期4卷 287-290页

作者： osamu Ishizuka Hiroya Mizusawa osamu Nishizawa Department of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390-8621 JapanDepartment of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390-8621 JapanDepartment of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390-8621 Japan

1 Introduction At the spinal level, the dopaminergic, the α1adrenergic and the neurokinin receptors play definite roles in the micturition control. From the anatomical point of view, the spinal center of micturition is located close to the center of erectile function. Recently, apomorphine is used for the treatment of erectile dysfunction and its mechanism of action is considered to be mainly through the central nervous system. 2 Dopaminergic receptors and bladder function at the spinal level

关键词： apomorphine penile erection micturition spinal cord

Effects of estradiol-17β and bisphenol A administered chronically to mice throughout pregnancy and lactation on the male pups＇ reproductive system

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Asian Journal of Andrology 2008年第2期10卷 271-276页

作者： Atsushi Okada osamu Kai College of Bioresource Sciences Nihon University Fujisawa 252-8510 Japan

Aim： To assess the effect of estradiol-17β （E2） and bisphenol A （BPA） administered chronically by implanting a silicone tube throughout pregnancy and lactation on male pups＇ reproductive system in ICR mice. Methods： Female mice were implanted with a tube filled with 10 ng, 500 ng, 1 μg, or 10 μg of E2, or 100 μg or 5 mg of BPA, before mating. The tube was kept in the mice throughout pregnancy and lactation, until the pups had weaned at 4 weeks of age. During the period, E2 was released from the tube at 120 pg or 6, 12 or 120 ng/day, and BPA at 1.2 or 60 μg/day. Results： Most of the mice given 1 μg and 10 lag of E2 did not maintain their pregnancy. However, the other groups showed high rates of birth, more than 70%. At age of 4 weeks, the male pups were killed. Body weight and reproductive organ weights （testes, epididymides and accessory reproductive glands） in the treated groups did not differ from the control values, whereas the percentage of seminiferous tubules in the testis with mature spermatids was significantly lower in the groups given 10 ng and 500 ng of E2 and 5 mg of BPA than that in the control. Conclusion： Chronic exposure to E2 and BPA might disrupt spermatogenesis in male pups. （Asian JAndrol 2008 Mar; 10： 271-276）

关键词： estradiol-17β bisphenol A chronic administration silicone tube spermatogenesis ICR mice

Expulsion of geopressured hydrothermal system along active faults and its relation to the occurrence of earthquakes in the Shinanogawa seismic belt, Japan

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Science China Earth Sciences 2005年第2期48卷 273-281页

作者： Yasue Oki osamu Sato Research Institute for Hazards in Snowy Areas Niigata University Niigata 950-2181JapanResearch Institute for Hazards in Snowy Areas Niigata UniversityNiigata 950-2181Japan

The 1995 Northern Niigata Earthquake (M 6.0) occurred at a shallow depth in the Niigata seismic gap. The anomaly areas in temperature, electrical conductivity and Cl- concentration of groundwater trend northeast as linear distribution in the epicentral area and are approximately coincident with the area of the seismic intensity 6 (JMA scale). The distributions of seismic intensity 6 and groundwater anomalies convincingly imaged the presence of a buried active fault beneath the epicentral area. The occurrence of this earthquake and the anomalies of groundwater were related to the expulsion of geopressured hydrothermal system (GHS). All epicenters of the destructive earthquakes along the Shinanogawa seismic belt are actually located in the buried active fault zones characterized by the areas of temperature and geochemical anomalies of groundwater. These earthquakes might have been triggered by the activity of GHS. The expulsion of GHS along an active fault in combination with the thermal softening of fault zone attributed to high rock temperature may reduce fracture strength of the rock, and trigger earthquake occurrence. The dimension of the anomaly area of groundwater temperature at the epicentral area reflected the scale of the earthquake fault. The linear anomaly areas of groundwater resulting from the expulsion of GHS and having no historical destructive earthquake are of the predicated areas of future destructive earthquakes. Monitoring of groundwater conditions in these areas may provide useful information regarding the future occurrence of earthquakes.

关键词： Shinanogawa seismic belt, 1995 Northern Niigata Earthquake, geopressured hydrothermal system (GHS),buried active fault, expulsion of GHS.

Role and limitations of rehabilitation-induced neural network remodeling after stroke

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Neural Regeneration Research 2018年第12期13卷 2087-2088页

作者： Naohiko Okabe osamu Miyamoto Second Department of Physiology Kawasaki Medical School

There is plenty of evidence that proves the beneficial and reliable effects of rehabilitation therapy,making it the most common treatment for patients with chronic *** is believed that rehabilitation improves functional recovery through neural network remodeling,which is observed as a motor map reorganization or functional connectivity change assessed by intracortical microstimulation or functional magnetic resonance imaging（MRI）.

关键词： Role and limitations of rehabilitation-induced neural network remodeling after stroke

Natural history of chronic hepatitis C in patients on hemodialysis: Case control study with 4-23 years of follow-up

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World Journal of Gastroenterology 2004年第15期10卷 2209-2212页

作者： Kunio Okuda osamu Yokosuka Department Medicine and Clinical Oncology Graduate School of MedicineChiba UniversityChiba 260-8670Japan

AIM:Hepatitis C virus(HCV)infection is very common among end-stage kidney disease patients on hemodialysis,but its natural history is not known. METHODS:In this study,189 dialysis patients(case) positive for HCV antibodies who were followed up for more than 4 years were compared with twice as many sex/age matched controls with chronic hepatitis C who were diagnosed in the same month as the case and followed up for comparable *** longest follow-up was 23 years in dialysis cases. The disease activities were graded into'asymptomatic'if ALT was less than 40(35 in cases)IU/L,'low activities'if ALT was 40(35)-79 IU/L,and'high activities'if ALT was above 80 IU/L during the last or latest 4 year period. RESULTS:All 25 dialysis cases who were followed up for more than 15 years were asymptomatic and 15 of them were negative for HCV *** the 50 controls followed up for more than 15 years,34 had high activities,and none deared HCV *** were 60 controls who were asymptomatic, but they were all positive for HCV RNA,while 22.3% of asymptomatic dialysis cases were RNA *** dialysis patients with chronic hepatitis C progressed to cirrhosis, whereas the disease progressed to cirrhosis in more than one quarter of the *** differences were highly significant(P<0.0001). CONCLUSION:Chronic hepatitic C among hemodialysis patients is mild in disease activity,and is not progressive, perhaps due to immunological abnormalities in these patients. Hepatic C virus is frequently cleared in asymptomatic dialysis patients during a long course.A possible mechanism for viral clearance is viral particle destruction on the surface of the dialyzer membrane.

关键词： Renal Dialysis Adult Aged Aged, 80 and over Case-Control Studies DNA, Viral Female Follow-Up Studies Hepacivirus Hepatitis C, Chronic Humans Male Middle Aged

Animal models for studying penile hemodynamics

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Asian Journal of Andrology 2002年第3期4卷 225-228页

作者： Hiroya Mizusawa osamu Ishizuka osamu Nishizawa Department of Urology National Nagano Hospital 1-27-21 Midorigaoka Ueda 386 0022 JapanDepartment of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390 8621 JapanDepartment of Urology Shinshu University School of Medicine 3-1-1 Asahi Matsumoto 390 8621 Japan

Animal models for the study of erectile function monitoring the changes in intracavernous pressure (ICP) during penile erection was reviewed. The development of new models using small commercially-available experimental animals, rats and mice, in the last decade facilitated in vivo investigation of erectile physiology. The techniqueenabled to evaluate even subtle erectile responses by analyzing ICP and systemic blood pressure. Moreover, the method has been well improved and studies using conscious animal models without the influence of any drug or anesthesia are more appropriate in exploring the precise physiological and pharmacological mechanisms in erection. Also, more natural and physiological sexual arousal instead of electrical or pharmacological stimulation is desirable in most of the *** article reviewed the development of ICP studies in rats and mice.

关键词： erectile dysfunction impotence intracavernous pressure sexual dysfunction corpus cavernosum electrophysiology

Gfarm/BB——Gfarm File System for Node-Local Burst Buffer

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Journal of Computer Science & Technology 2020年第1期35卷 61-71页

作者： osamu Tatebe Member ACM Shukuko Moriwake Yoshihiro Oyama Center for Computational Sciences University of TsukubaIbaraki 3058577Japan SURIGIKEN Co. Ltd.Tokyo 1000004Japan Faculty of Engineering Information and SystemsUniversity of TsukubaIbaraki 3058573Japan

Burst buffer has become a major component to meet the I/O performance requirement of HPC bursty *** paper proposes Gfarm/BB that is a file system for a burst buffer efficiently exploiting node-local storage *** node-local storages improve storage performance,they are only available during the job ***/BB should have better access and metadata performance while it should be constructed on-demand before the job *** improve the read and write performance,it exploits the file descriptor passing and remote direct memory access(RDMA).It improves the metadata performance by omitting the persistency and the redundancy since it is a temporal file *** RDMA,writes and reads bandwidth are improved by 1.7x and 2.2x compared with IP over InfiniBand(IPoIB),*** achieves 14700 operations per second in the directory creation performance,which is 13.4x faster than the fully persistent and redundant *** construction of Gfarm/BB takes 0.31 seconds using 2 *** benchmark and ARGOT-IO application I/O benchmark show the scalable performance improvement by exploiting the locality of node-local *** with BeeOND,Gfarm/BB shows 2.6x and 2.4x better performance in IOR write and read benchmarks,respectively,and it shows 2.5x better performance in ARGOT-IO.

关键词： burst buffer node-local storage on-demand file system remote direct memory access