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National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz Abu bakar Hafeez bhatti tariq Ali bangash Amna Subhan b.tt osama tariq b.tt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

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Improvement of sintering,nonlinear electrical,and dielectric properties of ZnO-based varistors doped with TiO2

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Chinese Physics b 2016年第6期25卷 575-580页

作者： osama A Desouky K E Rady bilbis Higher Institute of Engineering (bHIE) Bilbis Sharqia Egypt Engineering basic Sciences Department Faculty of engineering Menoufia University Shebin EI-Kom Egypt

The effects of TiO2 on sintering and nonlinear electrical properties of（98.5-x）ZnO–0.5MnO2–0.5Co2O3-0.5bi2O3–xTiO2（x = 0.3,0.5,0.7,0.9 mol%） ceramic varistors prepared by the ceramic technique are investigated in this *** optimum sintering temperature of the prepared samples is deduced by determining the firing shrinkage and water absorption *** optimum sintering temperature is found to be 1200℃,at which each of the samples shows a maximum firing shrinkage and minimum water *** minimum water absorption appears in a sample of x = 0.9 mol%.Higher sintering temperature and longer sintering time give rise to a reduction in bulk density due to the increased amount of porosity between the large grains of ZnO resulting from the rapid grain growth induced by the liquid phase *** crystal size of ZnO decreases with increasing TiO2 *** addition of TiO2 improves the nonlinear coefficient and attains its maximum value at x = 0.7 mol% of TiO2,further addition negatively affects it.A decrease in capacitance consequently in the dielectric constant is recorded with increasing the frequency in a range of 30 kHz–200 *** temperature and composition dependences of the dielectric constant and AC conductivity are also *** increase of temperature raises the dielectric constant because it increases ionic response to the field at any particular frequency.

关键词： ZnO varistors water absorption nonlinear electrical properties dielectric constant

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Advanced age and the clinical outcomes of transcatheter aortic valve implan-tation

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Journal of Geriatric Cardiology 2014年第2期11卷 163-170页

作者： osama Alsara Ahmad Alsarah Heather Laird-Fick Department of Internal Medicine Michigan State University B-301 Clinical Center East Lansing MI 48824 USA

Aortic valve stenosis （AS） is common in the elderly. Although surgical replacement of the valve has been the gold standard of management, many patients have been excluded from surgery because they were very old, frail, or had co-morbidities that increased operative risks. In the last decade, transcatheter aortic valve implantation （TAVI） has emerged as a new treatment option suitable for these patients. This article reviews the available literature on the role of TAVI in elderly patients with severe aortic stenosis. Published studies showed that elderly individuals who underwent TAVI experienced b.tter in-hospital recovery, and similar short and mid-term mortality compared to those underwent surgical treatment of AS. However, long-term outcomes of TAVI in elderly patients are still unknown. The available data in the literature on the ef-fect of advanced age on clinical outcomes of TAVI are limited, but the data that are available suggest that TAVI is a beneficial and tolerable procedure in very old patients. Some of the expected complications after TAVI are reported more in the oldest patients such as vascular in-jures. Other complications were comparable in TAVI patients regardless of their age group. However, very old patients may need closer monitoring to avoid further morbidities and mortality.

关键词： Aortic stenosis Transcatheter aortic valve implantation Surgical aortic valve replacement Geriatric

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Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment

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Current Medical Science 2021年第2期41卷 250-269页

作者： osama A.Elkashty Simon D.Tran McGill Craniofacial Tissue Engineering and Stem Cells Laboratory Faculty of DentistryMcGill UniversityMontreal H3A 0G4Canada Department of Oral Pathology Faculty of DentistryMansoura UniversityMansoura 35516Egypt

Tumorigenicity-inhibiting compounds have been identifled in our daily *** example,isothiocyanates(ITCs)found in cruciferous vegetables were reported to have potent cancer=prevention *** best characterized ITC is sulforaphane(SF).SF can simultaneously modulate multiple cellular targets involved in carcinogenesis,including(1)modulating carcinogen-metabolizing enzymes and blocking the action of mutagens;(2)inhibition of cell proliferation and induction of apoptosis;and(3)inhibition of neo-angiogenesis and *** targets cancer stem cells through modulation of nuclear factor kappa b(NF-κb),Sonic hedgehog(SHH),epithelial-mesenchymal transition,and Wnt/βcatenin *** chemotherapy/SF combination was tested in several studies and resulted in favorable *** its favorable toxicological profile,SF is a promising agent in cancer prevention and/or *** this article,we discuss the human metabolism of SF and its effects on cancer prevention,treatment,and targeting cancer stem cells,as well as providing a brief review of recent human clinical trials on SF.

关键词： sulforaphane isothiocyanates cancer chemoprevention antineoplastic agent

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Salmonella typhi infection in a tertiary institution in Nasarawa State,Nigeria

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Asian Pacific Journal of Tropical Medicine 2011年第2期4卷 137-139页

作者： Ishaleku D Sar tt Houmsou RS Microbiology Unit Department of Biological SciencesNasarawa State University KeffiP.M.B 1022 KeffiNigeria Department of biological Sciences University of MkarMkarP.M.B 017GbokoBenue StateNigeria Applied Zoology Unit Department of Biological SciencesTaraba State UniversityJalingoP.M.B 1167 JalingoTaraba StateNigeria

Objective:To evaluate the prevalence of Sabmonella typhi(***) among subjects attending College of Education Health Clinic,Akwanga,Nasarawa state from the year.2005 to 2007 and to recommend some preventive measures to the ***:blood samples were tested for infection using the widal ***:Out of the 793 patients examined,579(73.0%) were positive with 174(30.05%),254(43.86%) and 151(26.07%) for the years 2005,2006 and 2007 respectively. The age range with the highest prevalence of infection for the period was 21-30 with 207(35.75%) followed by 31-40 year group with 133(22.97%).Chi-square analysis showed no significant difference in infection between males and females(P>0.05).Conclusions:The results of this study provide a useful guide in the formulation of *** control measures in tertiary institutions in the State and also help to check the spread of the pathogen in the general population.

关键词： Salmonella typhi Infection Tertiary institution Nasarawa State

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Numerical Investigation of Rotating Stall in Centrifugal Compressor with Vaned and Vaneless Diffuser

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Journal of Thermal Science 2015年第4期24卷 323-333页

作者： Taher Halawa Mohamed Alqaradawi Mohamed S.Gadala Ibrahim Shahin osama badr Mechanical Engineering Department UBC-University of British ColumbiaVancouverB.C.Canada Mechanical Engineering Department Cairo University Mechanical & Industrial Engineering Department Qatar University Mechanical Engineering Department Abu Dhabi University Mechanical and Industrial Engineering Department Qatar UniversityDohaQatar Mechanical Engineering Department Benha University Mechanical Engineering Department British University

This study presents a numerical simulation of the stall and surge in a centrifugal compressor and presents a description of the stall development in two different *** first case is for a compressor with vaneless diffuser and the second is for a compressor with vaned diffuser of the vane island *** main aim of this study is to compare the flow characteristics and behavior for the two compressors near the surge operating condition and provide further understanding of the diffuser role when back flow occurs at *** showed that for a location near the diffuser entrance,the amplitude of the static pressure fluctuations for the vaneless diffuser case is higher than that for the vaned diffuser case near surge *** pressure fluctuations in the case of the vaneless diffuser appear with a gradual decrease of the mean pressure value as a part of the surge *** for the case of the vaned diffuser,the pressure drop during surge occurs faster than the case of the vaneless ***,results indicated that during surge in the case of vaneless diffuser,there is a region with low velocity and back flow that appears as a layer connecting all impeller passages near shroud surface and this layer develops in size with *** the other hand,for the case of vaned diffuser during surge,the low velocity regions appear in random locations in some passages and these regions expand with time towards the shroud *** showed that during stall,the impeller passages are exposed to identical impact from stall cells in the case of vaneless diffuser while the stall effect varies from passage to another in the case of the vaned diffuser.

关键词： centrifugal compressors rotating stall surge vaneless diffuser vaned diffuser

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The impacts of altitude and seed pretreatments on seedling emergence of Syrian juniper (Juniperus drupacea (Labill.) Ant. et Kotschy)

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Ecological Processes 2021年第1期10卷 112-117页

作者： Cengiz Yucedag Mehmet Cetin Halil baris Ozel Adel Easa Saad Abo Aisha osama b.Muragaa Alrabiti Akram Mohamed Omar AL.JAMA Faculty of Engineering-Architecture Department of Landscape ArchitectureBurdur Mehmet Akif Ersoy UniversityBurdurTurkey. Faculty of Engineering and Architecture Department of Landscape ArchitectureKastamonu UniversityKuzeykent Campus37150 KastamonuTurkey Faculty of Forestry Department of Forest EngineeringBartin UniversityBartinTurkey Institute of Science and Technology Graduate Programs of Material Science and EngineeringKastamonu UniversityKastamonuTurkey.

background:Syrian juniper is an economically important species and in danger of *** these reasons,the best seedling production methods of the species should be determined and its plantations should be *** aim of the study is to examine the impacts of altitude and different pretreatment combinations of cold and warm stratifications,citric acid,shaking seeds in b.ttles with crushed glass,and different stimulating agents including baikal EM1,biohumus,Polystimulin A6 and K hormones(PS-A6 and PS-K)on seed germination of Syrian *** conduct the study,the cones of the Syrian junipers were collected from three different altitudes(1000,1200,and 1400 m a.s.l.)within the boundaries of Forest Management Directorate of bozyazı,Mersin in *** seeds were subjected to three replicates per one treatment(altitude in interaction with pretreatment).There were 100 seeds per ***:Two-way ANOVA revealed significant effects of altitude,pretreatment,and their interaction on seedling emergence of Syrian *** from higher altitudes had higher germination rates in all *** highest percent emergence(85%)was recorded in the combination consisting of shaking with crushed glass,both cold and warm stratification,and successive application of stimulators PS-A6 and *** the treatments with most germinating seeds encompassed shaking in crushed glass or soaking in citric acid,both warm and cold stratifications,and application of stimulating ***:The use of seeds from higher altitudes should be considered for seedling production of Syrian juniper due to their higher germination *** altitudinal differences,specific pretreatments can rise germination potential more than twofold.

关键词： Auxin Citric acid Cytokine Germination Stratification

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TLSmell: Direct Identification on Malicious HttPs Encryption Traffic withSimple Connection-Specific Indicators

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Computer Systems Science & Engineering 2021年第4期37卷 105-119页

作者： Zhengqiu Weng Timing Chen Tiantian Zhu Hang Dong Dan Zhou osama Alfarraj School of Computer Science and Technology Zhejiang University of TechnologyHangzhou310023China Department of Information Technology Wenzhou PolytechnicWenzhou325035China Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia

Internet traffic encryption is a very common traffic protection *** internet traffic is protected by the encryption protocol called transport layersecurity (TLS). Although traffic encryption can ensure the security of communication, it also enables malware to hide its information and avoid being *** present, most of the malicious traffic detection methods are aimed at the unencrypted ones. There are some problems in the detection of encrypted traffic, suchas high false positive rate, difficulty in feature extraction, and insufficient practicability. The accuracy and effectiveness of existing methods need to be *** this paper, we present TLSmell, a framework that conducts maliciousencrypted HttPs traffic detection with simple connection-specific indicators byusing different classifiers based online training. We perform deep packet analysisof encrypted traffic through data pre-processing to extract effective features, andthen the online training algorithm is used for training and prediction. Withoutdecrypting the original traffic, high-precision malicious traffic detection and analysis are realized, which can guarantee user privacy and communication *** the same time, since there is no need to decrypt the traffic in advance, the effi-ciency of detecting malicious HttPs traffic will be greatly improved. Combinedwith the traditional detection and analysis methods, malicious HttPs traffic isscreened, and suspicious traffic is further analyzed by the expert through the context of suspicious behaviors, thereby improving the overall performance of malicious encrypted traffic detection.

关键词： Cyber security malware detection TLS feature engineering

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LogUAD: Log Unsupervised Anomaly Detection based on Word2Vec

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Computer Systems Science & Engineering 2022年第6期41卷 1207-1222页

作者： Jin Wang Changqing Zhao Shiming He Yu Gu osama Alfarraj Ahed Abugabah School of Computer and Communication Engineering Changsha University of Science&TechnologyChangsha410114China Department of Chemistry Institute of Inorganic and Analytical ChemistryGoethe-UniversityFrankfurt60438Germany Computer Science Department Community CollegeKing Saud UniversityRiyadh11437Saudi Arabia Zayed University CTIAbu Dhabi144534United Arab Emirates

System logs record detailed information about system operation and areimportant for analyzing the system's operational status and performance. Rapidand accurate detection of system anomalies is of great significance to ensure system stability. However, large-scale distributed systems are becoming more andmore complex, and the number of system logs gradually increases, which bringschallenges to analyze system logs. Some recent studies show that logs can beunstable due to the evolution of log statements and noise introduced by log collection and parsing. Moreover, deep learning-based detection methods take a longtime to train models. Therefore, to reduce the computational cost and avoid loginstability we propose a new Word2Vec-based log unsupervised anomaly detection method (LogUAD). LogUAD does not require a log parsing step and takesoriginal log messages as input to avoid the noise. LogUAD uses Word2Vec togenerate word vectors and generates weighted log sequence feature vectors withTF-IDF to handle the evolution of log statements. At last, a computationally effi-cient unsupervised clustering is exploited to detect the anomaly. We conductedextensive experiments on the public dataset from blue Gene/L (bGL). Experimental results show that the F1-score of LogUAD can be improved by 67.25%compared to LogCluster.

关键词： Log anomaly detection log instability word2Vec feature extraction

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Lecablock, an Alternative Construction Material for the Exterior Walls of Passive House

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Journal of building Construction and Planning Research 2014年第2期2卷 96-108页

作者： osama A.b.Hassan Petra Jonsson Department of Science and Technology Linkoping UniversityNorrkopingSweden Petra Jonsson Lindbacks byggPiteaSweden

In this paper it is attempted to investigate the Leca blocks as sustainable construction material for the exterior walls of passive house. The building physical properties of Leca design wall structure are studied along with the environmental impact and load-bearing capacity. To compare the results, a similar analysis is carried out considering the traditional wooden wall construction of passive houses. The results showed that Leca design wall structure can be an alternative sustainable solution to the traditional wooden wall structure of passive house, mainly due to its low U-value, its ability to handle moisture, and comparable structural load-bearing capacity. However, the wooden wall structure is more environmentally friendly than the Leca blocks due to its lower emissions to the environment and reduced energy use, especially during the manufacturing process.

关键词： U-Value Moisture Thermal bridges Passive House Energy Efficiency Load-bearing Capacity

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