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An.i-obesity effects of fucoidan.from Sargassum thun.ergii in.adipocytes an. high fat diet in.uced obese mice through in.ibitin. adipogen.c specific tran.cription.factor

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Food Scien.e an. Human.Welln.ss 2024年第3期13卷 1608-1616页

作者： Hyo-Geun.Lee H.H.A.C.k.Jayawardhan. Fen.qi Yan. D.P.n.gahawaththa n.M.Liyan.ge k.un.-Mo Son. Yun.San. Choi Seun.-Hon. Lee You-Jin.Jeon.Min.Cheol k.n. Departmen. of Marin. Life Scien.es Jeju National UniversityJeju 63243Republic of Korea Marin. Scien.e In.titute Jeju National UniversityJeju 63333Republic of Korea Research Group of Food Processin. Korea Food Research InstituteWanju 55365Republic of Korea Departmen. of Pharmoceutical En.in.erin. Soonchunhyang UniversityAsan 31538Republic of Korea

The prevalen.e of obesity has in.reased an. is a health con.ern.*** to the con.ern. regardin. syn.hetic an.i-obesity treatmen.s,n.wadays n.tural products become a *** studies proved that there is a poten.ial to use marin. algae as an.i-obesity ***,in.this study,the lipid in.ibitory effect of crude polysaccharide of amyloglucosidase-assisted hydrolysate from Sargassum thun.ergii(STAC)an. its fucoidan.fraction.(STAFs)on.3T3-L1 cells an. high-fat diet(HFD)-in.uced obese mice were *** to the results,the STAF3,showed the highest xylose con.en. an. exhibited sign.fican. in.ibitory effects on.lipid accumulation.by down.egulatin. adipogen.c an. lipogen.c protein. in.3T3-L1 ***,oral supplemen.ation.with STAC sign.fican.ly declin.d gain.in.body weight an. fat weight,an. serum lipid con.en.s in.an.HFD-in.uced obesity mouse *** an. chemical characterization. demon.trated that puritied STAF3 has con.isten. surface morphology an. small particle size,with similar structural characteristics as commercial ***,these results in.icate that STAC an. purified STAF3 from Sargassum thun.ergia is a poten. source to develop as an.n.i-obesity agen.s or fun.tion.l food products to coun.er obesity.

关键词： Sargassum thun.ergii Fucoidan An.i-obesity An.i-steatosis

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Comparison.of mismatch repair an. immun. check.oin. protein.profile with histopathological parameters in.pan.reatic,periampullary/ampullary,an. choledochal aden.carcin.mas

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World Journ.l of Gastroin.estin.l On.ology 2024年第3期16卷 875-882页

作者： Arzu Hazal Aydın.n.srin.Turhan Departmen. of Pathology Aksaray University Aksaray Training and Research HospitalAksaray 68200Turkey Departmen. of Pathology University of Health Sciences Ankara City HospitalAnkara 06800Turkey

BACk.ROUn. Pan.reatic,periampullary/ampullary,an. choledochal aden.carcin.mas are aggressive malign.n.ies with a poor *** check.oin. block.de is a promisin. treatmen. option.for several tumor types.H lon. termin.l repeatassociatin. 2(HHLA2),which is an.logous to programmed death-ligan. 1(PDL1),is a recen.ly discovered member of the B7/cluster of differen.iation.28 family an. is expressed in.man. *** To an.lyze the expression.of HHLA2 an. its association.with the pathologic biomark.rs that predict sen.itivity to *** n.n.ty-two aden.carcin.ma cases located in.the pan.reas,ampulla,an. distal common.bile duct were *** study assessed 106 pan.reaticoduoden.ctomy an. distal/total pan.reatectomy samples that were delivered to An.ara City Hospital between.2019 an. *** was con.ucted to examin. the expression.of Dn. mismatch repair(MMR),PD-L1,an. HHLA2 *** Patien.s with high HHLA2 expression.had a higher mean.age than.those with low *** HHLA2 expression.was associated with high perin.ural ***2 expression.was low in.pathological stage T3(pT)3 cases an. high in.pathological stage T1,T2,an. T4 *** was n. correlation.between.HHLA2 expression.an. the expression.of MMR protein. an. *** Evaluation.of HHLA2 expression.in.microsatellite stable an. PD-L1-n.gative tumors may be useful for predictin. the respon.e of in.ividuals to immun.therapy an. may serve as a n.vel therapeutic target for immun.therapy in.advan.ed-stage disease.

关键词： H lon. termin.l repeat-associatin. 2 Programmed death-ligan. 1 Aden.carcin.ma Pan.reas Ampulla of Vater Distal common.bile duct

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Ovarian.Tumors in.Sen.galese Women. Impact of D-Loop Mutation. between.Healthy an. Can.erous Tissues

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Open.Journ.l of Gen.tics 2024年第2期14卷 37-46页

作者： Rouguiyatou k. Fatimata Mbaye Bin.ta k.n.me Mback. Sembèn. Gen.mics Laboratory Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal

In.Sen.gal in.particular, ovarian.can.er, which is on. of the most common.gyn.cological can.ers, accoun.s for 2.8% of deaths. The most importan. risk.factor is gen.tic, with 10% of cases occurrin. in.a con.ext of gen.tic predisposition. The sequen.in. of the human.gen.me, which has led to the discovery of million. of sequen.e variation., mak.s it possible to study variation. within.sequen.es. These variation. are limited to Sin.le n.cleotide Polymorphisms (Sn.s) an. this common.form of polymorphism occurs approximately every 1000 bases in.the human.gen.me an. 1.8 million.Sn.s are curren.ly listed accordin. to [1]. The aim of this study is to gain.a better un.erstan.in. of the impact of mutation. in.the D-loop region.of mtDn. on.ovarian.can.er in.Sen.galese women. This study in.olved searchin. for mutation. in.our study population.after Dn. extraction.an. sequen.in.. Mutation. were foun. after a comparison.of our sequen.es with the Cambridge referen.e sequen.e (n._012920). The mutation. foun. in.the Dn. studied exten. from position.7 to position.16568 an. most of these mutation. are located in.the hypervariate zon.s (HV1 an. HV2). Heteroplasmy with three mutan. alleles was also foun. in.certain.varian.s. Common.mutation. were foun. in.both healthy an. can.erous tissues, with almost iden.ical frequen.ies in.both types of tissue. This en.bled us to un.erstan. the spread of tumor cells throughout the ovary.

关键词： Ovarian Can.er Mutation. D-Loop Heteroplasmy

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Assessin. Commun.ty Health In.erven.ion. in.Reducin. In.an. an. Child Mortality in.the Southeastern.Ben.n

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Open.Journ.l of Preven.ive Medicin. 2024年第1期14卷 17-28页

作者： Charles Sossa Jerome Daouda Gbadamassi Lamidhi Salami Colette Azan.jeme Clémen.e Meton.ou Moussiliou n. Paraiso Health Promotion.Departmen. Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin n.tion.l Medical an. San.tary In.titute University of Abomey-Calavi Cotonou Benin Health Policy an. Systems Departmen. Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin

Back.roun.: To reduce in.an. an. child mortality in.Ben.n. a pack.ge of high-impact in.erven.ion. per healthcare level was implemen.ed in.2009. This study aimed to assess the quality of commun.ty-based health in.erven.ion. in.reducin. in.an. an. child mortality within.the mun.cipality of Pobè in.southeastern.Ben.n. Methods: This was a cross-section.l evaluative study carried out in.n.vember 2021 focused on.children.aged 0 - 59 mon.hs, their mothers, health work.rs, commun.ty facilitators, commun.ty health work.rs an. the Town.Hall health focal poin.. Mothers an. their children.were targeted by cluster samplin., an. exhaustive selection.was used to recruit all other participan.s. Predetermin.d scores based on.ratin. criteria were used to assess the quality of commun.ty health in.erven.ion. usin. the “in.ut, process an. outcome” of Don.bedian.approach. Results: Over 300 mother-child couples, 46 commun.ty health work.rs, 7 health agen.s, 1 commun.ty facilitator an. 1 health focal poin. from Pobè town.hall were surveyed. In.erven.ion.quality was judged as “average”, with a score of 73.80%. The “in.uts” an. “outcomes” compon.n.s were the weak.st lin.s. Con.lusion. Improvin. access to the in.uts n.eded by commun.ty health work.rs can.en.an.e the quality of PIHI in.erven.ion..

关键词： Commun.ty-Based In.erven.ion. In.an. an. Child Mortality Ben.n

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Aberran. adult n.urogen.sis in.in.ractable epilepsy:can.GABAergic progen.tor tran.plan.ation.n.rmalize this process?

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n.ural Regen.ration.Research 2024年第7期19卷 1419-1420页

作者： Muhammad n.Arshad Jan.ce R.n.egele Departmen. of Biology Wesleyan UniversityMiddletownCTUSA Departmen. of n.uroscien.e Tufts University School of MedicineBostonMAUSA

Temporal lobe epilepsy(TLE) is a common.type of focal epilepsy characterized by seizure foci within.the temporal *** surgical resection.of the foci is an.established an. effective approach for con.rollin. seizures,both temporal lobes can.ot be removed,due to their promin.n. roles in.learn.n. an. ***,seizures in.uce chan.es to the temporal lobes that con.ribute to hyperexcitability,in.ludin. mossy fiber sproutin.,astrogliosis.

关键词： epilepsy progen.tor seizures

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Explorin. the Factors Associated with 12-Mon.h n.n.Return.to Work.amon. Motorcyclists In.olved in.Road Acciden.s

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Open.Journ.l of Preven.ive Medicin. 2024年第1期14卷 1-16页

作者： Yolain. Glèlè-Ahan.an.o Don.tien.Daddah Alphon.e k.ozehouen.Bella Houn.pè Dos San.os Moussiliou n. Paraiso Multidisciplin.ry Research Un.ty for Road Crashes Preven.ion.(ReMPARt) Department of Epidemiology and Bio-Statistics Regional Institute of Public Health University of Abomey-Calavi Ouidah Benin Region.l Direction.of Health Lokossa Benin Region.l Direction.of Health Abomey-Calavi Benin Health Promotion.Departmen. Regional Institute of Public Health Ouidah Benin

In.roduction. Motorcyclists bear a disproportion.te burden.of morbidity an. mortality from road acciden.s. In.addition. the con.equen.es of these acciden.s affect the ability of victims to return.to work. This study aimed to determin. the prevalen.e an. factors associated with n.n.return.to work.amon. survivin. motorcyclists in.olved in.road acciden.s 12 mon.hs after the even.. Materials an. Methods: It was a cross-section.l study con.ucted usin. data from a cohort of motorcyclists in.olved in.acciden.s an. recruited in.five hospitals in.Ben.n.from July 2019 to Jan.ary 2020. The depen.en. variable was n.n.return.to work.12 mon.hs after the acciden. (yes vs n.). The in.epen.en. variables were categorized in.o two groups: baselin. an. 12-mon.h follow-up variables. Logistic regression.was used to determin. the factors associated with n.n.return.to work.at 12 mon.hs amon. the participan.s. Results: Amon. the 362 participan.s, 55 (15.19%, 95% CI = 11.84 - 19.29) had n.t return.d to work.12 mon.hs after the acciden.. Risk.factors for n.n.return.to work.iden.ified were: smok.n. (aOR = 4.41, 95% CI = 1.44 - 13.56, p = 0.010), hospitalization.(aOR = 2.87, 95% CI = 1.14 - 7.24, p Con.lusion. The prevalen.e of n.n.return.to work.at 12 mon.hs was high amon. survivin. motorcyclists in.olved in.road acciden.s in.Ben.n. In.egrated support for patien.s based on.iden.ified risk.factors should effectively improve their return.to work.

关键词： Road Acciden. Return.to Work Motorcyclists Hospital Men.al Health Cohort Ben.n

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56 Years of the Marburg Virus—A Review of Therapeutics

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Open.Journ.l of Epidemiology 2024年第2期14卷 273-283页

作者： Michael M. Toza Emman.el Iman.olwa n.talia Shak.la Ferdin.n. n.ubi Han.oma Hatwik. Christabel n. Hik.ambo Departmen. of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Departmen. of Biology Chemistry and Physics School of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia Departmen. of Pharmaceutical Chemistry an. Pharmaceutics School of Pharmacy Kabarak University Nakuru Kenya Departmen. of Physiological Scien.es School of Medicine and Health Sciences Mulungushi University Livingstone Zambia

Back.roun.: The Marburg virus (MARV) is the causative agen. of Marburg virus disease (MVD). This filovirus first appeared in.1967 an. has sin.e caused several outbreak. with case fatality rates between.23% an. 90%. The earliest cases of MVD are thought to be caused by exposure to an.in.ected an.mal, either a reservoir host (some bat species, e.g., Rousettus aegyptiacus) or a spill-over host, such as n.n.human.primates. The virus is spread between.people by direct con.act with blood or other bodily fluids (in.ludin. saliva, sweat, faeces, urin., tears, an. breast milk. from in.ected in.ividuals. Despite the high fatality rate, the Marburg virus has n. vaccin. or drug treatmen.. Recen. outbreak. of the virus in.2023 in.Tan.an.a an. Equatorial Guin.a have reign.ted the n.ed to develop effective therapeutics, especially in.the wak. of the COVID-19 pan.emic. Purpose: This review seek. to highlight the drug discovery efforts aimed at developin. vaccin.s or possible treatmen.s as poten.ial therapeutics. Several existin. an.iviral agen.s are bein. probed, an. vaccin.s are in.pre-clin.cal an. clin.cal stages. n.tural products are also an.importan. source of possible drugs or lead compoun.s an. when.coupled with computation.l techn.ques, these strategies offer possible therapeutics for the Marburg virus, especially in.Africa, which has a high disease burden. Methods: Usin. the search en.in.s Google Scholar an. PubMed;k.ywords e.g. Marburg virus, Marburg treatmen.s, Marburg virus drug discovery were utilized. Several results were yielded, an. articles published in.recen. years were accepted in.o the fin.l *** an. Con.lusion. This study shows there is a growin. in.erest in.therapeutics for the Marburg virus, especially with the recen. outbreak. an. pan.emic preparedn.ss. In.tiatives that to support vaccin. developmen. an. access lik. the MARVAC con.ort time are critical to fightin. this public health threat.

关键词： Marburg Virus Vaccin.s An.ivirals Viruses Drug Discovery

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In.vivo astrocyte reprogrammin. followin. spin.l cord in.ury

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n.ural Regen.ration.Research 2024年第3期19卷 487-488页

作者： Yan.ick.n.Gerber Floren.e E.Perrin MMDn University of MontpellierEPHEINSERMMontpellierFrance In.titut Un.versitaire de Fran.e(IUF) ParisFrance

Harmful an. helpful roles of astrocytes in.spin.l cord in.ury(SCI):SCI in.uce gradable sen.ory,motor an. auton.mic impairmen.s that correlate with the lesion.severity an. the rostro-caudal location.of the in.ury *** absen.e of spon.an.ous axon.l regen.ration.after in.ury results from n.uron.in.rin.ic an. n.uron.extrin.ic ***,n.t on.y adult n.uron. display limited capability to regrow axon. but also the in.ury en.iron.en. con.ain. in.ibitors to axon.l regen.ration.an. a lack.of growth-promotin. *** other cell population. that respon. to the lesion.reactive astrocytes were first con.idered as on.y detrimen.al to spon.an.ous axon.l ***,astrocytes.

关键词： in.ury impairmen. programmin.

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n.t effect of air pollution.con.rols on.health risk.in.the Beijin.-Tian.in.Hebei region.durin. the 2022 win.er Olympics an. Paralympics

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Journ.l of En.iron.en.al Scien.es 2024年第1期135卷 560-569页

作者： Chan.qin. Lin.Peter k.k.Louie Alexis k.H.Lau Jimmy C.H.Fun. Zibin. Yuan.Min.hui Tao Xuguo Zhan. Md.Shak.aoat Hossain.Chen.cai Li Xian. Qian.Lao Division.of En.iron.en. an. Sustain.bility The Hong Kong University of Science and TechnologyHong KongChina En.iron.en.al Protection.Departmen. Hong Kong Government SARHong KongChina Departmen. of Civil an. En.iron.en.al En.in.erin. The Hong Kong University of Science and TechnologyHong KongChina Guan.don.-Hon.k.n.-Macao Join. Laboratory of Collaborative In.ovation.for En.iron.en.al Quality The Hong Kong University of Science and TechnologyHong KongChina Departmen. of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of En.iron.en. an. En.rgy South China University of TechnologyGuangzhou 510006China Hubei k.y Laboratory of Critical Zon. Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Departmen. of Public Health an. In.ormatics Jahangirnagar UniversityDhaka 1342Bangladesh Departmen. of Atmospheric an. Ocean.c Scien.es School of PhysicsPeking UniversityBeijing 100871China Jock.y Club School of Public Health an. Primary Care The Chinese University of Hong KongHong KongChina

Due to the n.n.lin.arity in.ozon.(O_(3))formation.reducin. the emission.of n.trogen.oxides(n._(x))may in.rease O_(3) *** the coun.eractive O_(3) respon.e to n._(x) reduction.overall impact of air pollution.con.rols can.be ambiguous when.the assessmen.s focus on.the chan.es in.pollutan. *** this study,a risk.based method was used to gauge the n.t effect of air pollution.con.rols on.mortality risk.in.the Beijin.–Tian.in.Hebei(BTH)region.durin. the 2022 Win.er Olympics an. Paralympics(WOP).This mega-even. presen.s a un.que opportun.ty to in.estigate the efficacy of deep cuts in.pollutan. *** show that O_(3) con.en.ration. greatly in.reased as n.trogen.dioxide(n._(2))con.en.ration. decreased in.the *** to the active photochemical formation.,O_(3) became the domin.n. pollutan. that affected human.health durin. the *** the substan.ial O_(3) in.reases,the health ben.fits of n._(2) reduction. overwhelmed the adverse health effects of O_(3) in.reases in.most region. of the BTH(at 81 out of 112 station.).After con.iderin. the impacts of particulate matter,the in.egrated health risk.of air pollution.mixtures declin.d almost everywhere in.the *** results un.erscore the great n.cessity of chan.in. the assessmen. paradigm of pollution.con.rol from usin. con.en.ration.based methods to usin. risk.based *** with the carbon.n.utrality policy,strin.en. con.rol of n._(x)emission.from combustion.sources is a promisin. way to achieve syn.rgistic con.rol solution. for air pollution.an. climate chan.e.

关键词： Ozon. n.trogen.dioxide Health risk Carbon.n.utrality Mega-even.s

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Recon.tructive surgery for phan.om an. residual limb pain.in.post-con.lict settin.s

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Chin.se Journ.l of Plastic an. Recon.tructive Surgery 2024年第1期6卷 54-55页

作者： Damián.Palafox Plastic an. Recon.tructive Surgery Departmen. Hospital Angeles Puebla

Traumatic amputation. remain.on. of the most frequen. an. disturbin. woun.s of armed con.lict. In.this scen.rio,most amputees develop residual an. phan.om limb pain. impactin. their quality of life. There are several elective surgical procedures available for both con.ition., such as n.uroma excision.followed by n.rve recon.truction.n.rve relocation. e.g., surgically implan.in. a tran.ected n.rve in.o a muscle, n.rve tran.fers in.cases of associated paralysis, an. most recen.ly, regen.rative peripheral n.rve in.erface surgery. When.ver possible in.the postcon.lict phase, a coordin.ted effort between.travelin. human.tarian.surgeon. specializin. in.recon.tructive microsurgery an. local healthcare providers is essen.ial for successfully treatin. phan.om an. chron.c residual limb pain.in.post-con.lict amputees. While providin. a detailed logistical framework.for global human.tarian.mission. is beyon. the scope of this article, we provide a brief perspective on.a topic of utmost importan.e for recon.tructive surgeon. worldwide: the high-quality care an. treatmen. of refugees an. those whose lives have been.impacted by con.lict, disaster, or displacemen..

关键词： Residual limb pain Phan.om limb pain Refugees Recon.tructive surgery Microsurgery Amputees

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