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The rela.ionship between dNa.fra.menta.ion a.d the intensity of morphologica.ly a.norma. huma. sperma.ozoa

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a.ia. pa.ific Journa. of Reproduction 2024年第1期13卷 22-27页

作者： Mercedes González-Ma.tínez Pa.cua. Sánchez-Ma.tín Ca.men lópez-Fernández Stephen d.Johnston Ja.me Gosálvez Clínica.Ginemed Unidad de ReproducciónSevillaSpain depa.tment of Biology Universidad Autónoma de MadridCantoblancoMadridSpain School of Environment The University of QueenslandGattonAustralia School of Veterina.y Science The University of QueenslandGattonAustralia

Objective:To determine the rela.ionship between tera.ozoospermia.a.d sperm dNa.fra.menta.ion(SdF)in the huma. ***:This retrospective study included 100 normozoospermic men a. a.control cohort(a.norma. forms>14%),210 pa.ients with a.high level of a.norma. forms(≤4%)a.d 65 pa.ients presenting with a.modera.e level of a.norma. forms(>4%to≤14%)ba.ed on the World Hea.th Orga.iza.ion *** morphology wa. a.sessed using bright field *** dNa.fra.menta.ion wa. a.sessed using the sperm chroma.in dispersion ***-pa.a.etric a.a.yses were conducted to exa.ine the rela.ionship between a.norma. sperm morphology a.d sperm dNa.fra.menta.ion;receiver opera.ing cha.a.teristic(ROC)a.a.yses were conducted to a.sess sensitivity a.d specificity of this ***:a.correla.ion a.a.ysis revea.ed tha. the higher the proportion of a.norma. sperma.ozoa.in the eja.ula.e,the higher the level of SdF(Spea.ma.'s Rho=-0.230;Pa.t differences in the proportion of SdF were found when a.l cohorts were compa.ed(Pa.t differences were a.so reta.ned when the different cohorts were compa.ed *** a.a.ysis showed a.modera.e but significa.t predictive va.ue for SdF to differentia.e pa.ients with different levels of ***:a.though a.a.ysis of a.more continuous ra.ge of va.ues for tera.ozoospermia.would help further cla.ify a.y ca.sa. rela.ionship with SdF,there is clea.ly a.synergistic or coincident a.filia.ion between these va.ia.les tha. needs to be a.knowledged by the clinicia. when interpreting the spermiogra..

关键词： Tera.ozoospermia Sperm morphology Sperm dNa.fra.menta.ion Ma.e fa.tor Huma. reproduction Huma. fertility

Genetica.ly-a.d environmenta.ly-dependent processes drive interspecific a.d intra.pecific divergence in the Chinese relict endemic genus dipteronia

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Pla.t diversity 2024年第5期46卷 585-599页

作者： Ta. Zhou Xia.da. Chen Jordi lópez-Pujol Guoqing Ba. Sonia.Herra.do-Mora.ra.Neus Nua.a.t Xia. Zha.g Yuemei Zha. Guifa.g Zha. Key la.ora.ory of Resource Biology a.d Biotechnology in Western China.Ministry of Educa.ion) College of Life SciencesNorthwest UniversityXi'an 710069China School of Pha.ma.y Xi'an Jiaotong UniversityXi'an 710061China College of life Science Shanxi Normal UniversityTaiyuanChina Bota.ic Institute of Ba.celona.IBB) CSIC-CMCNBBarcelona 08038CataloniaSpain Escuela.de Ciencia. a.bienta.es Universidad Espíritu Santo(UEES)Samborondón 091650Ecuador Sha.nxi Engineering Resea.ch Centre for Conserva.ion a.d Utiliza.ion of Bota.ica. Resources Xi'an Botanical Garden of Shaanxi ProvinceXi'an 710061China School of Biologica. Sciences Guizhou Education UniversityGuiyangChina

China.is a.hotspot of relict pla.t species tha. were once widesprea. throughout the Northern *** resea.ch ha. demonstra.ed tha. the occurrence of long-term sta.le refugia.in the mounta.nous regions of centra. a.d south-western China.a.lowed their persistence through the la.e Neogene clima.e *** of these relict linea.es is dipteronia.a. oligotypic tree genus with a.fossil record extending to the ***,we investiga.ed the genetic va.ia.ility,demogra.hic dyna.ics a.d diversifica.ion pa.terns of the two currently recognized dipteronia.species(dipteronia.sinensis a.d ***).Molecula. da.a.were obta.ned from 45 popula.ions of dipteronia.by genotyping three cpdNa.regions,two single copy nuclea. genes a.d 15 simple sequence repea. *** genetic study wa. combined with niche compa.ison a.a.yses on the environmenta. spa.e,ecologica. niche modeling,a.d la.dsca.e connectivity *** found tha. the two dipteronia.species ha.e highly diverged both in genetic a.d ecologica. *** the incipient specia.ion processes tha. ca. be observed in ***,the occurrence of long-term sta.le refugia.a.d,pa.ticula.ly,a.dispersa. corridor a.ong da.a.Sha.-west Qinling,likely ensured its genetic a.d ecologica. integrity to *** study will not only help us to understa.d how popula.ions of dipteronia.species responded to the tectonic a.d clima.ic cha.ges of the Cenozoic,but a.so provide insight into how a.cto-Tertia.y relict pla.ts in Ea.t a.ia.survived,evolved,a.d diversified.

关键词： dipteronia Interspecific/intra.pecific divergence Genetic structure Clima.ic niche divergence dispersa. corridor

Promotion of structura. pla.ticity in a.ea.V2 of visua. cortex prevents a.a.nst object recognition memory deficits in a.ing a.d a.zheimer's disea.e rodents

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Neura. Regenera.ion Resea.ch 2024年第8期19卷 1835-1841页

作者： Irene Na.a.ro-loba.o Ma.ia. Ma.mudi-Ma.tín Ma.uel F.lópez-a.a.da.Jua. F.lópez-Téllez Gloria.delga.2} Pa.lo Gra.a.2}s-durán Celia.Ga.na.Romero Ma.ta.Ca.retero-Rey Sinforia.o Posa.a. Ma.ía.E.Quiros-Ortega.Za.a. U.Kha. la.ora.ory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain depa.tment of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investiga.ión Biomédica.en Red de Enfermeda.es Neurodegenera.iva.(CIBERNEd) Institute of Health Carlos IIIMadridSpain the donders Institute for Bra.n Cognition a.d Beha.iour Radboud UniversityNijmegenThe Netherlands the Bra.n Meta.ta.is Group National Cancer Research Centre(CNIO)MadridSpain the depa.tment of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often a.socia.ed with a.ing a.d ma.y psychia.ric,neurologica.,a.d neurodegenera.ive disea.es,ha. been a.cha.lenging issue for *** till now,a.l potentia. drug ca.dida.es ha.e fa.led to produce sa.isfa.ctory ***,in the sea.ch for a.solution,we found tha. a.trea.ment with the gene corresponding to the RGS14414protein in visua. a.ea.V2,a.bra.n a.ea.connected with bra.n circuits of the ventra. strea. a.d the media. tempora. lobe,which is crucia. for object recognition memory(ORM),ca. induce enha.cement of *** this study,we demonstra.ed tha. the sa.e trea.ment with RGS14414in visua. a.ea.V2,which is rela.ively una.fected in neurodegenera.ive disea.es such a. a.zheimer s disea.e,produced longla.ting enha.cement of ORM in young a.ima.s a.d prevent ORM deficits in rodent models of a.ing a.d a.zheimer’s ***,we found tha. the prevention of memory deficits wa. media.ed through the upregula.ion of neurona. a.bo riza.ion a.d spine density,a. well a. a. increa.e in bra.n-derived neurotrophic fa.tor(BdNF).a.knockdown of BdNF gene in RGS14414-trea.ed a.ing ra.s a.d a.zheimer s disea.e model mice ca.sed complete loss in the upregula.ion of neurona. structura. pla.ticity a.d in the prevention of ORM *** findings suggest tha. BdNF-media.ed neurona. structura. pla.ticity in a.ea.V2 is crucia. in the prevention of memory deficits in RGS14414-trea.ed rodent models of a.ing a.d a.zheimer’s ***,our findings of RGS14414gene-media.ed a.tiva.ion of neurona. circuits in visua. a.ea.V2 ha.e thera.eutic releva.ce in the trea.ment of memory deficits.

关键词： beha.iora. performa.ce bra.n-derived neurotrophic fa.tor cognitive dysfunction episodic memory memory circuit a.tiva.ion memory deficits memory enha.cement object recognition memory prevention of memory loss regula.or of G protein signa.ing

Resista.ce of full-sca.e bea.s a.a.nst close-in *** modeling a.d field tests

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defence Technology（防务技术） 2024年第10期40卷 35-47页

作者： a.Pra.0} a.a.a.ón R.Ca.tedo a.P.Sa.tos l.M.lópez M.Chiquito M.Bermejo C.Oggeri Escuela.Politécnica.Superior déa.ila Universidad de SalamancaÁvila05003Spain E.T.S.I.Mina. y Energía Universidad Politecnica de MadridMadrid28003Spain depa.tment of Engineering Aviation and TechnologySaint Louis UniversityMadrid28003Spain depa.tment of Environment Land and Infrastructure Engineering(DIATI)Politecnico di TorinoTorino10129Italy

This pa.er explores the performa.ces of a.finite element simula.ion including four concrete models a.plied to a.full-sca.e reinforced concrete bea. subjected to bla.t *** test da.a.ha. been used to compa.e model results for ea.h *** numerica. modelling ha. been,ca.ried out using the suita.le code *** code integra.es bla.t loa. routine(CONWEP)for the explosive description a.d four different ma.eria. models for the concrete including:Ka.a.ozia.&Ca.e Concrete,Winfrith,Continuous Surfa.e Ca. Model a.d RiedeleHierma.ereThoma.models,with concrete meshing ba.ed on 10,15,a.d 20 *** full-sca.e bea.s were tested:four of them used for the initia. ca.ibra.ion of the numerica. model a.d two more tests a. lower sca.ed *** ca.ibra.ion,field da.a.obta.ned employing pressure a.d a.celerometers tra.sducers were compa.ed with the results derived from the numerica. *** surfa.es a.d the sha.e of rupture in the bea.s ha.e been used a. references for *** of the meshing on a.celera.ions ha. been put in evidence a.d for some models the sha.e a.d size of the da.a.e in the bea.s produced ma.imum differences a.ound 15%.In a.l ca.es,the va.ia.ions between ma.eria. a.d mesh models a.e shown a.d discussed.

关键词： Bla.t test Numerica. simula.ion lS-dYNA Concrete model Mesh effect Full-sca.e bea.s

Semiotics a.d politica. discourse in the post-truth era

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la.gua.e a.d Semiotic Studies 2024年第1期10卷 65-82页

作者： BetülÇa.a.pına. Mura. Ka.elioğlu V.doğa. Güna. Istinye University IstanbulTürkiye School of Foreign la.gua.es T C Mardin Artuklu UniversityMardinTürkiye Fa.ulty of litera.ure Department of LinguisticsDokuz Eylül UniversityIzmirTürkiye

The concept of post-truth ha. been on the world’s a.enda.since *** this concept,which is frequently encountered in politica. life,provides the spea.er with a.freer spea.ing ***,instea. of presenting the rea.ity to their constituents a. it is,wa.t to resha.e this rea.ity a.cording to their own ideology a.d present it to the *** ha.e certa.n objectives in crea.ing such a.virtua. *** a.ms ca. be listed a. keeping the voters,increa.ing the voting potentia.,a.d a.tra.ting undecided voters to their *** common result of a.l these a.ms is to ga.n politica. power or to rema.n in the existing ***-truth rea.ity is constructed rela.ively more ea.ily in socia. media.*** construction of rea.ity ca. be through beliefs or *** such wa.s,the recipient is tried to be persua.ed,a.d thus beha.iora. cha.ge is *** of the most necessa.y subjects for this a.tificia. rea.ity a.mosphere is the *** idea.tha. the a.ti-subject does not know the truth tha. we(you a.d I)know a.d believe a.d is trying to destroy it is the ma.n theme of post-truth *** try to persua.e the voters to believe in their own truth by expressing this idea.to *** a.e ma.y exa.ples of this a.ound the *** this study,firstly,the concept of post-truth is exa.ined a.d its va.ious definitions a.e *** distinctions between the concepts of rea. a.d truth a.e a.a.yzed a.d then it is expla.ned how a.d for wha. purposes the concept of post-truth is used in *** the compa.ison of post-truth a.d fa.e news,the concept is discussed within the fra.ework of sender-receiver intera.tion in terms of *** concept is tried to be elucida.ed with the moda.ities such a./convincing/,/believing/,/being/,/a.pea.ing/.Besides,using the semiotic squa.e,the study a.so tries to revea. the different purposes a.d forms of use of the concept of *** a.result,it ha. been observed

关键词： semiotics discourse politics post-truth fa.e news

a.New Fra.ework for Softwa.e Vulnera.ility detection Ba.ed on a. a.va.ced Computing

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Computers, Ma.eria.s & Continua 2024年第6期79卷 3699-3723页

作者： Bui Va. Cong Cho do Xua. depa.tment of Informa.ion Technology University of Economics and Technical IndustriesHanoi100000Vietnam Fa.ulty of Informa.ion Security Posts and Telecommunications Institute of TechnologyHanoi100000Vietnam

The detection of softwa.e vulnera.ilities written in C a.d C++la.gua.es ta.es a.lot of a.tention a.d interest *** pa.er proposes a.new fra.ework ca.led drCSE to improve softwa.e vulnera.ility *** uses a. intelligent computa.ion technique ba.ed on the combina.ion of two methods:Reba.a.cing da.a.a.d representa.ion lea.ning to a.a.yze a.d eva.ua.e the code property gra.h(CPG)of the source code for detecting a.norma. beha.ior of softwa.e *** do tha.,drCSE performs a.combina.ion of 3 ma.n processing techniques:(i)building the source code fea.ure profiles,(ii)reba.a.cing da.a.a.d(iii)contra.tive *** which,the method(i)extra.ts the source code’s fea.ures ba.ed on the vertices a.d edges of the *** method of reba.a.cing da.a.ha. the function of supporting the tra.ning process by ba.a.cing the experimenta. ***,contra.tive lea.ning techniques lea.n the importa.t fea.ures of the source code by finding a.d pulling simila. ones together while pushing the outliers *** experiment pa.t of this pa.er demonstra.es the superiority of the drCSE Fra.ework for detecting source code security vulnera.ilities using the Verum *** a.result,the method proposed in the a.ticle ha. brought a.pretty good performa.ce in a.l metrics,especia.ly the Precision a.d Reca.l scores of 39.35%a.d 69.07%,respectively,proving the efficiency of the drCSE *** performs better tha. other a.proa.hes,with a.5%boost in Precision a.d a.5%boost in ***,this is considered the best resea.ch result for the softwa.e vulnera.ility detection problem using the Verum da.a.et a.cording to our survey to da.e.

关键词： Source code vulnera.ility source code vulnera.ility detection code property gra.h fea.ure profile contra.tive lea.ning da.a.reba.a.cing

Increa.ed CO2 levels during the First Ha.f of Incuba.ion a. High a.titude Modifies Embryonic development of Fertile leghorn Breeder Eggs

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Food a.d Nutrition Sciences 2024年第7期15卷 524-547页

作者： Ma.co a. Juárez-Estra.a.Erik I. lópez-Ruiz Sonia.lópez-Cordova.Guillermo Tellez-Isa.a. Oma. F. Pra.2}-Rebolledo depa.ta.ento de Medicina.y Zootecnia.de a.es Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autnoma de Mxico Ciudad de Mxico Mxico depa.tment of Poultry Science Division of Agriculture University of Arkansas Fayetteville USA Fa.ulta. de Medicina.Veterina.ia.y Zootecnia Universidad de Colima Tecomn Mxico

The excha.ge of oxygen (O2) a.d ca.bon dioxide (CO2) within a. incuba.or ha. a.significa.t impa.t on embryonic development (Ed) a.d ha.ching processes. This study exa.ines the influence of non-ventila.ion (NV) conditions during the first ten da.s of incuba.ion a. high a.titudes on leghorn hens ha.ching eggs. Five hundred four ha.ching eggs were equa.ly divided into three trea.ment groups a.d pla.ed in twelve incuba.ors (R = 4). The first group wa. subjected to sta.da.d ventila.ed conditions (V) during the setting pha.e. The ventila.ion inlet holes of the rema.ning incuba.ors in the NV trea.ments were closed with either micropore (M) or polypropylene (P) ta.e, referred to a. NVM a.d NVP groups, respectively. These two different a.rtight settings were intended to a.low for a.gra.ua. rise in CO2 na.ura.ly genera.ed by the embryos. Results indica.e tha. ca.bon dioxide concentra.ion gra.ua.ly increa.ed during the first ha.f of incuba.ion, rea.hing 1.42% in the NVM group a.d 1.20% in the NVP group, while the V condition group rema.ned a. 0.15%. From 10 da.s of incuba.ion onwa.ds, norma. V conditions were restored in a.l incuba.ors. The highest ha.cha.ility of fertile eggs (HFE) wa. shown by the NVP group (55.7%), followed by the V (52.6%) a.d NVM (38.6%) groups. The NVP group showed a.grea.er yolk-free body ma.s (YFBM) from 10 da.s of incuba.ion until the ha.ch ba.ket tra.sfer. NV conditions during the first 10 da.s of incuba.ion a. high a.titude produced higher YFBM with gra.ua.ly decrea.ing yolk sa. ma.s. In compa.ison to the NVM a.d V conditions, the pa.ticula. NVP condition showed a.beneficia. impa.t on the qua.ity of ha.ched chicks. Susta.ning NVP condition (1.2% of CO2) throughout the first ha.f of incuba.ion a. high a.titude genera.ed the optima. environment in the incuba.or ensuring the best ha.cha.ility results. This study highlights how importa.t it is for ha.chery ma.a.ers to recognize the influence of low O2 a.d high levels of CO2 on the development tra.ectori

关键词： Non-Ventila.ion Hyperca.nia Hypoxia Egg Ma.s loss Ha.cha.ility Embryonic Morta.ity Ha.chling Chick Qua.ity

Novel insights into d-Pinitol ba.ed thera.ies:a.link between ta. hyperphosphoryla.ion a.d insulin resista.ce

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Neura. Regenera.ion Resea.ch 2024年第2期19卷 289-295页

作者： dina.Medina.Vera.a.tonio Jesús lópez-Ga.bero Jua. a.tonio Na.a.ro Ca.los Sa.jua. Elena.Ba.xera. Jua. deca.a.Ferna.do Rodríguez de Fonseca Instituto de Investiga.ión Biomédica.de Mála.a.y Pla.a.orma.en Na.omedicina.IBIMa.Pla.a.orma.BIONa.d UGC Salud MentalMálagaSpain Fa.ulta. de Ciencia. Universidad de MálagaMálagaSpain CIBER Enfermeda.es Ca.diova.cula.es(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordea.x INSERMNeurocentre MagendieBordeauxFrance Euronutra.S.l.Ca.le Joha.nes Kepler MálagaSpain depa.ta.ento de Bioquímica.y Biología.Molecula. Facultad de MedicinaUniversidad de MálagaMálagaSpain

a.zheimer’s disea.e is a.neurodegenera.ive disorder cha.a.terized by the a.yloid a.cumula.ion in the bra.ns of pa.ients with a.zheimer’s *** pa.hogenesis of a.zheimer’s disea.e is ma.nly media.ed by the phosphoryla.ion a.d a.grega.ion of ta. *** the multiple ca.ses of ta. hyperphosphoryla.ion,bra.n insulin resista.ce ha. genera.ed much a.tention,a.d inositols a. insulin sensitizers,a.e currently considered ca.dida.es for drug *** present na.ra.ive review revises the intera.tions between these three elements:a.zheimer’s disea.e-ta.-inositols,which ca. eventua.ly identify ta.gets for new disea.e modifiers ca.a.le of bringing hope to the millions of people a.fected by this deva.ta.ing disea.e.

关键词： a.zheimer’s disea.e cyclin-dependent kina.e 5 dia.etes d-Pinitol inositols insulin resista.ce kina.es phosphoryla.ion PI3K/a.t ta.

Mea.uring Impa.t of lea. Ma.ufa.turing Tools for Continuous Improvement on Economic Susta.na.ility

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Journa. of Systems Science a.d Systems Engineering 2024年第4期33卷 452-474页

作者： luis Ja.ier Márquez Figueroa.Jorge luis Ga.cía.a.ca.a. a.med I.Osma. a.fonso Jesús Gil lópez Ya.ha. a.ya.fa. Mika.Silla.pää Ma.douh El Ha. a.sa. depa.tment of Electrica. Engineering a.d Computer Science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico depa.tment of Industria. Engineering a.d Ma.ufa.turing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico School of Chemistry a.d Chemica. Engineering Queens UniversityBelfastNorthern IrelandUK depa.tment of Economic a.d Ma.a.eria. Sciences University of La RiojaLa RiojaSpain depa.tment of Chemica. Engineering University of JohannesburgJohannesburgSouth Africa depa.tment of Susta.na.le a.d Renewa.le Energy Engineering University of SharjahSharjahUAE

Using lea. Ma.ufa.turing(lM)tools in production processes is crucia. for compa.ies’economic,environmenta.,a.d socia. susta.na.ility *** study shows a.structura. equa.ion model(SEM)tha. shows the rela.ionship between lM Tools like Ka.zen(Ka.),Gemba.GEM),Va.ue Strea. Ma.ping(VSM)a.d Key Performa.ce Indica.or(KPI)with Economic Susta.na.ility(ECS).Seven hypotheses were eva.ua.ed with da.a.from 179 responses to a.questionna.re a.out the Mexica. ma.uila.0}ra.industry,showing tha. these va.ia.les a.e *** a.95%confidence level,the model wa. eva.ua.ed using the pa.tia. lea.t squa.es *** findings indica.e tha. the rela.ionships between Ka. a.d GEM a.d Ka. a.d VSM ha.e the strongest rela.ionship,followed by VSM a.d ECS;however,VSM ha. the strongest effect on *** on these findings,it is recommended tha. ma.a.ers a.0}pt a.continuous improvement(Ka.)a.proa.h ba.ed on working directly on the shop floor(GEM a.d VSM)to support their decisions rega.ding economic growth(ECS).

关键词： lea. ma.ufa.turing economic susta.na.ility structura. equa.ion model qua.ity improvement