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Effect of hepatic iron concentration reduction on hepatic fibrosis and damage in rats with cholestatic liver disease

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World Journal of Gastroenterology 2006年第2期12卷 240-245页

作者： Gil Peretz Gabriela Link orit pappo Rafael Bruck Zvi Ackerman Department of Internal Medicine Hebrew University- Hadassah Medical CenterMount Scopus CampusJerusalemIsrael Department of Human Nutrition and Metabolism Hebrew University Hadassah Medical SchoolJerusalemIsrael Department of Pathology Hebrew University-Hadassah Medical CenterJerusalemIsrael Department of Gastroenterology and Hepatology The EWolfson Medical CenterHolonand Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

AIM： TO assess the effect of iron reduction after phlebotomy in rats with ＂normal＂ hepatic iron concentration （HIC） on the progression of hepatic fibrosis, as a result of bile duct ligation （BDL）. METHODS： Rats underwent phlebotomy before or after sham operation or BDL. Animals undergone only BDL or sham operation served as controls. Two weeks after surgery, indices of hepatic damage and fibrosis were evaluated. RESULTS： Phlebotomy lowered HIC. Phlebotomy after BDL was associated with body weight increase, lower hepatic weight, less portal hypertension, less periportal necrosis, less portal inflammation, lower hepatic activity index score and higher albumin levels. On the other hand, phlebotomy before BDL was associated with body weight decrease and hepatic activity index score increase. Phlebotomy after sham operation was not associated with any hepatic or systemic adverse effects. CONCLUSION： Reduction of HIC after induction of liver damage may have beneficial effects in BDL rats. However, iron deficiency could induce impairment of liver function and may make the liver more susceptible to insults like BDL.

关键词： Iron Phlebotomy Bile duct ligation Hepatic activity index Rat.

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Antioxidant therapy for chronic hepatitis C after failure of interferon:Results of phase Ⅱ randomized,double-blind placebo controlled clinical trial

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World Journal of Gastroenterology 2007年第40期13卷 5317-5323页

作者： Ezra Gabbay Ehud Zigmond orit pappo Nila Hemed Mina Rowe George Zabrecky Robert Cohen Yaron Ilan Liver Unit Department of Medicine Department of Pathology Hebrew UniversityHadassah Medical CenterJerusalem IL-91120Israel Marcus Foundation AtlantaUnited States

AIM： TO assess the safety and efficacy of antioxidant therapy for patients with chronic hepatitis C virus （HCV） infection.METHODS： One hundred chronic HCV infection patients failed in interferon treatment were enrolled and randomly assigned to receive combined intravenous and oral antioxidants or placebo, or oral treatment alone, Primary end points were liver enzymes, HCV-RNA levels and histology.RESULTS： Combined oral and intravenous antioxidant therapy was associated with a significant decline in ALT levels in 52% of patients who received antioxidant therapy vs 20% of patients who received placebo （P = 0.05）. Histology activity index （HAI） score at the end of treatment was reduced in 48% of patients who received antioxidant therapy vs 26% of patients who received placebo （P = 0.21）. HCV-RNA levels decreased by l-log or more in 28% of patients who received antioxidant therapy vs 12% who received placebo （P = NS）. In part 11 of the trial, oral administration of antioxidants was not associated with significant alterations in any of the end points.CONCLUSION： Antioxidant therapy has a mild beneficial effect on the inflammatory response of chronic HCV infection patients who are non-responders to interferon. Combined antiviral and antioxidant therapy may be beneficial for these patients.

关键词： Hepatitis C virus Antioxidant therapy Histology activity index Glycyrrhiza L-g utathione

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Late onset fulminant Wilson's disease:A case report and review of the literature

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World Journal of Gastroenterology 2014年第46期20卷 17656-17660页

作者： Ella Weitzman orit pappo Peretz Weiss Moshe Frydman Yael Haviv-Yadid Ziv Ben Ari Liver Disease Center Sheba Medical CenterRamat Gan 52621Israel Department of Pathology Sheba Medical CenterRamat Gan 52621Israel Institute of Genetics Sheba Medical CenterRamat Gan 52621Israel Intensive Care Unit Sheba Medical CenterRamat GanTel Aviv UniversityRamat Gan 52621Israel Sackler School of Medicine Tel Aviv UniversityTel Aviv 69975Israel

Wilson’s disease(WD)is an autosomal recessive inherited disorder of hepatic copper *** can be present in different clinical conditions,with the most common ones being liver disease and neuropsychiatric *** cases present symptoms at<40years of ***,few reports exist in the literature on patients in whom the disease presented beyond this *** this report,we present a case of late onset fulminant WD in a 58-year-old patient in whom the diagnosis was established clinically,by genetic analysis of the ATP7B gene disclosing rare mutations(G1099S and c.1707+3ins T)as well as by high hepatic copper *** also reviewed the relevant *** diagnosis of WD with late onset presentation is easily *** diagnostic features and the geneticbackground in patients with late onset WD are not different from those in patients with early onset WD,except for the *** treatments for this disorder that can be fatal are available and will prevent or reverse many manifestations if the disease is discovered early.

关键词： Wilson's disease Late onset Fulminant ATP7B gene mutations Copper

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