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Light(Science & Applications) 2015年第1期4卷 267-273页

作者： Jun Ho Son Byungrae Cho SoonGweon Hong Sang Hun Lee ori Hoxha Amanda J Haack Luke P Lee Department of Bioengineering University of CaliforniaBerkeleyCA 94720USA Berkeley Sensor and Actuator Center University of CaliforniaBerkeleyCA 94720USA Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCA 94720USA Biophysics Graduate Program University of CaliforniaBerkeleyCA 94720USA

Nucleic acid amplification and quantification via polymerase chain reaction(PCR)is one of the most sensitive and powerful tools for clinical laboratories,precision medicine,personalized medicine,agricultural science,forensic science and environmental *** multiplex PCR,characterized by low power consumption,compact size and simple operation,is ideal for timely diagnosis at the point-of-care(POC).Although several fast/ultrafast PCR methods have been proposed,the use of a simple and robust PCR thermal cycler remains challenging for POC ***,we present an ultrafast photonic PCR method using plasmonic photothermal light-to-heat conversion via photon–electron–phonon *** demonstrate an efficient photonic heat converter using a thin gold(Au)film due to its plasmon-assisted high optical absorption(approximately 65%at 450 nm,the peak wavelength of heat source light-emitting diodes(LEDs)).The plasmon-excited Au film is capable of rapidly heating the surrounding solution to over 150℃ within 3 *** this method,ultrafast thermal cycling(30 cycles;heating and cooling rate of 12.7960.93℃ s^(-1) and 6.660.29℃ s^(-1),respectively)from 55℃(temperature of annealing)to 95℃(temperature of denaturation)is accomplished within 5 *** photonic PCR thermal cycles,we demonstrate here successful nucleic acid(λ-DNA)*** simple,robust and low cost approach to ultrafast PCR using an efficient photonic-based heating procedure could be generally integrated into a variety of devices or procedures,including on-chip thermal lysis and heating for isothermal amplifications.

关键词： genomics light-emitting diodes(LEDs) molecular diagnostics personalized medicine plasmonics point-of-care(POC)diagnostics polymerase chain reaction(PCR)

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Blood loss,predictors of bleeding,transfusion practice and strategies of blood cell salvaging during liver transplantation

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World Journal of Hepatology 2013年第1期5卷 1-15页

作者： Feltracco Paolo Brezzi Marialuisa Barbieri Stefania Galligioni Helmut Milevoj Moira Carollo Cristiana ori Carlo Department of Medicine UO Anesthesia and Intensive Care University Hospital of PadovaVia Cesare Battisti25635128 PadovaItaly

Blood loss during liver transplantation (OLTx) is a common consequence of pre-existing abnormalities of the hemostatic system,portal hypertension with multiple collateral vessels,portal vein thrombosis,previous abdominal surgery,splenomegaly,and poor "functional" recovery of the new *** intrinsic coagulopathic features of end stage cirrhosis along with surgical technical difficulties make transfusion-free liver transplantation a major challenge,and,despite the improvements in understanding of intraoperative coagulation profiles and strategies to control blood loss,the requirements for blood or blood products remains *** impact of blood transfusion has been shown to be significant and independent of other well-known predictors of *** effects on immunomodulation and an increased risk of postoperative complications and mortality have been repeatedly *** hemodilution,the extensive utilization of thromboelastogram and the use of autotransfusion devices are among the commonly adopted procedures to limit the amount of blood *** use of intraoperative blood salvage and autologous blood transfusion should still be considered an important method to reduce the need for allogenic blood and the associated *** this article we report on the common preoperative and intraoperative factors contributing to blood loss,intraoperative transfusion practices,anesthesiologic and surgical strategies to prevent blood loss,and on intraoperative blood salvaging techniques and autologous blood *** though the advances in surgical technique and anesthetic management,as well as a better understanding of the risk factors,have resulted in a steady decrease in intraoperative bleeding,most patients still bleed *** transfusion therapy is still a critical feature during OLTx and various studies have shown a large variability in the use of blood products among different centers and even among indi

关键词： Transplantation surgery Liver dysfunction Liver transplant Intraoperative bleeding Intraoperative transfusion Autotransfusion Autologous transfusions Transfusion requirements Blood salvage Cell salvage

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互联网上的投资组合选择

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系统工程理论与实践 2002年第12期22卷 73-80页

作者：董纪昌汪寿阳徐山鹰邓小铁 Y.Nakam ori 中国科学院数学与系统科学研究院系统科学研究所北京100080 香港城市大学计算机科学系 School of Knowledge Science Japan Advanced Institute of Science and Technology

　讨论基于Internet(Browser/WebServer方式)的投资组合选择系统.首先简要地介绍了Markowitz投资组合理论以及互联网上构建投资组合的意义,接着分析构建投资组合的几种基于Browser/WebServer的系统和给出网上投资组合系统的一个应用实例... 详细信息

　讨论基于Internet(Browser/WebServer方式)的投资组合选择系统.首先简要地介绍了Markowitz投资组合理论以及互联网上构建投资组合的意义,接着分析构建投资组合的几种基于Browser/WebServer的系统和给出网上投资组合系统的一个应用实例,最后提出在互联网上构建投资组合值得关注的几个问题.

关键词：互联网投资组合选择股票证券市场 Internet

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Unusual Presenting Syndrome of Rheumatoid Arthritis Exacerbation

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Open Journal of Rheumatology and Autoimmune Diseases 2012年第1期2卷 1-2页

作者： Tatiana Reitblat Olga Reitblat ori Elkayam Department of Rheumatology Tel Aviv Medical Centre and The “Sackler” Faculty of Medicine Tel Aviv University Tel Aviv Israel. Rheumatology Unit Barzilai Medical Centre Ashkelon Israel

We herewith report the rare case of a patient with juvenile rheumatoid arthritis who developed on 2 occasions the clinical picture of an isolated unilateral palsy of the inferior oblique muscle—Brown’s syndrome, following pregnancies, each time in a different eye. Although the eye is frequently involved in rheumatoid arthritis (RA), the Brown’s syndrome is seldom reported in literature with regards to RA.

关键词： Brown’s Syndrome Juvenile Rheumatoid Arthritis Rheumatoid Arthritis

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The comparative efficacy of ezetimibe added to atorvastatin 10 mg versus uptitration to atorvastatin 40 mg in subgroups of patients aged 65 to 74 years or greater than or equal to 75 years

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Journal of Geriatric Cardiology 2011年第1期8卷 1-11页

作者： ori Ben-Yehuda Nanette K. Wenger Christian Constance Franklin Zieve Mary E. Hanson Jian-Xin Lin Arvind K. Shah Charlotte Jones-Burton Andrew M. Tershakovec University of California San Diego 200 West Arbor Drive La Jolla CA 92103 USA Emory University School of Medicine 49 Jess Hill Jr Dr SE Atlanta GA 30303 USA SHopital Maisonneuve-Rosemont Recherche Clinique/Polyclinique 5415 Boulevard de l＇Assomption Suite 295 Montreal Quebec QC H1T2M4 Canada McGuire VA Medical Center 1201 Broad Rock Blvd （151） Richmond VA 23249 USA Merck-Sharp ＆ Dohme One Merck Drive Whitehouse Station NJ 08889 USA

Background Coronary heart disease （CHD） risk increases with age; yet lipid-lowering therapies are significantly under-utilized in patients 〉 65 years. The objective was to evaluate the safety and efficacy of lipid-lowering therapies in older patients treated with atorvastatin 10 nag ＋ ezetimibe 10 mg （EZ/Atorva） vs. increasing the atorvastatin dose to 40 mg, Methods Patients 〉 65 years with atherosclerotic vascular disease （LDL-C ≥1.81 mmol/L） or at high risk for coronary heart disease （LDL-C 〉 2.59 mmol/L） were randomized to EZ/Atorva for 12 wk vs. uptitration to atorvastatin 20 nag for 6 wk followed by atorvastatin 40 nag for 6 wk. The percent change in LDL-C and other lipid parameters and percent patients achieving prespecified LDL-C levels were assessed after 12 wk. Results EZ/Atorva produced greater reductions in most lipid parameters vs. uptitration of atorvastatin in patients 〉 75 years （n = 228）, generally consistent with patients 65-74 years （n = 812）. More patients achieved LDL-C targets with combination therapy vs. monotherapy in both age groups at 6 wk and in patients 〉 75 years at 12 wk. At 12 wk, more patients 〉 75 years achieved LDL-C targets with monotherapy vs. combination therapy. EZ/Atorva produced more favorable improvements in most lipids vs. doubling or quadrupling the atorvastatin dose in patients 〉 75 years, generally consistent with the findings in patients 65-74 years. Conclusions Our results extended previous findings demonstrating that ezetimibe added to a statin provided a generally well-tolerated therapeutic option for improving the lipid profile in patients 65 to 74 years and 〉 75 years of age.

关键词： cholesterol absorption inhibitor LDL-C hypercholesterolemia statin

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Training in translational research for graduate students at the University of Toronto

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中国病理生理杂志 2009年第11期25卷 2242-2242页

作者： ori D. Rotstein Institute of Medical Science University of Toronto

The Institute of Medical Science (IMS) was established as an institute within the School of Graduate Studies at the University of Toronto in 1968 to serve as a graduate unit for the Clinical Departments in the Faculty of Medicine. In this role,the IMS offers a doctoral stream program in medical science leading to the Master of Science and Doctor of Philosophy degrees. Translational research,as a means of moving new discovery to improvement in patient outcome,has become a central theme of graduate education in our Institute. To this end,we have developed a curriculum offering which is intended to provide all new students with a defined skill set relevant to Translational Research and at the same time,to provide students with flexible offerings which would enhance their specific research programs. The course,spread over two years,will have three separate components:(1) there will be lectures focusing on research fundamentals and the basics of translational research; (2) there will be student presentations to hone presentation skills and get valuable feedback from fellow students and faculty mentors; (3) there will be elective modules,where students can select from a number of course offerings in order to round out training. These modules include subjects such as the fundamentals of clinical trials,the basics of qualitative research,an approach to the role of proteomics and genomics in research and the business of science. As part of this modular program,we have created a program 'clinical exposure for non-clinicians' with the hope that graduate students will be able to gain some understanding of the clinical relevance of their research activities. Over time,these modular offerings will be expanded based on a needs assessment from our students. The presentation will describe the IMS and its mission and will overview the structure and content of this course offering.

关键词：研究生教育多伦多大学转化型训练医学科学博士学位医学院硕士学位

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Toll样受体参与小鼠肝脏缺血再灌注损伤

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中华肝脏病杂志 2003年第7期11卷 424-426页

作者：吴河水王琳田元 ori Rotstein 华中科技大学同济医学院附属协和医院普外科武汉430022 华中科技大学同济医学院附属协和医院儿科武汉430022 Toronto General Research Institute University of TorontoTorontoCanada

目的探讨Toll样受体是否参与小鼠肝脏缺血再灌注损伤及其机制。方法用Toll样受体缺损小鼠(C3H/Hej,Hej组)和野生型(C3H/Heouj,Heouj组)小鼠复制部分肝脏缺血再灌注损伤模型,于缺血45min,再灌注1h和3h处死动物,检测血清天门冬氨酸氨基... 详细信息

目的探讨Toll样受体是否参与小鼠肝脏缺血再灌注损伤及其机制。方法用Toll样受体缺损小鼠(C3H/Hej,Hej组)和野生型(C3H/Heouj,Heouj组)小鼠复制部分肝脏缺血再灌注损伤模型,于缺血45min,再灌注1h和3h处死动物,检测血清天门冬氨酸氨基转移酶(AST)和血清肿瘤坏死因子α(TNFα)的含量;并以northern blot及髓过氧化物酶(MPO)试验分别检测缺血肝组织TNFα mRNA的表达和MPO的含量。结果(1)再灌注1、3h,与假手术组相比,小鼠血浆AST明显升高,但Hej组明显低于Heouj组(661.83U/L±106.09U/L和1215.5U/L±174.03U/L,t=-6.65,P<0.01;1145.17U/L±132.43U/L和2958.17U/L±186.81U/L,t=-5.57,P<0.01);(2)再灌注3h时,与假手术组相比,Hej组和Heouj组小鼠血清TNFα浓度明显升高,且前者明显低于后者(152.39pg/ml±43.3pg/ml和249.12pg/ml±51.89pg/ml,t=-3.13,P<0.05);(3)再灌注1h,除假手术组外,Hej组和Heouj组小鼠缺血肝组织内可见TNFα mRNA的表达,但前者的表达水平明显低于后者,杂交带密度分析显示两者之间差异有显著性(80.3±28.8与189.4±24.6,t=-3.25,P<0.05);(4)再灌注3h,与假手术组相比,Hej组和Heouj组小鼠缺血肝组织内MPO含量明显升高,且前者含量明显低于后者(0.059±0.004和0.173±0.025,F=33.49,P<0.01)。结?

关键词： Toll样受体小鼠肝脏缺血缺血再灌注损伤肝组织手术

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Development of a Virtual Environment for Simulation of a 3D Road Profile Using OpenCRG and MATLAB GUI

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Engineering（科研） 2021年第12期13卷 677-689页

作者： Théophile Roch ori N’Golo Mamadou Kone Sibiri Traore Université Felix Houphouë t Boigny de Cocody Laboratoire de Technologie UFR SSMT Cote d’Ivoire Institut Pédagogique National de l’Enseignement Technique et Professionnel (IPNETP) Département de Génie Mécanique Cote d’Ivoire

In vehicle dynamics, there are wide applications concerning the simulation of vehicles on roads. These simulation applications relate to vehicle driving, ride comfort and durability. An accurate prediction of simulation results requires reliability and efficiency of road representations. The MATLAB graphical user interface module, called MATLAB GUI, is used to develop virtual simulation laboratories that allow the user to interact with a computer program using graphical objects. In this context, the aim of this article is to use the MATLAB OpenCRG suite of tools and the MATLAB GUI to develop a virtual environment for simulating a 3D road profile. A three-dimensional model of a pothole with variable parameters is developed and integrated into the 3D road profile.

关键词： 3D Road Profile Pothole OpenCRG MATLAB GUI

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C++从入门到精通版

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1996年

作者：（美）Nathan Gurewich （美）ori Gurewich 方斌等译

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IBM WebSphere电子商务解决方案

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2001年

作者：（美）Ron Ben-Natan （美） ori Sasson 魏鸿等译

电子商务软件包全集:本书从基础入手，介绍了安装和运行WebSphere的方法，创建动态的、多功能的Web站点，使用WebSphere工具高效管理和共享站点文件，创建基于XML的应用等内容。

ISBN: (纸本)7115091315

关键词：网络服务器电子商务

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