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Understanding mechanisms of the pathogenesis of nonalcoholic fatty liver disease

World Journal of Gastroenterology 2010年第18期16卷 2223-2226页

作者： Metin Basaranoglu Serra Kayacetin Nevin Yilmaz Ertugrul Kayacetin orhan tarcin Abdullah Sonsuz Division of Gastroenterology Ankara Yüksek Ihtisas Hospital Department of Pathology Konya Education and Teaching Hospital Mugla University School of MedicineGI/Transplant Hepatology Division of Gastroenterology Meram Medical FacultySelcuk University Division of Gastroenterology Yeni Yüzyil University Division of Gastroenterology Cerrahpasa Medical FacultyIstanbul University

A central issue in the understanding of the pathogenesis of nonalcoholic fatty liver disease is the problem of the underlying mechanisms which are not fully *** the setting of excessive central adiposity,insulin resistance is the major underlying cause of fat accumulation in *** of the difficulties with human trials,several animal models have been developed for this purpose mainly characterized as follows:genetically disturbed or murine fatty liver,methionine-choline deficient diet fed or murine steatohepatitis,and high-fat or sucrose diet fed *** these animal models have provided useful information,none of them accurately reflect genetic,metabolic and biochemical characteristics of the human disease.

关键词： Nonalcoholic fatty liver disease Pathogenesis Rat Rodents

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Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats

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World Journal of Gastroenterology 2006年第42期12卷 6835-6841页

作者： Ali Riza Soylu Nurettin Aydogdu Umit Nusret Basaran Semsi Altaner orhan tarcin Nursal Gedik Hasan Umit Ahmet Tezel Gulbin Dokmeci Huseyin Baloglu Mevlut Ture Kemal Kutlu Kadir Kaymak Division of Gastroenterology Trakya University Edirne Turkey Department of Physiology Trakya University Edirne Turkey Department of Pediatric Surgery Trakya University Edirne Turkey Department of Pathology Trakya University Edirne Turkey Division of Gastroenterology Gumussuyu Military Hospital Istanbul Turkey Department of Biochemistry Kas?mpasa Naval Hospital Istanbul Turkey Department of Pathology Haydarpasa GATA/ Education Hospital Istanbul Turkey Department of Biostatistics Trakya University Edirne Turkey

AIM： To investigate whether antioxidants vitamin E and C can retard development of hepatic fibrosis in the bilian/obstructed rats. METHODS： Fifty Wistar albino rats were randomly assigned to 5 groups （10 rats in each）. Bile duct was ligated in 40 rats and they were treated as follows： group vitC, vitamin C 10 mg/kg sc daily; group vitE, vitamin E 15 mg/kg sc daily; group vitEC, both of the vitamins; bile duct-ligated （BDL, control） group, physiological saline sc. The fifth group was assigned to sham operation. At the end of fourth week, the rats were decapitated, and hepatic tissue biochemical collagen content and collagen surface area were measured. Hepatic tissue specimens were histopathologically evaluated according to Scheuer system. Serum hyaluronate levels were measured by ELISA method. RESULTS： Despite being higher than sham group, hepatic collagen level was significantly decreased in each of the vitC, vitE and vitEC groups （32.7 ± 1.2, 33.8 ± 2.9, 36.7 ± 0.5 ）μg collagen/mg protein, respectively） compared to BDL （48.3 ± 0.6 mg collagen/g protein）（P 〈 0.001 for each vitamin group）. Each isolated vitamin C, isolated vitamin E and combined vitamin E/C supplementation prevented the increase in hepatic collagen surface density （7.0% ± 1.1%, 6.2% ± 1.7%, 12.3% ± 2.0%, respectively） compared to BDL （17.4% ± 5.6%）（P 〈 0.05 for each）. The same beneficial effect of vitamin C, vitamin E and combined vitamin E/C treatment was also observed on the decrease of serum hyaluronate levels compared to BDL group （P 〈 0.001）. The relative liver and spleen weights, serum transaminases, cholestatic enzymes, bilirubins and histopathological inflammation scores were not different between the antioxidant treatment groups and the control. However, fibrosis staging scores were obviously reduced only in the vitamin E/C combination group （vit EC： 2.4 ± 0.8 vs BDL： 3.1 ± 0.7; P 〈 0.05）. CONCLUSION： Each antioxidant vitamin E, vitamin C and their combination retard hepatic fibrosis in bi

关键词： Hepatic fibrosis Biliary obstruction Collagen Vitamin E Vitamin C

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